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1. Full Text Analgesic Efficacy and Safety of Oxycodone in Combination With Naloxone as Prolonged Release Tablets in Patients With Moderate to Severe Chronic Pain
by Vondrackova, Dana and Leyendecker, Petra and Meissner, Winfried and Hopp, Michael and Szombati, Istvan and Hermanns, Kai and Ruckes, Christian and Weber, Susanne and Grothe, Birgit and Fleischer, Wolfgang and Reimer, Karen
Journal of Pain, ISSN 1526-5900, 2008, Volume 9, Issue 12, pp. 1144 - 1154
Abstract This randomized, double-blind, placebo- and active-controlled, parallel-group study was designed to demonstrate the superiority of oxycodone in... 
Anesthesia & Perioperative Care | Pain Medicine | prolonged release | naloxone | bowel function | chronic pain | Oxycodone | MORPHINE | BOWEL DYSFUNCTION | RANDOMIZED CONTROLLED-TRIAL | DIABETIC-NEUROPATHY | CANCER | NEUROSCIENCES | OPIOID-RELATED CONSTIPATION | CLINICAL NEUROLOGY | ORAL NALOXONE | Narcotic Antagonists - administration & dosage | Humans | Male | Dose-Response Relationship, Drug | Analgesics, Opioid - adverse effects | Time Factors | Low Back Pain - psychology | Female | Oxycodone - adverse effects | Drug Therapy, Combination | Severity of Illness Index | Oxycodone - therapeutic use | Double-Blind Method | Drug Administration Schedule | Oxycodone - administration & dosage | Narcotic Antagonists - adverse effects | Analgesics, Opioid - therapeutic use | Naloxone - therapeutic use | Treatment Outcome | Constipation - chemically induced | Low Back Pain - drug therapy | Pain Measurement - methods | Narcotic Antagonists - therapeutic use | Analgesics, Opioid - administration & dosage | Naloxone - adverse effects | Naloxone - administration & dosage | Chronic Disease | Delayed-Action Preparations | Care and treatment | Naloxone | Pain | Backache | Analysis | Index Medicus
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2. Full Text Effectiveness of Scotland's National Naloxone Programme for reducing opioid‐related deaths: a before (2006–10) versus after (2011–13) comparison
by Bird, Sheila M and McAuley, Andrew and Perry, Samantha and Hunter, Carole
Addiction, ISSN 0965-2140, 05/2016, Volume 111, Issue 5, pp. 883 - 891
Aims To assess the effectiveness for Scotland's National Naloxone Programme (NNP) by comparison between 2006–10 (before) and 2011–13 (after NNP started in... 
effectiveness | statistical power | Before/after policy evaluation | take‐home naloxone | national naloxone programme | prison release opioid‐related deaths | causality | opioid‐related deaths | Effectiveness | Prison release opioid-related deaths | Take-home naloxone | Causality | Statistical power | National naloxone programme | Opioid-related deaths | Before | COST-EFFECTIVENESS | PRISON | PSYCHIATRY | PREVENTION | SUBSTANCE ABUSE | RELEASE | prison release opioid-related deaths | opioid-related deaths | HEROIN OVERDOSE | INJECTION-DRUG USERS | after policy evaluation | SUBSTITUTION THERAPY | HEPATITIS-C VIRUS | HOME EMERGENCY NALOXONE | take-home naloxone | LINKAGE | Analgesics, Opioid - economics | Humans | Middle Aged | Analgesics, Opioid - poisoning | Male | Naloxone - therapeutic use | Treatment Outcome | Scotland - epidemiology | Narcotic Antagonists - economics | Opioid-Related Disorders - rehabilitation | Opioid-Related Disorders - economics | Narcotic Antagonists - therapeutic use | Cost-Benefit Analysis | Opioid-Related Disorders - mortality | Adult | Female | Aged | Naloxone - economics | Prisoners | Analysis | Naloxone | Narcotics | Drug prevention | Drug addiction | Research Report | Research Reports
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3. EVZIO: A New Delivery System for Naloxone
by William J Lorman
Journal of Addictions Nursing, ISSN 1088-4602, 10/2015, Volume 26, Issue 4, p. 217
Naloxone
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4. Full Text Non‐stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll‐like receptor 4 (TLR4)
by Hutchinson, Mark R and Zhang, Yingning and Brown, Kimberley and Coats, Benjamen D and Shridhar, Mitesh and Sholar, Paige W and Patel, Sonica J and Crysdale, Nicole Y and Harrison, Jacqueline A and Maier, Steven F and Rice, Kenner C and Watkins, Linda R
European Journal of Neuroscience, ISSN 0953-816X, 07/2008, Volume 28, Issue 1, pp. 20 - 29
Although activated spinal cord glia contribute importantly to neuropathic pain, how nerve injury activates glia remains controversial. It has recently been... 
(+)‐naltrexone | stereoselectivity | (+)‐naloxone | microglia | Stereoselectivity | (+)-naltrexone | (+)-naloxone | Microglia | MECHANICAL ALLODYNIA | ACTIVATION | TACTILE ALLODYNIA | SPINAL-CORD | OPIOIDERGIC SYSTEMS | PROINFLAMMATORY CYTOKINES | NEUROSCIENCES | RAT MODEL | PERIPHERAL NEUROPATHY | HIV-1 ENVELOPE GLYCOPROTEIN | GLIA | Naltrexone - therapeutic use | Microglia - metabolism | Humans | Male | Pain - chemically induced | Pain - metabolism | Naltrexone - pharmacology | Narcotic Antagonists - metabolism | Pain - drug therapy | Behavior, Animal - drug effects | Toll-Like Receptor 4 - antagonists & inhibitors | Naltrexone - metabolism | Biomarkers - metabolism | Injections, Spinal | Cell Line | Naloxone - metabolism | Rats | Behavior, Animal - physiology | Naloxone - therapeutic use | Rats, Sprague-Dawley | Toll-Like Receptor 4 - metabolism | Animals | Narcotic Antagonists - therapeutic use | Signal Transduction - drug effects | Naloxone - pharmacology | Narcotic Antagonists - pharmacology | Signal Transduction - physiology | Pain Measurement | Naltrexone | Naloxone | Index Medicus
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5. Full Text A Systematic Review of Community Opioid Overdose Prevention and Naloxone Distribution Programs
by Clark, Angela K and Wilder, Christine M and Winstanley, Erin L
Journal of Addiction Medicine, ISSN 1932-0620, 05/2014, Volume 8, Issue 3, pp. 153 - 163
Community-based opioid overdose prevention programs (OOPPs) that include the distribution of naloxone have increased in response to alarmingly high overdose... 
Opioid overdose | Naloxone | Overdose prevention | Substance abuse services | UNITED-STATES | INTRANASAL NALOXONE | opioid overdose | SUBSTANCE ABUSE | PROVIDING NALOXONE | overdose prevention | OPIATE OVERDOSE | TAKE-HOME NALOXONE | HEROIN OVERDOSE | INJECTION-DRUG USERS | PRESCRIPTION | NEW-YORK-CITY | SAN-FRANCISCO | substance abuse services | naloxone | Community Mental Health Services - organization & administration | Drug Overdose - drug therapy | Humans | Drug Overdose - mortality | Drug Overdose - prevention & control | Naloxone - therapeutic use | Narcotics - adverse effects | Narcotic Antagonists - therapeutic use | Narcotic Antagonists - supply & distribution | Community Mental Health Services - methods | Program Evaluation | Naloxone - supply & distribution | Opioid-Related Disorders - complications
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6. Full Text Pharmacokinetics of a new, nasal formulation of naloxone
by Tylleskar, Ida and Skulberg, Arne Kristian and Nilsen, Turid and Skarra, Sissel and Jansook, Phatsawee and Dale, Ola
European Journal of Clinical Pharmacology, ISSN 0031-6970, 5/2017, Volume 73, Issue 5, pp. 555 - 562
Nasal naloxone is wanted for bystander administration in opioid overdose and as a needle-free alternative for emergency medical personnel. Epidemiologic... 
Biomedicine | Nasal | Naloxone | Intranasal | Overdose | Bioavailability | Pharmacology/Toxicology | Pharmacokinetics | DRUG | INTRANASAL NALOXONE | MANAGEMENT | VALIDATION | DELIVERY | TRIAL | SUSPECTED HEROIN OVERDOSE | INTRAMUSCULAR NALOXONE | PHARMACOLOGY & PHARMACY | HUMAN VOLUNTEERS | OPIOID OVERDOSE | Narcotic Antagonists - administration & dosage | Narcotic Antagonists - blood | Area Under Curve | Humans | Middle Aged | Narcotic Antagonists - adverse effects | Biological Availability | Male | Administration, Intranasal | Naloxone - blood | Young Adult | Tandem Mass Spectrometry | Naloxone - adverse effects | Adolescent | Chromatography, Liquid | Adult | Female | Naloxone - administration & dosage | Narcotic Antagonists - pharmacokinetics | Naloxone - pharmacokinetics | Mass spectrometry | Liquid chromatography | Prescription drugs | Pharmacology | Kinetics | Drug overdose
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7. Full Text Clinical provision of improvised nasal naloxone without experimental testing and without regulatory approval: imaginative shortcut or dangerous bypass of essential safety procedures?
by Strang, John and McDonald, Rebecca and Tas, Basak and Day, Ed
Addiction, ISSN 0965-2140, 04/2016, Volume 111, Issue 4, pp. 574 - 582
Context Take‐home naloxone is increasingly provided to prevent heroin overdose deaths. Naloxone 0.4–2.0 mg is licensed for use by injection. Some clinicians... 
nasal | overdose | heroin | unlicensed | opioid | Death | emergency | naloxone | Naloxone | Nasal | Unlicensed | Opioid | Overdose | Emergency | Heroin | INTRANASAL NALOXONE | SERIES | OPIOID OVERDOSE PREVENTION | PSYCHIATRY | RANDOMIZED-TRIAL | SUBSTANCE ABUSE | DEATHS | SUSPECTED HEROIN OVERDOSE | EMERGENCY MEDICAL-SERVICES | INTRAMUSCULAR NALOXONE | HOME NALOXONE | HUMAN VOLUNTEERS | Heroin Dependence - complications | Narcotic Antagonists - administration & dosage | Humans | Naloxone - adverse effects | Drug Overdose - prevention & control | Health Policy - legislation & jurisprudence | Narcotic Antagonists - adverse effects | Drug Overdose - complications | Naloxone - administration & dosage | Self Care - methods | Administration, Intranasal | Self Care - adverse effects | Drugs | Clinical trials | Safety and security measures | Drug addiction | Drug overdose | Drug therapy | Medical ethics
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8. Full Text A randomised controlled trial of sublingual buprenorphine–naloxone film versus tablets in the management of opioid dependence
by Lintzeris, N and Leung, S.Y and Dunlop, A.J and Larance, B and White, N and Rivas, G.R and Holland, R.M and Degenhardt, L and Muhleisen, P and Hurley, M and Ali, R
Drug and Alcohol Dependence, ISSN 0376-8716, 2013, Volume 131, Issue 1, pp. 119 - 126
Abstract Background Buprenorphine–naloxone sublingual film was introduced in 2011 in Australia as an alternative to tablets. This study compared the two... 
Psychiatry | Opioid dependency | Buprenorphine–naloxone tablets | Randomised controlled trial | Buprenorphine–naloxone film | Opioid substitution therapy | Buprenorphine-naloxone tablets | Buprenorphine-naloxone film | COST-EFFECTIVENESS | AUSTRALIA | QUALITY | PSYCHIATRY | SUBSTANCE ABUSE | INDUCTION | DIVERSION | MAINTENANCE | NORBUPRENORPHINE | PARENTERAL ABUSE | INJECTION | METHADONE | Opioid-Related Disorders - drug therapy | Administration, Sublingual | Double-Blind Method | Tablets | Buprenorphine - blood | Humans | Middle Aged | Male | Treatment Outcome | Opioid-Related Disorders - blood | Chemistry, Pharmaceutical | Naloxone - blood | Dose-Response Relationship, Drug | Buprenorphine - administration & dosage | Adult | Female | Disease Management | Naloxone - administration & dosage | Medical policy | Medical colleges | Drug abuse | Neurosciences | Naloxone | Buprenorphine | Public health
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9. Full Text On the front lines of the opioid epidemic: Rescue by naloxone
by Skolnick, Phil
European Journal of Pharmacology, ISSN 0014-2999, 09/2018, Volume 835, pp. 147 - 153
Naloxone is a specific, high affinity opioid antagonist that has been used to treat suspected or confirmed overdose for more than 40 years. Naloxone use was... 
Opioid overdose - naloxone – fentanyl – heroin – nalmefene - AMPAkines | UNITED-STATES | INTRANASAL NALOXONE | heroin | ANALGESIC ABUSE | nalmefen | SUSPECTED NARCOTIC OVERDOSE | AMPAkines | Opioid overdose | INDUCED RESPIRATORY DEPRESSION | BIASED AGONISM | fentanyl | DOUBLE-BLIND | naloxone | PHARMACOLOGY & PHARMACY | HEALTHY-VOLUNTEERS | BRAIN MEMBRANES | IMPROVISED NASAL NALOXONE | Opioid-Related Disorders - epidemiology | Drug Overdose - drug therapy | Narcotic Antagonists - therapeutic use | Naloxone - pharmacology | Humans | Narcotic Antagonists - pharmacology | Naloxone - therapeutic use | Drugs | Medical personnel | Overdose | Naloxone | Emergency medical services | Opioids
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10. Full Text Fixed-ratio combination oxycodone/naloxone compared with oxycodone alone for the relief of opioid-induced constipation in moderate-to-severe noncancer pain
by Simpson, K and Leyendecker, P and Hopp, M and Müller-Lissner, S and Löwenstein, O and De Andrés, J and Troy Ferrarons, J and Bosse, B and Krain, B and Nichols, T and Kremers, W and Reimer, K
Current Medical Research and Opinion, ISSN 0300-7995, 12/2008, Volume 24, Issue 12, pp. 3503 - 3512
ABSTRACT Objective: Opioid therapy is frequently associated with treatment-limiting constipation. Naloxone is an opioid antagonist with low oral systemic... 
Bowel function | Naloxone | Prolonged release | Oxycodone | Chronic pain | OXYCODONE | PROLONGED RELEASE | CHRONIC PAIN | BOWEL FUNCTION | NALOXONE | MEDICINE, RESEARCH & EXPERIMENTAL | MORPHINE | METHYLNALTREXONE | BOWEL DYSFUNCTION | CONTROLLED-RELEASE OXYCODONE | RANDOMIZED CONTROLLED-TRIAL | DIABETIC-NEUROPATHY | ORAL NALOXONE | MEDICINE, GENERAL & INTERNAL | CANCER PAIN | ANALGESIA | Narcotic Antagonists - administration & dosage | Humans | Middle Aged | Male | Delayed-Action Preparations - administration & dosage | Analgesics, Opioid - adverse effects | Pain - drug therapy | Aged, 80 and over | Adult | Female | Constipation - drug therapy | Oxycodone - adverse effects | Double-Blind Method | Oxycodone - administration & dosage | Europe | Narcotic Antagonists - adverse effects | Ambulatory Care | Constipation - chemically induced | Outpatients | Delayed-Action Preparations - adverse effects | Analgesics, Opioid - administration & dosage | Naloxone - adverse effects | Adolescent | Aged | Primary Health Care | Naloxone - administration & dosage | Drug Combinations | Index Medicus
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11. Full Text Naloxone without the needle − systematic review of candidate routes for non-injectable naloxone for opioid overdose reversal
by Strang, John and McDonald, Rebecca and Alqurshi, Abdulmalik and Royall, Paul and Taylor, David and Forbes, Ben
Drug and Alcohol Dependence, ISSN 0376-8716, 2016, Volume 163, pp. 16 - 23
Highlights • Deaths from opioid overdose can be prevented by prompt injection of the opiate antagonist naloxone. • After 40 years of injection-based naloxone,... 
Psychiatry | Buccal | Naloxone | Nasal | Opioid | Deaths | Overdose | Drug development | Sublingual | Heroin | INTRANASAL NALOXONE | PSYCHIATRY | SUBSTANCE ABUSE | DELIVERY | TRIAL | EMERGENCY MEDICAL-SERVICES | PHARMACOKINETICS | INTRAMUSCULAR NALOXONE | NASAL NALOXONE | HUMAN VOLUNTEERS | MIDAZOLAM | Narcotic Antagonists - administration & dosage | Administration, Sublingual | Drug Overdose - drug therapy | Drug Overdose - diagnosis | Humans | Drug Overdose - prevention & control | Analgesics, Opioid - therapeutic use | Naloxone - therapeutic use | Administration, Buccal | Administration, Intranasal | Narcotic Antagonists - therapeutic use | Analgesics, Opioid - administration & dosage | Needles | Clinical Trials as Topic - methods | Naloxone - administration & dosage | Drugs | Respiratory agents | Analysis
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12. Full Text Pharmacological characterization of the opioid inactive isomers -naloxone as antagonists of toll-like receptor 4
by Wang, X and Zhang, Y and Peng, Y and Hutchinson, M R and Rice, K C and Yin, H and Watkins, L R
British Journal of Pharmacology, ISSN 0007-1188, 03/2016, Volume 173, Issue 5, p. 856
The toll-like receptor TLR4 is involved in neuropathic pain and in drug reward and reinforcement. The opioid inactive isomers (+)-naltrexone and (+)-naloxone... 
Naloxone | Naltrexone
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13. Full Text Naloxone laws facilitate the establishment of overdose education and naloxone distribution programs in the United States
by Lambdin, Barrot H and Davis, Corey S and Wheeler, Eliza and Tueller, Stephen and Kral, Alex H
Drug and Alcohol Dependence, ISSN 0376-8716, 07/2018, Volume 188, pp. 370 - 376
The opioid overdose crisis in the United States continues to worsen. Opioid overdose mortality is entirely preventable with timely administration of naloxone.... 
Opioid overdose mortality | Policy analysis | Naloxone laws | Naloxone programs | DRUG | PREVENTION PROGRAMS | PSYCHIATRY | IMPLEMENTATION | INCREASES | SUBSTANCE ABUSE | DEATHS | LAYPERSONS | PROVIDING NALOXONE | EMERGENCY MEDICAL-SERVICES | PRESCRIBING NALOXONE | ACCESS | Patient Education as Topic - legislation & jurisprudence | United States - epidemiology | Opioid-Related Disorders - drug therapy | Humans | Drug Overdose - mortality | Drug Overdose - prevention & control | Patient Education as Topic - trends | Male | Naloxone - therapeutic use | Opioid-Related Disorders - epidemiology | Analgesics, Opioid - adverse effects | Narcotic Antagonists - therapeutic use | Drug Overdose - epidemiology | Female | Opioid-Related Disorders - prevention & control | Databases, Factual - trends | Retrospective Studies | Cohort Studies | Drugs | Overdose | Naloxone | Laws, regulations and rules | Education | Mortality
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14. Full Text Effectiveness of Injectable Extended-Release Naltrexone vs Daily Buprenorphine-Naloxone for Opioid Dependence: A Randomized Clinical Noninferiority Trial
by Tanum, Lars and Solli, Kristin Klemmetsby and Latif, Zill-e-Huma and Benth, Jurate Šaltyte and Opheim, Arild and Sharma-Haase, Kamni and Krajci, Peter and Kunøe, Nikolaj
JAMA Psychiatry, ISSN 2168-622X, 12/2017, Volume 74, Issue 12, pp. 1197 - 1205
IMPORTANCE: To date, extended-release naltrexone hydrochloride has not previously been compared directly with opioid medication treatment (OMT), currently the... 
MORTALITY | HEROIN | DETOXIFICATION | IMPLANT | RELAPSE | PLACEBO | PSYCHIATRY | OUTCOMES | INDUCTION | ORAL NALTREXONE | ADDICTION | Substance Abuse Detection - methods | Diagnostic and Statistical Manual of Mental Disorders | Narcotic Antagonists - administration & dosage | Opioid-Related Disorders - drug therapy | Administration, Oral | Humans | Opioid-Related Disorders - diagnosis | Male | Treatment Outcome | Drug Monitoring - methods | Injections, Intramuscular | Psychiatric Status Rating Scales | Buprenorphine, Naloxone Drug Combination - administration & dosage | Opiate Substitution Treatment - methods | Adult | Female | Buprenorphine, Naloxone Drug Combination - pharmacokinetics | Naloxone - administration & dosage | Narcotic Antagonists - pharmacokinetics | Delayed-Action Preparations | Naloxone - pharmacokinetics | Online First | Original Investigation | Research
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15. Full Text A Review of Opioid Overdose Prevention and Naloxone Prescribing: Implications for Translating Community Programming Into Clinical Practice
by Mueller, Shane R and Walley, Alexander Y and Calcaterra, Susan L and Glanz, Jason M and Binswanger, Ingrid A
Substance Abuse, ISSN 0889-7077, 04/2015, Volume 36, Issue 2, pp. 240 - 253
Background: As physicians have increased opioid prescribing, overdose deaths from pharmaceutical opioids have substantially increased in the United States.... 
Prevention | overdose | primary care | opioids | UNITED-STATES | INTRANASAL NALOXONE | SUBSTANCE ABUSE | OPIATE OVERDOSE | TAKE-HOME NALOXONE | SUSPECTED HEROIN OVERDOSE | INJECTION-DRUG USERS | NEW-YORK-CITY | SAN-FRANCISCO | INTRAMUSCULAR NALOXONE | DISTRIBUTING NALOXONE | Analgesics, Opioid - adverse effects | Health Services Accessibility | Humans | Drug Overdose - prevention & control | General Practice - methods | Naloxone - therapeutic use | Community Health Services - methods |