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receptor, notch3 (495) 495
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receptors, notch - genetics (284) 284
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gene expression regulation, neoplastic (61) 61
genetics & heredity (61) 61
receptor, notch4 (58) 58
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medicine (52) 52
abridged index medicus (51) 51
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Journal Article
Cancer Research, ISSN 0008-5472, 05/2005, Volume 65, Issue 9, pp. 3555 - 3561
Notch3 is a member of an evolutionarily conserved family of cell surface receptors important in cell-fate determination in both vertebrates and invertebrates.... 
CELLS | ONCOLOGY | RAS | PHOSPHATASE | CASCADE | ELEGANS VULVAL DEVELOPMENT | SIGNAL-REGULATED KINASE | EPITHELIAL DIFFERENTIATION | NEOPLASTIC TRANSFORMATION | EXPRESSION | INTRACELLULAR DOMAIN | Dual Specificity Phosphatase 1 | Receptor, Epidermal Growth Factor - genetics | MAP Kinase Signaling System - physiology | Phosphorylation | Humans | Lung Neoplasms - metabolism | Phosphoprotein Phosphatases - metabolism | Cell Growth Processes - physiology | Lung Neoplasms - pathology | Protein Tyrosine Phosphatases - metabolism | Quinazolines | Proto-Oncogene Proteins - biosynthesis | Receptors, Cell Surface - antagonists & inhibitors | Immediate-Early Proteins - metabolism | Protein Tyrosine Phosphatases - genetics | Receptors, Notch | Transfection | Phosphoprotein Phosphatases - biosynthesis | Cell Cycle Proteins - genetics | Receptors, Cell Surface - biosynthesis | Receptors, Cell Surface - physiology | Protein Phosphatase 1 | Lung Neoplasms - genetics | Proto-Oncogene Proteins - antagonists & inhibitors | Protein Tyrosine Phosphatases - biosynthesis | Receptor, Epidermal Growth Factor - biosynthesis | Lung Neoplasms - enzymology | Down-Regulation | Immediate-Early Proteins - biosynthesis | Cell Cycle Proteins - metabolism | Enzyme Inhibitors - pharmacology | Proto-Oncogene Proteins - genetics | Cell Cycle Proteins - biosynthesis | Tyrphostins - pharmacology | Immediate-Early Proteins - genetics | Phosphoprotein Phosphatases - genetics | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Proto-Oncogene Proteins - physiology | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Receptor, Notch3 | Apoptosis - physiology | Mitogen-Activated Protein Kinases - metabolism | Receptors, Cell Surface - genetics | Index Medicus
Journal Article
Stroke, ISSN 0039-2499, 05/2015, Volume 46, Issue 5, pp. 1337 - 1343
Journal Article
Blood, ISSN 0006-4971, 07/2011, Volume 118, Issue 2, pp. 380 - 389
Although many literature data are available on the role of Notch signaling in T-cell acute lymphoblastic leukemia (ALL) biology, the importance of this... 
MULTIPLE-MYELOMA | CYTOCHROME-C | SURVIVAL | STEM-CELLS | INHIBITION | ACUTE LYMPHOBLASTIC-LEUKEMIA | NOVO DRUG-RESISTANCE | DEATH | DIFFERENTIATION | HEMATOLOGY | LINEAGE | Receptors, Notch - metabolism | Humans | Bone Marrow Cells - physiology | Apoptosis - genetics | Cell Communication - physiology | Receptors, Notch - genetics | Intercellular Signaling Peptides and Proteins - physiology | Intercellular Signaling Peptides and Proteins - metabolism | Membrane Proteins - physiology | Serrate-Jagged Proteins | Jagged-2 Protein | Membrane Proteins - metabolism | B-Lymphocytes - pathology | Tumor Cells, Cultured | Mesenchymal Stromal Cells - physiology | Jagged-1 Protein | Calcium-Binding Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Membrane Proteins - genetics | Stromal Cells - metabolism | Intercellular Signaling Peptides and Proteins - genetics | Mesenchymal Stromal Cells - metabolism | Receptors, Notch - physiology | Proto-Oncogene Proteins - genetics | Signal Transduction - genetics | Cell Communication - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Calcium-Binding Proteins - physiology | Proto-Oncogene Proteins - physiology | Receptor, Notch3 | Signal Transduction - physiology | Stromal Cells - physiology | Bone Marrow Cells - metabolism | Receptor, Notch4 | Calcium-Binding Proteins - genetics | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 2007, Volume 117, Issue 12, pp. 3988 - 4002
High serum levels of IL-6 correlate with poor outcome in breast cancer patients. However, no data are available on the relationship between IL-6 and mammary... 
CANCER-CELLS | INITIATING CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | GENE SIGNATURE | CARBONIC-ANHYDRASE-IX | STEM-CELLS | STEM/PROGENITOR CELLS | SELF-RENEWAL | GROWTH-FACTOR | EXTRACELLULAR PH | IN-VITRO PROPAGATION | Carbonic Anhydrases - biosynthesis | Carcinoma, Ductal - genetics | Receptors, Notch - metabolism | Carbonic Anhydrases - genetics | Carcinoma, Ductal - pathology | Humans | Antigens, Neoplasm - biosynthesis | Spheroids, Cellular - pathology | Neoplasm Proteins - pharmacology | Receptors, Notch - genetics | Autocrine Communication - drug effects | Mammary Glands, Human - metabolism | Neoplasm Proteins - metabolism | RNA, Messenger - metabolism | Stem Cells - metabolism | Breast Neoplasms - metabolism | Serrate-Jagged Proteins | Female | Carcinoma, Ductal - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Interleukin-6 - metabolism | Gene Expression Regulation, Neoplastic - genetics | Carbonic Anhydrase IX | Jagged-1 Protein | Antigens, Neoplasm - genetics | Cell Hypoxia - drug effects | Calcium-Binding Proteins | Interleukin-6 - genetics | Neoplasm Invasiveness | Intercellular Signaling Peptides and Proteins | RNA, Messenger - genetics | Spheroids, Cellular - metabolism | Mammary Glands, Human - pathology | Up-Regulation - genetics | Autocrine Communication - genetics | Membrane Proteins | Up-Regulation - drug effects | Breast Neoplasms - genetics | RNA, Neoplasm - biosynthesis | Interleukin-6 - pharmacology | Breast Neoplasms - pathology | Cell Line, Tumor | RNA, Neoplasm - genetics | Stem Cells - pathology | Receptor, Notch3 | Cell Hypoxia - genetics | Breast cancer | Genetic aspects | Research | Gene expression | Health aspects | Interleukin-6 | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Journal of Cell Science, ISSN 0021-9533, 06/2017, Volume 130, Issue 11, pp. 1952 - 1964
Many pathways dysregulated in prostate cancer are also involved in epithelial differentiation. To better understand prostate tumor initiation, we sought to... 
Development | NOTCH | p38-MAPK | Luminal cell differentiation | Prostate | MYC | TRANSCRIPTION FACTORS | HALF-LIFE | TARGET | SIGNALING PATHWAYS | ACTIVATION | C-MYC | E-CADHERIN | CELL BIOLOGY | EPITHELIAL-CELLS | MESSENGER-RNA | EXPRESSION | Amyloid Precursor Protein Secretases - genetics | RNA, Small Interfering - genetics | Epithelial Cells - metabolism | Luciferases - metabolism | Epithelial Cells - drug effects | Humans | Half-Life | Male | RNA, Messenger - metabolism | Prostate - metabolism | Luciferases - genetics | Receptor, Notch3 - antagonists & inhibitors | HEK293 Cells | Receptor, Notch3 - genetics | Cell Differentiation | p38 Mitogen-Activated Protein Kinases - metabolism | Epithelial Cells - cytology | Genes, Reporter | Pyrazoles - pharmacology | Receptor, Notch3 - metabolism | Signal Transduction | RNA, Messenger - genetics | Gene Expression Regulation | p38 Mitogen-Activated Protein Kinases - genetics | Imidazoles - pharmacology | RNA Stability | Proto-Oncogene Proteins c-myc - metabolism | Naphthalenes - pharmacology | Amyloid Precursor Protein Secretases - metabolism | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Prostate - cytology | Proto-Oncogene Proteins c-myc - genetics | Pyridines - pharmacology | Thiazoles - pharmacology | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Primary Cell Culture | Cell Line, Transformed | RNA, Small Interfering - metabolism | Transcription | Epithelial cells | Differentiation (biology) | MAP kinase | Radioactive half-life | Activation | Myc protein | Cell differentiation | Kinases | Ribonucleic acid--RNA | Signaling | Cell activation | Cell death | Notch protein | Inhibition | Prostate cancer | Secretase | Cancer | mRNA stability | Index Medicus
Journal Article
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 2013, Volume 210, Issue 4, pp. 683 - 697
Journal Article
Journal of Cancer Research and Clinical Oncology, ISSN 0171-5216, 05/2016, Volume 142, Issue 5, pp. 981 - 993
There is still a debate on the extent to which Notch3 signaling is involved in lung carcinogenesis and whether such function is dependent on cancer type or... 
Small interfering RNA (siRNA) | Human lung cancer | Notch3 intracellular domain (N3ICD) plasmid | Notch3 signaling | STEM-CELLS | METASTASIS | ADENOCARCINOMA | PROLIFERATION | LINES | EPITHELIAL-MESENCHYMAL TRANSITION | ONCOLOGY | DIFFERENTIATION | RECEPTORS | CARCINOMA | TUMORIGENESIS | RNA, Small Interfering - genetics | Adenocarcinoma - pathology | Cell Proliferation | Receptors, Notch - metabolism | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Lung Neoplasms - metabolism | Gene Expression Regulation, Neoplastic | Lung Neoplasms - pathology | Receptors, Notch - genetics | Immunoenzyme Techniques | Small Cell Lung Carcinoma - metabolism | Receptors, Notch - antagonists & inhibitors | Adenocarcinoma - metabolism | Epithelial-Mesenchymal Transition | Biomarkers, Tumor - metabolism | Adenocarcinoma - genetics | Tumor Cells, Cultured | Real-Time Polymerase Chain Reaction | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Signal Transduction | Carcinoma, Non-Small-Cell Lung - genetics | RNA, Messenger - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Small Cell Lung Carcinoma - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Small Cell Lung Carcinoma - pathology | Cell Cycle | Fluorescent Antibody Technique | Receptor, Notch3 | Apoptosis | Cell Movement | Proteins | Squamous cell carcinoma | RNA | Analysis | Cancer cells | Stem cells | Lung cancer, Non-small cell | Index Medicus
Journal Article
Oncogene, ISSN 0950-9232, 07/2018, Volume 37, Issue 28, pp. 3839 - 3851
Several studies have revealed that endosomal sorting controls the steady-state levels of Notch at the cell surface in normal cells and prevents its... 
ONCOLOGY | ACETYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | RECEPTOR | ENDOCYTOSIS | ACTIVATING MUTATIONS | CELL BIOLOGY | Apoptosis - drug effects | Humans | Protein Transport - physiology | Protein Transport - drug effects | RNA, Messenger - metabolism | Cell Movement - physiology | Histone Deacetylase 6 - metabolism | Leukemia-Lymphoma, Adult T-Cell - drug therapy | Lysosomes - metabolism | T-Lymphocytes - metabolism | Gene Expression Regulation, Neoplastic - drug effects | T-Lymphocytes - pathology | Gene Expression Regulation, Neoplastic - physiology | Hydroxamic Acids - pharmacology | Receptor, Notch3 - metabolism | Jurkat Cells | Cell Proliferation - physiology | Leukemia-Lymphoma, Adult T-Cell - pathology | Mice, SCID | Cell Movement - drug effects | Animals | Leukemia-Lymphoma, Adult T-Cell - metabolism | Cell Line, Tumor | Mice, Inbred NOD | Signal Transduction - physiology | Cell Proliferation - drug effects | Mice | Apoptosis - physiology | RNA, Small Interfering - metabolism | Enzymes | Care and treatment | Gene mutations | Development and progression | Hydrolases | Genetic aspects | Cellular signal transduction | Acute lymphocytic leukemia | Gene expression | Health aspects | Histone deacetylase | Acute lymphatic leukemia | Therapeutic applications | Leukemia | mRNA | Lymphocytes T | Malignancy | Lymphatic leukemia | Kinases | Cell surface | Proteins | Cell lines | Dynein | Post-translation | Trichostatin A | Notch3 protein | Apoptosis | Tumors | Cancer | Index Medicus | Paediatric cancer | Lysosomes | Acute lymphocytic leukaemia | Target identification
Journal Article