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Journal of Clinical Oncology, ISSN 0732-183X, 12/2013, Volume 31, Issue 34, pp. 4333 - 4342
Journal Article
Circulation, ISSN 0009-7322, 12/2016, Volume 134, Issue 23, pp. 1848 - 1862
Journal Article
Development (Cambridge), ISSN 0950-1991, 07/2017, Volume 144, Issue 14, pp. 2629 - 2639
Arterial specification and differentiation are influenced by a number of regulatory pathways. While it is known that the Vegfa-Notch cascade plays a central... 
Arterial enhancer | Human | Endothelial cell | Mouse | Notch1 | Zebrafish | Transcriptional regulation | SoxF | Artery | CELLS | ENDOTHELIAL-GROWTH-FACTOR | ENHANCER | DEVELOPMENTAL BIOLOGY | SPECIFICATION | VASCULAR MORPHOGENESIS | LETHALITY | PATHWAY | MUTATIONS | REDUNDANT ROLES | Human Umbilical Vein Endothelial Cells | Humans | Arteries - embryology | Male | Arteriovenous Malformations - embryology | SOXF Transcription Factors - metabolism | Arteries - metabolism | Receptor, Notch1 - deficiency | Gene Expression Regulation, Developmental | Female | Amino Acid Sequence | Signal Transduction | Animals, Genetically Modified | Zebrafish Proteins - metabolism | Mice, Inbred C57BL | Mice, Transgenic | Receptor, Notch1 - metabolism | Mice, Knockout | Pregnancy | Sequence Homology, Amino Acid | Zebrafish Proteins - deficiency | Animals | Arteriovenous Malformations - genetics | Enhancer Elements, Genetic | Arteriovenous Malformations - metabolism | Mice | Zebrafish Proteins - genetics | Receptor, Notch1 - genetics | SOXF Transcription Factors - deficiency | SOXF Transcription Factors - genetics | Deoxyribonuclease | Signal transduction | Transcription factors | Enhancers | Clonal deletion | Hypersensitivity | Gene regulation | Aorta | Notch protein | Endothelial cells | Binding sites | 204 | Biological Sciences | Naturvetenskap | Biologiska vetenskaper | Natural Sciences
Journal Article
Nature Medicine, ISSN 1078-8956, 01/2009, Volume 15, Issue 1, pp. 50 - 58
Gamma-secretase inhibitors (GSIs) block the activation of the oncogenic protein Notch homolog-1 (NOTCH1) in T cell acute lymphoblastic leukemia (T-ALL).... 
MEDICINE, RESEARCH & EXPERIMENTAL | INDUCED APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR EXPRESSION | CYCLE ARREST | SRG3 | CELL BIOLOGY | NOTCH1 CONFERS | GOBLET CELLS | GENE | LINE | DIFFERENTIATION | PROMOTER | Glucocorticoids - administration & dosage | Glucocorticoids - therapeutic use | Cyclins - genetics | Receptors, Glucocorticoid - metabolism | Cyclin D2 | Enzyme Inhibitors - administration & dosage | Bcl-2-Like Protein 11 | Membrane Proteins - physiology | Apoptosis Regulatory Proteins - genetics | Female | Homeostasis - drug effects | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Dexamethasone - administration & dosage | Membrane Proteins - genetics | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Gene Expression Regulation, Leukemic - drug effects | Proto-Oncogene Proteins - genetics | Mice, SCID | Mice, Knockout | Dexamethasone - therapeutic use | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Models, Biological | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Homeostasis - physiology | Proto-Oncogene Proteins - physiology | Receptors, Glucocorticoid - genetics | Apoptosis Regulatory Proteins - physiology | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Receptor, Notch1 - antagonists & inhibitors | Receptor, Notch1 - genetics | Receptors, Glucocorticoid - physiology | Receptor, Notch1 - physiology | Drug Resistance, Neoplasm - drug effects | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 44, pp. 18178 - 18191
Unlike age-matched men, premenopausal women benefit from cardiovascular protection. Estrogens protect against apoptosis of endothelial cells (ECs), one of the... 
Endothelium, Vascular - cytology | Tumor Necrosis Factor-alpha - metabolism | Apoptosis - drug effects | Humans | Receptor, Notch1 - chemistry | Endothelium, Vascular - drug effects | Estrogen Receptor beta - metabolism | Protease Inhibitors - pharmacology | Estrogen Receptor alpha - agonists | Estrogen Receptor beta - agonists | Estrogen Receptor beta - genetics | Protein Processing, Post-Translational - drug effects | RNA Interference | Receptor, Notch1 - agonists | Human Umbilical Vein Endothelial Cells - cytology | Estrogen Receptor alpha - metabolism | Protein Interaction Domains and Motifs | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Estrogen Receptor beta - antagonists & inhibitors | Peptide Fragments - genetics | Endothelium, Vascular - immunology | Recombinant Proteins - metabolism | Estradiol - metabolism | Peptide Fragments - metabolism | Cells, Cultured | Recombinant Proteins - chemistry | Estrogen Receptor alpha - antagonists & inhibitors | Receptor, Notch1 - metabolism | Amyloid Precursor Protein Secretases - metabolism | Peptide Fragments - chemistry | Estrogen Receptor alpha - genetics | Signal Transduction - drug effects | Endothelium, Vascular - metabolism | Peptide Fragments - agonists | Proto-Oncogene Proteins c-akt - agonists | Protein Kinase Inhibitors - pharmacology | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Receptor, Notch1 - genetics | Tumor Necrosis Factor-alpha - antagonists & inhibitors | estrogen | Notch pathway | tumor necrosis factor (TNF) | ERβ | estrogen receptor | Notch1 | apoptosis | Akt | endothelial dysfunction | Cell Biology
Journal Article
Nature, ISSN 0028-0836, 2015, Volume 526, Issue 7574, pp. 519 - 524
Journal Article
Nature Cell Biology, ISSN 1465-7392, 09/2016, Volume 18, Issue 9, pp. 979 - 992
Senescence, a persistent form of cell-cycle arrest, is often associated with a diverse secretome, which provides complex functionality for senescent cells... 
CLEARANCE | ONCOGENE | PANCREATIC-CANCER | LIVER | GROWTH | TUMOR-SUPPRESSOR | DIFFERENTIATION | FATE | CELLULAR SENESCENCE | BETA | CELL BIOLOGY | Animals | Cellular Senescence | Humans | Cell Line, Tumor | Cell Cycle Checkpoints - physiology | Mice, Transgenic | Receptor, Notch1 - metabolism | Receptor, Notch1 - genetics | Transforming Growth Factor beta - metabolism
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 504, Issue 7480, pp. 456 - 459
Journal Article
Nature Cell Biology, ISSN 1465-7392, 06/2011, Volume 13, Issue 6, pp. 694 - 701
Journal Article
Blood, ISSN 0006-4971, 02/2013, Volume 121, Issue 8, pp. 1403 - 1412
Journal Article