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2014, Methods in molecular biology, ISBN 1493911384, Volume 1187.
Web Resource
Cancer Research, ISSN 0008-5472, 09/2011, Volume 71, Issue 18, pp. 6061 - 6072
One important function of endothelial cells in glioblastoma multiforme (GBM) is to create a niche that helps promote self-renewal of cancer stem-like cells... 
INITIATING CELLS | DLL4 | ANGIOGENESIS | ONCOLOGY | VASCULAR NICHE | NEUROGENESIS | CENTRAL-NERVOUS-SYSTEM | SUBVENTRICULAR ZONE | PERIVASCULAR NICHE | INHIBITS TUMOR-GROWTH | BRAIN-TUMORS | RNA, Small Interfering - genetics | Nestin | Receptors, Notch - metabolism | Humans | Brain Neoplasms - pathology | Glycoproteins - metabolism | Cell Growth Processes - physiology | Intercellular Signaling Peptides and Proteins - biosynthesis | Receptors, Notch - genetics | Brain Neoplasms - metabolism | Antigens, CD - metabolism | Gene Knockdown Techniques | Membrane Proteins - deficiency | Peptides - metabolism | Neoplastic Stem Cells - metabolism | Receptors, Notch - biosynthesis | Serrate-Jagged Proteins | Neoplastic Stem Cells - pathology | Glioblastoma - metabolism | Intercellular Signaling Peptides and Proteins - deficiency | Receptors, Notch - deficiency | Calcium-Binding Proteins - biosynthesis | Stem Cell Niche | Endothelial Cells - metabolism | Membrane Proteins - genetics | Intercellular Signaling Peptides and Proteins - genetics | Calcium-Binding Proteins - deficiency | AC133 Antigen | Nerve Tissue Proteins - metabolism | Xenograft Model Antitumor Assays | Membrane Proteins - biosynthesis | Animals | Glioblastoma - pathology | Mice | Endothelial Cells - pathology | RNA, Small Interfering - administration & dosage | Intermediate Filament Proteins - metabolism | Calcium-Binding Proteins - genetics | Brain | glioblastoma multiforme | Tumor cells | Glioblastoma | Endothelial cells | Endothelium | Molecular modelling | Stem cells | Microenvironments | Microvasculature | Notch protein | neurospheres | Cancer | Tumors | Index Medicus | Notch ligand | Endothelial cell | niche | glioblastoma | cancer stem cell
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2017, Volume 12, Issue 10, pp. e0185762 - e0185762
Notch is a major oncogenic driver in T cell acute lymphoblastic leukemia (T-ALL), in part because it binds to an enhancer that increases expression of MYC.... 
TARGET | MULTIDISCIPLINARY SCIENCES | BONE-MARROW | C-MYC | SENSITIVITY | MICE | LEUKEMIA/LYMPHOMA | INHIBITORS | NEGATIVE REGULATORY REGION | EXPRESSION | ACTIVATING MUTATIONS | Receptor, Notch3 - metabolism | Immunoglobulin J Recombination Signal Sequence-Binding Protein - biosynthesis | Response Elements | Signal Transduction | Humans | Gene Expression Regulation, Leukemic | Receptor, Notch1 - metabolism | Proto-Oncogene Proteins c-myc - biosynthesis | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Cell Line, Tumor | Receptor, Notch3 - genetics | Proto-Oncogene Proteins c-myc - genetics | Receptor, Notch1 - genetics | Immunoglobulin J Recombination Signal Sequence-Binding Protein - genetics | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Care and treatment | Chromatin | Genetic transcription | Research | Acute lymphocytic leukemia | Diagnosis | T cells | Divergence | Leukemia | Genomics | Lymphocytes T | Genomes | Biology | Regulatory sequences | Myc protein | Medical schools | Cell growth | Lymphocytes | Bone marrow | Bioinformatics | Public health | Deoxyribonucleic acid--DNA | Acute lymphatic leukemia | Lymphatic leukemia | Mammals | Pathology | Landscapes | Hospitals | Womens health | Ligands | Notch protein | Mutation | Binding sites | Cancer | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Fatigue & Fracture of Engineering Materials & Structures, ISSN 8756-758X, 06/2012, Volume 35, Issue 6, pp. 538 - 555
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2014, Volume 111, Issue 2, pp. 705 - 710
Journal Article
2010, 1st ed., Current topics in developmental biology, ISBN 0123809142, Volume 92., xvi, 530 p., [24] p. of plates
Notch signaling is an evolutionarily conserved pathway in multicellular organisms that regulates cell-fate determination during development and in stem cells.... 
Notch proteins | Notch genes | Cellular signal transduction | Pre-clinical Medicine: Basic Sciences
Book
Nature, ISSN 0028-0836, 05/2017, Volume 545, Issue 7654, pp. 360 - 364
Journal Article
2014, Methods in molecular biology, ISBN 1493911384, Volume 1187.
Web Resource
2007, ISBN 1584656271, xvi, 214
Book
Nature, ISSN 0028-0836, 04/2010, Volume 464, Issue 7291, pp. 1052 - 1057
The four receptors of the Notch family are widely expressed transmembrane proteins that function as key conduits through which mammalian cells communicate to... 
B-CELLS | ANTI-P185HER2 ANTIBODY | ANGIOGENESIS | MULTIDISCIPLINARY SCIENCES | REGULATORY REGION | MALIGNANT-MELANOMA | MUTATIONS | LEUKEMIA | GAMMA-SECRETASE | CANCER-THERAPY | INHIBITS TUMOR-GROWTH | Angiogenesis Inhibitors - immunology | Neoplasms - metabolism | NIH 3T3 Cells | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - pathology | Receptor, Notch2 - antagonists & inhibitors | Receptors, Notch - metabolism | Humans | Goblet Cells - drug effects | Receptors, Notch - genetics | Peptide Library | Receptors, Notch - antagonists & inhibitors | Antibody Specificity - immunology | Angiogenesis Inhibitors - therapeutic use | Antibodies - immunology | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Antibodies - therapeutic use | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Angiogenesis Inhibitors - pharmacology | Receptor, Notch1 - immunology | Neoplasms - blood supply | Receptor, Notch2 - immunology | Antibodies - adverse effects | Neoplasms - drug therapy | Antibodies - pharmacology | Animals | Signal Transduction - drug effects | Neovascularization, Pathologic - drug therapy | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Goblet Cells - pathology | Receptor, Notch1 - antagonists & inhibitors | Neoplasms - pathology | Receptors, Notch - immunology | Viral antibodies | Proteases | Proteolysis | Physiological aspects | Antibodies | Research | Properties | Membrane proteins | Cell growth | Cell cycle | Cancer | Crystal structure | Apoptosis | Receptors | Inhibitors | Toxicity | Notches | Mathematical models | Inhibition | Signalling | Diseases | Index Medicus
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 02/2018, Volume 233, Issue 2, pp. 1455 - 1467
We have identified in zebrafish, that the transmembrane protein Tmem230a is a novel regulator of angiogenesis by its capacity to regulate the number of the... 
Delta/Notch signaling | blood vessel formation growth | Vegf signaling | angiogenesis | transmembrane protein 230 | PHYSIOLOGY | EPHRIN-B2 | NOTCH | CELL BIOLOGY | DLL4 | ARTERIES | Delta | Notch signaling | SPADETAIL | IN-VIVO | NETWORK FORMATION | EMBRYONIC VASCULAR DEVELOPMENT | KNOCKDOWN | EXPRESSION | Amino Acid Sequence | Cell Proliferation | Signal Transduction | Animals, Genetically Modified | Endothelial Cells - metabolism | Membrane Proteins - genetics | Receptors, Notch - metabolism | Zebrafish Proteins - metabolism | Receptors, Notch - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Zebrafish - embryology | Zebrafish - genetics | Animals | Gene Expression Regulation, Developmental | Base Sequence | Zebrafish - metabolism | Conserved Sequence | Membrane Proteins - metabolism | Zebrafish Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Neovascularization, Physiologic | Embryonic development | Drug discovery | Endothelial growth factors | Endothelium | Cell proliferation | Network formation | Leukocyte migration | Migration | Blood vessels | Zebrafish | Gene expression | Arteries | Endothelial cells | Regeneration (physiology) | Embryonic growth stage | Angiogenesis | Regeneration | Signal transduction | Signaling | Embryogenesis | Conserved sequence | Cell number | Notch protein | Aberration | Vascular endothelial growth factor | Cell migration | Index Medicus
Journal Article
American Journal of Roentgenology, ISSN 0361-803X, 10/2016, Volume 207, Issue 4, pp. 836 - 845
Journal Article
European Journal of Mechanics / A Solids, ISSN 0997-7538, 05/2014, Volume 45, pp. 32 - 40
The aim of this research was to present a brittle fracture model for predicting the compressive failure load of engineering components weakened by V-notches... 
V-notch with end hole (VO-notch) | Brittle fracture | Compressive notch fracture toughness | MIXED-MODE | ELASTIC-MATERIALS | POLYCRYSTALLINE GRAPHITE | FAILURE CRITERIA | COMPONENTS | SHAPED NOTCHES | LOCAL ENERGY | SHARP NOTCH | U-NOTCHES | MECHANICS | ISOSTATIC GRAPHITE | Stresses | Compressing | Notches | Mathematical models | Criteria | Failure | Fracture toughness
Journal Article
Journal of Cell Science, ISSN 0021-9533, 02/2004, Volume 117, Issue 6, pp. 889 - 897
Journal Article
Current Drug Targets, ISSN 1389-4501, 2010, Volume 11, Issue 6, pp. 745 - 751
Journal Article
Oncogene, ISSN 0950-9232, 09/2011, Volume 30, Issue 39, pp. 4075 - 4086
Notch signaling is often and aberrantly activated by hypoxia during tumor progression; however, the exact pathological role of hypoxia-induced Notch signaling... 
hypoxia | breast cancer | cancer stem-like cells | Jagged2 | Notch | SURVIVAL | ACTIVATION | INDUCIBLE-FACTOR 1-ALPHA | NOTCH LIGANDS | ADENOCARCINOMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | AKT | PROLIFERATION | CELL BIOLOGY | OVEREXPRESSION | GENE | ONCOLOGY | GENETICS & HEREDITY | BONE | Phosphorylation | Cell Survival | Membrane Proteins - genetics | Receptors, Notch - metabolism | Humans | Intercellular Signaling Peptides and Proteins - genetics | Receptors, Notch - genetics | Cadherins - biosynthesis | Breast Neoplasms - metabolism | Cell Hypoxia | Intercellular Signaling Peptides and Proteins - metabolism | Stromal Cells | Neoplasm Metastasis | Breast Neoplasms - genetics | Neoplastic Stem Cells - metabolism | Breast Neoplasms - pathology | Cell Line, Tumor | Jagged-2 Protein | Neoplastic Stem Cells - pathology | Female | Membrane Proteins - metabolism | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Cadherins - genetics | Oncogene Protein v-akt - metabolism | Care and treatment | Breast cancer | Genetic aspects | Research | Gene expression | Stem cells | Immunohistochemistry | Genetic markers | Cellular biology | Hypoxia | Metastasis | Tumors | Cell survival | Invasiveness | Tumor cells | AKT protein | Bone tumors | Metastases | Bone cancer | Databases | stromal cells | E-Cadherin | Bone marrow | Notch protein | Secretase | Index Medicus
Journal Article