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The Journal of biological chemistry, ISSN 0021-9258, 06/2013, Volume 288, Issue 23, pp. 16761 - 16774
The objective of the study was to investigate how inflammatory cytokines, IL-1 beta, and TNF-alpha control NOTCH signaling activity in nucleus pulposus (NP) cells... 
MATRIX METALLOPROTEINASES | BACK-PAIN | TUMOR-NECROSIS-FACTOR | KAPPA-B ACTIVATION | BASIC SCIENCE | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEGRADATION | TNF-ALPHA | EXPRESSION | FACTOR-ALPHA | Tumor Necrosis Factor-alpha - metabolism | Transcription Factor HES-1 | Homeodomain Proteins - metabolism | Humans | Middle Aged | Tumor Necrosis Factor-alpha - genetics | Male | Receptor, Notch2 - genetics | Interleukin-1beta - genetics | Promoter Regions, Genetic - genetics | Transcription Factor RelA - genetics | Intervertebral Disc Degeneration - metabolism | MAP Kinase Signaling System | Intervertebral Disc Degeneration - pathology | Basic Helix-Loop-Helix Transcription Factors - metabolism | Interleukin-1beta - metabolism | Cell Cycle Proteins - genetics | Adult | Female | Intervertebral Disc - pathology | Repressor Proteins - metabolism | Intervertebral Disc Degeneration - genetics | Cell Line | Basic Helix-Loop-Helix Transcription Factors - genetics | Cell Cycle Proteins - metabolism | Receptor, Notch2 - metabolism | Rats | Repressor Proteins - genetics | Intervertebral Disc - metabolism | Receptor, Notch1 - metabolism | Homeodomain Proteins - genetics | Animals | Transcription Factor RelA - metabolism | Aged | Receptor, Notch1 - genetics | Intervertebral Disc | Nucleus Pulposus | Chondrocytes | Cytokine | Glycobiology and Extracellular Matrices | NF-kappa B (NF-KB) | Notch Pathway | Osteoarthritis
Journal Article
Journal Article
Journal Article
Journal of cellular and molecular medicine, ISSN 1582-1838, 2018, Volume 22, Issue 1, pp. 261 - 276
Journal Article
Journal Article
Evidence-based complementary and alternative medicine, ISSN 1741-427X, 11/2017, Volume 2017, pp. 2198323 - 12
Journal Article
The FASEB Journal, ISSN 0892-6638, 09/2017, Volume 31, Issue 9, pp. 3831 - 3847
.... We investigated whether PHD3 controls HIF‐1 transcriptional activity in nucleus pulposus (NP) cells through the pyruvate kinase muscle (PKM)‐2‐Jumonji domain–containing protein (JMJD5) axis. PHD3−/− mice (12.5 mo old... 
hypoxia | skeletal tissue | transcription factor | intervertebral disc | PKM2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | PYRUVATE-KINASE M2 | HYDROXYLATION | FACTOR-I | CANCER | CELL BIOLOGY | INHIBITION | BIOLOGY | GENE-EXPRESSION | NF-KAPPA-B | PROMOTES | Nucleus Pulposus - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Membrane Proteins - genetics | Humans | Gene Expression Regulation | Nucleus Pulposus - cytology | Thyroid Hormones - genetics | Jumonji Domain-Containing Histone Demethylases - genetics | Intervertebral Disc Degeneration - metabolism | Procollagen-Proline Dioxygenase - metabolism | Intervertebral Disc Degeneration - pathology | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Procollagen-Proline Dioxygenase - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Thyroid Hormones - metabolism | HEK293 Cells | Membrane Proteins - metabolism | Mice | Jumonji Domain-Containing Histone Demethylases - metabolism | Glucose transporter | Hypoxia-inducible factor 1 | Transcription | Pyruvate kinase | Muscles | Pyruvic acid | Lactate dehydrogenase | Nucleus pulposus | Intervertebral discs | Nuclei | L-Lactate dehydrogenase | Glucose dehydrogenase | Animal tissues | Hypoxia | Degeneration | Nuclei (cytology) | Prolyl hydroxylase | Lactic acid | Vascular endothelial growth factor | Transporter | Research
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 02/2018, Volume 33, Issue 2, pp. 338 - 355
.... The health of the avascular nucleus pulposus (NP) plays a crucial role in the development of this pathology... 
NUCLEUS PULPOSUS | CELL/TISSUE SIGNALING–TRANSCRIPTION FACTORS | PH REGULATION | CARBONIC ANHYDRASE | INTERVERTEBRAL DISC | HIF‐1 | CHONDROCYTE AND CARTILAGE BIOLOGY | HIF-1 | LACTATE FLUX | BACK-PAIN | TUMOR PH | LUMBAR RHIZOPATHIES | ENDOCRINOLOGY & METABOLISM | INTERVERTEBRAL DISC CELLS | XII | ENERGY-METABOLISM | EXTRACELLULAR PH | CELL | TRANSCRIPTION FACTOR | EXPRESSION | TISSUE SIGNALING-TRANSCRIPTION FACTORS | Protons | Humans | Promoter Regions, Genetic - genetics | Carbonic Anhydrases - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Isoenzymes - metabolism | HEK293 Cells | Carbonic Anhydrase IX - metabolism | Response Elements - genetics | Carbon Dioxide - metabolism | Oxidation-Reduction | Cell Survival | Lactic Acid - metabolism | Oxygen Consumption | Nucleus Pulposus - pathology | Rats | Mitochondria - metabolism | Carbonic Anhydrase Inhibitors - pharmacology | Mice, Knockout | Animals | Intracellular Space - metabolism | Bicarbonates - metabolism | Glycolysis | Protein Binding | Hydrogen-Ion Concentration | Glucose metabolism | Enzymes | RNA | Analysis | Carbonates | Hydrogen-ion concentration | Backache | Hypoxia-inducible factor 1 | Chromatin | Immunoprecipitation | Carbon dioxide | Acidification | Nucleus pulposus | Intervertebral discs | pH effects | Nuclei | Bicarbonate | Metabolic flux | Hypoxia-inducible factor 1a | Pain | Degeneration | Recycling | Cell survival | Hydration | Data processing | Sodium | Isoforms | Hypoxia | Lactic acid | Intracellular | mRNA stability | Chondrocyte and Cartilage Biology | Intervertebral Disc | Carbonic anhydrase | Tissue Signaling- Transcription Factors | Nucleus Pulposus | pH regulation | Cell
Journal Article
Osteoarthritis and cartilage, ISSN 1063-4584, 2016, Volume 24, Issue 2, pp. 206 - 212
...) and the inner gel-like center, the nucleus pulposus (NP). The elastic NP can function to relieve stress and maintain IVD function by distributing hydraulic pressure evenly to annulus and endplate... 
Rheumatology | Biomaterial | Nucleus pulposus | Gene therapy | Stem cell | PROTEOGLYCANS | TISSUE | RABBIT MODEL | INTERVERTEBRAL DISC DEGENERATION | RHEUMATOLOGY | MESENCHYMAL STEM-CELLS | TRANSPLANTATION | IN-VIVO | MOLECULAR THERAPY | GENE-TRANSFER | ORTHOPEDICS | SCAFFOLD | Tissue Scaffolds | Regeneration | Stem Cell Transplantation - methods | Intervertebral Disc | Humans | In Vitro Techniques | Genetic Therapy - methods | Intervertebral Disc Degeneration - therapy | Gene expression
Journal Article