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Alcohol, ISSN 0741-8329, 2015, Volume 49, Issue 3, pp. 229 - 236
Journal Article
Journal Article
Journal Article
Peptides, ISSN 0196-9781, 05/2017, Volume 91, pp. 40 - 48
We previously reported a series of novel endomorphin analogs with unnatural amino acid modifications. These analogs display good binding affinity and... 
Spinal antinociception | Antagonist | Endomorphin | Antibody | Dynorphin | CORD | MORPHINE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | INVOLVEMENT | RELEASE | MU-OPIOID RECEPTOR | POTENT | PEPTIDOMIMETICS | ADMINISTERED ENDOMORPHIN-1 | ENDOCRINOLOGY & METABOLISM | PHARMACOLOGY & PHARMACY | ANALGESIA | Analgesics, Opioid - antagonists & inhibitors | Naltrexone - analogs & derivatives | Opioid Peptides - pharmacology | Analgesics, Opioid - pharmacology | Male | Enkephalin, Leucine - administration & dosage | Opioid Peptides - administration & dosage | Receptors, sigma - antagonists & inhibitors | Dynorphins - chemistry | Enkephalin, Methionine - pharmacology | Pain - metabolism | Enkephalin, Leucine - antagonists & inhibitors | Naltrexone - pharmacology | Enkephalin, Methionine - chemistry | Pain - drug therapy | Enkephalin, Leucine - pharmacology | Analgesics, Opioid - chemistry | Antibodies - immunology | Enkephalin, Methionine - administration & dosage | Naltrexone - administration & dosage | Oligopeptides - chemistry | Enkephalin, Methionine - antagonists & inhibitors | Injections, Spinal | Oligopeptides - antagonists & inhibitors | Receptors, Opioid, kappa - antagonists & inhibitors | Receptors, Opioid, mu - antagonists & inhibitors | Dynorphins - antagonists & inhibitors | Enkephalin, Leucine - chemistry | Analgesia | Opioid Peptides - chemistry | Animals | Dynorphins - administration & dosage | Analysis of Variance | Analgesics, Opioid - administration & dosage | Naloxone - pharmacology | Opioid Peptides - antagonists & inhibitors | Narcotic Antagonists - pharmacology | Dynorphins - pharmacology | Mice | Oligopeptides - administration & dosage | Naloxone - administration & dosage | Oligopeptides - pharmacology | Pain Measurement | Fluorine - chemistry | Viral antibodies | Antibodies | Yuan (China) | Analysis | Index Medicus
Journal Article
Peptides, ISSN 0196-9781, 2010, Volume 31, Issue 2, pp. 339 - 345
In our previous paper we reported synthesis and biological activity of two cyclic analogs of endomorphin-2 (EM-2): Tyr-c(Lys-Phe-Phe-Asp)-NH and... 
μ-, δ-Opioid receptor | Solid phase peptide synthesis | Hot-plate test | Binding studies | SIDE-CHAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | DERMORPHIN ANALOGS | ANTINOCICEPTIVE ACTIVITY | CARBONYL BRIDGE | BRAIN-BARRIER PERMEABILITY | PEPTIDES | OPIOID RECEPTOR | PHARMACOLOGY & PHARMACY | ENZYMATIC DEGRADATION | ENKEPHALIN ANALOGS | mu-, delta-Opioid receptor | BETA-PROLINE | Naltrexone - analogs & derivatives | Receptors, Opioid, delta - metabolism | Endorphins - chemistry | Injections, Intravenous | Analgesics, Opioid - chemical synthesis | Rats, Wistar | Injections, Intraventricular | Male | Receptors, Opioid, mu - agonists | Tissue Extracts - metabolism | Peptides, Cyclic - chemistry | Peptides, Cyclic - metabolism | Endorphins - chemical synthesis | Brain - metabolism | Endorphins - therapeutic use | Naltrexone - pharmacology | Analgesics, Opioid - chemistry | Cell Membrane - metabolism | Oligopeptides - chemistry | Amino Acid Sequence | Pain - prevention & control | Receptors, Opioid, mu - metabolism | Rats | Analgesics, Opioid - therapeutic use | Oligopeptides - metabolism | Mice, Inbred Strains | Receptors, Opioid, mu - antagonists & inhibitors | Brain - drug effects | Endorphins - metabolism | Animals | Peptides, Cyclic - chemical synthesis | Narcotic Antagonists - pharmacology | Peptides, Cyclic - therapeutic use | Mice | Analgesics, Opioid - metabolism | Pain Measurement | Receptors, Opioid, delta - agonists | Index Medicus
Journal Article
Journal Article
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2007, Volume 17, Issue 21, pp. 5916 - 5917
The presence of a 6,7-fused indole group in the indolomorphinans was considered to be responsible for the delta opioid selectivity for this class of ligands.... 
Tolerance | Dual-profile ligands | CHEMISTRY, MEDICINAL | NALTRINDOLE | ANTAGONIST | dual-profile ligands | NALTREXONE | LIGANDS | MORPHINE | CHEMISTRY, ORGANIC | RECEPTORS | tolerance | DEPENDENCE | Morpholines - pharmacology | Halogens - chemistry | Receptors, Opioid, delta - drug effects | Receptors, Opioid, mu - drug effects | Morpholines - chemistry | Index Medicus
Journal Article
Journal Article
BRITISH JOURNAL OF PHARMACOLOGY, ISSN 0007-1188, 07/2018, Volume 175, Issue 14, pp. 2869 - 2880
Background and Purpose The receptor antagonists have potential for treating neuropsychiatric disorders. We have investigated the in vivo pharmacology of a... 
RESTRAINT STRESS | SELECTIVE ANTAGONIST | INDUCED BEHAVIORAL-RESPONSES | CONDITIONED PLACE PREFERENCE | ANIMAL-MODELS | KAPPA-OPIOID RECEPTOR | PHARMACOLOGY & PHARMACY | MAJOR DEPRESSIVE DISORDER | LOW-DOSE NALTREXONE | KNOCKOUT MICE | FORCED SWIM STRESS
Journal Article