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1. Full Text Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity
by Guilinger, John P and Pattanayak, Vikram and Reyon, Deepak and Tsai, Shengdar Q and Sander, Jeffry D and Joung, J Keith and Liu, David R
Nature methods, ISSN 1548-7091, 2014, Volume 11, Issue 4, pp. 429 - 435
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Biochemical Research Methods | Science & Technology | Cell Line | Deoxyribonucleases - genetics | Gene Targeting | Protein Engineering - methods | Base Sequence | Humans | Protein Binding | Substrate Specificity - physiology | DNA - metabolism | Binding Sites | Deoxyribonucleases - metabolism | Physiological aspects | Nucleases | Genetic transcription | Research | DNA binding proteins | Genetic engineering | Deoxyribonucleic acid--DNA | Cells | Index Medicus
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2. Full Text Genome-wide nucleosome specificity and function of chromatin remodellers in ES cells
by De Dieuleveult, Maud and Yen, Kuangyu and Hmitou, Isabelle and Depaux, Arnaud and Boussouar, Fayçal and Dargham, Daria Bou and Jounier, Sylvie and Humbertclaude, Hélène and Ribierre, Florence and Baulard, Céline and Farrell, Nina P and Park, Bongsoo and Keime, Céline and Carrière, Lucie and Berlivet, Soizick and Gut, Marta and Gut, Ivo and Werner, Michel and Deleuze, Jean-François and Olaso, Robert and Aude, Jean-Christophe and Chantalat, Sophie and Pugh, B. Franklin and Gérard, Matthieu
Nature (London), ISSN 0028-0836, 02/2016, Volume 530, Issue 7588, pp. 113 - 116
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Gene Expression Regulation | Genome - genetics | Chromatin Assembly and Disassembly | Nucleosomes - metabolism | Substrate Specificity | Mouse Embryonic Stem Cells - cytology | Nuclear Proteins - metabolism | Nucleosomes - genetics | RNA Polymerase II - metabolism | Promoter Regions, Genetic - genetics | Mouse Embryonic Stem Cells - metabolism | DNA-Binding Proteins - metabolism | Transcription Factors - metabolism | DNA Helicases - metabolism | Animals | Micrococcal Nuclease - metabolism | Transcription Initiation Site | Trans-Activators - metabolism | Mice | Histones - metabolism | Chromatin | Genome-wide association studies | Genetic aspects | Research | Embryonic stem cells | Genomes | RNA polymerase | Gene expression | Embryos | Deoxyribonucleic acid--DNA | Cells | Index Medicus | Life Sciences
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3. Full Text Improving CRISPR-Cas nuclease specificity using truncated guide RNAs
by Fu, Yanfang and Sander, Jeffry D and Reyon, Deepak and Cascio, Vincent M and Joung, J Keith
Nature biotechnology, ISSN 1087-0156, 2014, Volume 32, Issue 3, pp. 279 - 284
Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Genetic research | Nucleases | Genetic engineering | Research | RNA | Methods | Enzymes | Mutation | Ribonucleic acid--RNA | Genomics | Index Medicus
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4. Full Text Evolved Cas9 variants with broad PAM compatibility and high DNA specificity
by Hu, Johnny H and Miller, Shannon M and Geurts, Maarten H and Tang, Weixin and Chen, Liwei and Sun, Ning and Zeina, Christina M and Gao, Xue and Rees, Holly A and Lin, Zhi and Liu, David R
Nature (London), ISSN 0028-0836, 04/2018, Volume 556, Issue 7699, pp. 57 - 63
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | CRISPR-Associated Proteins - genetics | Humans | Transcriptional Activation | Directed Molecular Evolution | DNA - metabolism | Substrate Specificity - genetics | CRISPR-Cas Systems - genetics | Deoxyribonucleases - metabolism | Genome, Human - genetics | DNA - genetics | Streptococcus pyogenes - genetics | Nucleotide Motifs | CRISPR-Associated Proteins - metabolism | Streptococcus pyogenes - enzymology | HEK293 Cells | Gene Editing - methods | Mutation | DNA Cleavage | Genetic variation | Streptococcus pyogenes | Genetic aspects | Nucleotide sequencing | Observations | Methods | DNA sequencing | CRISPR | Phages | Biological evolution | Cloning | Adenine | Editing | Cell division | Genomes | Research | RNA polymerase | Mammals | Gene expression | Experiments | Mammalian cells | Proteins | Design | Gene disruption | Transcription activation | Evolution | Nuclease | Compatibility | Deoxyribonucleic acid--DNA | Index Medicus
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5. Full Text Kinetic Basis for DNA Target Specificity of CRISPR-Cas12a
by Strohkendl, Isabel and Saifuddin, Fatema A and Rybarski, James R and Finkelstein, Ilya J and Russell, Rick
Molecular cell, ISSN 1097-2765, 09/2018, Volume 71, Issue 5, pp. 816 - 824.e3
rate-limiting binding | RNA-protein enzyme | RNA/DNA thermodynamics | AsCpf1 | RNA-guided nuclease | CRISPR-Cas system | RNA/DNA assembly | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | RNA, Guide - genetics | CRISPR-Associated Proteins - genetics | Humans | Bacterial Proteins - genetics | CRISPR-Cas Systems - genetics | DNA - genetics | Protein Binding | Acidaminococcus - genetics | Clustered Regularly Interspaced Short Palindromic Repeats - genetics | Gene Editing - methods | Kinetics | Nucleic Acid Conformation | DNA Cleavage | Enzymes | Nucleases | DNA binding proteins | RNA | Genomics | DNA | Index Medicus
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6. Full Text Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer
by Provasi, Elena and Genovese, Pietro and Lombardo, Angelo and Magnani, Zulma and Liu, Pei-Qi and Reik, Andreas and Chu, Victoria and Paschon, David E and Zhang, Lei and Kuball, Jurgen and Camisa, Barbara and Bondanza, Attilio and Casorati, Giulia and Ponzoni, Maurilio and Ciceri, Fabio and Bordignon, Claudio and Greenberg, Philip D and Holmes, Michael C and Gregory, Philip D and Naldini, Luigi and Bonini, Chiara
Nature medicine, ISSN 1078-8956, 05/2012, Volume 18, Issue 5, pp. 807 - 815
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Gene Transfer Techniques | Zinc Fingers | Jurkat Cells | Humans | Deoxyribonucleases, Type II Site-Specific - pharmacology | Molecular Sequence Data | Leukemia - immunology | Base Sequence | T-Cell Antigen Receptor Specificity | Lentivirus - genetics | T-Lymphocytes - immunology | Receptors, Antigen, T-Cell - genetics | WT1 Proteins - genetics | Nucleases | Care and treatment | Leukemia | Physiological aspects | Genetic aspects | Research | Zinc finger proteins | Gene therapy | T cells | Enzymes | Antigens | Lymphocytes | Immunotherapy | Genetics | T cell receptors | Index Medicus
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7. Full Text An unbiased genome-wide analysis of zinc-finger nuclease specificity
by Gabriel, Richard and Lombardo, Angelo and Arens, Anne and Miller, Jeffrey C and Genovese, Pietro and Kaeppel, Christine and Nowrouzi, Ali and Bartholomae, Cynthia C and Wang, Jianbin and Friedman, Geoffrey and Holmes, Michael C and Gregory, Philip D and Glimm, Hanno and Schmidt, Manfred and Naldini, Luigi and Von Kalle, Christof
Nature biotechnology, ISSN 1087-0156, 09/2011, Volume 29, Issue 9, pp. 816 - 823
Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Fundamental and applied biological sciences. Psychology | Biotechnology | Biological and medical sciences | Diverse techniques | Molecular and cellular biology | Gene Targeting | Humans | Substrate Specificity | Genetic Loci | HIV Integrase - metabolism | DNA Breaks, Double-Stranded | Sequence Analysis, DNA | Genetic Vectors - genetics | Endodeoxyribonucleases - genetics | HIV Integrase - genetics | Endodeoxyribonucleases - metabolism | Cell Line, Tumor | Protein Binding | Lentivirus - genetics | Zinc Fingers - genetics | Binding Sites | Cluster Analysis | Physiological aspects | Nucleases | Zinc finger proteins | Research | DNA binding proteins | Analysis | Genomes | Zinc | Deoxyribonucleic acid--DNA | Index Medicus
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8. Full Text Defining and improving the genome-wide specificities of CRISPR-Cas9 nucleases
by Tsai, Shengdar Q and Joung, J. Keith
Nature reviews. Genetics, ISSN 1471-0056, 05/2016, Volume 17, Issue 5, pp. 300 - 312
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | DNA - genetics | Genetic Engineering | Endonucleases - metabolism | Genome, Human | CRISPR-Cas Systems - genetics | Humans | Nucleases | Genome-wide association studies | Genetic engineering | Properties | Methods | Innovations | Index Medicus
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9. Full Text Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells
by Kleinstiver, Benjamin P and Tsai, Shengdar Q and Prew, Michelle S and Nguyen, Nhu T and Welch, Moira M and Lopez, Jose M and McCaw, Zachary R and Aryee, Martin J and Joung, J Keith
Nature biotechnology, ISSN 1087-0156, 01/2016, Volume 34, Issue 8, pp. 869 - 874
Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Clustered Regularly Interspaced Short Palindromic Repeats - physiology | Endonucleases - genetics | Humans | Bacterial Proteins - genetics | Substrate Specificity | Base Pair Mismatch | Endonucleases - metabolism | CRISPR-Cas Systems - genetics | Genome, Human - genetics | Chromosome Mapping - methods | Protein Binding | Bacterial Proteins - metabolism | Enzyme Activation | Binding Sites | Nucleases | Usage | Genome-wide association studies | RNA | Physiological aspects | Genetic aspects | Cells | Biotechnology | Genomics | Mutation | Index Medicus
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