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1. Full Text Nox family NADPH oxidases: Molecular mechanisms of activation
by Brandes, Ralf P and Weissmann, Norbert and Schröder, Katrin
Free Radical Biology and Medicine, ISSN 0891-5849, 11/2014, Volume 76, pp. 208 - 226
NADPH oxidases of the Nox family are important enzymatic sources of reactive oxygen species (ROS). Numerous homologue-specific mechanisms control the activity... 
p22phox | Oxygen-derived free radicals | Activity control | Phosphorylation | NADPH oxidase | Nox | PROTEIN-KINASE-C | OXYGEN SPECIES PRODUCTION | GLUCOSE-6-PHOSPHATE-DEHYDROGENASE DEFICIENCY DECREASES | BIOCHEMISTRY & MOLECULAR BIOLOGY | INHIBITS SUPEROXIDE FORMATION | COUPLED REDOX REGULATION | RESPIRATORY BURST OXIDASE | INDUCED OXIDATIVE STRESS | ENDOCRINOLOGY & METABOLISM | NUCLEOTIDE EXCHANGE FACTOR | SMOOTH-MUSCLE-CELLS | PHOSPHORYLATION-INDUCED ACTIVATION | Inflammation - pathology | Animals | Reactive Oxygen Species - metabolism | Humans | NADPH Oxidases - metabolism | Cardiovascular Diseases - enzymology | Cardiovascular Diseases - pathology | Inflammation - enzymology | Oxidases | Physiological aspects | Fatty acids | Protein-protein interactions | Epidermal growth factor | Hydrogen peroxide | Heme | Superoxide | Transforming growth factors | Adenylic acid | Mitogens | Protein kinases
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2. Full Text Pathophysiological Roles of NADPH Oxidase/Nox Family Proteins in the Vascular System - Review and Perspective
by Ago, Tetsuro and Kuroda, Junya and Kamouchi, Masahiro and Sadoshima, Junichi and Kitazono, Takanari
Circulation Journal, ISSN 1346-9843, 2011, Volume 75, Issue 8, pp. 1791 - 1800
It has been established that oxidative stress plays a crucial role in the development and progression of vascular diseases. Besides the mitochondria, the NADPH... 
NADPH oxidase/Nox | Reactive oxygen species | Vascular diseases | OXYGEN SPECIES PRODUCTION | OXIDATIVE STRESS | CARDIAC & CARDIOVASCULAR SYSTEMS | SUPEROXIDE-PRODUCTION | ANGIOTENSIN-II | II-MEDIATED HYPERTENSION | NAD(P)H OXIDASE | NOX-FAMILY | UP-REGULATION | TRANSCRIPTIONAL REGULATION | HYPOXIA-INDUCIBLE FACTOR-2-ALPHA | Blood Vessels - enzymology | Mitochondria - metabolism | Reactive Oxygen Species - metabolism | Vascular Diseases - enzymology | Humans | NADPH Oxidases - metabolism
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3. Full Text Structure, regulation and evolution of Nox‐family NADPH oxidases that produce reactive oxygen species
by Sumimoto, Hideki
The FEBS Journal, ISSN 1742-464X, 07/2008, Volume 275, Issue 13, pp. 3249 - 3277
NADPH oxidases of the Nox family exist in various supergroups of eukaryotes but not in prokaryotes, and play crucial roles in a variety of biological... 
p22phox | p40phox | p47phox | Rac | Nox | Noxo1 | Noxa1 | p67phox | Duox | Rboh | p67 | p22 | p47 | p40 | GTP-BINDING PROTEIN | PX DOMAIN | CYTOCHROME BF COMPLEX | CHRONIC GRANULOMATOUS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | p22(phox) | RESPIRATORY BURST OXIDASE | p47(phox) | p67(phox) | FERRIC-CHELATE REDUCTASE | SRC HOMOLOGY-3 DOMAINS | PROLINE-RICH REGION | p40(phox) | PHOSPHORYLATION-INDUCED ACTIVATION | TANDEM SH3 DOMAINS | Amino Acid Sequence | Reactive Oxygen Species | Molecular Conformation | NADPH Oxidases - metabolism | Molecular Sequence Data | Cytoplasm - metabolism | Phylogeny | Naegleria - metabolism | Amino Acid Motifs | Protein Interaction Mapping | Gene Expression Regulation, Enzymologic | Animals | Models, Biological | Protein Conformation | Evolution, Molecular | Oxidases | Superoxide | Protein binding | Enzymes | Chemical reactions | Biochemistry | Oxidation | Molecular structure
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4. Full Text The NADPH Oxidase Family and its Inhibitors
by Kleniewska, Paulina and Piechota, Aleksandra and Skibska, Beata and Gorąca, Anna
Archivum Immunologiae et Therapiae Experimentalis, ISSN 0004-069X, 8/2012, Volume 60, Issue 4, pp. 277 - 294
The classical nicotinamide adenine dinucleotide phosphate (NADPH) oxidase was originally detected in neutrophils as a multicomponent enzyme that catalyzes the... 
Reactive oxygen species | Biomedicine | Immunology | Nox family | Nox inhibitors | NADPH oxidase | Cardiovascular disease | Pharmacology/Toxicology | PROTEIN-KINASE-C | SPONTANEOUSLY HYPERTENSIVE-RATS | SUPEROXIDE-GENERATING OXIDASE | CHRONIC GRANULOMATOUS-DISEASE | LOW-DENSITY-LIPOPROTEIN | IMMUNOLOGY | COLON EPITHELIAL-CELLS | VASCULAR SMOOTH-MUSCLE | HUMAN ENDOTHELIAL-CELLS | RESPIRATORY BURST OXIDASE | CHOLESTEROL-FED RABBITS | NADPH Oxidases - classification | Reactive Oxygen Species - metabolism | Cardiovascular Diseases - metabolism | Cardiovascular Diseases - drug therapy | Humans | NADPH Oxidases - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | NADPH Oxidases - metabolism | Endothelium, Vascular - drug effects | Enzyme Inhibitors - therapeutic use | Animals | Protein Isoforms - metabolism | Endothelium, Vascular - metabolism | Enzyme Inhibitors - chemistry | Oxidative Stress - drug effects | Myocytes, Smooth Muscle - drug effects | Myocytes, Smooth Muscle - metabolism
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5. Full Text Nox/Duox Family of NADPH Oxidases: Lessons from Knockout Mouse Models
by Sirokmány, Gábor and Donkó, Ágnes and Geiszt, Miklós
Trends in Pharmacological Sciences, ISSN 0165-6147, 2016, Volume 37, Issue 4, pp. 318 - 327
Nox/Duox NADPH oxidases are now considered the primary, regulated sources of reactive oxygen species (ROS). These enzymes are expressed in diverse cells and... 
Advanced Basic Science | Nox4 | Nox3 | Duox1 | Duox2 | NADPH oxidase | Nox1 | ACTIVATION | REACTIVE OXYGEN | MICE DEFICIENT | NOX FAMILY | NOX1/NADPH OXIDASE | MISSENSE MUTATION | PHARMACOLOGY & PHARMACY | HYDROGEN-PEROXIDE | DUAL OXIDASE | LACTOPEROXIDASE-THIOCYANATE | BLOOD-PRESSURE | NADH, NADPH Oxidoreductases - genetics | Animals | NADH, NADPH Oxidoreductases - deficiency | Humans | Mice | NADH, NADPH Oxidoreductases - metabolism | Mice, Knockout | Oxidases | Genetically modified animals | Animal experimentation | Physiological aspects | Biological products
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6. Full Text NOX family NADPH oxidases: Not just in mammals
by Bedard, Karen and Lardy, Bernard and Krause, Karl-Heinz
Biochimie, ISSN 0300-9084, 2007, Volume 89, Issue 9, pp. 1107 - 1112
NOX family NADPH oxidases are enzymes whose biological function is electron transport and the generation of reactive oxygen species (ROS). NOX enzymes in... 
Fungus | Reactive oxygen species | Animals | NADPH oxidase | NOX | DUOX | Plants | CELLS | IRON UPTAKE | BIOCHEMISTRY & MOLECULAR BIOLOGY | OXIDATIVE BURST | SACCHAROMYCES-CEREVISIAE | CAENORHABDITIS-ELEGANS | fungus | plants | FERRIC REDUCTASE | reactive oxygen species | GENES | animals | HOMOLOGS | ARABIDOPSIS | DUAL OXIDASE | Mammals - genetics | Mammals - metabolism | Reactive Oxygen Species - metabolism | Fungi - enzymology | NADPH Oxidases - metabolism | Phylogeny | Fungi - genetics | Plants - enzymology | Plants - genetics | Models, Biological | NADPH Oxidases - genetics | Evolution, Molecular | Fungi | Life Sciences | Reactive Oxygen Species | Biochemistry, Molecular Biology | Biomolecules | Mammals | NADPH Oxidase
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7. Full Text Detection of reactive oxygen species derived from the family of NOX NADPH oxidases
by Maghzal, Ghassan J and Krause, Karl-Heinz and Stocker, Roland and Jaquet, Vincent
Free Radical Biology and Medicine, ISSN 0891-5849, 11/2012, Volume 53, Issue 10, pp. 1903 - 1918
NADPH oxidases (NOX) are superoxide anion radical (O )-generating enzymes. They form a family of seven members, each with a specific tissue distribution. They... 
Oxidative stress | Reactive oxygen species | Hydrogen peroxide | NOX | NADPH oxidase | Fluorescence | Superoxide anion radical | Mass spectrometry | Probes | HPLC | LEUKEMIA-CELL-LINE | CHRONIC GRANULOMATOUS-DISEASE | NITRIC-OXIDE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | IMAGING HYDROGEN-PEROXIDE | XYLENOL ORANGE METHOD | ENDOCRINOLOGY & METABOLISM | FLUORESCENT-PROBES | LUMINOL ANALOG L-012 | INTRACELLULAR SUPEROXIDE FORMATION | LIVING CELLS | Cytochromes c - chemistry | Cell-Free System | Electron Spin Resonance Spectroscopy | Oxidation-Reduction | Biosensing Techniques | Superoxides - analysis | Biological Assay | Tetrazolium Salts - chemistry | NADH, NADPH Oxidoreductases - metabolism | Reactive Oxygen Species - analysis | Oxidases | Heterocyclic compounds | Liquid chromatography | Superoxide
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8. Full Text Molecular mechanisms of hypertension: role of Nox family NADPH oxidases
by Sedeek, Mona and Hébert, Richard L and Kennedy, Chris R and Burns, Kevin D and Touyz, Rhian M
Current Opinion in Nephrology and Hypertension, ISSN 1062-4821, 03/2009, Volume 18, Issue 2, pp. 122 - 127
PURPOSE OF REVIEWMolecular mechanisms contributing to the pathoetiology of hypertension are complex, involving many interacting systems such as signaling... 
Vascular remodeling | Oxidative stress | Blood pressure | Free radicals | Nadph oxidase | Nox | blood pressure | free radicals | ACTIVATED PROTEIN-KINASE | vascular remodeling | BLOOD-PRESSURE | SIGNAL-TRANSDUCTION | NAD(P)H OXIDASE | RENOVASCULAR HYPERTENSION | RENIN-ANGIOTENSIN SYSTEM | NADPH oxidase | UROLOGY & NEPHROLOGY | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | HYDROGEN-PEROXIDE | VASCULAR ENDOTHELIAL-CELLS | oxidative stress | Membrane Glycoproteins - physiology | Animals | Reactive Oxygen Species - metabolism | Membrane Proteins - physiology | Humans | NADPH Oxidase 5 | NADPH Oxidase 4 | NADPH Oxidase 2 | NADPH Oxidases - physiology | NADPH Oxidase 1 | Hypertension - etiology
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