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1. Full Text The role of disturbed pH dynamics and the Na + /H + exchanger in metastasis
by Casavola, Valeria and Cardone, Rosa A and Reshkin, Stephan J
Nature Reviews Cancer, ISSN 1474-175X, 10/2005, Volume 5, Issue 10, pp. 786 - 795
Recent research has highlighted the fundamental role of the tumour's extracellular metabolic microenvironment in malignant invasion. This microenvironment is... 
BREAST-CANCER CELLS | CD44 INTERACTION | EXTRACELLULAR ACIDIFICATION | PERICELLULAR PROTEOLYSIS | RHOA ACTIVATION | ONCOLOGY | AEROBIC GLYCOLYSIS | TUMOR-CELL-MIGRATION | INTRACELLULAR PH | NA-H EXCHANGER | CATHEPSIN-B | Neoplasms - metabolism | Signal Transduction | Neoplasm Invasiveness | Sodium-Hydrogen Exchangers - physiology | Humans | Cation Transport Proteins - physiology | Sodium-Hydrogen Exchangers - chemistry | Neoplasm Metastasis | Animals | Membrane Proteins - chemistry | Membrane Proteins - physiology | Mice | Cation Transport Proteins - chemistry | Neoplasms - pathology | Sodium-Hydrogen Exchanger 1 | Hydrogen-Ion Concentration | Control | Physiological aspects | Genetic aspects | Metastasis | Research | Identification and classification | Risk factors | Oncogenes
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2. Na+ -H+ exchanger, pH regulation and cancer
by Reshkin, Stephan J and Cardone, Rosa A and Harguindey, Salvador
Recent Patents on Anti-Cancer Drug Discovery, ISSN 1574-8928, 2013, Volume 8, Issue 1, pp. 85 - 99
Cancer cells and tissues, regardless of their origin and genetic background, have an aberrant regulation of hydrogen ion dynamics leading to a reversal of the... 
HOE642 | NHE1 | pH and cancer | Tumor microenvironment | Cariporide | H | Proton transport in cancer | Invasion | Angiogenesis | Amiloride | Na | exchanger | MDR | Growth factors | proton transport in cancer | CELL STRUCTURES | TUMOR INVASION | Na+/H+ exchanger | growth factors | MYOCARDIAL-INFARCTION | INTRACELLULAR-PH | angiogenesis | ION TRANSLOCATION | MOLECULAR-ORIGINS | SODIUM-HYDROGEN EXCHANGER | invasion | ONCOLOGY | cariporide | PHARMACOLOGY & PHARMACY | EXTRACELLULAR-MATRIX | tumor microenvironment | MELANOMA-CELLS | CATHEPSIN-B
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3. Full Text Structural and functional analysis of the Na+/H+ exchanger
by Slepkov, Emily R and Rainey, Jan K and Sykes, Brian D and Fliegel, Larry
Biochemical Journal, ISSN 0264-6021, 02/2007, Volume 401, Issue 3, pp. 623 - 633
The mammalian NHE (Na+/H+ exchanger) is a ubiquitously expressed integral membrane protein that regulates intracellular pH by removing a proton in exchange for... 
Intracellular pH | exchanger (NHE) | Cation transport | Membrane protein | Structure-function analysis | NhaA | ACTIVATED PROTEIN-KINASE | MYOCARDIAL-INFARCTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CARBOXYL-TERMINAL REGION | X-RAY-STRUCTURE | ESCHERICHIA-COLI | CALCINEURIN HOMOLOGOUS PROTEIN | intracellular pH | Na+/H+ exchanger (NHE) | SODIUM-HYDROGEN EXCHANGER | structure-function analysis | membrane protein | NA-H EXCHANGE | MOLECULAR-CLONING | cation transport | TRANSMEMBRANE SEGMENT-IV | Sodium-Hydrogen Exchangers - chemistry | Animals | Sodium-Hydrogen Exchangers - metabolism | H+ exchanger (NHE) | CaM, calmodulin | pHi, intracellular pH | Review | CAII, carbonic anhydrase II | NHE, Na+ | ERK1 | H+ exchanger | IL, intracellular loop | structure–function analysis | TM, transmembrane | CHP, calcineurin homologous protein | EL, extracellular loop | ERM, ezrin, radixin and moesin | SERCA, sarcoplasmic | 2, extracellular-signal-regulated kinase 1 | endoplasmic reticulum Ca2+-ATPase | PIP2, phosphatidylinositol 4,5-bisphosphate | Na+ | HSP70, heat-shock protein 70 | MAPK, mitogen-activated protein kinase
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4. Full Text Physiological role and regulation of the Na+/H+ exchanger
by Malo, Mackenzie E and Fliegel, Larry
Canadian Journal of Physiology and Pharmacology, ISSN 0008-4212, 11/2006, Volume 84, Issue 11, pp. 1081 - 1095
In mammalian eukaryotic cells, the Na+/H+ exchanger is a family of membrane proteins that regulates ions fluxes across membranes. Plasma membrane isoforms of... 
Phosphorylation | Ischemia | pH regulation | Heart hypertrophy | exchanger | Membrane proteins | heart hypertrophy | HAMSTER LUNG FIBROBLASTS | PHYSIOLOGY | Na+/H+ exchanger | ACTIVATED PROTEIN-KINASE | CALCINEURIN HOMOLOGOUS PROTEIN | GROWTH-FACTOR ACTIVATION | II SIGNAL-TRANSDUCTION | ischemia | membrane proteins | AMILORIDE-SENSITIVE NA&/H | PHARMACOLOGY & PHARMACY | NA-H EXCHANGE | SMOOTH-MUSCLE-CELLS | MOLECULAR-CLONING | RAT VENTRICULAR MYOCYTES | phosphorylation
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5. Full Text Induction of apoptosis and differentiation by Na/H exchanger 1 modulation in acute myeloid leukemia cells
by Hyun, Shin Young and Na, Eun Jung and Jang, Ji Eun and Chung, Haerim and Kim, Soo Jeong and Kim, Jin Seok and Kong, Jee Hyun and Shim, Kwang Yong and Lee, Jong In and Min, Yoo Hong and Cheong, June-Won
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 11/2019, Volume 519, Issue 4, pp. 887 - 893
We investigated the effect of the modulation of Na/H exchanger 1 (NHE1) on apoptosis, differentiation, and chemoresistance in acute myeloid leukemia (AML)... 
Cytarabine | Leukemia cells | Na/H exchanger 1 | PMA | Acute myeloid leukemia | HMA
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6. Full Text Topological analysis of the Na+/H+ exchanger
by Liu, Yongsheng and Basu, Arghya and Li, Xiuju and Fliegel, Larry
BBA - Biomembranes, ISSN 0005-2736, 10/2015, Volume 1848, Issue 10, pp. 2385 - 2393
The mammalian Na /H exchanger isoform 1 (NHE1) is a ubiquitously expressed integral membrane protein present in mammalian cells. It is made up of a hydrophobic... 
Topology model | Membrane protein | Na+/H+ exchanger | pH regulation | Na + /H + exchanger | Na(+)/H(+) exchanger | MYOCARDIUM | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | MODEL | NHE1 ISOFORM | INHIBITION | BIOPHYSICS | AMINO-ACIDS | FUNCTIONAL-ANALYSIS | ANTIPORTER | TRANSMEMBRANE SEGMENT-IV | Amino Acid Sequence | Mutagenesis, Site-Directed | Cricetulus | Models, Chemical | Models, Molecular | Molecular Sequence Data | Sodium-Hydrogen Exchangers - metabolism | Sodium-Hydrogen Exchangers - chemistry | Sodium-Hydrogen Exchangers - ultrastructure | Animals | Protein Binding | Protein Conformation | Binding Sites | CHO Cells
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7. Full Text Class effects of SGLT2 inhibitors in mouse cardiomyocytes and hearts: inhibition of Na+/H+ exchanger, lowering of cytosolic Na+ and vasodilation
by Uthman, Laween and Baartscheer, Antonius and Bleijlevens, Boris and Schumacher, Cees A and Fiolet, Jan W. T and Koeman, Anneke and Jancev, Milena and Hollmann, Markus W and Weber, Nina C and Coronel, Ruben and Zuurbier, Coert J
Diabetologia, ISSN 0012-186X, 2018, Volume 61, Issue 3, pp. 722 - 726
Aims/hypothesis Sodium-glucose cotransporter 2 (SGLT2) inhibitors (SGLT2i) constitute a novel class of glucose-lowering (type 2) kidney-targeted agents. We... 
Heart failure | Medicine & Public Health | Human Physiology | Sodium | Na + /H + exchanger | Cardiac | Metabolic Diseases | Internal Medicine | Diabetes | SGLT2i | Vasodilation | Na | exchanger | H | Na+/H+ exchanger | NHE-1 | MODEL | FAILURE | HYPERTROPHY | ENDOCRINOLOGY & METABOLISM | EMPAGLIFLOZIN | Glucosides - pharmacology | Sodium-Hydrogen Exchangers - drug effects | Canagliflozin - pharmacology | Sodium-Glucose Transporter 2 - metabolism | Male | Sodium-Glucose Transporter 2 Inhibitors | Sodium - metabolism | Sulfonamides - pharmacology | Sodium-Hydrogen Exchangers - metabolism | Animals | Myocytes, Cardiac - drug effects | Aminopyridines - pharmacology | Myocytes, Cardiac - metabolism | Cytosol - metabolism | Benzhydryl Compounds - pharmacology | Mice | Kidneys | Calcium | Hydrogen | Syngeneic grafts | Na+/H+-exchanging ATPase | Diabetes mellitus | Cardiomyocytes | Phosphocreatine | pH effects | Heart diseases | Binding sites | H+ exchanger | Na+ | Short Communication
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8. Full Text The Na+/H+ exchanger in metastasis
by Amith, Schammim Ray and Fliegel, Larry
Aging, ISSN 1945-4589, 07/2016, Volume 8, Issue 7, pp. 1291 - 1291
Na+/H+ exchanger | Metastasis | Triple-negative breast cancer | triple-negative breast cancer | Na plus /H plus exchanger | metastasis | NEGATIVE BREAST-CANCER | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | Animals | Neoplasm Invasiveness | Triple Negative Breast Neoplasms - metabolism | Humans | Triple Negative Breast Neoplasms - pathology | Sodium-Hydrogen Exchangers - metabolism
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9. Full Text Structural and functional changes in the na+ /h+ exchanger isoform 1, induced by erk1/2 phosphorylation
by Fliegel, Larry
International Journal of Molecular Sciences, ISSN 1661-6596, 05/2019, Volume 20, Issue 10, p. 2378
The human Na+/H+ exchanger isoform 1 (NHE1) is a plasma membrane transport protein that plays an important role in pH regulation in mammalian cells. Because of... 
ERK (extracellular signal-regulated kinase) | Phosphorylation | Membrane transport | Scaffolding | exchanger | Intrinsically disordered protein | PH regulation | CHRONIC INHIBITION | AMINO-ACIDS SER | intrinsically disordered protein | scaffolding | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEART-FAILURE | INTRACELLULAR PH | pH regulation | CHEMISTRY, MULTIDISCIPLINARY | SODIUM-HYDROGEN EXCHANGER | H+ exchanger | Na+ | membrane transport | MOLECULAR-CLONING | ACTIVATED PROTEIN-KINASES | phosphorylation | SIGNAL-REGULATED KINASE | DEPENDENT ACTIVATION | NA-H EXCHANGER | Na+/H+ exchanger
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10. Full Text Physiological role and regulation of the Na+/H+ exchanger
by Malo, Mackenzie E and Fliegel, Larry
Canadian Journal of Physiology and Pharmacology, ISSN 0008-4212, 11/2006, Volume 84, Issue 11, pp. 1081 - 1095
In mammalian eukaryotic cells, the Na+/H+ exchanger is a family of membrane proteins that regulates ions fluxes across membranes. Plasma membrane isoforms of... 
heart hypertrophy | membrane proteins | ischémie | exchanger | protéines membranaires | échangeur Na | pH regulation | phosphorylation | hypertrophie cardiaque | ischemia | régulation du pH | Neoplasms - metabolism | Heart Diseases - metabolism | Allosteric Regulation | Humans | Molecular Conformation | Cell Growth Processes - physiology | Sodium-Hydrogen Exchangers - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Sodium-Hydrogen Exchangers - chemistry | Animals | Hormones - metabolism | Cation Transport Proteins - metabolism | Isoenzymes - metabolism | Protein Binding | Cell Membrane - metabolism | Protein Processing, Post-Translational | Enzyme Activation | Cell Differentiation - physiology | Sodium-Hydrogen Exchanger 1 | Intracellular Fluid - metabolism | Hydrogen-Ion Concentration | Studies | Proteins | Membranes | Anatomy & physiology | Anemia
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11. Full Text The Na+/H+ exchanger NHE1 localizes as clusters to cryptic lamellipodia and accelerates collective epithelial cell migration
by Jensen, Helene H and Pedersen, Gitte A and Morgen, Jeanette J and Parsons, Maddy and Pedersen, Stine F and Nejsum, Lene N
The Journal of Physiology, ISSN 0022-3751, 02/2019, Volume 597, Issue 3, pp. 849 - 867
Key points Exogenous Na+/H+ exchanger 1 (NHE1) expression stimulated the collective migration of epithelial cell sheets Stimulation with epidermal growth... 
NHE1 | Na+/H+ exchanger | collective cell migration | MDCK cells | metastasis | EGF | Na | exchanger | H | ORTHOGONAL ARRAYS | CANCER-CELLS | PHYSIOLOGY | NEUROSCIENCES | INVASION | PDGFR-ALPHA | CHANNELS | EXPRESSION | POLARIZATION | Epidermal growth factor | Metastasis | Carrier proteins | Calcium-binding proteins | Cells | Fluorescence microscopy | Morphogenesis | Embryogenesis | Cysts | Hydrogen | Epithelial cells | Na+/H+-exchanging ATPase | Pseudopodia | Cell migration | Cell adhesion & migration | Cancer
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12. Full Text The Na⁺/H⁺ Exchanger NHE1 Is Required for Directional Migration Stimulated via PDGFR-α in the Primary Cilium
by Linda Schneider and Christian-Martin Stock and Peter Dieterich and Bo Hammer Jensen and Lotte Bang Pedersen and Peter Satir and Albrecht Schwab and Søren Tvorup Christensen and Stine Falsig Pedersen
The Journal of Cell Biology, ISSN 0021-9525, 4/2009, Volume 185, Issue 1, pp. 163 - 176
We previously demonstrated that the primary cilium coordinates platelet-derived growth factor (PDGF) receptor (PDGFR)alpha-mediated migration in... 
Up regulation | Cell growth | NIH 3T3 cells | Epithelial cells | Interphase | Cell cycle | Fibroblasts | Cell membranes | Cells | Cilia | SIGNAL-TRANSDUCTION | ACTIVATION | SERUM DEPRIVATION | ERM PROTEINS | CELL-MIGRATION | KINASE | INTRACELLULAR PH | GROWTH-FACTOR | MELANOMA-CELLS | NA-H EXCHANGER | CELL BIOLOGY | Cilia - physiology | Cell Line | NIH 3T3 Cells | Up-Regulation | Cation Transport Proteins - antagonists & inhibitors | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Signal Transduction | Sodium-Hydrogen Exchangers - physiology | Amiloride - analogs & derivatives | Cation Transport Proteins - physiology | Platelet-Derived Growth Factor - pharmacology | RNA, Messenger - metabolism | Cell Movement - genetics | Cell Movement - physiology | Cilia - metabolism | Receptor, Platelet-Derived Growth Factor alpha - physiology | Cation Transport Proteins - analysis | Animals | Sodium-Hydrogen Exchangers - analysis | Amiloride - pharmacology | Mice | Sodium-Hydrogen Exchanger 1 | Sodium-Hydrogen Exchangers - antagonists & inhibitors
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13. Full Text Molecular biology of the myocardial Na+ /H+ exchanger
by Fliegel, Larry
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 2007, Volume 44, Issue 2, pp. 228 - 237
Abstract The mammalian Na+ /H+ exchanger is a pH regulatory membrane protein that uses the sodium gradient to translocate one intracellular proton in exchange... 
Cardiovascular | Promoter | Sodium–hydrogen exchange | Sodium–lithium exchange | Cation binding | Gene splicing | Tissue distribution | pH regulation | Ischemia/reperfusion | Sodium-hydrogen exchange | Sodium-lithium exchange | PIG VENTRICULAR MYOCYTE | PROTEIN-KINASE-C | CARDIAC & CARDIOVASCULAR SYSTEMS | NEONATAL-RAT CARDIOMYOCYTES | SODIUM-LITHIUM COUNTERTRANSPORT | MESSENGER-RNA EXPRESSION | sodium-lithium exchange | H+ EXCHANGER | TRANSMEMBRANE SEGMENT-VII | tissue distribution | CELL BIOLOGY | ischemia/reperfusion | sodium-hydrogen exchange | gene splicing | GENE-EXPRESSION | promoter | HYDROGEN EXCHANGER | NA/H EXCHANGER | cation binding | Sodium-Hydrogen Exchangers - chemistry | Animals | Humans | Myocardium - metabolism | Cloning, Molecular | Sodium-Hydrogen Exchangers - genetics | Sodium-Hydrogen Exchangers - antagonists & inhibitors | Protein Transport | Sodium-Hydrogen Exchangers - metabolism
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