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Virology, ISSN 0042-6822, 09/2019, Volume 535, pp. 74 - 82
The DcCoV UAE-HKU23 coronavirus is a newly-found betacoronavirus (betaCoV) that can infect human cells. The viral spike protein plays pivotal roles in... 
Evolution | DcCoV UAE-HKU23 | Spike (S) | N-terminal domain (NTD) | Crystal structure | RECEPTOR | SIALIC-ACID | REFINEMENT | VIROLOGY | BOVINE CORONAVIRUS | OC43 | SEQUENCE | CORONAVIRUS MERS-COV | INFECTION | BINDING | MIDDLE-EAST | Structure | Analysis | Cells | Crystals
Journal Article
Biophysical Chemistry, ISSN 0301-4622, 07/2019, Volume 250, p. 106174
The structural integrity of N-terminal domain (NTD) of TAR DNA-binding protein-43 (TDP-43) is essential for the biological functions of TDP-43 involved in... 
Mutations | Stability | Dysfunction | Intermolecular interactions | Molecular dynamics simulation | Flexibility | NTD | MOLECULAR-DYNAMICS | RNA | INCLUSIONS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, PHYSICAL | MECHANISMS | FRONTOTEMPORAL LOBAR DEGENERATION | BINDING PROTEIN 43 | FRUSTRATION | BIOPHYSICS | ENERGY LANDSCAPE | AGGREGATION
Journal Article
by Park, SC and Park, IG and Kim, H and Lee, JM
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1422-0067, 04/2019, Volume 20, Issue 7
Four members of the retinoic acid-related orphan receptor alpha (ROR alpha) family (ROR alpha 1, ROR alpha 2, ROR alpha 3 and ROR alpha 4) are transcription... 
ANDROGEN RECEPTOR | TRANSCRIPTIONAL ACTIVATION | COMPLEX | ORPHAN NUCLEAR RECEPTORS | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | BETA-CATENIN | IDENTIFICATION | CHEMISTRY, MULTIDISCIPLINARY | ROR-ALPHA | prostate cancer | beta-catenin pathway | ROR alpha 1 | Wnt | EXPRESSION | NTD
Journal Article
Vaccine, ISSN 0264-410X, 2016, Volume 35, Issue 1, pp. 10 - 18
Journal Article
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 11/2006, Volume 399, Issue 3, pp. 373 - 385
Nrf1 (nuclear factor-erythroid 2 p45 subunit-related factor 1) and Nrf2 regulate ARE (antioxidant response element)-driven genes. At its N-terminal end, Nrf1... 
Kelch-like ECH-associated protein 1 (Keap1) | Nuclear factor-erythroid 2 p45 subunit-related factor 2 (Nrf2) | Oxidative stress | Nuclear factor-erythroid 2 p45 subunit-related factor 1 (Nrf1) | Antioxidant response element | Endoplasmic reticulum | FACTOR TCF11 | nuclear factor-erythroid 2 p45 subunit-related factor 1 (Nrf1) | nuclear factor-erythroid 2 p45 subunit-related factor 2 (Nrf2) | DETOXIFYING ENZYMES | BIOCHEMISTRY & MOLECULAR BIOLOGY | Kelch-like ECH-associated protein 1 (Keap 1) | MEDIATED EXPRESSION | NUCLEAR EXPORT | reticulum | CONSENSUS SEQUENCE | GENE-EXPRESSION | EMBRYONIC LETHALITY | endoplasmic | antioxidant response element | oxidative stress | INDUCIBLE EXPRESSION | Cytoskeletal Proteins - genetics | Humans | Transcriptional Activation | DNA, Complementary - genetics | Cercopithecus aethiops | Endoplasmic Reticulum - metabolism | Molecular Sequence Data | Protein Transport - physiology | Structure-Activity Relationship | Nuclear Respiratory Factor 1 - genetics | Recombinant Fusion Proteins - metabolism | Cytoskeletal Proteins - deficiency | Cell Nucleus - metabolism | Nuclear Respiratory Factor 1 - metabolism | Fibroblasts | NF-E2-Related Factor 2 - genetics | Cytoskeletal Proteins - physiology | Kelch-Like ECH-Associated Protein 1 | Genes, Reporter | Protein Structure, Tertiary | Amino Acid Sequence | Mutagenesis, Site-Directed | Cells, Cultured | Nuclear Respiratory Factor 1 - chemistry | Rats | Nuclear Proteins - metabolism | Epithelial Cells | Amino Acid Motifs | Mice, Knockout | Adaptor Proteins, Signal Transducing - physiology | Animals | Adaptor Proteins, Signal Transducing - deficiency | NF-E2-Related Factor 2 - metabolism | Adaptor Proteins, Signal Transducing - genetics | Mice | NF-E2-Related Factor 2 - chemistry | COS Cells | Neh2L, Nrf2-ECH homology 2-like | Nrf1, Nrf2, and Nrf3, nuclear factor-erythroid 2 p45 subunit-related factors 1, 2 and 3 | NuPAGE, Novex® PAGE | TCF11, transcription factor 11 | Gal4D, Gal4 DNA-binding domain | PBGD, porphobilinogen deaminase | SREBP, sterol-regulatory-element-binding protein | CNC, cap ‘n’ collar | Maf, musculoaponeurotic fibrosarcoma retrovirus transforming gene | NQO1, NAD(P)H:quinone oxidoreductase 1 | SV40, simian virus 40 | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | Luc, luciferase | nqo1-Luc | UAS, a Gal4-specific binding site | ARE, antioxidant response element | CREB, cyclic-AMP-response-element-binding protein | LDS, lithium dodecyl sulfate | bZIP, basic region-leucine zipper | FITC, fluorescein isothiocyanate | Keap1, Kelch-like ECH-associated protein 1 | DAPI, 4′,6-diamidino-2-phenylindole | P, promoter (as in P−1016 | TK, thymidine kinase promoter | β-gal, β-galactosidase | GCLM, glutamate cysteine ligase modifier | NTD, N-terminal domain | KO, knockout | MEF, mouse embryonic fibroblast | NHB, N-terminal homology box | endoplasmic reticulum
Journal Article
Journal Article
Protein Science, ISSN 0961-8368, 09/2005, Volume 14, Issue 9, pp. 2414 - 2420
Journal Article
Biochemical Journal, ISSN 0264-6021, 05/2015, Volume 467, Issue 3, pp. 365 - 386
In the last decade, the ubiquitin-proteasome system has emerged as a valid target for the development of novel therapeutics. E3 ubiquitin ligases are... 
Ubiquitin |