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Aging Cell, ISSN 1474-9718, 10/2017, Volume 16, Issue 5, pp. 1094 - 1103
Cellular senescence has been implicated in normal aging, tissue homeostasis, and tumor suppression. Although p53 has been shown to be a central mediator of... 
senescence | Akt | NOX | reactive oxygen species | p53 | NOX4 | CELLS | ACTIVATION | P53-INDUCED SENESCENCE | MTOR | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | OVEREXPRESSION | INHIBITION | ONCOGENIC RAS | GROWTH ARREST | ACCUMULATION | Interleukin-8 - genetics | RNA, Small Interfering - genetics | Epithelial Cells - metabolism | Reactive Oxygen Species - metabolism | Tumor Suppressor Protein p53 - antagonists & inhibitors | Proto-Oncogene Proteins p21(ras) - genetics | Epithelial Cells - drug effects | Humans | Cellular Senescence - drug effects | NF-kappa B - metabolism | Proto-Oncogene Proteins c-akt - genetics | Tumor Suppressor Protein p53 - genetics | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Cell Cycle Checkpoints - genetics | Interleukin-8 - metabolism | Epithelial Cells - cytology | Mechanistic Target of Rapamycin Complex 2 - genetics | Proto-Oncogene Proteins c-akt - metabolism | Interleukin-6 - metabolism | Fibroblasts - metabolism | Proto-Oncogene Proteins p21(ras) - metabolism | Lymphocytes - metabolism | Cellular Senescence - genetics | Promoter Regions, Genetic | NADPH Oxidase 4 - genetics | Interleukin-6 - genetics | Signal Transduction | Gene Expression Regulation | Tumor Suppressor Protein p53 - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - antagonists & inhibitors | Lymphocytes - cytology | Morpholines | Mechanistic Target of Rapamycin Complex 2 - metabolism | NADPH Oxidase 4 - metabolism | NF-kappa B - genetics | Cell Cycle Checkpoints - drug effects | Fibroblasts - drug effects | Lymphocytes - drug effects | Cell Line, Tumor | Protein Binding | Fibroblasts - cytology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Chromones | RNA, Small Interfering - metabolism | Tumor proteins | Analysis | TOR protein | NF-κB protein | Senescence | H-Ras protein | p53 Protein | Homeostasis | AKT protein | Rapamycin | Interleukin 6 | Signal transduction | Cyclin-dependent kinase inhibitor p21 | NOX4 protein | Cell cycle | Fibroblasts | Interleukin 8 | Index Medicus | Original
Journal Article
Journal Article
Nature Medicine, ISSN 1078-8956, 09/2016, Volume 22, Issue 9, pp. 1002 - 1012
Altered metabolism has been implicated in the pathogenesis of inflammatory diseases. NADPH oxidase 4 (NOX4), a source of cellular superoxide anions, has... 
MEDICINE, RESEARCH & EXPERIMENTAL | CARNITINE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PALMITOYLTRANSFERASE-I | CELL BIOLOGY | DIABETES-MELLITUS | NAD(P)H OXIDASE | METABOLISM | INSULIN-RESISTANCE | DISEASE | NOX4 | BETA-CELL | STRESS | Benzoxazoles - pharmacology | Metabolomics | Carnitine O-Palmitoyltransferase - genetics | Humans | Immunoblotting | Lipid Metabolism - immunology | DNA-Binding Proteins - metabolism | Calcium-Binding Proteins - immunology | Carnitine O-Palmitoyltransferase - metabolism | Adaptor Proteins, Signal Transducing - immunology | NADPH Oxidases - genetics | Fatty Acids - metabolism | Real-Time Polymerase Chain Reaction | Macrophages - immunology | Cytokines - immunology | Pyrazoles - pharmacology | Calcium-Binding Proteins - metabolism | Apoptosis Regulatory Proteins - immunology | DNA-Binding Proteins - immunology | Oxidation-Reduction | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | NADPH Oxidases - antagonists & inhibitors | NADPH Oxidase 4 | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Streptococcus pneumoniae | Triazoles - pharmacology | Macrophages - metabolism | Animals | NLR Family, Pyrin Domain-Containing 3 Protein - immunology | Inflammasomes - immunology | Lipid Metabolism - drug effects | Lipopolysaccharides - pharmacology | Macrophages - drug effects | Mice | Pyridines - pharmacology | Streptococcal Infections - immunology | Adaptor Proteins, Signal Transducing - metabolism | Oxidases | Transferases | Cellular signal transduction | Genetic aspects | Properties | Enzyme activation | Health aspects | Oxidation | Metabolism | Fatty acids | Cells | Index Medicus
Journal Article
Antioxidants & Redox Signaling, ISSN 1523-0864, 05/2016, Volume 24, Issue 14, pp. 795 - 812
Aims: Angiotensin II (Ang II) aggravates hepatic fibrosis by inducing NADPH oxidase (NOX)-dependent oxidative stress. Angiotensin-(1–7) [Ang-(1–7)], which... 
Original Research Communications | PATHWAYS | SYSTEM | OXIDATIVE STRESS | ACTIVATION | HEPATIC STELLATE CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOCRINOLOGY & METABOLISM | RATS | INJURY | MICE | STEATOHEPATITIS | HYPERTENSION | Liver - pathology | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Oxidative Stress | Rats, Wistar | Humans | Protein Multimerization | NADPH Oxidases - metabolism | Male | NF-kappa B - metabolism | Antioxidant Response Elements | Mitochondria, Liver - physiology | Peptide Fragments - physiology | Renin-Angiotensin System | Liver Cirrhosis - metabolism | Oxidation-Reduction | Signal Transduction | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Liver - metabolism | Peptide Fragments - administration & dosage | Angiotensin I - administration & dosage | Cells, Cultured | NADPH Oxidase 4 | Toll-Like Receptor 4 - metabolism | Collagen Type I - biosynthesis | Animals | Angiotensin I - physiology | Myeloid Differentiation Factor 88 - metabolism | Smad Proteins - metabolism | Connective Tissue Growth Factor - metabolism | Reactive oxygen species | Care and treatment | Angiotensin II receptor blockers | Fibrosis | Dosage and administration | Inflammation | Research | Risk factors | Oxidative stress | Smad protein | Hydrogen peroxide | Liver | Collagens | Innovations | Activation | NAD(P)H oxidase | Antioxidants | Proteins | Mitochondria | NOX4 protein | Synthesis | Modulation | Toll-like receptors | Inhibition | Angiotensin II | NRF2 protein | Glutathione | NF-κB protein | Stellate cells | RNA-mediated interference | siRNA | TLR4 protein | IL-1β | Bile duct | Immune systems | Pyrin protein | Ribonucleic acids | Collagen | Angiotensin | MyD88 protein | Bile | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2017, Volume 12, Issue 7, pp. e0180393 - e0180393
Although dipeptidyl peptidase-4 inhibitors, a class of antidiabetic drugs, have various pleiotropic effects, it remains undetermined whether gemigliptin has a... 
PHOSPHATE | ARTERIAL MEDIAL CALCIFICATION | OXIDATIVE STRESS | IN-VITRO | PHOSPHATIDYLINOSITOL 3-KINASE | MULTIDISCIPLINARY SCIENCES | OSTEOBLASTIC DIFFERENTIATION | CATENIN | UREMIC RATS | AKT | RUNX2 GENE-EXPRESSION | Reactive Oxygen Species - metabolism | Transcription Factor Pit-1 - metabolism | Calcium - metabolism | NADPH Oxidases - metabolism | Male | Core Binding Factor Alpha 1 Subunit - metabolism | Dipeptidyl-Peptidase IV Inhibitors - pharmacology | Aorta, Abdominal - drug effects | Vascular Calcification - metabolism | Transcription Factor Pit-1 - genetics | Renal Insufficiency, Chronic - genetics | NADPH Oxidases - genetics | Myocytes, Smooth Muscle - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Transcription Factor Pit-1 - antagonists & inhibitors | Phosphates - pharmacology | Wnt Signaling Pathway | Muscle, Smooth, Vascular - drug effects | Rats | Pyrimidines - pharmacology | Vascular Calcification - pathology | Rats, Sprague-Dawley | Reactive Oxygen Species - antagonists & inhibitors | Frizzled Receptors - genetics | Renal Insufficiency, Chronic - chemically induced | Muscle, Smooth, Vascular - metabolism | Vascular Calcification - genetics | Myocytes, Smooth Muscle - pathology | Phosphatidylinositol 3-Kinases - metabolism | Proto-Oncogene Proteins c-akt - genetics | Renal Insufficiency, Chronic - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Aorta, Abdominal - pathology | Aorta, Abdominal - metabolism | Myocytes, Smooth Muscle - metabolism | Gene Expression Regulation | Intercellular Signaling Peptides and Proteins - genetics | Adenine | Frizzled Receptors - metabolism | Vascular Calcification - prevention & control | NADPH Oxidase 4 | Piperidones - pharmacology | Renal Insufficiency, Chronic - pathology | Phosphatidylinositol 3-Kinases - genetics | Muscle, Smooth, Vascular - pathology | Animals | Phosphates - antagonists & inhibitors | Primary Cell Culture | Core Binding Factor Alpha 1 Subunit - genetics | Complications and side effects | Chronic kidney failure | Calcification | Genetic aspects | Hypoglycemic agents | Dosage and administration | Research | Drug therapy | Calcification (ectopic) | Phosphates | Drugs | Oxidative stress | Reactive oxygen species | Transcription factors | Nephrology | Wnt protein | Calcium | Frizzled protein | Oxidase | AKT protein | Smooth muscle | SOST protein | Kinases | NAD(P)H oxidase | Proteins | Signal transduction | Pit1 protein | Biomedical materials | NOX4 protein | Phosphate | Rodents | Aorta | Attenuation | Biocompatibility | Cbfa-1 protein | Oxygen | Peptidase | Internal medicine | Diabetes mellitus | Markers | Gene expression | 1-Phosphatidylinositol 3-kinase | Calcium phosphates | Medicine | Studies | Inhibitors | Kidney diseases | Diabetes | Dkk1 protein | Differentiation | Index Medicus
Journal Article
Laboratory Investigation, ISSN 0023-6837, 03/2019, Volume 99, Issue 3, pp. 387 - 398
Polymerase delta-interacting protein 2 (Poldip2) is a multi-functional protein with numerous roles in the vasculature, including the regulation of cell... 
CYCLIN-DEPENDENT KINASES | MEDICINE, RESEARCH & EXPERIMENTAL | NADPH OXIDASE | ARREST | REACTIVE OXYGEN | CELL NUCLEAR ANTIGEN | DELTA-INTERACTING PROTEIN-2 | DNA-POLYMERASE-DELTA | NOX4 | DEGRADATION | PATHOLOGY | BINDING | RNA, Small Interfering - genetics | Muscle, Smooth, Vascular - metabolism | Atherosclerosis - genetics | Humans | Myocytes, Smooth Muscle - pathology | Mitochondrial Proteins - genetics | Gene Knockdown Techniques | Mitochondrial Proteins - metabolism | Nuclear Proteins - deficiency | Superoxides - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Mitochondrial Proteins - deficiency | Nuclear Proteins - genetics | Myocytes, Smooth Muscle - metabolism | Atherosclerosis - pathology | Cell Proliferation - genetics | Down-Regulation | Carrier Proteins - antagonists & inhibitors | Cell Proliferation - physiology | Rats | Nuclear Proteins - metabolism | Neointima - metabolism | Atherosclerosis - metabolism | Mice, Knockout | Carrier Proteins - genetics | Neointima - prevention & control | Muscle, Smooth, Vascular - pathology | Animals | Carrier Proteins - metabolism | Nuclear Proteins - antagonists & inhibitors | Neointima - pathology | Mice | Proliferating Cell Nuclear Antigen - metabolism | Cell proliferation | GTP-binding protein | Femur | Muscles | Smooth muscle | siRNA | Wire | Arteries | Proteins | Polymerase | Cyclin-dependent kinase inhibitor p21 | Arteriosclerosis | Atherosclerosis | Cell cycle | Proliferating cell nuclear antigen | Aorta | Extracellular matrix | Cell migration | Injuries | Apoptosis
Journal Article
Journal Article
Journal Article
PLOS ONE, ISSN 1932-6203, 04/2015, Volume 10, Issue 4, pp. e0122275 - e0122275
The effects of Corexit 9500A (CE) on respiratory epithelial surfaces of terrestrial mammals and marine animals are largely unknown. This study investigated the... 
C-REACTIVE PROTEIN | GULF-OF-MEXICO | NADPH OXIDASE | HORIZON OIL-SPILL | OXIDATIVE STRESS | MULTIDISCIPLINARY SCIENCES | HYDROGEN-PEROXIDE | ENDOTHELIAL-CELL APOPTOSIS | E-CADHERIN | PARACELLULAR PERMEABILITY | DIOCTYL SODIUM SULFOSUCCINATE | Focal Adhesion Kinase 1 - genetics | Gills - enzymology | Heme Oxygenase-1 - metabolism | Bronchi - enzymology | Reactive Oxygen Species - metabolism | Cadherins - metabolism | Apoptosis - drug effects | Edema - genetics | Epithelial Cells - drug effects | Humans | Actins - metabolism | Caspase 3 - metabolism | NADPH Oxidases - metabolism | Zonula Occludens-2 Protein - metabolism | Occludin - metabolism | Actins - genetics | Bronchi - drug effects | Occludin - genetics | Heme Oxygenase-1 - genetics | Gills - drug effects | C-Reactive Protein - metabolism | Caspase 3 - genetics | NADPH Oxidases - genetics | Zonula Occludens-1 Protein - metabolism | Cadherins - genetics | Epithelial Cells - cytology | Bronchi - cytology | Focal Adhesion Kinase 1 - metabolism | Lipids - toxicity | Zonula Occludens-1 Protein - genetics | Permeability - drug effects | Surface-Active Agents - toxicity | Gene Expression Regulation | Brachyura | Zebrafish | C-Reactive Protein - genetics | NADPH Oxidase 4 | Mice, Knockout | Zonula Occludens-2 Protein - genetics | Edema - metabolism | Animals | Epithelial Cells - enzymology | Mice | Edema - chemically induced | Edema - pathology | Organometallic Compounds - pharmacology | C-reactive protein | Physiological aspects | Research | Permeability | B cells | Muscle proteins | Apoptosis | Oxidative stress | Reactive oxygen species | Epithelial cells | Terrestrial environments | Membrane permeability | Caspase-3 | E-cadherin | NAD(P)H oxidase | Antioxidants | Proteins | Reaction products | Respiratory tract | Crustaceans | NOX4 protein | Actin | Heme | Inhibition | Carbon monoxide | Marine animals | Aquatic animals | Edema | Crabs | Gills | Heme oxygenase (decyclizing) | Caspase | Epithelium | Blue crabs | Zonula occludens-1 protein | Oxygenase | Lungs | Marine organisms | Cytoskeleton | Focal adhesion kinase | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2016, Volume 11, Issue 4, pp. e0154157 - e0154157
Platelet derived growth factor (PDGF) orchestrates wound healing and tissue regeneration by regulating recruitment of the precursor mesenchymal stromal cells... 
SIGNAL-TRANSDUCTION | CHEMOTAXIS | MULTIDISCIPLINARY SCIENCES | IN-VIVO | SMOOTH-MUSCLE-CELLS | HYDROGEN-PEROXIDE | MECHANISMS | GROWTH-FACTOR | AKT/PROTEIN KINASE-B | NADPH OXIDASES | PROTEIN-KINASES | NIH 3T3 Cells | RNA, Small Interfering - genetics | Humans | NADPH Oxidases - metabolism | Proto-Oncogene Proteins c-akt - genetics | Mesenchymal Stem Cells - cytology | Mesenchymal Stem Cells - drug effects | Mitogen-Activated Protein Kinase 1 - genetics | Acetophenones - pharmacology | HEK293 Cells | NADPH Oxidases - genetics | Chromones - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Mesenchymal Stem Cells - metabolism | Phosphatidylinositol 3-Kinase - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Oxidation-Reduction | Signal Transduction | NADPH Oxidases - antagonists & inhibitors | Gene Expression Regulation | Morpholines - pharmacology | NADPH Oxidase 4 | Platelet-Derived Growth Factor - pharmacology | Hydrogen Peroxide - metabolism | Cell Movement - drug effects | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Phosphatidylinositol 3-Kinase - genetics | Mice | Primary Cell Culture | Dual Oxidases | Platelet-Derived Growth Factor - antagonists & inhibitors | Mitogen-Activated Protein Kinase 1 - metabolism | RNA, Small Interfering - metabolism | Fibroblasts | Platelet-derived growth factor | Research | Regeneration (Biology) | Cell migration | Stem cells | Cell culture | Oxidative stress | Phosphorylation | Hydrogen peroxide | Mesenchyme | Smooth muscle | AKT protein | Activation | Biochemistry | Kinases | Cell adhesion & migration | Recruitment | Proteins | Cell activation | NOX4 protein | Epidermal growth factor | Catalase | Cell cycle | Cardiology | Wound healing | Tissue engineering | Extracellular signal-regulated kinase | 1-Phosphatidylinositol 3-kinase | Medicine | Regeneration | Signaling | Stromal cells | Intracellular | Index Medicus
Journal Article