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nvp-auy922 (79) 79
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hsp90 heat-shock proteins - antagonists & inhibitors (51) 51
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European Journal of Cancer, ISSN 0959-8049, 2010, Volume 46, Issue 3, pp. 678 - 684
NVP-AUY922, a potent heat shock protein (HSP) 90 inhibitor, downregulates the expression of many oncogenic proteins, including the human epidermal growth... 
Zirconium-89 | Biomarker | Breast cancer | HER2 | Positron emission tomography | Heat shock protein 90 | NVP-AUY922
Journal Article
Journal of Thoracic Oncology, ISSN 1556-0864, 04/2018, Volume 13, Issue 4, pp. 576 - 584
In this phase 2 study, we evaluated the activity of AUY922 in pretreated patients with stage IV NSCLC. Patients with advanced NSCLC were divided into... 
EGFR mutation | KRAS mutation | NSCLC | HSP90 inhibitor | ALK rearrangement | AUY922 | GANETESPIB | NVP-AUY922 | ONCOLOGY | RESPIRATORY SYSTEM
Journal Article
Current Topics in Medicinal Chemistry, ISSN 1568-0266, 10/2016, Volume 16, Issue 25, pp. 2753 - 2764
Heat shock proteins (HSPs) present as a double edged sword. While they play an important role in maintaining protein homeostasis in a normal cell, cancer cells... 
HSP90 | N-Terminal | Inhibitor | Chaperone | Cancer | FDG-PET | CO-CHAPERONES | COMPLEX | CHEMISTRY, MEDICINAL | HEAT-SHOCK-PROTEIN-90 | MOLECULAR CHAPERONES | POSTTRANSLATIONAL MODIFICATIONS | INHIBITOR NVP-AUY922 | PHASE-I | BINDING
Journal Article
by Gao, C and Peng, YN and Wang, HZ and Fang, SL and Zhang, M and Zhao, Q and Liu, J
CURRENT PHARMACEUTICAL DESIGN, ISSN 1381-6128, 2019, Volume 25, Issue 8, pp. 849 - 855
Heat shock protein 90 (Hsp90) plays an essential role in various physiological and pathological processes. It activates client proteins to participate in tumor... 
client protein | cancer treatment | CELLS | HSP90 MOLECULAR CHAPERONE | EFFICACY | ATPase | CRYSTAL-STRUCTURE | signaling pathway | RECEPTOR | NVP-AUY922 | 17-DMAG | IN-VITRO | inhibitor | RESISTANCE | PHARMACOLOGY & PHARMACY | EXPRESSION | Heat shock protein 90
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 09/2012, Volume 18, Issue 18, pp. 4973 - 4985
Journal Article
European Journal of Cancer, ISSN 0959-8049, 02/2010, Volume 46, Issue 3, pp. 678 - 684
NVP-AUY922, a potent heat shock protein (HSP) 90 inhibitor, downregulates the expression of many oncogenic proteins, including the human epidermal growth... 
Zirconium-89 | Biomarker | TRASTUZUMAB | Breast cancer | NVP-AUY922 | BREAST-CANCER | HEAT-SHOCK PROTEINS | THERAPY | GROWTH | ERBB2 | DEGRADATION | 17-AAG | HER2 | Positron emission tomography | EXPRESSION | HEAT-SHOCK-PROTEIN-90 INHIBITOR | Heat shock protein 90 | ONCOLOGY
Journal Article
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, ISSN 1619-7070, 08/2017, Volume 44, Issue 8, pp. 1328 - 1336
c-MET and its ligand hepatocyte growth factor are often dysregulated in human cancers. Dynamic changes in c-MET expression occur and might predict drug... 
HSP90 | ZR-89-BEVACIZUMAB PET | IMMUNO-PET | HEPATOCYTE GROWTH-FACTOR | DOWN-REGULATION | PHASE-II | KINASE INHIBITORS | HSP90 INHIBITOR NVP-AUY922 | TUMOR XENOGRAFT | CELL LUNG-CANCER | BREAST-CANCER | Erlotinib | c-MET | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Zr-89 | PET | Onartuzumab
Journal Article
BBA - Molecular Cell Research, ISSN 0167-4889, 03/2012, Volume 1823, Issue 3, pp. 756 - 766
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 11/2019, Volume 9, Issue 1, pp. 1 - 8
Heat shock protein 90 (Hsp90) is a widely investigated target for anticancer therapy. The experimental Hsp90 inhibitors ICPD47 and ICPD62 demonstrated... 
HYPERTHERMIA | DEGRADATION | COMBINATION | EXPRESSION | MULTIDISCIPLINARY SCIENCES | NVP-AUY922 | Hsp90 protein | Cell culture | Gemcitabine | 5-Fluorouracil | Heat shock proteins | Tumor cell lines | Cervix | Antimetabolites | Doxorubicin | Spheroids | Investigations | Antitumor agents | Osteosarcoma | Pancreatic cancer | Cell lines | Antitumor activity | Hyperthermia | Cervical cancer | Tumors
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 07/2012, Volume 18, Issue 13, pp. 3562 - 3570
Journal Article
Molecular pharmaceutics, ISSN 1543-8384, 11/2012, Volume 9, Issue 11, pp. 2995 - 3002
Human epidermal growth factor receptor-2 (HER2) directed therapy potentially can be improved by insight in drug effects on HER2 expression. This study... 
HSP90 | HERCEPTIN FAB FRAGMENTS | HSP90 INHIBITOR | TRASTUZUMAB | lapatinib | DOWN-REGULATION | COMBINATION | 17AAG | NVP-AUY922 | METASTATIC BREAST-CANCER | GROWTH | HER2 | MONOCLONAL-ANTIBODIES | PET | MEDICINE, RESEARCH & EXPERIMENTAL | PHARMACOLOGY & PHARMACY
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