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biosynthesis (15) 15
chemistry, multidisciplinary (13) 13
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catalysis (10) 10
nosl (10) 10
tryptophan lyase nosl (10) 10
biochemistry & molecular biology (9) 9
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Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 437 - 7
Nosiheptide is a prototypal thiopeptide antibiotic, containing an indole side ring in addition to its thiopeptide-characteristic macrocylic scaffold. This... 
MUTAGENESIS | METHIONINE ENZYME NOSL | ANALOGS | MECHANISTIC INSIGHTS | MULTIDISCIPLINARY SCIENCES | TRYPTOPHAN LYASE NOSL | SHUNT PRODUCTS | THIOPEPTIDE ANTIBIOTICS | PRECURSOR PEPTIDE | ADENOSYLMETHIONINE METHYLTRANSFERASE NOSN | PEPTIDE NATURAL-PRODUCTS | Enzymes | Biosynthesis | Nosiheptide | Natural products | Dissection | Indole
Journal Article
Chemical communications (Cambridge, England), ISSN 1359-7345, 08/2016, Volume 52, Issue 69, pp. 10555 - 10558
The radical SAM enzyme NosL catalyzes the conversion of l-Trp to 3-methyl-2-indolic acid, and this reaction is initiated by the 5'-deoxyadenosyl (dAdo)... 
Journal Article
Chemical Communications, ISSN 1359-7345, 2017, Volume 53, Issue 64, pp. 8952 - 8955
Decarboxylation is a fundamentally important reaction in biology and involves highly diverse mechanisms. Here we report amechanistic study of the non-oxidative... 
TRYPTOPHAN LYASE NOSL | ADENOSYLMETHIONINE ENZYMES | DESII | CHEMISTRY, MULTIDISCIPLINARY | INSIGHTS | HEMN
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 01/2018, Volume 140, Issue 2, pp. 542 - 545
Tryptophan lyase (NosL) catalyzes the formation of 3-methylindole-2-carboxylic acid and 3-methylindole from l-tryptophan. In this paper, we provide evidence... 
SYNTHASE | CATALYSIS | MUTAGENESIS | METHIONINE ENZYME NOSL | ANALOGS | BIOSYNTHESIS | CHEMISTRY, MULTIDISCIPLINARY | INSIGHTS | Tryptophan | Cyanides | Chemical properties | Carbon monoxide
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 12/2016, Volume 138, Issue 50, pp. 16184 - 16187
Tryptophan lyase (NosL) is a radical S-adenosyl-l-methionine (SAM) enzyme that catalyzes the formation of 3-methyl-2-indolic acid from l-tryptophan. In this... 
BIOTIN SYNTHASE | CATALYSIS | MUTAGENESIS | INSERTION | METHIONINE ENZYME NOSL | MECHANISTIC INSIGHTS | BIOSYNTHESIS | REQUIRES | MENAQUINONE | CHEMISTRY, MULTIDISCIPLINARY | SAM ENZYMES | Chemical bonds | Chemical properties | Ketones | Analysis | Olefins
Journal Article
Biochemistry, ISSN 0006-2960, 01/2019, Volume 58, Issue 1, pp. 36 - 39
Sulfoxides and sulfones are commonly found in nature as a result of thioether oxidation, whereas only a very few enzymes have been found to metabolize these... 
CATALYSIS | ADENOSYLMETHIONINE ENZYMES | ANALOG | MECHANISTIC INSIGHTS | CRYSTAL-STRUCTURE | BIOSYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRYPTOPHAN LYASE NOSL | SAM CHEMISTRY | REDUCTASES | INTERMEDIATE
Journal Article
Chemical communications (Cambridge, England), ISSN 1359-7345, 05/2017, Volume 53, Issue 37, pp. 5235 - 5238
NosN is a class C radical S-adenosylmethionine (SAM) methyltransferase (RSMT) involved in the biosynthesis of nosiheptide, a clinically interesting thiopeptide... 
Journal Article
ACS Chemical Biology, ISSN 1554-8929, 05/2018, Volume 13, Issue 5, pp. 1111 - 1122
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 09/2016, Volume 55, Issue 39, pp. 11845 - 11848
Radical S‐adenosyl‐l‐methionine (SAM) enzymes utilize a [4Fe‐4S] cluster to bind SAM and reductively cleave its carbon–sulfur bond to produce a highly reactive... 
radical addition | thiopeptides | SAM analogues | S-adenosylmethionine | biosynthesis | TRYPTOPHAN | CATALYSIS | METHIONINE ENZYME NOSL | MECHANISTIC INSIGHTS | CHEMISTRY, MULTIDISCIPLINARY | LYASE | Sulfur compounds | Enzymes | Hydrogen | Olefins | Physiological aspects | Nucleosides | Free radicals (Chemistry)
Journal Article
by Wu, YJ and Wu, RZ and Mandalapu, D and Ji, XJ and Chen, T and Ding, W and Zhang, Q
ORGANIC & BIOMOLECULAR CHEMISTRY, ISSN 1477-0520, 02/2019, Volume 17, Issue 7, pp. 1809 - 1812
Journal Article
Journal Article
Synlett, ISSN 0936-5214, 01/2017, Volume 28, Issue 2, pp. 143 - 147
Abstract The radical S -adenosylmethionine (SAM) enzyme NosL catalyzes the conversion of l -tryptophan ( l -Trp) into 3-methyl-2-indolic acid (MIA) in the... 
synpacts | thiopeptide | nucleosides | rearrangement | biosynthesis | catalytic promiscuity | CATALYSIS | S-ADENOSYLMETHIONINE-ENZYME | CHEMISTRY, ORGANIC | LYSINE 2,3-AMINOMUTASE | SPORE PHOTOPRODUCT LYASE | ADENOSYL-L-METHIONINE | NATURAL-PRODUCT BIOSYNTHESIS | MECHANISTIC INSIGHTS | SUPERFAMILY | TRYPTOPHAN LYASE | NOSL
Journal Article
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ISSN 0002-7863, 12/2018, Volume 140, Issue 48, pp. 16661 - 16668
The radical S-adenosyl-L-methionine tryptophan lyase uses radical-based chemistry to convert L-tryptophan into 3-methyl-2-indolic acid, a fragment in the... 
ANTIBIOTICS | NOCATHIACINS | ANALOGS | MECHANISTIC INSIGHTS | CRYSTAL-STRUCTURE | HYDG | ENZYME NOSL | NOSIHEPTIDE | IDENTIFICATION | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
by Ji, XJ and Mo, TL and Liu, WQ and Ding, W and Deng, ZX and Zhang, Q
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, ISSN 1433-7851, 05/2019, Volume 58, Issue 19, pp. 6235 - 6238
HemN is a radical S-adenosyl-l-methionine (SAM) enzyme that catalyzes the oxidative decarboxylation of coproporphyrinogen III to produce protoporphyrinogen IX,... 
TRYPTOPHAN | METHYLTRANSFERASE | radicals | heme | METHIONINE ENZYME NOSL | CRYSTAL-STRUCTURE | ESCHERICHIA-COLI | reaction mechanisms | enzymes | CHEMISTRY, MULTIDISCIPLINARY | SIDE-RING SYSTEM | biosynthesis | INSIGHTS
Journal Article
Chemical Communications, ISSN 1359-7345, 2017, Volume 53, Issue 37, pp. 5235 - 5238
NosN is a class C radical S-adenosylmethionine (SAM) methyltransferase (RSMT) involved in the biosynthesis of nosiheptide, a clinically interesting thiopeptide... 
MUTAGENESIS | SAM ENZYME | ANALOGS | MECHANISTIC INSIGHTS | BIOSYNTHESIS | TRYPTOPHAN LYASE NOSL | DEPENDENT METHYLTRANSFERASES | METHYL TRANSFER | L-METHIONINE ENZYME | RLMN | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Chemical Communications, ISSN 1359-7345, 2016, Volume 52, Issue 69, pp. 10555 - 10558
The radical SAM enzyme NosL catalyzes the conversion of L-Trp to 3-methyl-2-indolic acid, and this reaction is initiated by the 5'-deoxyadenosyl (dAdo)... 
TRYPTOPHAN | CATALYSIS | METHIONINE ENZYME NOSL | ACCURATE DOCKING | TYROSINE | GLIDE | BIOSYNTHETIC PATHWAYS | DESII | CHEMISTRY, MULTIDISCIPLINARY | INSIGHTS | Enzymes | Hydrogen storage | Amines | Dehydrogenation | Chemical reactions | Conversion | Thiamine | Radicals
Journal Article
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