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Neuron (Cambridge, Mass.), ISSN 0896-6273, 09/2019, Volume 103, Issue 5, pp. 802 - 819.e11
motor neurons | ALS-FTD | planar molecule | stress granule | TDP-43 | high-content screening | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Small Molecule Libraries - pharmacology | Humans | DNA-Binding Proteins - metabolism | Frontotemporal Dementia - metabolism | Cytoplasmic Granules - metabolism | HEK293 Cells | RNA Helicases - genetics | Stress, Physiological - drug effects | DNA Helicases - genetics | Motor Neurons - drug effects | Cell Line | Cytoplasmic Granules - drug effects | DNA-Binding Proteins - drug effects | Intrinsically Disordered Proteins | Neural Stem Cells - drug effects | Poly-ADP-Ribose Binding Proteins - genetics | Heterogeneous-Nuclear Ribonucleoprotein Group A-B - metabolism | RNA-Binding Protein FUS - metabolism | Motor Neurons - metabolism | High-Throughput Screening Assays | Amyotrophic Lateral Sclerosis - metabolism | RNA Recognition Motif Proteins - genetics | Induced Pluripotent Stem Cells | Neural Stem Cells - metabolism | Protein Aggregation, Pathological - metabolism | Proteins | Motor neurons | RNA-binding protein | Disease | Neurodegenerative diseases | Stem cells | Dementia disorders | Amyotrophic lateral sclerosis | Mutation | Ribonucleic acid--RNA | Frontotemporal dementia | Localization | Index Medicus
Journal Article
Nature neuroscience, ISSN 1097-6256, 02/2018, Volume 21, Issue 2, pp. 228 - 239
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | C9orf72 Protein - genetics | Active Transport, Cell Nucleus - physiology | Humans | Nuclear Envelope - ultrastructure | Male | Drosophila Proteins - metabolism | Cerebral Cortex - cytology | DNA-Binding Proteins - metabolism | Frontotemporal Dementia - metabolism | Protein Aggregation, Pathological - pathology | Female | C9orf72 Protein - metabolism | Active Transport, Cell Nucleus - genetics | Neuroblastoma - pathology | Frontotemporal Dementia - pathology | Frontotemporal Dementia - genetics | Animals, Genetically Modified | Amyotrophic Lateral Sclerosis - genetics | Drosophila | Mice, Inbred C57BL | Cells, Cultured | Nuclear Pore - genetics | DNA-Binding Proteins - genetics | Nuclear Pore - metabolism | DNA-Binding Proteins - ultrastructure | Amyotrophic Lateral Sclerosis - pathology | Animals | Larva | Amyotrophic Lateral Sclerosis - metabolism | C9orf72 Protein - ultrastructure | Embryo, Nonmammalian | Mice | Drosophila Proteins - genetics | Nuclear Envelope - pathology | Protein Aggregation, Pathological - metabolism | Fibroblasts | Amyotrophic lateral sclerosis | Research | Protein binding | Brain | Neurons | Biotin | Ribonucleic acid--RNA | Pathology | DNA-binding protein | Nucleoporins | RNA transport | Aggregates | Stem cells | Dementia disorders | Mutation | Transport | Protein transport | Frontotemporal dementia | Pluripotency | Deoxyribonucleic acid--DNA | Index Medicus
Journal Article
Nature structural & molecular biology, ISSN 1545-9993, 12/2013, Volume 20, Issue 12, pp. 1443 - 1449
Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Protein Structure, Tertiary | Amino Acid Sequence | DNA-Binding Proteins - physiology | RNA-Binding Proteins - physiology | Humans | RNA-Binding Proteins - chemistry | Models, Molecular | Molecular Sequence Data | Cystic Fibrosis Transmembrane Conductance Regulator - metabolism | DNA-Binding Proteins - chemistry | DNA-Binding Proteins - metabolism | RNA Splicing - physiology | Base Composition | Nuclear Magnetic Resonance, Biomolecular | Cystic Fibrosis Transmembrane Conductance Regulator - genetics | Binding Sites | RNA-Binding Proteins - metabolism | Research | Binding proteins | Genetic regulation | Identification and classification | RNA splicing | Proteins | Cystic fibrosis | Molecular structure | Ribonucleic acid--RNA | Neurodegeneration | Index Medicus
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 11/2005, Volume 280, Issue 45, pp. 37572 - 37584
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | DNA-Binding Proteins - metabolism | Multigene Family | Alternative Splicing - genetics | Humans | RNA Splicing - genetics | Protein Binding | Cystic Fibrosis Transmembrane Conductance Regulator - genetics | Exons - genetics | Heterogeneous-Nuclear Ribonucleoprotein Group A-B - metabolism | Cystic Fibrosis Transmembrane Conductance Regulator - metabolism | HeLa Cells | DNA-Binding Proteins - chemistry | Index Medicus
Journal Article
Human molecular genetics, ISSN 0964-6906, 02/2017, Volume 26, Issue 4, pp. 790 - 800
Biochemistry & Molecular Biology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Tumor Necrosis Factor-alpha - metabolism | alpha Karyopherins - metabolism | Frontotemporal Lobar Degeneration - pathology | Membrane Glycoproteins - metabolism | Nuclear Localization Signals - genetics | Humans | Tumor Necrosis Factor-alpha - genetics | DNA-Binding Proteins - metabolism | Nuclear Pore Complex Proteins - genetics | DNA Repeat Expansion | Frontotemporal Lobar Degeneration - metabolism | C9orf72 Protein | Neurons - metabolism | Inclusion Bodies - metabolism | Nuclear Pore Complex Proteins - metabolism | Amyotrophic Lateral Sclerosis - genetics | Nuclear Localization Signals - metabolism | Rats | DNA-Binding Proteins - genetics | Membrane Glycoproteins - genetics | Proteins - genetics | Amyotrophic Lateral Sclerosis - pathology | Inclusion Bodies - genetics | Animals | Proteins - metabolism | Amyotrophic Lateral Sclerosis - metabolism | alpha Karyopherins - genetics | Frontotemporal Lobar Degeneration - genetics | Index Medicus
Journal Article
Acta neuropathologica, ISSN 0001-6322, 12/2016, Volume 132, Issue 6, pp. 859 - 873
Pathology | Neurosciences | Medicine & Public Health | Alzheimer’s disease | TDP-43 | β-Amyloid | Forebrain | Nuclear depletion | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Alzheimer Disease - complications | Neurodegenerative Diseases - etiology | Humans | Male | DNA-Binding Proteins - deficiency | Alzheimer Disease - pathology | Antineoplastic Agents, Hormonal - therapeutic use | Cognition Disorders - etiology | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Plaque, Amyloid - etiology | Female | Autophagy - genetics | Disease Models, Animal | Prosencephalon - pathology | Plaque, Amyloid - pathology | Mice, Inbred C57BL | Alzheimer Disease - drug therapy | Presenilin-1 - genetics | Mice, Transgenic | Cognition Disorders - genetics | Mitochondria - metabolism | Mitochondria - pathology | DNA-Binding Proteins - genetics | Plaque, Amyloid - genetics | Amyloid beta-Protein Precursor - genetics | Animals | Presenilin-1 - metabolism | Tamoxifen - therapeutic use | Mice | Alzheimer Disease - genetics | Index Medicus | Alzheimer's disease
Journal Article
Journal of cell science, ISSN 0021-9533, 11/2008, Volume 121, Issue 22, pp. 3778 - 3785
RNA recognition motifs | Nuclear-cytoplasmic shuttling | hnRNP | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cytoplasm - chemistry | Protein Structure, Tertiary | Cell Line | Sequence Deletion | Nuclear Localization Signals - genetics | Humans | Cytoplasm - metabolism | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | Amino Acid Motifs | Protein Transport | DNA-Binding Proteins - metabolism | Cell Nucleus - metabolism | Cell Nucleus - genetics | Cell Nucleus - chemistry | Cytoplasm - genetics | HeLa Cells | Index Medicus
Journal Article
Nature communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 4406 - 13
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Polytene Chromosomes - metabolism | DNA-Binding Proteins - toxicity | Humans | Male | Nuclear Proteins - metabolism | Genetic Loci | Drosophila Proteins - metabolism | RNA, Untranslated - genetics | Transcription Elongation, Genetic | Drosophila melanogaster - metabolism | Transcription Factors - metabolism | Transcriptional Elongation Factors - metabolism | Animals | Models, Biological | RNA, Small Nuclear - genetics | HEK293 Cells | Protein Binding | Female | Immunoprecipitation | Target recognition | Toxicity | Amyotrophic lateral sclerosis | Ribonucleic acid--RNA | snRNA | Proteins | Neurodegeneration | Coding | Degeneration | Frontotemporal dementia | Non-coding RNA | Elongation | Index Medicus
Journal Article
Nucleic acids research, ISSN 0305-1048, 03/2019, Volume 47, Issue 5, pp. 2487 - 2505
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Coiled Bodies - genetics | Molecular Chaperones | Cell Nucleolus - genetics | RNA, Guide - genetics | Amyotrophic Lateral Sclerosis - genetics | Humans | Ribonucleoproteins, Small Nuclear - genetics | Cytidine - analogs & derivatives | DNA-Binding Proteins - genetics | Proteins - genetics | Amyotrophic Lateral Sclerosis - pathology | RNA, Small Nuclear - genetics | Cytidine - genetics | Coiled Bodies - metabolism | HeLa Cells | Telomerase | Index Medicus | Molecular Biology
Journal Article