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Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2011, Volume 108, Issue 19, pp. 8003 - 8008
.... By combining cryoelectron microscopy analysis with a characterization of NS1 amphipathic properties, we show that the secreted NS1 hexamer forms a lipoprotein particle with an open-barrel protein... 
Molecules | Lipoproteins | Secretion | Dengue | HDL lipoproteins | Lipids | Triglycerides | Dengue virus | Detergents | Fatty acids | Amphiphilic proteins | Dengue hemorrhagic fever | Arbovirus | amphiphilic proteins | CELLS | RNA | FORM | GLYCOPROTEIN NS1 | MULTIDISCIPLINARY SCIENCES | arbovirus | PATHOGENESIS | dengue hemorrhagic fever | secretion | LIPID PROFILE | ENCEPHALITIS | WEST-NILE | FEVER | REVEALS | Cell Line | Protein Subunits | Recombinant Proteins - ultrastructure | Drosophila | Humans | Protein Multimerization | Dengue Virus - ultrastructure | Cercopithecus aethiops | Models, Molecular | Recombinant Proteins - chemistry | Dengue Virus - chemistry | Cryoelectron Microscopy | Lipoproteins, HDL - ultrastructure | Viral Nonstructural Proteins - chemistry | Animals | Computer Simulation | HEK293 Cells | Protein Structure, Quaternary | Lipoproteins, HDL - chemistry | Nuclear Magnetic Resonance, Biomolecular | Imaging, Three-Dimensional | Viral Nonstructural Proteins - ultrastructure | Vero Cells | Dengue viruses | Genetic aspects | Lipid metabolism | Viral Nonstructural Proteins/ultrastructure | Lipoproteins, HDL/ultrastructure | Life Sciences | Recombinant Proteins/chemistry | Lipoproteins, HDL/chemistry | Viral Nonstructural Proteins/chemistry | Dengue Virus/ultrastructure | Dengue Virus/chemistry | Recombinant Proteins/ultrastructure | Microbiology and Parasitology | Biological Sciences
Journal Article
PLoS pathogens, ISSN 1553-7374, 2013, Volume 9, Issue 4, p. e1003256
Influenza A virus (IAV) triggers a contagious and potentially lethal respiratory disease. A protective IL-1 beta response is mediated by innate receptors in... 
INTERLEUKIN-1 | RNA | RESPIRATORY VIRAL-INFECTION | INNATE IMMUNE-RESPONSE | RIG-I | MICROBIOLOGY | INDUCTION | NS1 PROTEIN | ANTIVIRAL RESPONSES | INTERFERON | VIROLOGY | EPITHELIAL-CELLS | PARASITOLOGY | Epithelial Cells - metabolism | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Caspase 1 - metabolism | Male | Tripartite Motif Proteins | Lung - virology | RNA Interference | Respiratory Mucosa - immunology | HEK293 Cells | Cytoskeletal Proteins - metabolism | Lung - metabolism | Toll-Like Receptor 3 - genetics | DEAD-box RNA Helicases - metabolism | Influenza A Virus, H1N1 Subtype - metabolism | Macrophages - immunology | DEAD Box Protein 58 | Respiratory Mucosa - cytology | Signal Transduction | Cells, Cultured | Ubiquitin-Protein Ligases - metabolism | Ferrets | Toll-Like Receptor 3 - metabolism | Transcription Factors - metabolism | Carrier Proteins - genetics | DEAD-box RNA Helicases - genetics | Animals | Carrier Proteins - metabolism | Interferon-beta - metabolism | Caspase 1 - genetics | CARD Signaling Adaptor Proteins | Viral Nonstructural Proteins - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Cytoskeletal Proteins | Toll-Like Receptor 3 | Interferon-beta | Lung | Macrophages | Life Sciences | Influenza A Virus, H1N1 Subtype | Caspase 1 | Carrier Proteins | Viral Nonstructural Proteins | DEAD-box RNA Helicases | Inflammasomes | Respiratory Mucosa | Epithelial Cells | Virology | Ubiquitin-Protein Ligases | Microbiology and Parasitology | Adaptor Proteins, Signal Transducing | Transcription Factors | Proteins | Medical research | Experiments | Respiratory diseases | Influenza
Journal Article
PLoS pathogens, ISSN 1553-7374, 2011, Volume 7, Issue 2, p. e1001278
Journal Article
Biochimica et biophysica acta. Biomembranes, ISSN 0005-2736, 2011, Volume 1808, Issue 2, pp. 510 - 515
Viral ion channels are short membrane proteins with 50–120 amino acids and play an important role either in regulating virus replication, such as virus entry... 
Viral ion channels | HIV-1 | Picornavirus | Coronavirus | Influenza | HCV | PBCV-1 | COXSACKIEVIRUS 2B PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEPATITIS-C-VIRUS | M2 PROTEIN | ESCHERICHIA-COLI-CELLS | BIOPHYSICS | INFLUENZA-A VIRUS | CORONAVIRUS ENVELOPE PROTEIN | MODULATING CYCLOPHILIN LIGAND | VPU PROTEIN | M-2 PROTON CHANNEL | INTEGRAL MEMBRANE GLYCOPROTEIN | Viral Matrix Proteins - genetics | Humans | Ion Channels - genetics | Ion Channels - drug effects | Viral Proteins - metabolism | Potassium Channels - metabolism | Viral Nonstructural Proteins - chemistry | Human Immunodeficiency Virus Proteins - chemistry | Viral Envelope Proteins - metabolism | Viral Matrix Proteins - metabolism | Viral Proteins - drug effects | Ion Channels - chemistry | Antiviral Agents - pharmacology | Viral Envelope Proteins - genetics | Viral Proteins - chemistry | Viral Regulatory and Accessory Proteins - genetics | Viral Nonstructural Proteins - genetics | Viral Proteins - genetics | Viral Regulatory and Accessory Proteins - metabolism | Potassium Channels - genetics | Host-Pathogen Interactions | Human Immunodeficiency Virus Proteins - metabolism | Animals | Ion Channels - metabolism | Viral Matrix Proteins - chemistry | Viral Envelope Proteins - chemistry | Human Immunodeficiency Virus Proteins - genetics | Potassium Channels - chemistry | Viral Nonstructural Proteins - metabolism | Viral Regulatory and Accessory Proteins - chemistry | Virus diseases | Ion channels | Viral proteins | Hepatitis C virus | Membrane proteins
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2012, Volume 338, Issue 6108, pp. 810 - 814
Fluorescent proteins (FPs) are widely used as optical sensors, whereas other light-absorbing domains have been used for optical control of protein localization or activity... 
Proteins | Enzymes | Delta cells | NIH 3T3 cells | REPORTS | Fluorescence | Pseudopodia | Dimers | Cell membranes | Optical control | P branes | SPATIOTEMPORAL CONTROL | ACTIVATION | GTPASES | MULTIDISCIPLINARY SCIENCES | LIGHT | INDUCTION | EXCHANGE FACTORS | LOV DOMAIN | LIVING CELLS | MOTILITY | Darkness | NIH 3T3 Cells | Pseudopodia - ultrastructure | Native Polyacrylamide Gel Electrophoresis | Humans | Protein Multimerization | Adaptor Proteins, Vesicular Transport - genetics | Optogenetics | Adaptor Proteins, Vesicular Transport - metabolism | Recombinant Fusion Proteins - metabolism | Viral Nonstructural Proteins - chemistry | Light | Protein Engineering | Serine Endopeptidases - genetics | Luminescent Proteins - chemistry | Adaptor Proteins, Vesicular Transport - chemistry | Cell Membrane - metabolism | Protein Structure, Tertiary | Models, Molecular | Viral Nonstructural Proteins - genetics | Serine Endopeptidases - chemistry | Recombinant Fusion Proteins - chemistry | Animals | Pseudopodia - metabolism | Recombinant Fusion Proteins - genetics | Luminescent Proteins - genetics | Protein Conformation | Viral Nonstructural Proteins - metabolism | Mice | Serine Endopeptidases - metabolism | HeLa Cells | Luminescent Proteins - metabolism | Physiological aspects | Photoreception | Research | Fluorescent proteins | Sensors | Cellular biology | Activated | Exposure | Optical sensors | Detection
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2017, Volume 292, Issue 44, pp. 18024 - 18043
Non-structural protein 5B (NS5B) is the RNA-dependent RNA polymerase that catalyzes replication of the hepatitis C virus (HCV... 
NONNUCLEOSIDE INHIBITORS | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | allosteric regulation | RNA-protein interaction | MOLECULAR-WEIGHT PROTEINS | VIRAL REPLICATION | RELAXATION DISPERSION EXPERIMENTS | REPLICATION COMPARTMENT | METHYL-TROSY | STRUCTURAL BASIS | nuclear magnetic resonance (NMR) | NONSTRUCTURAL PROTEIN | FUZZY COMPLEXES | protein-protein interaction | protein dynamic | Triazoles - chemistry | RNA Replicase - metabolism | RNA Replicase - antagonists & inhibitors | Antiviral Agents - metabolism | Pyrones - pharmacology | Pyrones - chemistry | Viral Nonstructural Proteins - chemistry | Isoleucine - chemistry | Oligoribonucleotides - metabolism | Antiviral Agents - chemistry | Enzyme Inhibitors - chemistry | Gene Deletion | Nuclear Magnetic Resonance, Biomolecular | Protein Interaction Domains and Motifs | Oligoribonucleotides - chemistry | Peptide Fragments - genetics | Allosteric Regulation - drug effects | Recombinant Proteins - metabolism | Antiviral Agents - pharmacology | Peptide Fragments - metabolism | Mutagenesis, Site-Directed | Enzyme Inhibitors - metabolism | RNA Replicase - genetics | Allosteric Site - drug effects | Enzyme Inhibitors - pharmacology | Solubility | Models, Molecular | Protein Refolding - drug effects | Recombinant Proteins - chemistry | Viral Nonstructural Proteins - genetics | Intrinsically Disordered Proteins - genetics | Triazoles - pharmacology | Point Mutation | Triazoles - metabolism | Hepacivirus - enzymology | Peptide Fragments - chemistry | Intrinsically Disordered Proteins - chemistry | Peptide Fragments - antagonists & inhibitors | RNA Replicase - chemistry | Protein Conformation | Viral Nonstructural Proteins - metabolism | Pyrones - metabolism | Viral Nonstructural Proteins - antagonists & inhibitors | Intrinsically Disordered Proteins - metabolism | Life Sciences | Biomolecules | Biochemistry, Molecular Biology | Molecular Bases of Disease
Journal Article
Cancer cell, ISSN 1535-6108, 2004, Volume 6, Issue 6, pp. 611 - 623
ONYX-015 is an adenovirus that lacks the E1B-55K gene product for p53 degradation. Thus, ONYX-015 was conceived as an oncolytic virus that would selectively... 
NUCLEAR-LOCALIZATION | APOPTOSIS | CHROMOSOME-TRANSLOCATION | REPLICATION | MESSENGER-RNA | ONCOLOGY | E1B 55-KILODALTON PROTEIN | TIME QUANTITATIVE PCR | ADENOVIRUS E4ORF6 | TRANSLATION | NUCLEOPORIN GENE | CELL BIOLOGY | Gene Expression - genetics | Virus Replication - genetics | Humans | Viral Proteins - metabolism | Cytopathogenic Effect, Viral - genetics | Caspase 3 | RNA Transport | Capsid Proteins - metabolism | HCT116 Cells | Cell Cycle Proteins - metabolism | In Situ Hybridization, Fluorescence | Caspase Inhibitors | Blotting, Western | Proto-Oncogene Proteins c-mdm2 | Models, Biological | Adenovirus E1A Proteins - genetics | Epithelial Cells - virology | Viral Nonstructural Proteins - metabolism | Adenoviruses, Human - genetics | Adenoviridae - metabolism | Mutation | Adenoviruses, Human - metabolism | Capsid Proteins - genetics | Neoplasms - metabolism | Epithelial Cells - metabolism | DNA, Viral - biosynthesis | Neoplasms - virology | Caspases - metabolism | Neoplasms - genetics | Adenovirus E1A Proteins - metabolism | Polymerase Chain Reaction | Adenoviridae - genetics | Cell Cycle Proteins - genetics | Protein Biosynthesis - genetics | RNA, Viral - metabolism | Adenovirus E1B Proteins - metabolism | Nuclear Proteins - genetics | Adenovirus E1B Proteins - genetics | Proto-Oncogene Proteins - metabolism | Epithelial Cells - radiation effects | Cyclin-Dependent Kinase Inhibitor p21 | Cells, Cultured | Tumor Suppressor Protein p53 - metabolism | Viral Nonstructural Proteins - genetics | Viral Plaque Assay | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | bcl-2-Associated X Protein | Poly(ADP-ribose) Polymerases - metabolism | Viral Vaccines | Tumor Suppressor Protein p14ARF - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Apoptosis
Journal Article
Virology, ISSN 0042-6822, 2008, Volume 370, Issue 2, pp. 295 - 309
.... Nonstructural protein 3 (NS3) of HCV possesses serine protease, nucleoside triphosphatase, and helicase activities, while NS4A functions as a cofactor for the NS3 serine protease... 
Infectious Disease | Double-strand DNA breaks | γ-H2AX foci | Ataxia-telangiectasia mutated | Nonstructural protein NS3/4A | Oncogenesis | Hepatitis C virus | DNA repair | double-strand DNA breaks | DOUBLE-STRAND BREAKS | CELL-LINES | DAMAGE | NUCLEAR-LOCALIZATION | gamma-H2AX foci | VIROLOGY | HISTONE H2AX PHOSPHORYLATION | GENE | oncogenesis | IN-VIVO | hepatitis C virus | ataxia-telangiectasia mutated | INFECTION | nonstructural protein NS3/4A | ADAPTER PROTEIN | RNA-POLYMERASE | Phosphorylation | Humans | DNA Repair - physiology | Hepacivirus - genetics | Cytoplasm - metabolism | Hepacivirus - pathogenicity | Cell Cycle Proteins - chemistry | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Viral Proteins - physiology | Cell Cycle Proteins - genetics | Hepacivirus - physiology | Binding Sites | Carrier Proteins - physiology | Recombinant Proteins - metabolism | Cell Line | DNA-Binding Proteins - physiology | Protein-Serine-Threonine Kinases - physiology | Protein-Serine-Threonine Kinases - genetics | Recombinant Proteins - chemistry | Viral Nonstructural Proteins - genetics | Viral Proteins - genetics | Recombinant Proteins - genetics | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | Viral Nonstructural Proteins - physiology | Carrier Proteins - genetics | Tumor Suppressor Proteins - physiology | Radiation Tolerance - physiology | Protein-Serine-Threonine Kinases - chemistry | HeLa Cells | Cell Cycle Proteins - physiology | Replicon | Genetic research | Hepatitis C | Proteases | DNA | Radiation | HEPATOMAS | NUCLEOSIDES | IONIZING RADIATIONS | DNA DAMAGES | LYMPHOMAS | IRRADIATION | RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS | HEPATITIS | SERINE | DNA REPAIR | RADIOSENSITIVITY | PROTEINS | VIRUSES
Journal Article
Structure (London), ISSN 0969-2126, 2017, Volume 25, Issue 2, pp. 219 - 230
...). Here, we present a structural characterization of the molecular complexes formed by the non-structural 3A proteins from two species of the Kobuvirus genus of the Picornaviridae family and the 3A... 
molecular dynamics simulations | Aichivirus | GOLD | ACBD3 | Kobuvirus | structure | RECRUITMENT | POLIOVIRUS 3A | COMPLEX | DOMAIN | RNA REPLICATION | ORGANELLES | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | BIOPHYSICS | DYNAMICS | AICHI VIRUS | PI4KIII-BETA | BINDING | Adaptor Proteins, Signal Transducing - chemistry | Virus Replication - genetics | Humans | Crystallography, X-Ray | Kobuvirus - metabolism | Unilamellar Liposomes - chemistry | Kobuvirus - genetics | Viral Nonstructural Proteins - chemistry | Cloning, Molecular | Membrane Proteins - metabolism | Protein Interaction Domains and Motifs | Protein Stability | Binding Sites | Recombinant Proteins - metabolism | Cell Line | Protein Conformation, alpha-Helical | Gene Expression | Membrane Proteins - genetics | Recombinant Proteins - chemistry | Viral Nonstructural Proteins - genetics | Recombinant Proteins - genetics | Molecular Dynamics Simulation | Amino Acid Motifs | Host-Pathogen Interactions | Membrane Proteins - chemistry | Protein Conformation, beta-Strand | Adaptor Proteins, Signal Transducing - genetics | Protein Binding | Viral Nonstructural Proteins - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Proteins | Antiviral agents | RNA | Crystals | Molecular dynamics | Structure | Protein binding
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 6/2016, Volume 113, Issue 24, pp. E3403 - E3412
Type I IFNs are key cytokines mediating innate antiviral immunity. cGMP-AMP synthase, ritinoic acid-inducible protein 1 (RIG... 
Signaling | Innate immunity | Type I interferon | Transcription factor | Crystal structure | transcription factor | CYCLIC GMP-AMP | signaling | RECOGNITION | MECHANISM | PHOSPHORYLATION | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | DIMERIZATION | type I interferon | 2ND-MESSENGER | innate immunity | crystal structure | DEGRADATION | RECEPTORS | INSIGHTS | Adaptor Proteins, Signal Transducing - chemistry | Humans | Adaptor Proteins, Vesicular Transport - genetics | Rotavirus - immunology | Rotavirus - genetics | CREB-Binding Protein - chemistry | Rotavirus - chemistry | Rotavirus Infections - genetics | Interferon Regulatory Factor-3 - genetics | CREB-Binding Protein - genetics | Viral Nonstructural Proteins - chemistry | Adaptor Proteins, Signal Transducing - immunology | Interferon Regulatory Factor-3 - chemistry | Protein Domains | Adaptor Proteins, Vesicular Transport - chemistry | Interferon Regulatory Factor-3 - immunology | Viral Nonstructural Proteins - immunology | Membrane Proteins - genetics | Viral Nonstructural Proteins - genetics | Membrane Proteins - immunology | Adaptor Proteins, Vesicular Transport - immunology | Immunity, Innate | Amino Acid Motifs | Rotavirus Infections - immunology | Immune Evasion | Membrane Proteins - chemistry | Adaptor Proteins, Signal Transducing - genetics | CREB-Binding Protein - immunology | Phosphates | Cytokines | Observations | Health aspects | Protein-protein interactions | Immunoproteins | BASIC BIOLOGICAL SCIENCES | 60 APPLIED LIFE SCIENCES | Biological Sciences | PNAS Plus
Journal Article
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