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Nature (London), ISSN 1476-4687, 01/2018, Volume 554, Issue 7690, pp. 112 - 117
...) I-and II-dependent transcriptional arms of ribosome biogenesis(5), we uncovered a previously unappreciated mechanism linking nucleolar dysfunction, ribosomal DNA (rDNA... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Xenopus | Chromatin - metabolism | Cell Nucleolus - pathology | Embryonic Stem Cells - cytology | Mandibulofacial Dysostosis - embryology | Humans | Protein Transport - drug effects | DNA-Directed RNA Polymerases - deficiency | RNA, Ribosomal - genetics | RNA Polymerase I - antagonists & inhibitors | Mandibulofacial Dysostosis - genetics | Cell Nucleus - metabolism | Skull - pathology | Nuclear Proteins - deficiency | Cell Nucleolus - drug effects | Stress, Physiological - drug effects | Neural Crest - enzymology | Benzothiazoles - pharmacology | Phenotype | Zebrafish Proteins - deficiency | Ribosomes - genetics | Mice | DNA Damage | HeLa Cells | Embryonic Stem Cells - metabolism | RNA Helicases - metabolism | Mandibulofacial Dysostosis - pathology | Neural Crest - pathology | Ribosomal Proteins - biosynthesis | Ribosomes - metabolism | DNA, Ribosomal - metabolism | Phosphoproteins - metabolism | Zebrafish - embryology | Cell Nucleus - pathology | Cell Nucleolus - metabolism | DEAD-box RNA Helicases - deficiency | DEAD-box RNA Helicases - metabolism | Nuclear Proteins - genetics | DNA, Ribosomal - genetics | Cell Nucleolus - genetics | Ribosomal Proteins - genetics | Tumor Suppressor Protein p53 - metabolism | RNA, Ribosomal - metabolism | Nuclear Proteins - metabolism | Phosphoproteins - genetics | Organ Specificity | DEAD-box RNA Helicases - genetics | Animals | Phosphoproteins - deficiency | RNA, Ribosomal - biosynthesis | Cell Nucleus - drug effects | Naphthyridines - pharmacology | Apoptosis | Nucleolus organizer region | Genetic aspects | Gene mutations | Observations | Neural crest | Craniofacial dysostosis | Chromatin | Transcription | Genomics | p53 Protein | Genes | DNA damage | Ribosomal DNA | Disorders | Homeostasis | Biosynthesis | Genomes | DNA-directed RNA polymerase | Proteins | DNA helicase | Nucleoli | Embryogenesis | Cell activation | RNA processing | Chemical synthesis | Deoxyribonucleic acid--DNA | Anemia | rRNA | RNA polymerase | Ribonucleic acid--RNA | Embryonic growth stage | DNA biosynthesis | Craniofacial growth | Stem cells | Mutation | Developmental disabilities | Tumors | RNA helicase | Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 09/2013, Volume 8, Issue 9, pp. e74334 - e74334
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 11/2012, Volume 109, Issue 50, pp. 20467 - 20472
Impairment of ribosomal biogenesis can activate the p53 protein independently of DNA damage... 
Up regulation | Cell nucleolus | Ribosomal proteins | Ribosomes | Cell cycle | Antibodies | HeLa cells | Small interfering RNA | Cell aggregates | Cellular immunity | Ribosomal stress | Proteasome | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | RNA, Small Interfering - genetics | Up-Regulation | Tumor Suppressor Protein p53 - antagonists & inhibitors | Humans | Stress, Physiological | Ribosomes - metabolism | RNA, Messenger - metabolism | Tumor Suppressor Protein p53 - genetics | Ribosomal Proteins - metabolism | Base Sequence | Cell Nucleolus - metabolism | Tumor Suppressor Proteins - genetics | Active Transport, Cell Nucleus | Protein Stability | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-mdm2 - metabolism | Ribosomal Proteins - antagonists & inhibitors | Tumor Suppressor Proteins - metabolism | Ribosomal Proteins - genetics | RNA, Messenger - genetics | Tumor Suppressor Protein p53 - metabolism | Nuclear Proteins - metabolism | Transcription Factors - genetics | Transcription Factors - metabolism | Animals | Models, Biological | Cell Line, Tumor | Mice | Proteasome Endopeptidase Complex - metabolism | Dactinomycin - pharmacology | Promyelocytic Leukemia Protein | DNA damage | Physiological aspects | Biosynthesis | Stress (Physiology) | Research | Health aspects | Index Medicus | ribosomal stress | Biological Sciences | proteasome
Journal Article