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PLoS ONE, ISSN 1932-6203, 10/2011, Volume 6, Issue 10, p. e26622
We have previously demonstrated that clock genes contribute to the homeostatic aspect of sleep regulation. Indeed, mutations in some clock genes modify the... 
MOLECULAR CHARACTERIZATION | CIRCADIAN-CLOCK | MESSENGER-RNA | OVERLAPPING ROLES | DEPRIVATION | E-BOX BINDING | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | PERIPHERAL-TISSUES | RHYTHM | EXPRESSION | ARNTL Transcription Factors - genetics | Basic Helix-Loop-Helix Transcription Factors - genetics | Mice, Inbred C57BL | Transcriptional Activation | ARNTL Transcription Factors - metabolism | Male | Sleep Deprivation - genetics | CLOCK Proteins - genetics | DNA Primers | Nerve Tissue Proteins - genetics | Sleep Deprivation - metabolism | Cerebral Cortex - metabolism | DNA-Binding Proteins - metabolism | Nerve Tissue Proteins - metabolism | CLOCK Proteins - metabolism | Animals | Basic Helix-Loop-Helix Transcription Factors - metabolism | Chromatin Immunoprecipitation | Base Sequence | Polymerase Chain Reaction | Protein Binding | Female | Mice | Brain | Chromatin | Messenger RNA | Genes | Liver | DNA | Genetic aspects | Genetic transcription | DNA binding proteins | Sleep deprivation | Molecular machines | Transcription factors | Phosphorylation | Cerebral cortex | Sleep loss | Immunoprecipitation | Genomics | Forebrain | Homeostasis | NPAS2 protein | Genomes | Regulatory sequences | CLOCK protein | Nuclei | Gene sequencing | Proteins | Sleep disorders | Period 1 protein | Animal tissues | Cell cycle | Period 2 protein | Bioinformatics | Deoxyribonucleic acid--DNA | Sleep and wakefulness | Biological clocks | Binding | Circadian rhythms | Deprivation | Nucleotide sequence | Cortex | Circadian rhythm | Gene expression | Sleep | BMAL1 protein | Cryptochromes | Mutation | Deoxyribonucleic acid
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2004, Volume 279, Issue 8, pp. 7091 - 7097
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2013, Volume 123, Issue 12, pp. 5389 - 5400
Brain aging is associated with diminished circadian clock output and decreased expression of the core clock proteins, which regulate many aspects of cellular... 
MEDICINE, RESEARCH & EXPERIMENTAL | NERVOUS-SYSTEM | CYCLOOXYGENASE-2 | RHYTHMS | IN-VIVO | ADAPTATION | GENE-EXPRESSION | COMPONENTS | BMAL1 | BRAIN | NPAS2 | Neurons - pathology | Oxidative Stress | Neuroglia - pathology | Nerve Tissue Proteins - deficiency | Cerebral Cortex - pathology | Nerve Degeneration - physiopathology | Nerve Degeneration - genetics | Period Circadian Proteins - deficiency | CLOCK Proteins - deficiency | Mice, Neurologic Mutants | Gliosis - pathology | ARNTL Transcription Factors - deficiency | RNA Interference | Neurons - metabolism | Corpus Striatum - pathology | Basic Helix-Loop-Helix Transcription Factors - deficiency | Period Circadian Proteins - physiology | Basic Helix-Loop-Helix Transcription Factors - physiology | CLOCK Proteins - physiology | Gliosis - genetics | Nerve Tissue Proteins - physiology | Oxidation-Reduction | Brain - physiopathology | Mice, Inbred C57BL | Circadian Rhythm - genetics | Gene Expression Regulation - physiology | Circadian Rhythm - physiology | Hippocampus - pathology | Mice, Knockout | Animals | Aging - physiology | Homeostasis - physiology | Brain - pathology | Sleep Disorders, Circadian Rhythm - physiopathology | Neuroglia - metabolism | Locomotion - physiology | ARNTL Transcription Factors - physiology | Homeostasis - genetics | Circadian rhythms | Physiological aspects | Homeostasis | Nervous system | Degeneration | Research | Brain | Oxidative stress | Neurodegeneration | Rodents | Circadian rhythm | Behavior | Kinases | Gene expression | Age
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2012, Volume 7, Issue 11, p. e50602
Journal Article
Journal Article
Biochemistry, ISSN 0006-2960, 06/2008, Volume 47, Issue 23, pp. 6157 - 6168
Journal Article
Journal Article
Journal Article
Aging, ISSN 1945-4589, 2010, Volume 2, Issue 12, pp. 936 - 944
Circadian clock is implicated in the regulation of aging. The transcription factor CLOCK, a core component of the circadian system, operates in complex with... 
Circadian rhythms | Aging | Transcription | Dermatitis | PHYSIOLOGY | transcription | MECHANISM | circadian rhythms | NPAS2 | CELL BIOLOGY | RESPONSES | dermatitis | DISRUPTION | GENE | OSCILLATORS | MOUSE CLOCK | COMPONENT | aging | MAMMALS
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2013, Volume 8, Issue 8, p. e71684
Chronic ethanol consumption disrupts several metabolic pathways including beta-oxidation and lipid biosynthesis, facilitating the development of alcoholic... 
CARDIOMYOCYTE CIRCADIAN CLOCK | PHASE-SHIFTS | ALCOHOL | TOLERANCE | MULTIDISCIPLINARY SCIENCES | MOUSE | DISEASE | MICE | PERIPHERAL-TISSUES | EXPRESSION | MAMMALIAN CLOCK | Suprachiasmatic Nucleus - drug effects | Liver - pathology | Ethanol - metabolism | Circadian Clocks - drug effects | Liver - metabolism | Mice, Inbred C57BL | Circadian Rhythm - genetics | Male | Mice, Transgenic | Circadian Clocks - genetics | Triglycerides - metabolism | Gene Expression Regulation - drug effects | Ethanol - pharmacology | Animals | Period Circadian Proteins - metabolism | Liver - drug effects | Period Circadian Proteins - genetics | Suprachiasmatic Nucleus - metabolism | Mice | Circadian Rhythm - drug effects | Alcohol, Denatured | Liver diseases | Genes | Cytochrome P-450 | Alcohol | Triglycerides | Suprachiasmatic nucleus | Bioluminescence | Neurosciences | Liver | Neurobiology | Oscillations | Homeostasis | NPAS2 protein | Lipids | Biosynthesis | Kinases | Metabolic syndrome | Nuclei | Proteins | Fatty liver | Period 1 protein | Pathways | Metabolites | Rodents | Physiology | Oxidation | Lipid metabolism | Period 2 protein | Biological clocks | Circadian rhythms | Consumption | Carbohydrates | Ethanol | Circadian rhythm | Gene expression | Metabolism | Fatty acids | Diurnal | Steatosis | Pathology | Diet | BMAL1 protein | Cryptochromes | Metabolic pathways
Journal Article
Diabetologia, ISSN 0012-186X, 10/2017, Volume 60, Issue 10, pp. 2011 - 2020
Journal Article