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Spine, ISSN 0362-2436, 09/2005, Volume 30, Issue 17, pp. 1940 - 1948
Study Design. This study examines changes in the production of extracellular matrix molecules as well as the induction of tissue degradation in in vitro formed... 
Proteoglycan | Tumor necrosis factor-alpha | Matrix metalloproteinases | Extracellular matrix degradation | Collagen | Intervertebral disc | Aggrecanase | Nucleus pulposus | intervertebral disc | aggrecanase | HUMAN INTERVERTEBRAL DISC | HERNIATED DISC | collagen | METALLOPROTEINASES | extracellular matrix degradation | CLINICAL NEUROLOGY | proteoglycan | DEGENERATION | tumor necrosis factor-alpha | IN-VITRO | MESSENGER-RNA | ARTICULAR-CARTILAGE | BASIC SCIENCE | nucleus pulposus | GENE-EXPRESSION | NITRIC-OXIDE | ORTHOPEDICS | matrix metalloproteinases | Extracellular Matrix Proteins - biosynthesis | Gene Expression - drug effects | Humans | Extracellular Matrix - metabolism | Dose-Response Relationship, Drug | Chondroitin Sulfate Proteoglycans - drug effects | Lectins, C-Type - metabolism | Cattle | Aggrecans | Intervertebral Disc - pathology | Extracellular Matrix Proteins - metabolism | Lectins, C-Type - drug effects | Tissue Culture Techniques | Extracellular Matrix Proteins - genetics | Chondroitin Sulfate Proteoglycans - metabolism | Proteoglycans - metabolism | Intervertebral Disc - metabolism | Recombinant Proteins - pharmacology | Extracellular Matrix Proteins - drug effects | Recombinant Proteins - administration & dosage | Tissue Inhibitor of Metalloproteinases - metabolism | Collagen - metabolism | Tumor Necrosis Factor-alpha - pharmacology | ADAM Proteins - metabolism | Animals | Tumor Necrosis Factor-alpha - physiology | Tumor Necrosis Factor-alpha - administration & dosage | Matrix Metalloproteinases - metabolism
Journal Article
Journal of Orthopaedic Research, ISSN 0736-0266, 02/2020, Volume 38, Issue 2, pp. 438 - 449
Journal Article
Journal Article
Tissue Engineering Part A, ISSN 1937-3341, 08/2017, Volume 23, Issue 15-16, pp. 837 - 846
Recent studies suggested that notochordal cells (NCs) and NC-conditioned medium (NCCM) can stimulate cell viability and matrix production of nucleus pulposus... 
Special Focus Articles | Coculture | Cell therapy | Notochordal cell-rich nucleus pulposus | Intervertebral disc | Nucleus pulposus cells | intervertebral disc | nucleus pulposus cells | ANNULUS FIBROSUS CELLS | CULTURE | MESENCHYMAL STEM-CELLS | CELL & TISSUE ENGINEERING | CELL BIOLOGY | IN-VITRO | coculture | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | cell therapy | notochordal cell-rich nucleus pulposus | INTERVERTEBRAL DISC REGENERATION | MATRIX HOMEOSTASIS | SENESCENCE | STROMAL CELLS | CONDITIONED MEDIUM | INFLAMMATORY MEDIATORS | Notochord - cytology | Rabbits | Cell Proliferation | Cell Survival | Glycosaminoglycans - metabolism | Cell Count | Humans | Middle Aged | Cells, Cultured | Gene Expression Regulation | Extracellular Matrix - metabolism | Male | Nucleus Pulposus - cytology | DNA - metabolism | Coculture Techniques - methods | Intervertebral Disc Degeneration - pathology | Phenotype | Animals | Cellular Senescence | Female | Cell proliferation | Cell culture | Senescence | Collagen (type II) | Arthritis | Nucleus pulposus | Intervertebral discs | Bone surgery | Nuclei | Engineering | Cell cycle | Aging | Extracellular matrix | Physiology | Conditioning | Deoxyribonucleic acid--DNA | Explants | Incubation | Tissue engineering | Digestive system | Digestion | Gene expression | Studies | Regeneration | Orthopedics | Stem cells | Nuclei (cytology) | Laboratory animals | Viability | In vitro methods and tests
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 12/2017, Volume 118, Issue 12, pp. 4862 - 4871
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 02/2018, Volume 33, Issue 2, pp. 338 - 355
ABSTRACT Intervertebral disc degeneration is a ubiquitous condition closely linked to chronic low‐back pain. The health of the avascular nucleus pulposus (NP)... 
NUCLEUS PULPOSUS | CELL/TISSUE SIGNALING–TRANSCRIPTION FACTORS | PH REGULATION | CARBONIC ANHYDRASE | INTERVERTEBRAL DISC | HIF‐1 | CHONDROCYTE AND CARTILAGE BIOLOGY | HIF-1 | LACTATE FLUX | BACK-PAIN | TUMOR PH | LUMBAR RHIZOPATHIES | ENDOCRINOLOGY & METABOLISM | INTERVERTEBRAL DISC CELLS | XII | ENERGY-METABOLISM | EXTRACELLULAR PH | CELL | TRANSCRIPTION FACTOR | EXPRESSION | TISSUE SIGNALING-TRANSCRIPTION FACTORS | Protons | Humans | Promoter Regions, Genetic - genetics | Carbonic Anhydrases - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Isoenzymes - metabolism | HEK293 Cells | Carbonic Anhydrase IX - metabolism | Response Elements - genetics | Carbon Dioxide - metabolism | Oxidation-Reduction | Cell Survival | Lactic Acid - metabolism | Oxygen Consumption | Nucleus Pulposus - pathology | Rats | Mitochondria - metabolism | Carbonic Anhydrase Inhibitors - pharmacology | Mice, Knockout | Animals | Intracellular Space - metabolism | Bicarbonates - metabolism | Glycolysis | Protein Binding | Hydrogen-Ion Concentration | Glucose metabolism | Enzymes | RNA | Analysis | Carbonates | Hydrogen-ion concentration | Backache | Hypoxia-inducible factor 1 | Chromatin | Immunoprecipitation | Carbon dioxide | Acidification | Nucleus pulposus | Intervertebral discs | pH effects | Nuclei | Bicarbonate | Metabolic flux | Hypoxia-inducible factor 1a | Pain | Degeneration | Recycling | Cell survival | Hydration | Data processing | Sodium | Isoforms | Hypoxia | Lactic acid | Intracellular | mRNA stability | Chondrocyte and Cartilage Biology | Intervertebral Disc | Carbonic anhydrase | Tissue Signaling- Transcription Factors | Nucleus Pulposus | pH regulation | Cell
Journal Article
Journal Article