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Current Drug Targets, ISSN 1389-4501, 05/2016, Volume 17, Issue 6, pp. 702 - 719
The increasing multi-drug resistance has become a major threat to the public health. Overexpression of multidrug efflux pumps is one of the major mechanisms of... 
MexAB-OprM | Efflux pumps | Multi-drug resistance | Efflux pump inhibitors | NorA | AcrAB-TolC | ANTIBIOTIC EFFLUX | NORA MULTIDRUG TRANSPORTER | ENTEROBACTER-AEROGENES | ESCHERICHIA-COLI | ANTIMICROBIAL RESISTANCE | GRAM-NEGATIVE BACTERIA | PSEUDOMONAS-AERUGINOSA | IN-VIVO | PHARMACOLOGY & PHARMACY | STAPHYLOCOCCUS-AUREUS | efflux pumps | efflux pump inhibitors
Journal Article
ChemMedChem, ISSN 1860-7179, 08/2017, Volume 12, Issue 16, pp. 1293 - 1302
Journal Article
Medicinal Research Reviews, ISSN 0198-6325, 11/2019, Volume 39, Issue 6, pp. 2460 - 2504
Bacterial infections are an increasingly serious issue worldwide. The inability of existing therapies to treat multidrug‐resistant pathogens has been... 
AcrAB‐TolC | efflux pump inhibitor | structure‐activity relationship | MexAB‐OprM | NorA | bacterial resistance | multidrug efflux systems
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2018, Volume 61, Issue 17, pp. 7827 - 7848
Antimicrobial resistance (AMR) represents a hot topic in drug discovery. Besides the identification of new antibiotics, the use of nonantibiotic molecules to... 
IN-VITRO | BACTERIA | CHEMISTRY, MEDICINAL | NORA | ANTIBIOTIC-RESISTANCE | BIOLOGICAL EVALUATION | FLUOROQUINOLONE RESISTANCE | GENETICALLY RELATED STRAINS | STAPHYLOCOCCUS-AUREUS | MULTIDRUG EFFLUX | BIOFILM FORMATION | Index Medicus
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 01/2019, Volume 27, Issue 2, pp. 343 - 353
[Display omitted] •Synthesis of amino acid conjugates of 3-(1-chloro-3,4-dihydronaphthalen-2-yl) acrylic acid.•Screening for NorA inhibitors against... 
Ethidium bromide | NorA efflux pump inhibitors | Amino acids | Antibacterial | Tetralone | Ciprofloxacin | Staphylococcus aureus | STRAINS | ANTIBIOTICS | CHEMISTRY, MEDICINAL | ANALOGS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PIPERINE | CHEMISTRY, ORGANIC | MECHANISMS | POTENT | EVOLUTION | BIOLOGICAL EVALUATION | RESISTANCE
Journal Article
PLoS One, ISSN 1932-6203, 2011, Volume 6, Issue 4, p. e18127/1
Background: Traditional antibiotics are increasingly suffering from the emergence of multidrug resistance amongst pathogenic bacteria leading to a range of... 
PLANT | TRANSPORTER | NORA | CHLOROGENIC ACID | ANALOGS | MULTIDISCIPLINARY SCIENCES | BERBERINE | ANTIBIOTIC-ACTIVITY | MULTIDRUG-RESISTANCE | IDENTIFICATION | DERIVATIVES | Anti-Infective Agents - toxicity | Hemolysis - drug effects | Plant Extracts - chemistry | Gram-Positive Bacteria - physiology | Plant Extracts - toxicity | Gram-Positive Bacteria - drug effects | Plant Extracts - pharmacology | Anti-Infective Agents - pharmacology | Drug Resistance, Multiple - drug effects | Humans | Berberine - metabolism | ATP-Binding Cassette Transporters - chemistry | Anti-Infective Agents - chemistry | ATP-Binding Cassette Transporters - metabolism | Quinic Acid - pharmacology | Biofilms - drug effects | Quinic Acid - analogs & derivatives | Quinic Acid - toxicity | Artemisia absinthium - chemistry | Models, Molecular | Quinic Acid - chemistry | Drug Synergism | Gram-Positive Bacteria - metabolism | Animals | Protein Conformation | Anti-Bacterial Agents - pharmacology | Drug resistance in microorganisms | Biological products | Antibiotics | Analysis | Nuclear magnetic resonance spectroscopy | Bacteria | Liquid chromatography | Health aspects | Mass spectrometry | Infection control | Potentiation | Health sciences | Antimicrobial activity | Nuclear magnetic resonance--NMR | Gram-positive bacteria | Clinical isolates | Cytotoxicity | Antiinfectives and antibacterials | Magnetic resonance spectroscopy | Proteins | Microorganisms | Caffeoylquinic acid | Docking | Columns (structural) | Efflux | Spectroscopy | Pathogens | Berberine | Purification | Dermatology | Bioassays | Multidrug resistance | Antimicrobial agents | Mass spectroscopy | Glycoproteins | Chlorogenic acid | Chemical compounds | Substrates | Plant extracts | Medicine | Hospitals | Biofilms | Molecular modelling | Inhibitors | Acids | Magnetic permeability | Natural products | Phenols | phenolic compounds | Infection | N.M.R | chlorogenic acid | derivatives | multidrug-resistance | antibiotic-activity | nora | transporter | protein | analogs | chlorogenic acids | staphylococcus-aureus | berberine | Nuclear magnetic resonance | NMR
Journal Article
Journal Article
FRONTIERS IN GENETICS, ISSN 1664-8021, 01/2019, Volume 9, p. 710
NorA is the best studied efflux system of Staphylococcus aureus and therefore frequently used as a model for investigating efflux-mediated resistance in this... 
MUTAGENESIS | norA | SUSCEPTIBILITY | FLUOROQUINOLONE RESISTANCE | variability | efflux | ANTIMICROBIAL RESISTANCE | BIOCIDES | OVEREXPRESSION | FREQUENCY | GENETICS & HEREDITY | CHLORHEXIDINE | EXPRESSION | Staphylococcus aureus | NUCLEOTIDE-SEQUENCE | alleles | Genetic aspects | Clinical coding | Research | Biological diversity
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2008, Volume 16, Issue 22, pp. 9847 - 9857
Piperine analogs derived from piperine have been shown to possess potent efflux pump inhibitory activity against NorA system of Staphylococcus aureus having... 
Piperine analogs | Ciprofloxacin | NorA efflux pumps inhibitor | Potentiator | CHEMISTRY, MEDICINAL | MEDIATED DRUG-RESISTANCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANTIBACTERIAL | CHEMISTRY, ORGANIC | FLUOROQUINOLONE RESISTANCE | MULTIPLE | P-GLYCOPROTEIN | MULTIDRUG-RESISTANCE | DERIVATIVES | STRAIN | MOLECULAR-MECHANISMS | AMIDES | Polyunsaturated Alkamides - chemistry | Nucleic Acid Synthesis Inhibitors - pharmacology | Alkaloids - chemical synthesis | Ethidium - metabolism | Microbial Sensitivity Tests | Piperidines - pharmacology | Anti-Bacterial Agents - chemistry | Benzodioxoles - chemistry | Benzodioxoles - chemical synthesis | Polyunsaturated Alkamides - chemical synthesis | Staphylococcus aureus - metabolism | Bacterial Proteins - antagonists & inhibitors | Piperidines - chemistry | Alkaloids - pharmacology | Enzyme Inhibitors - pharmacology | Ciprofloxacin - pharmacology | Multidrug Resistance-Associated Proteins - antagonists & inhibitors | Piperidines - chemical synthesis | Nucleic Acid Synthesis Inhibitors - chemistry | Polyunsaturated Alkamides - pharmacology | Ciprofloxacin - chemistry | Bacterial Proteins - metabolism | Anti-Bacterial Agents - pharmacology | Staphylococcus aureus - drug effects | Multidrug Resistance-Associated Proteins - metabolism | Alkaloids - chemistry | Benzodioxoles - pharmacology | Staphylococcus aureus
Journal Article