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Current Opinion in Structural Biology, ISSN 0959-440X, 02/2014, Volume 24, Issue 1, pp. 132 - 140
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 11/2012, Volume 48, Issue 3, pp. 409 - 421
The exosome is a complex involved in the maturation of rRNA and sn-snoRNA, in the degradation of short-lived noncoding RNAs, and in the quality control of RNAs... 
II TRANSCRIPTS | RAPID TRANSFER-RNA | OXIDATIVE STRESS | MATURE TRANSFER-RNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | POLY(A) POLYMERASE | QUALITY-CONTROL | RIBOSOMAL-RNA | SACCHAROMYCES-CEREVISIAE | BIDIRECTIONAL PROMOTERS | NUCLEAR EXOSOME | CELL BIOLOGY | Introns - genetics | Oligonucleotide Array Sequence Analysis | RNA Processing, Post-Transcriptional | RNA, Transfer - metabolism | Saccharomyces cerevisiae - genetics | RNA, Ribosomal - metabolism | Substrate Specificity | RNA Precursors - genetics | Gene Expression Profiling | Saccharomyces cerevisiae Proteins - genetics | RNA, Ribosomal - genetics | RNA, Small Nucleolar - genetics | RNA, Fungal - metabolism | Saccharomyces cerevisiae - metabolism | Blotting, Northern | RNA, Small Nucleolar - metabolism | Saccharomyces cerevisiae Proteins - metabolism | RNA, Transfer - genetics | Exosome Multienzyme Ribonuclease Complex - metabolism | RNA Precursors - metabolism | RNA, Fungal - genetics | Mutation | Exosome Multienzyme Ribonuclease Complex - genetics | Analysis | Transfer RNA | RNA Precursors | Introns | Quantitative Methods | Biochemistry, Molecular Biology | Genomics | Cellular Biology | RNA, Transfer | Bacteriology | Life Sciences | Microbiology and Parasitology | RNA, Ribosomal | RNA, Small Nucleolar | Saccharomyces cerevisiae Proteins | RNA, Fungal | Subcellular Processes | Exosome Multienzyme Ribonuclease Complex | Molecular biology | Saccharomyces cerevisiae
Journal Article
Molecular Cell, ISSN 1097-2765, 2011, Volume 43, Issue 4, pp. 624 - 637
Journal Article
Molecular Cell, ISSN 1097-2765, 11/2016, Volume 64, Issue 4, pp. 734 - 745
The eukaryotic RNA exosome is an essential and conserved 3′-to-5′ exoribonuclease complex that degrades or processes nearly every class of cellular RNA. The... 
X-ray crystallography | RNA | RNA decay | click chemistry | exoribonuclease | nuclear | exosome | multi-subunit complex | structure | Saccharomyces cerevisiae - genetics | Allosteric Regulation | Substrate Specificity | Crystallography, X-Ray | Protein Subunits - metabolism | Saccharomyces cerevisiae - metabolism | Thermodynamics | Cell Nucleus - metabolism | Exosome Multienzyme Ribonuclease Complex - chemistry | Cloning, Molecular | Escherichia coli - metabolism | Exosome Multienzyme Ribonuclease Complex - metabolism | Protein Interaction Domains and Motifs | RNA, Fungal - genetics | Exosome Multienzyme Ribonuclease Complex - genetics | Binding Sites | Exosome Multienzyme Ribonuclease Complex - ultrastructure | Protein Subunits - genetics | Recombinant Proteins - metabolism | Protein Conformation, alpha-Helical | Gene Expression | RNA, Fungal - chemistry | Models, Molecular | Recombinant Proteins - chemistry | RNA Cleavage | Recombinant Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Amino Acid Motifs | RNA, Fungal - metabolism | Cell Nucleus - genetics | Protein Conformation, beta-Strand | Escherichia coli - genetics | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Protein Subunits - chemistry | Saccharomyces cerevisiae Proteins - chemistry | Phosphates | Structure | Crystals
Journal Article
by Wang, JS and Chen, JY and Wu, GF and Zhang, HL and Du, X and Chen, SL and Zhang, L and Wang, K and Fan, J and Gao, SX and Wu, XD and Zhang, SX and Kuai, B and Zhao, P and Chi, BK and Wang, LT and Li, GH and Wong, CCL and Zhou, Y and Li, JS and Yun, CH and Cheng, H
GENES & DEVELOPMENT, ISSN 0890-9369, 05/2019, Volume 33, Issue 9-10, pp. 536 - 549
The exosome functions in the degradation of diverse RNA species, yet how it is negatively regulated remains largely unknown. Here, we show that NRDE2 forms a... 
MTR4 recruitment | mRNA export | PROTEIN | CRYSTAL-STRUCTURE | QUALITY CONTROL | DEVELOPMENTAL BIOLOGY | ARCH DOMAIN | NUCLEAR EXOSOME | CELL BIOLOGY | MESSENGER-RNAS | the nuclear exosome | TREX COMPLEX | GENETICS & HEREDITY | DEGRADATION | NRDE2 | CRYO-EM STRUCTURE | HELICASE
Journal Article
Molecular Cell, ISSN 1097-2765, 11/2016, Volume 64, Issue 3, pp. 520 - 533
The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its co-factor Mtr4p/hMTR4, which links to... 
RNA exosome | PAXT connection | nuclear RNA decay | poly(A) tail | NEXT complex | TELOMERASE RNA | MESSENGER-RNA | CRYPTIC UNSTABLE TRANSCRIPTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | RNA-QUALITY-CONTROL | MOLECULAR ARCHITECTURE | TARGETING COMPLEX | POLY(A)-BINDING PROTEIN | 3'-END MATURATION | POLY(A) TAIL LENGTH | BINDING-PROTEINS | CELL BIOLOGY | RNA Helicases - metabolism | RNA, Small Interfering - genetics | RNA-Binding Proteins - genetics | Humans | RNA, Messenger - metabolism | Cell Nucleus - metabolism | HEK293 Cells | Exosome Multienzyme Ribonuclease Complex - metabolism | RNA Helicases - genetics | Exosome Multienzyme Ribonuclease Complex - genetics | Nuclear Proteins - genetics | Poly(A)-Binding Protein I - genetics | Binding Sites | RNA-Binding Proteins - antagonists & inhibitors | RNA, Messenger - genetics | Carrier Proteins - antagonists & inhibitors | Poly(A)-Binding Protein I - metabolism | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Poly A - genetics | Transcription Factors - genetics | RNA Stability - genetics | Transcription Factors - metabolism | Carrier Proteins - genetics | Poly A - metabolism | Carrier Proteins - metabolism | Cell Nucleus - genetics | Nuclear Proteins - antagonists & inhibitors | Poly(A)-Binding Protein I - antagonists & inhibitors | Protein Binding | HeLa Cells | RNA-Binding Proteins - metabolism | RNA, Small Interfering - metabolism | Zinc compounds | RNA | Molecular biology | Protein binding
Journal Article