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1. Full Text beta-Funaltrexamine Displayed Anti-Inflammatory and Neuroprotective Effects in Cells and Rat Model of Stroke
by Wu, Chih-Cheng and Chang, Cheng-Yi and Shih, Kuei-Chung and Hung, Chih-Jen and Wang, Ya-Yu and Lin, Shih-Yi and Chen, Wen-Ying and Kuan, Yu-Hsiang and Liao, Su-Lan and Wang, Wen-Yi and Chen, Chun-Jung
International journal of molecular sciences, ISSN 1422-0067, 06/2020, Volume 21, Issue 11, p. 3866
Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Naltrexone - analogs & derivatives | Naltrexone - therapeutic use | Neuroprotective Agents - therapeutic use | Tumor Necrosis Factor-alpha - metabolism | Arginase - metabolism | Male | NF-kappa B - metabolism | Antigens, CD - metabolism | Neuroglia - drug effects | Brain - metabolism | Naltrexone - pharmacology | Neuroprotective Agents - pharmacology | Interleukin-1beta - metabolism | Anti-Inflammatory Agents - therapeutic use | Neurons - metabolism | Neurons - drug effects | Brain - cytology | Anti-Inflammatory Agents - pharmacology | Cells, Cultured | Rats | Receptors, Cell Surface - metabolism | Stroke - drug therapy | Rats, Sprague-Dawley | Brain - drug effects | Dinoprostone - metabolism | Animals | Antigens, Differentiation, Myelomonocytic - metabolism | Cyclic AMP Response Element-Binding Protein - metabolism | Lipopolysaccharides - pharmacology | Neuroglia - metabolism | Nitric Oxide - metabolism | Interferon-gamma - pharmacology | Index Medicus | neuroinflammation | stroke | opioid | microglia polarization
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2. Full Text Stress produces aversion and potentiates cocaine reward by releasing endogenous dynorphins in the ventral striatum to locally stimulate serotonin reuptake
by Schindler, Abigail G and Messinger, Daniel I and Smith, Jeffrey S and Shankar, Haripriya and Gustin, Richard M and Schattauer, Selena S and Lemos, Julia C and Chavkin, Nicholas W and Hagan, Catherine E and Neumaier, John F and Chavkin, Charles
The Journal of neuroscience, ISSN 0270-6474, 12/2012, Volume 32, Issue 49, pp. 17582 - 17596
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Naltrexone - analogs & derivatives | Narcotic Antagonists - administration & dosage | Microinjections - methods | Nucleus Accumbens - metabolism | Dynorphins - physiology | Male | Synaptosomes - metabolism | Stress, Psychological - psychology | Corpus Striatum - metabolism | Raphe Nuclei - metabolism | Nicotine - adverse effects | Brain - metabolism | Naltrexone - pharmacology | Serotonin Plasma Membrane Transport Proteins - genetics | Substance Withdrawal Syndrome - metabolism | Stress, Psychological - metabolism | Membrane Transport Proteins - metabolism | Dynorphins - metabolism | Narcotic Antagonists - pharmacokinetics | Naltrexone - administration & dosage | Dopamine - metabolism | G-Protein-Coupled Receptor Kinase 3 - genetics | Receptors, Opioid, kappa - antagonists & inhibitors | p38 Mitogen-Activated Protein Kinases - physiology | G-Protein-Coupled Receptor Kinase 3 - physiology | Mice, Inbred C57BL | p38 Mitogen-Activated Protein Kinases - genetics | Mice, Transgenic | Avoidance Learning - physiology | Mice, Knockout | Receptors, Opioid, kappa - physiology | Serotonin Plasma Membrane Transport Proteins - metabolism | Cocaine - pharmacology | Animals | Raphe Nuclei - drug effects | Raphe Nuclei - physiology | Signal Transduction - drug effects | Serotonin - metabolism | Signal Transduction - physiology | Avoidance Learning - drug effects | Mice | Reward | Nucleus Accumbens - drug effects | Index Medicus
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3. Full Text Constitutive μ-Opioid Receptor Activity Leads to Long-Term Endogenous Analgesia and Dependence
by G. Corder and S. Doolen and R. R. Donahue and M. K. Winter and B. L. Jutras and Y. He and X. Hu and J. S. Wieskopf and J. S. Mogil and D. R. Storm and Z. J. Wang and K. E. McCarson and B. K. Taylor
Science (American Association for the Advancement of Science), ISSN 0036-8075, 9/2013, Volume 341, Issue 6152, pp. 1394 - 1399
Receptors | Spinal cord | Pain | Opioid receptors | REPORTS | Opiates | Sensitization | Physical trauma | Behavioral neuroscience | Hyperalgesia | Opioid analgesics | Fundamental and applied biological sciences. Psychology | Vertebrates: nervous system and sense organs | Neurology | Biological and medical sciences | Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors | Nervous system as a whole | Medical sciences | Nervous system (semeiology, syndromes) | Hyperalgesia - chemically induced | Naltrexone - analogs & derivatives | Acute Pain - metabolism | Spinal Cord - drug effects | Spinal Cord - metabolism | Freund's Adjuvant - pharmacology | Hyperalgesia - metabolism | Isoflurane - pharmacology | Adenosine Monophosphate - metabolism | Receptors, Opioid, mu - metabolism | Receptors, N-Methyl-D-Aspartate - metabolism | Male | Adenylyl Cyclases - metabolism | Receptors, Opioid, mu - agonists | Receptors, Opioid, mu - antagonists & inhibitors | Nociceptive Pain - metabolism | Chronic Pain - metabolism | Naltrexone - pharmacology | Animals | Substance Withdrawal Syndrome - metabolism | Mice | Disease Models, Animal | Index Medicus
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4. Full Text Prodynorphin-Derived Peptides Are Critical Modulators of Anxiety and Regulate Neurochemistry and Corticosterone
by Wittmann, Walter and Schunk, Eduard and Rosskothen, Iris and Gaburro, Stefano and Singewald, Nicolas and Herzog, Herbert and Schwarzer, Christoph
Neuropsychopharmacology (New York, N.Y.), ISSN 0893-133X, 02/2009, Volume 34, Issue 3, pp. 775 - 785
Hypothalamic-pituitary-adrenal axis | Paraventricular | κ-opioid receptor | Amygdala | Prodynorphin knockout | Stress | Pharmacology & Pharmacy | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Psychiatry | Science & Technology | Biological and medical sciences | Medical sciences | Naltrexone - analogs & derivatives | Enkephalins - metabolism | Mesencephalon - metabolism | Brain Stem - metabolism | Dynorphins - physiology | Male | Neuropeptide Y - genetics | Mice, Knockout - metabolism | Raphe Nuclei - metabolism | Morphinans | Neuropeptide Y - metabolism | Enkephalins - genetics | Naltrexone - pharmacology | Protein Precursors - physiology | Female | Enkephalins - physiology | Corticosterone - blood | Neuropeptides - genetics | Anxiety - metabolism | Neuropeptide Y - physiology | Exploratory Behavior | Receptors, Opioid, kappa - antagonists & inhibitors | Protein Precursors - genetics | Mice, Inbred C57BL | Receptors, Opioid, kappa - agonists | Amygdala - metabolism | Anxiety - physiopathology | Neuropeptides - metabolism | Guanidines | 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer - pharmacology | Corticotropin-Releasing Hormone - metabolism | Protein Precursors - metabolism | Animals | Hypothalamus - metabolism | Maze Learning | Mice | Stress, Psychological - physiopathology | Index Medicus | stress | amygdala | prodynorphin knockout | hypothalamic–pituitary–adrenal axis | paraventricular nucleus
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5. Full Text Orexigenic effects of endomorphin-2 (EM-2) related to decreased CRH gene expression and increased dopamine and norepinephrine activity in the hypothalamus
by Brunetti, Luigi and Ferrante, Claudio and Orlando, Giustino and Recinella, Lucia and Leone, Sheila and Chiavaroli, Annalisa and Di Nisio, Chiara and Shohreh, Rugia and Manippa, Fabio and Ricciuti, Adriana and Mollica, Adriano and Vacca, Michele
Peptides (New York, N.Y. : 1980), ISSN 0196-9781, 10/2013, Volume 48, pp. 83 - 88
Corticotrophin-releasing hormone | Norepinephrine | Dopamine | Hypothalamus | Endomorphin-2 | Feeding | Pharmacology & Pharmacy | Biochemistry & Molecular Biology | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Naltrexone - analogs & derivatives | Orexins | Arcuate Nucleus of Hypothalamus - metabolism | Humans | Rats | Neuropeptides - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Oligopeptides - metabolism | Arcuate Nucleus of Hypothalamus - physiology | Corticotropin-Releasing Hormone - metabolism | Feeding Behavior - drug effects | Gene Expression Regulation - drug effects | Nerve Tissue Proteins - metabolism | Neuropeptide Y - metabolism | Pro-Opiomelanocortin - metabolism | Animals | Hypothalamus - metabolism | Norepinephrine - metabolism | Serotonin - metabolism | Corticotropin-Releasing Hormone - genetics | Oligopeptides - administration & dosage | Naltrexone - administration & dosage | Agouti-Related Protein | Dopamine - metabolism | Phenols | Gene expression | Genes | Index Medicus
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6. Full Text Mice Lacking GPR88 Show Motor Deficit, Improved Spatial Learning, and Low Anxiety Reversed by Delta Opioid Antagonist
by Meirsman, Aura C and Le Merrer, Julie and Pellissier, Lucie P and Diaz, Jorge and Clesse, Daniel and Kieffer, Brigitte L and Becker, Jérôme A.J
Biological psychiatry (1969), ISSN 0006-3223, 2015, Volume 79, Issue 11, pp. 917 - 927
Psychiatry | Ethological scoring of anxiety | GPR88 agonist-induced GTPγS binding | Gene clustering | Medium spiny neurons | Psychiatric disorders | Spatial learning | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Naltrexone - analogs & derivatives | Receptors, Opioid, delta - metabolism | Dendrites - pathology | Male | Anxiety - drug therapy | Corpus Striatum - metabolism | Spatial Learning - physiology | Naltrexone - pharmacology | Female | Anxiety - metabolism | Corpus Striatum - pathology | Dopamine - metabolism | Dendrites - drug effects | Dendrites - metabolism | Movement Disorders - pathology | Receptors, Opioid, mu - metabolism | Mice, Inbred C57BL | Spatial Learning - drug effects | Amygdala - metabolism | Hippocampus - pathology | Amygdala - pathology | Anxiety - pathology | Mice, Knockout | Hippocampus - metabolism | Movement Disorders - metabolism | Animals | Receptors, G-Protein-Coupled - deficiency | Narcotic Antagonists - pharmacology | Serotonin - metabolism | Receptors, G-Protein-Coupled - genetics | Movement Disorders - drug therapy | G proteins | Anxiety | Brain research | Genetic transcription | Neurons | Index Medicus | Life Sciences | Human health and pathology | Other | Psychiatrics and mental health | medium spiny neurons | spatial learning | gene clustering | ethological scoring of anxiety | psychiatric disorders
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7. Full Text Molecular control of δ-opioid receptor signalling
by Fenalti, Gustavo and Giguere, Patrick M and Katritch, Vsevolod and Huang, Xi-Ping and Thompson, Aaron A and Cherezov, Vadim and Roth, Bryan L and Stevens, Raymond C
Nature (London), ISSN 0028-0836, 2014, Volume 506, Issue 7487, pp. 191 - 196
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Naltrexone - analogs & derivatives | Receptors, Opioid, delta - metabolism | Humans | Naltrexone - chemistry | Crystallography, X-Ray | Structure-Activity Relationship | Sodium - metabolism | Arrestins - metabolism | Narcotic Antagonists - chemistry | Naltrexone - pharmacology | Narcotic Antagonists - metabolism | Receptors, Opioid, delta - genetics | Receptors, Opioid, delta - antagonists & inhibitors | Asparagine - genetics | Naltrexone - metabolism | Allosteric Regulation - drug effects | Allosteric Site - genetics | Sodium - pharmacology | Allosteric Regulation - genetics | Mutagenesis, Site-Directed | Receptors, Opioid, delta - chemistry | Allosteric Site - drug effects | Models, Molecular | Signal Transduction - drug effects | beta-Arrestins | Asparagine - metabolism | Narcotic Antagonists - pharmacology | Ligands | Receptors, Opioid, delta - agonists | Index Medicus | sodium regulation | constitutive activity | human opioid receptor | arrestin | functional selectivity | GPCR signaling | allostery
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8. Full Text Pharmacological characterization of the opioid inactive isomers (+)‐naltrexone and (+)‐naloxone as antagonists of toll‐like receptor 4
by Wang, X and Zhang, Y and Peng, Y and Hutchinson, M R and Rice, K C and Yin, H and Watkins, L R
British journal of pharmacology, ISSN 0007-1188, 03/2016, Volume 173, Issue 5, pp. 856 - 869
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Tumor Necrosis Factor-alpha - metabolism | Cell Line | Microglia - metabolism | Phagocytosis - drug effects | Reactive Oxygen Species - metabolism | Microglia - drug effects | Cells, Cultured | Male | Rats, Sprague-Dawley | Toll-Like Receptor 4 - metabolism | Naltrexone - pharmacology | Animals | Interferon-beta - metabolism | Interleukin-1beta - metabolism | Naloxone - pharmacology | Narcotic Antagonists - pharmacology | Lipopolysaccharides - pharmacology | Mice | Toll-Like Receptor 4 - antagonists & inhibitors | Macrophages, Peritoneal - metabolism | Nitric Oxide - metabolism | Macrophages, Peritoneal - drug effects | Narcotics | Rodents | Reactive oxygen species | Animal models | Three axis | Fluorescence | Activation | Neuropathy | Macrophages | Naltrexone | Isomers | Western blotting | Lipopolysaccharides | Pain | Interleukin 1 | Toll-like receptors | Reinforcement | Drug interaction | Inhibition | Enzyme-linked immunosorbent assay | NF-κB protein | Opioid receptors | JNK protein | Inflammation | TLR4 protein | Microglia | Signaling | Naloxone | Inhibitors | Interferon regulatory factor 3 | Tumor necrosis factor | Cocaine | Phagocytosis | Peritoneum | Index Medicus | Research Papers | Research Paper
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9. Full Text Non‐stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll‐like receptor 4 (TLR4)
by Hutchinson, Mark R and Zhang, Yingning and Brown, Kimberley and Coats, Benjamen D and Shridhar, Mitesh and Sholar, Paige W and Patel, Sonica J and Crysdale, Nicole Y and Harrison, Jacqueline A and Maier, Steven F and Rice, Kenner C and Watkins, Linda R
The European journal of neuroscience, ISSN 0953-816X, 07/2008, Volume 28, Issue 1, pp. 20 - 29
(+)‐naltrexone | stereoselectivity | (+)‐naloxone | microglia | Stereoselectivity | (+)-naltrexone | (+)-naloxone | Microglia | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Naltrexone - therapeutic use | Microglia - metabolism | Humans | Male | Pain - chemically induced | Pain - metabolism | Naltrexone - pharmacology | Narcotic Antagonists - metabolism | Pain - drug therapy | Behavior, Animal - drug effects | Toll-Like Receptor 4 - antagonists & inhibitors | Naltrexone - metabolism | Biomarkers - metabolism | Injections, Spinal | Cell Line | Naloxone - metabolism | Rats | Behavior, Animal - physiology | Naloxone - therapeutic use | Rats, Sprague-Dawley | Toll-Like Receptor 4 - metabolism | Animals | Narcotic Antagonists - therapeutic use | Signal Transduction - drug effects | Naloxone - pharmacology | Narcotic Antagonists - pharmacology | Signal Transduction - physiology | Pain Measurement | Naltrexone | Naloxone | Index Medicus
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