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Methods in Molecular Biology, ISSN 1064-3745, 2016, Volume 1401, pp. 3 - 29
Journal Article
ChemBioChem, ISSN 1439-4227, 01/2019, Volume 20, Issue 2, pp. 147 - 152
Nonribosomal peptide synthetases (NRPSs) are responsible for the synthesis of a variety of bioactive natural products with clinical and economic significance.... 
natural product biosynthesis | molecular dynamic simulations | epimerization | enzyme inhibitors | nonribosomal peptide synthetase (NRPS) | MODULE | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CONDENSATION | ALANINE RACEMASE | Domains | Gramicidin | Peptides | Natural products | Amino acids | Crosslinking | Biosynthesis | Catalysis | Biological activity
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 02/2016, Volume 1401, pp. 273 - 278
Bioinformatic sequence analysis allows the functional characterization of newly sequenced proteins. Nonribosomal peptide synthetases (NRPSs) are multi-modular... 
Nonribosomal | Classifier | Synthetases | Bioinformatics | Peptide | NRPSsp | Protein Structure, Tertiary | Bacteria - metabolism | Bacteria - chemistry | Peptide Synthases - chemistry | Models, Biological | Protein Binding | Substrate Specificity | Bacteria - enzymology | Software | Internet | Proteomics - methods | Peptide Synthases - metabolism
Journal Article
Yaoxue Xuebao, ISSN 0513-4870, 07/2018, Volume 53, Issue 7, pp. 1080 - 1089
Journal Article
Journal of Bacteriology, ISSN 0021-9193, 11/2018, Volume 200, Issue 21
One mechanism by which bacteria and fungi produce bioactive natural products is the use of nonribosomal peptide synthetases (NRPSs). Many NRPSs in bacteria... 
Combinatorial biosynthesis | Nonribosomal peptide synthetase | MbtH-like protein | Myxococcus xanthus | Natural products | nonribosomal peptide synthetase | ADENYLATION | ACTIVATION | DOMAIN | TRANSCRIPTION | MICROBIOLOGY | IDENTIFICATION | natural products | combinatorial biosynthesis | STRUCTURAL BASIS | BIOSYNTHESIS | CLUSTER | DELETIONS
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 09/2014, Volume 53, Issue 38, pp. 10105 - 10108
Nonribosomal peptide synthetases (NRPSs) are multifunctional enzymes that produce a wide array of bioactive peptides. Here we show that a single... 
click chemistry | mutagenesis | nonribosomal peptide | adenylation domain | diketopiperazine
Journal Article
Applied and Environmental Microbiology, ISSN 0099-2240, 2019, Volume 85, Issue 13
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2002, Volume 99, Issue 19, pp. 12120 - 12125
The synthesis of the catecholic siderophore bacillibactin is accomplished by the nonribosomal peptide synthetase (NRPS) encoded by the dhb operon. DhbE is... 
Enzymes | Siderophores | Biological Sciences | Hydrogen bonds | Active sites | Substrate specificity | Crystals | Amino acids | Ligands | Enzyme substrates | Crystal structure | Antibiotic biosynthesis | X-ray crystal structure | Adenylation domain | Nonribosomal peptide synthesis | Siderophore formation | SITE | ANTIBIOTICS | antibiotic biosynthesis | FIREFLY LUCIFERASE | MULTIDISCIPLINARY SCIENCES | adenylation domain | RIFAMYCIN | nonribosomal pepticle synthesis | ADENYLATE-FORMING ENZYMES | BIOSYNTHESIS | siderophore formation | SUPERFAMILY | OPERON | PROTEINS | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Amino Acid Sequence | Catalytic Domain | Adenosine Monophosphate - metabolism | Models, Molecular | Molecular Sequence Data | Recombinant Proteins - chemistry | Substrate Specificity | Crystallography, X-Ray | Bacillus subtilis - enzymology | Recombinant Proteins - genetics | Static Electricity | Peptide Synthases - genetics | Amino Acid Motifs | Bacillus subtilis - genetics | Peptide Synthases - metabolism | Oligopeptides - biosynthesis | Sequence Homology, Amino Acid | Peptide Synthases - chemistry | Esters - chemistry | Cloning, Molecular | Protein Conformation | Oligopeptides - chemistry | Synthesis | Peptides | Ligases | Structure-activity relationship | Analysis | nonribosomal peptide synthesis
Journal Article
ACS Synthetic Biology, ISSN 2161-5063, 2019, Volume 8, Issue 4, pp. 661 - 667
Nonribosomal peptide synthetases assemble a considerable number of structurally complex peptides of pharmacological importance. This turns them into important... 
cyclodepsipeptides | natural products | nonribosomal peptide synthetase | protein engineering | combinatorial biosynthesis | MODULE | CYCLOHEXADEPSIPEPTIDES | BIOSYNTHESIS | CONSTRUCTION | ENNIATINS | BIOCHEMICAL RESEARCH METHODS
Journal Article