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1. Full Text Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity
by Guilinger, John P and Pattanayak, Vikram and Reyon, Deepak and Tsai, Shengdar Q and Sander, Jeffry D and Joung, J Keith and Liu, David R
Nature Methods, ISSN 1548-7091, 2014, Volume 11, Issue 4, pp. 429 - 435
Although transcription activator-like effector nucleases (TALENs) can be designed to cleave chosen DNA sequences, TALENs have activity against related... 
SYSTEM | DISEASE | BIOCHEMICAL RESEARCH METHODS | ZFNS | EFFECTOR NUCLEASES | KNOCKOUT | ZINC-FINGER NUCLEASES | GENOME | REVEALS | Cell Line | Deoxyribonucleases - genetics | Gene Targeting | Protein Engineering - methods | Base Sequence | Humans | Protein Binding | Substrate Specificity - physiology | DNA - metabolism | Binding Sites | Deoxyribonucleases - metabolism | Physiological aspects | Nucleases | Genetic transcription | Research | DNA binding proteins | Genetic engineering | Deoxyribonucleic acid--DNA | Cells
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2. Full Text Rationally engineered Cas9 nucleases with improved specificity
by Slaymaker, Ian M and Gao, Linyi and Zetsche, Bernd and Scott, David A and Yan, Winston X and Zhang, Feng
Science, ISSN 0036-8075, 01/2016, Volume 351, Issue 6268, pp. 84 - 88
The RNA-guided endonuclease Cas9 is a versatile genome-editing tool with a broad range of applications from therapeutics to functional annotation of genes.... 
COMPLEX | ENDONUCLEASE | GENOME-EDITING SPECIFICITY | RECOGNITION | CRISPR RNA | MULTIDISCIPLINARY SCIENCES | SEED SEQUENCE | TARGET DNA | SYSTEMS | Point Mutation | Endonucleases - genetics | Mutagenesis | RNA, Guide - genetics | Humans | Streptococcus pyogenes - enzymology | Bacterial Proteins - chemistry | Bacterial Proteins - genetics | Protein Engineering | Protein Conformation | DNA Cleavage | Endonucleases - chemistry | Nucleases | DNA binding proteins | Analysis | Genomics | Streptococcus | Genetic aspects | Nucleotide sequencing | Observations | Health aspects | Methods | Protein binding | DNA sequencing | Bacteria | Genetic engineering | Deoxyribonucleic acid--DNA | Immune system | Immune systems | Genes | Deoxyribonucleic acid | Cleavage | Genomes | Loci
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3. Full Text Small molecule-triggered Cas9 protein with improved genome-editing specificity
by Davis, Kevin M and Pattanayak, Vikram and Thompson, David B and Zuris, John A and Liu, David R
Nature Chemical Biology, ISSN 1552-4450, 05/2015, Volume 11, Issue 5, pp. 316 - 318
Directly modulating the activity of genome-editing proteins has the potential to increase their specificity by reducing activity following target locus... 
NUCLEASE SPECIFICITY | RNA | NICKASES | HUMAN-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CLEAVAGE | DIRECTED EVOLUTION | MAMMALIAN-CELLS | DELIVERY | INTEIN
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4. Full Text Genome-wide nucleosome specificity and function of chromatin remodellers in ES cells
by De Dieuleveult, Maud and Yen, Kuangyu and Hmitou, Isabelle and Depaux, Arnaud and Boussouar, Fayçal and Dargham, Daria Bou and Jounier, Sylvie and Humbertclaude, Hélène and Ribierre, Florence and Baulard, Céline and Farrell, Nina P and Park, Bongsoo and Keime, Céline and Carrière, Lucie and Berlivet, Soizick and Gut, Marta and Gut, Ivo and Werner, Michel and Deleuze, Jean-François and Olaso, Robert and Aude, Jean-Christophe and Chantalat, Sophie and Pugh, B. Franklin and Gérard, Matthieu
Nature, ISSN 0028-0836, 02/2016, Volume 530, Issue 7588, pp. 113 - 116
ATP-dependent chromatin remodellers allow access to DNA for transcription factors and the general transcription machinery, but whether mammalian chromatin... 
PROMOTERS | MULTIDISCIPLINARY SCIENCES | EMBRYONIC STEM-CELLS | GENES | ARCHITECTURE | TRANSCRIPTION ELONGATION | PLURIPOTENCY | ESBAF | DIFFERENTIATION | CPG ISLANDS | BINDING | Gene Expression Regulation | Genome - genetics | Chromatin Assembly and Disassembly | Nucleosomes - metabolism | Substrate Specificity | Mouse Embryonic Stem Cells - cytology | Nuclear Proteins - metabolism | Nucleosomes - genetics | RNA Polymerase II - metabolism | Promoter Regions, Genetic - genetics | Mouse Embryonic Stem Cells - metabolism | DNA-Binding Proteins - metabolism | Transcription Factors - metabolism | DNA Helicases - metabolism | Animals | Micrococcal Nuclease - metabolism | Transcription Initiation Site | Trans-Activators - metabolism | Mice | Histones - metabolism | Chromatin | Genome-wide association studies | Genetic aspects | Research | Embryonic stem cells | Genomes | RNA polymerase | Gene expression | Embryos | Deoxyribonucleic acid--DNA | Cells | Life Sciences
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5. Full Text Improving CRISPR-Cas nuclease specificity using truncated guide RNAs
by Fu, Yanfang and Sander, Jeffry D and Reyon, Deepak and Cascio, Vincent M and Joung, J Keith
Nature Biotechnology, ISSN 1087-0156, 2014, Volume 32, Issue 3, pp. 279 - 284
Clustered, regularly interspaced, short palindromic repeat (CRISPR) RNA-guided nucleases (RGNs) are highly efficient genome editing tools(1-3).... 
ZINC-FINGER TARGETER | TRANSCRIPTION FACTORS | HUMAN GENOME | NICKING | ZIFIT | NICKASES | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | HUMAN-CELLS | GENES | SYSTEMS | TOOL | Endonucleases - genetics | RNA, Guide - genetics | CRISPR-Associated Proteins - genetics | RNA, Guide - metabolism | Humans | Bacterial Proteins - genetics | Molecular Sequence Data | DNA - metabolism | Endonucleases - metabolism | Endonucleases - chemistry | DNA - genetics | DNA - chemistry | RNA, Guide - chemistry | Base Sequence | CRISPR-Associated Proteins - metabolism | Genetic research | Nucleases | Genetic engineering | Research | RNA | Methods | Enzymes | Mutation | Ribonucleic acid--RNA | Genomics | Index Medicus
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6. Full Text Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer
by Provasi, Elena and Genovese, Pietro and Lombardo, Angelo and Magnani, Zulma and Liu, Pei-Qi and Reik, Andreas and Chu, Victoria and Paschon, David E and Zhang, Lei and Kuball, Jurgen and Camisa, Barbara and Bondanza, Attilio and Casorati, Giulia and Ponzoni, Maurilio and Ciceri, Fabio and Bordignon, Claudio and Greenberg, Philip D and Holmes, Michael C and Gregory, Philip D and Naldini, Luigi and Bonini, Chiara
Nature Medicine, ISSN 1078-8956, 05/2012, Volume 18, Issue 5, pp. 807 - 815
The transfer of high-avidity T cell receptor (TCR) genes isolated from rare tumor-specific lymphocytes into polyclonal T cells is an attractive cancer... 
MEDICINE, RESEARCH & EXPERIMENTAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR EXPRESSION | VERSUS-HOST-DISEASE | CELL BIOLOGY | METASTATIC MELANOMA | THERAPY | MEMORY | CANCER REGRESSION | ENHANCED ANTITUMOR-ACTIVITY | DIFFERENTIATION | TCR CHAINS | LYMPHOCYTES | Gene Transfer Techniques | Zinc Fingers | Jurkat Cells | Humans | Deoxyribonucleases, Type II Site-Specific - pharmacology | Molecular Sequence Data | Leukemia - immunology | Base Sequence | T-Cell Antigen Receptor Specificity | Lentivirus - genetics | T-Lymphocytes - immunology | Receptors, Antigen, T-Cell - genetics | WT1 Proteins - genetics | Nucleases | Care and treatment | Leukemia | Physiological aspects | Genetic aspects | Research | Zinc finger proteins | Gene therapy | T cells | Enzymes | Antigens | Lymphocytes | Immunotherapy | Genetics | T cell receptors
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7. Full Text An unbiased genome-wide analysis of zinc-finger nuclease specificity
by Gabriel, Richard and Lombardo, Angelo and Arens, Anne and Miller, Jeffrey C and Genovese, Pietro and Kaeppel, Christine and Nowrouzi, Ali and Bartholomae, Cynthia C and Wang, Jianbin and Friedman, Geoffrey and Holmes, Michael C and Gregory, Philip D and Glimm, Hanno and Schmidt, Manfred and Naldini, Luigi and Von Kalle, Christof
Nature Biotechnology, ISSN 1087-0156, 09/2011, Volume 29, Issue 9, pp. 816 - 823
Zinc-finger nucleases (ZFNs) allow gene editing in live cells by inducing a targeted DNA double-strand break (DSB) at a specific genomic locus. However,... 
VECTOR INTEGRATION | DNA CLEAVAGE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENE MODIFICATION | IN-VIVO | SITES | DOUBLE-STRAND BREAKS | RESTRICTION ENZYMES | KNOCKOUT | MAMMALIAN-CELLS | LENTIVIRAL VECTORS | Gene Targeting | Humans | Substrate Specificity | Genetic Loci | HIV Integrase - metabolism | DNA Breaks, Double-Stranded | Sequence Analysis, DNA | Genetic Vectors - genetics | Endodeoxyribonucleases - genetics | HIV Integrase - genetics | Endodeoxyribonucleases - metabolism | Cell Line, Tumor | Protein Binding | Lentivirus - genetics | Zinc Fingers - genetics | Binding Sites | Cluster Analysis | Physiological aspects | Nucleases | Zinc finger proteins | Research | DNA binding proteins | Analysis | Genomes | Zinc | Deoxyribonucleic acid--DNA
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8. Full Text Evolved Cas9 variants with broad PAM compatibility and high DNA specificity
by Hu, Johnny H and Miller, Shannon M and Geurts, Maarten H and Tang, Weixin and Chen, Liwei and Sun, Ning and Zeina, Christina M and Gao, Xue and Rees, Holly A and Lin, Zhi and Liu, David R
Nature, ISSN 0028-0836, 04/2018, Volume 556, Issue 7699, pp. 57 - 63
A key limitation of the use of the CRISPR-Cas9 system for genome editing and other applications is the requirement that a protospacer adjacent motif (PAM) be... 
SYSTEM | CONTINUOUS DIRECTED EVOLUTION | ENDONUCLEASE | RECOGNITION | CRISPR-CAS9 NUCLEASES | MULTIDISCIPLINARY SCIENCES | OFF-TARGET CLEAVAGE | TRANSCRIPTION | CPF1 | GENOMIC DNA | BASE | CRISPR-Associated Proteins - genetics | Humans | Transcriptional Activation | Directed Molecular Evolution | DNA - metabolism | Substrate Specificity - genetics | CRISPR-Cas Systems - genetics | Deoxyribonucleases - metabolism | Genome, Human - genetics | DNA - genetics | Streptococcus pyogenes - genetics | Nucleotide Motifs | CRISPR-Associated Proteins - metabolism | Streptococcus pyogenes - enzymology | HEK293 Cells | Gene Editing - methods | Mutation | DNA Cleavage | Genetic variation | Streptococcus pyogenes | Genetic aspects | Nucleotide sequencing | Observations | Methods | DNA sequencing | CRISPR | Phages | Biological evolution | Cloning | Adenine | Editing | Cell division | Genomes | Research | RNA polymerase | Mammals | Gene expression | Experiments | Mammalian cells | Proteins | Design | Gene disruption | Transcription activation | Evolution | Nuclease | Compatibility | Deoxyribonucleic acid--DNA
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9. Full Text Defining and improving the genome-wide specificities of CRISPR-Cas9 nucleases
by Tsai, Shengdar Q and Joung, J. Keith
Nature Reviews Genetics, ISSN 1471-0056, 05/2016, Volume 17, Issue 5, pp. 300 - 312
CRISPR-Cas9 RNA-guided nucleases are a transformative technology for biology, genetics and medicine owing to the simplicity with which they can be programmed... 
STEM-CELLS | GENE KNOCKOUT | HUMAN-CELLS | EDITING SPECIFICITY | OFF-TARGET CLEAVAGE | GENETICS & HEREDITY | RNA-GUIDED ENDONUCLEASE | DNA-CLEAVAGE | CRISPR/CAS9 SYSTEMS | ZINC-FINGER NUCLEASES | ENGINEERED NUCLEASES | DNA - genetics | Genetic Engineering | Endonucleases - metabolism | Genome, Human | CRISPR-Cas Systems - genetics | Humans | Nucleases | Genome-wide association studies | Genetic engineering | Properties | Methods | Innovations
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10. Full Text Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity
by Ran, F. Ann and Hsu, Patrick D and Lin, Chie-Yu and Gootenberg, Jonathan S and Konermann, Silvana and Trevino, Alexandro E and Scott, David A and Inoue, Azusa and Matoba, Shogo and Zhang, Feng and Zhang, Yi
Cell, ISSN 0092-8674, 09/2013, Volume 154, Issue 6, pp. 1380 - 1389
Targeted genome editing technologies have enabled a broad range of research and medical applications. The Cas9 nuclease from the microbial CRISPR-Cas system is... 
SYSTEM | CELLS | BACTERIA | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENERATION | KNOCKOUT | NUCLEASE | CELL BIOLOGY | Streptococcus pyogenes - genetics | Gene Targeting - methods | Animals | RNA, Guide - genetics | Base Sequence | Streptococcus pyogenes - enzymology | Zygote - metabolism | Molecular Sequence Data | Mice | Genome | DNA Breaks, Double-Stranded | RNA | Genomics | Index Medicus
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