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1. Full Text Overexpression of CYB5R3 and NQO1, two NAD+‐producing enzymes, mimics aspects of caloric restriction
by Diaz‐Ruiz, Alberto and Lanasa, Michael and Garcia, Joseph and Mora, Hector and Fan, Frances and Martin‐Montalvo, Alejandro and Di Francesco, Andrea and Calvo‐Rubio, Miguel and Salvador‐Pascual, Andrea and Aon, Miguel A and Fishbein, Kenneth W and Pearson, Kevin J and Villalba, Jose Manuel and Navas, Placido and Bernier, Michel and de Cabo, Rafael
Aging Cell, ISSN 1474-9718, 08/2018, Volume 17, Issue 4, pp. e12767 - n/a
Summary Calorie restriction (CR) is one of the most robust means to improve health and survival in model organisms. CR imposes a metabolic program that leads... 
metabolic homeostasis | NQO1 | calorie restriction | CYB5R3 | aging | OXIDATION | ACTIVATION | HOMEOSTASIS | CYTOCHROME B REDUCTASE | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | DIETARY-PROTEIN | METABOLISM | INFLAMMATION | MEMBRANE REDOX SYSTEM | MICE | INTERVENTION | Chronic diseases | Physiological aspects | Oxidoreductases | Enzymes | Quinone oxidoreductase | Energy metabolism | Cytochrome b5 | Phenotypes | Nutrient deficiency | Dehydrogenases | Oxidoreductase | Quinone | Homeostasis | Metabolism | Survival | Carcinogenesis | NAD(P)H:quinone oxidoreductase | Dietary restrictions | NAD | NADH | Life span | Aging | Reductase | Cancer | Original
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2. Full Text Caloric restriction, caloric restriction mimetics, and healthy aging in Okinawa: controversies and clinical implications
by Willcox, Bradley J and Willcox, Donald C
Current Opinion in Clinical Nutrition and Metabolic Care, ISSN 1363-1950, 01/2014, Volume 17, Issue 1, pp. 51 - 58
PURPOSE OF REVIEWTo examine the role of two nutritional factors implicated in the healthy aging of the Okinawanscaloric restriction; and traditional foods with... 
Human longevity | Healthspan | Caloric restriction-mimetic | Lifespan | Caloric restriction | FUCOXANTHIN | LIFE-SPAN | IMPACT | NUTRITION & DIETETICS | DIETARY-RESTRICTION | HUMAN LONGEVITY | MECHANISM | CURCUMIN | ENDOCRINOLOGY & METABOLISM | NUTRIENT | BENEFITS | CLIMATE | Caloric Restriction | Cardiovascular Diseases - prevention & control | Humans | Japan | Seafood | Neoplasms - prevention & control | Longevity | Functional Food | Aging - physiology | Diet | Curcuma | Ipomoea batatas | Chronic Disease | Dementia - prevention & control
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3. Full Text Amino acid restriction increases β‐cell death under challenging conditions
by Mateus Gonçalves, Luciana and Vettorazzi, Jean Franciesco and Vanzela, Emerielle Cristine and Figueiredo, Mariana Sarto and Batista, Thiago Martins and Zoppi, Claudio Cesar and Boschero, Antonio Carlos and Carneiro, Everardo Magalhães
Journal of Cellular Physiology, ISSN 0021-9541, 10/2019, Volume 234, Issue 10, pp. 16679 - 16684
Malnutrition programs metabolism, favor dysfunction of β cells. We aimed to establish an in vitro protocol of malnutrition, assessing the effect of amino acid... 
apoptosis | β cell | insulin secretion | amino acid restriction | islets | beta cell | PHYSIOLOGY | DIET | GLUCOSE | INSULIN-SECRETION | MALNOURISHED MICE | CELL BIOLOGY | Protein kinase C | Calcium | Secretion | Therapeutic applications | Oscillations | Cytotoxicity | Amino acids | Lymphocytes T | Metabolism | Kinases | Insulin | Calcium signalling | Proteins | Organic chemistry | Molecular modelling | Cell death | Nutrient content | Malnutrition | Pancreas | Viability | Apoptosis
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4. Full Text Gluten and FODMAPS-Sense of a Restriction/When Is Restriction Necessary?
by Dieterich, W and Zopf, Y
NUTRIENTS, ISSN 2072-6643, 08/2019, Volume 11, Issue 8, p. 1957
Gluten-free diet (GFD) is enjoying increasingly popularity, although gluten-free products are considerably more expensive. GFD is absolutely necessary for... 
irritable bowel syndrome (IBS) | SENSITIVITY | MICROBIOTA | gluten-free diet (GFD) | FREE DIET | CELIAC-DISEASE | INTESTINAL INFLAMMATION | NUTRITION & DIETETICS | non-celiac gluten sensitivity (NCGS) | FUNGAL PROTEASES | celiac disease | DOUBLE-BLIND | low FODMAP diet | REDUCES SYMPTOMS | HEALTH | IRRITABLE-BOWEL-SYNDROME | Allergens | Animal models | Dysbacteriosis | Microbiomes | Clinical trials | Immunoglobulin E | Microbiota | Intestine | Gastroenterology | Respiratory tract diseases | Supplementation | Intestinal microflora | Gluten | Digestive tract | Nutrient deficiency | Digestive system | Dietary supplements | Weight loss | Probiotics | Celiac disease | Nutrient loss | Diet | Irritable bowel syndrome | Colitis | Autoimmune diseases
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5. Full Text Putting the K+ in K+aloric Restriction
by Lien, Evan C and Lau, Allison N and Vander Heiden, Matthew G
Immunity, ISSN 1074-7613, 05/2019, Volume 50, Issue 5, pp. 1129 - 1131
Metabolic changes affect T lymphocyte function, and understanding this phenomenon could improve immunotherapy. In a recent paper in , report that tumor... 
TUMOR MICROENVIRONMENT | IMMUNOLOGY | Amino acids | Lymphocytes T | Gene expression | Nutrient uptake | Metabolism | Cancer therapies | Dietary restrictions | Studies | Metabolites | Lymphocytes | Immunotherapy | Epigenetics | Physiology | Potassium | Tumors
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6. Full Text Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila
by Grandison, Richard C and Piper, Matthew D. W and Partridge, Linda
Nature, ISSN 0028-0836, 12/2009, Volume 462, Issue 7276, pp. 1061 - 1064
Dietary restriction extends healthy lifespan in diverse organisms and reduces fecundity(1,2). It is widely assumed to induce adaptive reallocation of nutrients... 
SURVIVAL | LONGEVITY | MULTIDISCIPLINARY SCIENCES | NATURAL-SELECTION | GROWTH | MELANOGASTER | REPRODUCTION | FOOD | Drosophila melanogaster - metabolism | Amino Acids - metabolism | Insulin - metabolism | Animals | Drosophila melanogaster - physiology | Diet | Signal Transduction | Methionine - metabolism | Female | Random Allocation | Longevity - physiology | Oviposition - physiology | Amino acids | Food and nutrition | Health aspects | Drosophila | Analysis | Survival after airplane accidents, shipwrecks, etc | Insects | Nutrition | Metabolism | Reproduction | Methionine | Constrictions | Nutrients | Organisms | Feeding
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7. Full Text Energy restriction in renal protection
by Wang, Si-Yang and Cai, Guang-Yan and Chen, Xiang-Mei
British Journal of Nutrition, ISSN 0007-1145, 11/2018, Volume 120, Issue 10, pp. 1149 - 1158
Energy restriction (ER) has been widely studied as a novel intervention, and its ability to prolong life has been fully demonstrated. For example, ER can... 
Energy restriction | Oxidative stress | Sirtuin type 1 | Ageing | Inflammation | Autophagy | Kidney injury | LIFE-SPAN | DIABETIC-NEPHROPATHY | MODEST SALT REDUCTION | DIETARY RESTRICTION | BLOOD-PRESSURE | ISCHEMIA-REPERFUSION INJURY | NUTRITION & DIETETICS | CALORIC RESTRICTION | CHRONIC KIDNEY-DISEASE | PHOSPHATE RESTRICTION | TOR protein | Animal models | Senescence | Intensive care | Clinical trials | Amino acids | Systematic review | Kinases | AMP-activated protein kinase | Proteins | Energy | Rodents | Aging | Nutrients | Blood pressure | Growth factors | Age | Hypertension | Energy intake | Carbohydrates | Kidneys | AMP | Mortality | Rapamycin | Metabolism | SIRT1 protein | Studies | Nutrition research | Diet | Kidney diseases | Diabetes | Phagocytosis | Full Papers | Human and Clinical Nutrition | Sirtuin type 1: Autophagy
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8. Full Text Brain response to calorie restriction
by Fusco, Salvatore and Fusco, Salvatore and Pani, Giovambattista and Pani, Giovambattista
Cellular and Molecular Life Sciences, ISSN 1420-682X, 9/2013, Volume 70, Issue 17, pp. 3157 - 3170
Calorie restriction extends longevity and delays ageing in model organisms and mammals, opposing the onset and progression of an array of age-related diseases.... 
Life Sciences | Biochemistry, general | CREB | Life Sciences, general | Stem cell | Calorie restriction | Neurodegenerative disease | Nutrient sensing | Biomedicine general | Brain ageing | Cell Biology | LIFE-SPAN | LONG-TERM-MEMORY | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DIETARY RESTRICTION | AGRP NEURONS | SYNAPTIC PLASTICITY | NEURODEGENERATIVE DISEASES | CELL BIOLOGY | ENERGY-BALANCE | HEMATOPOIETIC STEM-CELLS | GENE-EXPRESSION PROFILE | Aging | Animals | Caloric Restriction | Brain - physiology | Longevity - physiology | Humans | Prevention | Nervous system diseases | Analysis | Stem cells | Diet | Mental disorders | Brain diseases | Age
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9. Full Text Calorie restriction suppresses age- Dependent hippocampal transcriptional signatures
by Schafer, Marissa J and Dolgalev, Igor and Alldred, Melissa J and Heguy, Adriana and Ginsberg, Stephen D
PLoS ONE, ISSN 1932-6203, 07/2015, Volume 10, Issue 7, p. e0133923
Calorie restriction (CR) enhances longevity and mitigates aging phenotypes in numerous species. Physiological responses to CR are cell-type specific and... 
PROFILE | MEMORY | MULTIDISCIPLINARY SCIENCES | NEUROTROPHIN EXPRESSION | MOUSE MODEL | GENE-EXPRESSION | LTP | NEURODEGENERATION | MICE | AMYLOID PRECURSOR PROTEIN | PLASTICITY | CA1 Region, Hippocampal - cytology | Synaptic Transmission - genetics | Caloric Restriction | RNA, Messenger - genetics | Gene Expression Profiling | Longevity - genetics | Neuroprotection - genetics | RNA, Messenger - metabolism | Body Weight - genetics | Animals | Aging - genetics | Aging - physiology | CA1 Region, Hippocampal - metabolism | Female | Transcription, Genetic | Mice | RNA sequencing | Aging | Genetic aspects | Genetic transcription | Research | Gene expression | Alzheimer's disease | Potentiation | Brain | Neuroprotection | Neurosciences | Transcription | Calcium | Memory | Genes | Genomes | Physiological responses | Gene sequencing | Proteins | Calcium signalling | Learning | Calreticulin | Neurodegeneration | Synaptic transmission | Rodents | Calcium buffering | Signatures | Age | Nutrient deficiency | Neurodegenerative diseases | Neurons | Long-term potentiation | GRP78 protein | Transthyretin | Heat shock proteins | Cyclic AMP response element-binding protein | Feeding | Pathology | Hypotheses | Brain research | Brain-derived neurotrophic factor | Life span | Klotho protein | Neural networks | Quality control | Protein disulfide-isomerase | Molecular biology | Hippocampus | Heat shock | Animal cognition
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10. Full Text Serotonin receptor htr6-mediated mtorc1 signaling regulates dietary restriction–induced memory enhancement
by Teng, Ling-Ling and Lu, Guan-Ling and Chiou, Lih-Chu and Lin, Wei-Sheng and Cheng, Ya-Yun and Hsueh, Tai-En and Huang, Yi-Ching and Hwang, Nai-Hsuan and Yeh, Jin-Wei and Liao, Ruey-Ming and Fan, Shou-Zen and Yen, Jui-Hung and Fu, Tsai-Feng and Tsai, Ting-Fen and Wu, Ming-Shiang and Wang, Pei- Yu
PLoS Biology, ISSN 1544-9173, 03/2019, Volume 17, Issue 3, p. e2007097
Dietary restriction (DR; sometimes called calorie restriction) has profound beneficial effects on physiological, psychological, and behavioral outcomes in... 
WATER MAZE | CREB | ANTAGONIST | FOOD-RESTRICTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CALORIC RESTRICTION | BIOLOGY | EXTENDS LIFE-SPAN | LUDWIGIA-OCTOVALVIS | SYNAPTIC PLASTICITY | 5-HT6 RECEPTOR | BRAIN | TOR protein | Potentiation | Brain | Neurosciences | Physiological effects | Insurance claims | Funding | Spine | Memory | Cognitive ability | Neurobiology | Amino acids | Biosynthesis | Kinases | Inactivation | Complexity | Proteins | Dendritic spines | Direct reduction | Trends | Supervision | Nutrient deficiency | Deactivation | Serotonin | Neurons | Long-term potentiation | Tryptophan | Rapamycin | Dietary intake | Investigations | Medicine | Signaling | Hospitals | Diet | Insects | Animal behavior | Diabetes | Hippocampus | Animal cognition
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11. Full Text Hypoxia-induced intrauterine growth restriction increases the susceptibility of rats to high-fat diet-induced metabolic syndrome
by Rueda-Clausen, Christian F and Dolinsky, Vernon W and Morton, Jude S and Proctor, Spencer D and Dyck, Jason R. B and Davidge, Sandra T
Diabetes, ISSN 0012-1797, 02/2011, Volume 60, Issue 2, pp. 507 - 516
OBJECTIVE-It is recognized that there is a remarkable variability in the systemic response to high-fat (HF) diets that cannot be completely explained by... 
NUTRIENT RESTRICTION | ACTIVATION | KINASE-C-THETA | INSULIN-RESISTANCE | MATERNAL HYPOXIA | GLUCOSE | ENDOCRINOLOGY & METABOLISM | BIRTH-WEIGHT | ADULT MALE | INDUCED OBESITY | PREGNANCY | Body Composition | Glucose Intolerance - metabolism | Dietary Fats - metabolism | Metabolic Syndrome - etiology | Disease Susceptibility - etiology | Disease Susceptibility - metabolism | Rats | Male | Metabolic Syndrome - metabolism | Fetal Growth Retardation - metabolism | Hypoxia - complications | Random Allocation | Rats, Sprague-Dawley | Blotting, Western | Hypoxia - metabolism | Pregnancy | Insulin - metabolism | Animals | Analysis of Variance | Fetal Growth Retardation - etiology | Lipids - blood | Female | Blood Glucose - metabolism | Cytokines - blood | Pregnancy, Complications of