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gel (37) 37
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aids (33) 33
inactivation (33) 33
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pregnancy (33) 33
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vagina - pathology (32) 32
dose-response relationship, drug (31) 31
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invitro (30) 30
vaginal microbicide (30) 30
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immunodeficiency-virus type-1 (29) 29
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vagina - microbiology (29) 29
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anti-hiv agents - pharmacology (27) 27
bacterial vaginosis (27) 27
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medicine, general & internal (27) 27
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cells, cultured (26) 26
hydrogen-ion concentration (26) 26
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contraceptive sponge (25) 25
double-blind method (25) 25
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vaginal creams, foams, and jellies - administration & dosage (25) 25
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anti-infective agents - pharmacology (23) 23
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Journal of Infectious Diseases, ISSN 0022-1899, 08/1999, Volume 180, Issue 2, pp. 426 - 437
To evaluate the effects of nonoxynol-9 (N-9) on the vaginal flora and epithelium, 48 women (16 in each group) were evaluated by use of quantitative vaginal... 
Nonoxynol-9
Journal Article
Journal Article
Contraception, ISSN 0010-7824, 12/2019, Volume 100, Issue 6, pp. 430 - 437
To evaluate a lactic-acid-containing diaphragm gel (Contragel®) approved outside the United States for use with a silicone rubber diaphragm (Caya®). The study... 
Caya | ContraGel | Diaphragm | Safety | Nonoxynol-9 | SILCS | VAGINAL MICROBICIDE | PREVENTION | ACCEPTABILITY | BACTERIAL VAGINOSIS | OBSTETRICS & GYNECOLOGY | BIOMARKERS | HIV | INFLAMMATION | SILCS DIAPHRAGM | IMMUNE MEDIATORS
Journal Article
AIDS, ISSN 0269-9370, 04/2011, Volume 25, Issue 7, pp. 957 - 966
Journal Article
The Journal of Infectious Diseases, ISSN 0022-1899, 11/2019, Volume 220, Issue 12, pp. 2009 - 2018
Vaginal lubricants are widely used both in-clinic and for personal use. Here, we employed monolayer and 3-dimensional vaginal epithelial cell models to show... 
INFECTIOUS DISEASES | MICROBIOLOGY | MICROBIOTA | PREVALENCE | IMMUNOLOGY | human vaginal epithelial cells | BACTERIAL VAGINOSIS | inflammatory mediators | genital inflammation | WOMEN | IN-VITRO | TRANSMISSION | INTRAVAGINAL PRACTICES | GRAM STAIN | 3-D cell culture | FEMALE SEX WORKERS | nonoxynol-9 | vaginal lubricants | cytotoxicity
Journal Article
Antiviral Therapy, ISSN 1359-6535, 2011, Volume 16, Issue 8, pp. 1219 - 1226
Background: A randomised, double-blind, placebo-controlled trial found the vaginal microbicide Carraguard unable to prevent HIV infection. A substudy assessed... 
INFECTIOUS DISEASES | TRANSMISSION | VIROLOGY | EFFICACY | NONOXYNOL-9 | PREVENTION | PHARMACOLOGY & PHARMACY
Journal Article
MedChemComm, ISSN 2040-2503, 2018, Volume 9, Issue 12, pp. 2106 - 2120
Here, we present an approach to novel hybrid biologically active compounds based on a combination of sterically hindered phenol and ammonium pharmacophores in... 
ISATIN | INACTIVATION | CHEMISTRY, MEDICINAL | VIRUS | ANTIOXIDANTS | NONOXYNOL-9 | DNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | TOXICITY | INHIBITOR | DERIVATIVES | AMINOPHOSPHONATES
Journal Article
mBio, ISSN 2161-2129, 11/2012, Volume 3, Issue 6
Vaginal HIV microbicides offer great promise in preventing HIV transmission, but failures of phase 3 clinical trials, in which microbicide-treated subjects had... 
CHLAMYDIA-TRACHOMATIS | FLORA | NONOXYNOL-9 | ACQUISITION | PREVENTION | NEISSERIA-GONORRHOEAE | MICROBIOLOGY | INFECTION | CELLULOSE SULFATE GEL | ASSOCIATION | BACTERIAL VAGINOSIS
Journal Article
Lancet, The, ISSN 0140-6736, 2007, Volume 370, Issue 9583, pp. 251 - 261
Journal Article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, 12/2014, Volume 24, Issue 24, pp. 5782 - 5786
A series of seventeen morpholin/piperidin-1-yl-carbamodithioate (3-19) were synthesized as topical vaginal microbicidal spermicides. The synthesized compounds... 
Trichomonas vaginalis | CHEMISTRY, MEDICINAL | Carbamodithioates | PREVENTION | CHEMISTRY, ORGANIC | Microbicidal | Nonoxynol-9 | MEDICINAL CHEMISTRY | TRICHOMONAS-VAGINALIS | HIV | MATCHED MOLECULAR PAIRS | AGENTS | INFECTION | TYPE-1 | DERIVATIVES | Spermicide | SPERM MOTILITY
Journal Article
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, ISSN 1868-596X, 2018, Volume 35, Issue 4, pp. 495 - 503
The HET-CAM (Hen's Egg Test-Chorioallantoic Membrane) assay is an in vitro alternative to the in vivo Draize rabbit eye test. This qualitative method assesses... 
MUCOADHESIVE | MEDICINE, RESEARCH & EXPERIMENTAL | IN-VITRO | REPLENS | DRUG-DELIVERY | PREDICT | NONOXYNOL-9 | MICROBICIDE | QUANTIFICATION | HET-CAM TEST | TOXICITY | Vagina | Physiological aspects | Product testing | Methods
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2010, Volume 5, Issue 2, p. e9310
Background: Tenofovir gel has entered into clinical trials for use as a topical microbicide to prevent HIV-1 infection but has no published data regarding... 
TOPICAL MICROBICIDES | SOUTH-AFRICA | MULTIDISCIPLINARY SCIENCES | FEMALE SEX WORKERS | CLINICAL-TRIALS | NONOXYNOL-9 VAGINAL GEL | DOUBLE-BLIND | NEISSERIA-GONORRHOEAE | RECTAL TRANSMISSION | EXPLANT CULTURE | PLACEBO-CONTROLLED TRIAL | Anti-HIV Agents - pharmacology | Colon - cytology | Humans | Colon - drug effects | Leukocytes, Mononuclear - virology | Rectum - virology | Tenofovir | HIV-1 - growth & development | Rectum - drug effects | Female | Colon - virology | Drug Evaluation, Preclinical | Caco-2 Cells | Cervix Uteri - drug effects | Cell Survival - drug effects | Adenine - analogs & derivatives | Leukocytes, Mononuclear - drug effects | Cervix Uteri - virology | Gels | HIV-1 - drug effects | Tissue Culture Techniques | Cells, Cultured | Adenine - pharmacology | Organophosphonates - pharmacology | Rectum - cytology | Leukocytes, Mononuclear - cytology | Cervix Uteri - cytology | Infection | Medical research | Algorithms | Microbiota (Symbiotic organisms) | Analysis | Medicine, Experimental | Permeability | HIV (Viruses) | Health aspects | Enzyme-linked immunosorbent assay | Viscosity | Immunohistochemistry | Epithelial cells | Prophylaxis | Clinical trials | Infections | Tissues | Prevention | Genital microflora | Microbicides | Acquired immune deficiency syndrome--AIDS | Human immunodeficiency virus--HIV | Safety | Explants | Effectiveness | Computer simulation | Vagina | Cultures | Data processing | Flora | Condoms | Osmotic pressure | Viability | Acquired immune deficiency syndrome | AIDS | HIV | Human immunodeficiency virus
Journal Article