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chemistry, organic (105) 105
carbonyl-compounds (73) 73
nucleophilic difluoromethylation (73) 73
fluorine (68) 68
chemistry, multidisciplinary (61) 61
difluoromethylation (51) 51
trifluoromethylation (49) 49
nucleophilic trifluoromethylation (37) 37
aldehydes (34) 34
ketones (30) 30
alcohols (24) 24
fluoroalkylation (24) 24
medicinal chemistry (24) 24
catalysis (23) 23
difluorocarbene (23) 23
chemistry, inorganic & nuclear (22) 22
copper-mediated difluoromethylation (22) 22
stereoselective-synthesis (22) 22
derivatives (21) 21
fluorinated sulfones (20) 20
reagents (20) 20
phenyl sulfone (19) 19
aryl (17) 17
reagent (17) 17
alkenes (16) 16
amines (16) 16
index medicus (15) 15
equivalent (14) 14
fluor (14) 14
fluorination (14) 14
synthesis (14) 14
asymmetric-synthesis (13) 13
direct nucleophilic difluoromethylation (13) 13
nucleophilic fluoroalkylation (13) 13
synthetic methods (13) 13
difluoromethyl phenyl sulfone (12) 12
ruppert-prakash reagent (12) 12
sulfones (12) 12
chemistry (11) 11
fluorides (11) 11
monofluoromethylation (11) 11
nucleophilic addition (11) 11
nucleophilic substitution (11) 11
stereoisomerism (11) 11
fluoroform (10) 10
iodides (10) 10
organic chemistry (10) 10
photoredox catalysis (10) 10
alkylation (9) 9
catalyzed trifluoromethylation (9) 9
copper (9) 9
fluoroalkylations (9) 9
hydrocarbons, fluorinated - chemistry (9) 9
imines (9) 9
organic-synthesis (9) 9
perfluoroalkylation (9) 9
alkyl-halides (8) 8
chemistry, applied (8) 8
efficient (8) 8
molecular structure (8) 8
organic-compounds (8) 8
radicals (8) 8
reactivity (8) 8
aromatic compounds (7) 7
aryl boronic acids (7) 7
building-block (7) 7
building-blocks (7) 7
efficient precursor (7) 7
enantioselective synthesis (7) 7
fluoroalkylation reactions (7) 7
methylation (7) 7
oxidative trifluoromethylation (7) 7
regioselectivity (7) 7
trimethylsilane (7) 7
amides (6) 6
analysis (6) 6
carbon (6) 6
catalysts (6) 6
esters (6) 6
ethers (6) 6
ethyl bromodifluoroacetate (6) 6
functional groups (6) 6
functional-group (6) 6
funktionelle gruppe (6) 6
gem-difluoroolefination (6) 6
heterocycles (6) 6
michael addition (6) 6
olefins (6) 6
organic compounds (6) 6
substrates (6) 6
sulfoximines (6) 6
sulfur (6) 6
acids (5) 5
activation (5) 5
aldol reaction (5) 5
alkene (5) 5
alpha,beta-unsaturated carboxylic-acids (5) 5
alpha-fluorosulfoximines (5) 5
amino-acids (5) 5
analogs (5) 5
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Chemical Communications, ISSN 1359-7345, 2009, Issue 48, pp. 7465 - 7478
The selective introduction of fluorine atom(s) and fluorinated moieties into organic molecules has become an important and fast-growing research field, since... 
PRACTICAL SYNTHESIS | TRIMETHYLSILYL FLUOROSULFONYLDIFLUOROACETATE TFDA | FLUORINATED SULFONES | PHENYL SULFONE | ENANTIOSELECTIVE CONJUGATE ADDITION | CARBONYL-COMPOUNDS | RADICAL TRIFLUOROMETHYLATION | NUCLEOPHILIC DIFLUOROMETHYLATION | STEREOSELECTIVE-SYNTHESIS | ORGANOFLUORINE COMPOUNDS | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ISSN 0002-7863, 07/2019, Volume 141, Issue 29, pp. 11398 - 11403
We report herein a highly efficient Cu-catalyzed protocol for the conversion of aliphatic carboxylic acids to the corresponding difluoromethylated analogues.... 
ALKENES | REAGENTS | DIRECT NUCLEOPHILIC DIFLUOROMETHYLATION | FLUORINE | ARYL | REDOX-ACTIVE ESTERS | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Current Organic Chemistry, ISSN 1385-2728, 07/2015, Volume 19, Issue 16, pp. 1638 - 1650
Journal Article
Organic Letters, ISSN 1523-7060, 08/2015, Volume 17, Issue 15, pp. 3802 - 3805
The difluoromethylation of terminal alkynes through the use of fluoroform as a source of difluorocabene is described. The choice of solvents and bases was... 
NUCLEOPHILIC TRIFLUOROMETHYLATION | EFFICIENT PRECURSOR | DIRECT CUPRATION | ENANTIOSELECTIVE FLUORINATION | BOND-FORMING REACTIONS | ELECTROGENERATED BASE | CHEMISTRY, ORGANIC | CARBONYL-COMPOUNDS | CUCF3 | C-NUCLEOPHILES | ALDEHYDES
Journal Article
Organic Letters, ISSN 1523-7060, 07/2016, Volume 18, Issue 14, pp. 3354 - 3357
Siladifluoromethylations and difluoromethylations on sp3, sp2, and sp carbons of lithiated carbamates, arenes, and terminal alkynes, respectively, have been... 
NUCLEOPHILIC TRIFLUOROMETHYLATION | ORGANOZINC REAGENTS | SP CARBON | DIFLUOROPROPARGYL BROMIDES | BUILDING-BLOCKS | COPPER-MEDIATED DIFLUOROMETHYLATION | CHEMISTRY, ORGANIC | TERMINAL ALKYNES | FUNCTIONAL-GROUPS | BOND ACTIVATION | C-NUCLEOPHILES
Journal Article
Tetrahedron, ISSN 0040-4020, 08/2018, Volume 74, Issue 32, pp. 4295 - 4297
The high demand for the biologically active CF H-molecules has stimulated significant efforts to develop efficient methods for the installation of CF H... 
Nucleophilic | Imines | Aldehydes | Decarboxylative | Difluoromethylation | DIFLUOROCARBENE | PHENYL SULFONE | COPPER-MEDIATED DIFLUOROMETHYLATION | CHEMISTRY, ORGANIC | CARBONYL-COMPOUNDS | ALCOHOLS | IODIDES | CATALYZED DIFLUOROMETHYLATION | ARYL | CARBOXYLIC-ACIDS | TRIFLUOROMETHYLATION | Schiff bases
Journal Article
Synthesis, ISSN 0039-7881, 08/2017, Volume 49, Issue 15, pp. 3394 - 3406
Journal Article
Organic Letters, ISSN 1523-7060, 08/2017, Volume 19, Issue 15, pp. 4150 - 4153
A method for facile difluoromethylation of various thiols using (difluoromethyl)­triphenyl­phosphonium bromide under mild reaction conditions is presented. The... 
REAGENT | ALKENES | ELECTRON-TRANSFER | PHENOLS | REACTIVITY | CHEMISTRY, ORGANIC | NUCLEOPHILIC-SUBSTITUTION REACTIONS | FLUORINE | TRIFLUOROMETHYLATION
Journal Article
by Wang, WQ and Yu, QW and Zhang, Q and Li, JW and Hui, F and Yang, JM and Lu, J
CHINESE JOURNAL OF ORGANIC CHEMISTRY, ISSN 0253-2786, 07/2018, Volume 38, Issue 7, pp. 1569 - 1585
Journal Article
ORGANIC LETTERS, ISSN 1523-7060, 10/2015, Volume 17, Issue 19, pp. 4882 - 4885
Difluoromethylation on sp(3) carbon of various nitrile compounds with lithium base and fluoroform (CF3H), which is an ideal difluoromethylating reagent, is... 
NUCLEOPHILIC TRIFLUOROMETHYLATION | EFFICIENT PRECURSOR | ACTIVATION | DIFLUOROCARBENE | IMINES | COPPER-MEDIATED DIFLUOROMETHYLATION | CONSTRUCTION | CHEMISTRY, ORGANIC | ARYL | ALDEHYDES
Journal Article
Chemistry – A European Journal, ISSN 0947-6539, 06/2016, Volume 22, Issue 26, pp. 8796 - 8800
The reaction mechanism for difluoromethylation of lithium enolates with fluoroform was analyzed computationally (DFT calculations with the artificial force... 
reaction mechanisms | carbenoids | computational chemistry | nucleophilic substitution | fluorine | Analysis | Fluorides | Enolates | Carbon-carbon composites | Fluoroform | Alkali metals | Metals | Lithium | Activation | Density | Carbon | Butterflies | Intermediates | Bimetals | Solvation | Computer applications | Mathematical models | Bonding | Carbonyls
Journal Article
Journal of Fluorine Chemistry, ISSN 0022-1139, 12/2015, Volume 180, pp. 186 - 191
Journal Article
Chinese Journal of Organic Chemistry, ISSN 0253-2786, 07/2018, Volume 38, Issue 7, pp. 1569 - 1585
Journal Article
Synthesis, ISSN 0039-7881, 12/2019, Volume 51, Issue 24, pp. 4549 - 4567
Journal Article
Organic Letters, ISSN 1523-7060, 11/2016, Volume 18, Issue 22, pp. 5912 - 5915
An atom-economical method for radical (phenylsulfonyl)­difluoromethylation of isocyanides with PhSO2CF2H under transition-metal-free conditions has been... 
MEDICINAL CHEMISTRY | MEDIATED TRIFLUOROMETHYLATION | ARENES | CATALYZED TRIFLUOROMETHYLATION | CHEMISTRY, ORGANIC | FLUORINE | NUCLEOPHILIC DIFLUOROMETHYLATION | ISONITRILES | DIFLUOROMETHYL PHENYL SULFONE | UNACTIVATED ALKENES | EQUIVALENT
Journal Article
Tetrahedron, ISSN 0040-4020, 03/2016, Volume 72, Issue 10, pp. 1351 - 1356
Easily available difluoromethylating reagent Me SiCF H enables multigram synthesis of difluoromethyl alcohols in good yields under mild conditions from a... 
Addition | Catalysis | Ketones | Fluorine | Nucleophilic difluoromethylation | IMINES | CHEMISTRY, ORGANIC | CARBONYL-COMPOUNDS | ARYL KETONES | ALDEHYDES | EFFICIENT | SALTS
Journal Article
Chemistry – A European Journal, ISSN 0947-6539, 05/2014, Volume 20, Issue 22, pp. 6795 - 6800
Unlike the facile synthesis of β‐monofluoromethyl alcohols by nucleophilic monofluoromethylation of epoxides, the synthesis of β‐difluoromethyl alcohols by... 
alcohols | difluoromethylation | sulfoximines | nucleophilic substitution | preorganization | REAGENT | BORON | FLUOROALKYLATION | CARBONYL-COMPOUNDS | POTENTIAL INHIBITORS | CHEMISTRY, MULTIDISCIPLINARY | SYNTHETIC UTILITY | FLUORINATED SULFONES | MONOFLUOROALKENES | TRIFLUOROMETHYLATION | Beta
Journal Article