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1. Full Text NMR analysis of free and lipid nanodisc anchored CEACAM1 membrane proximal peptides with Ca 2+ /CaM
by Ghazarian, Haike and Hu, Weidong and Mao, Allen and Nguyen, Tung and Vaidehi, Nagarajan and Sligar, Stephen and Shively, John E
Biochimica et Biophysica Acta - Biomembranes, ISSN 0005-2736, 04/2019, Volume 1861, Issue 4, pp. 787 - 797
CEACAM1, a homotypic transmembrane receptor with 12 or 72 amino acid cytosolic domain isoforms, is converted from inactive cis-dimers to active trans-dimers by... 
CEACAM1 | NMR | Phosphorylation | Lipid nanodisc | Calmodulin
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2. Full Text Cytochrome b 5 enhances androgen synthesis by rapidly reducing the CYP17A1 oxy-complex in the lyase step
by Duggal, Ruchia and Denisov, Ilia G and Sligar, Stephen G
FEBS Letters, ISSN 0014-5793, 07/2018, Volume 592, Issue 13, pp. 2282 - 2288
Cytochrome P450 17A1 (CYP17A1) catalyzes the synthesis of androgens from the steroid precursors pregnenolone and progesterone in a two-step reaction process:... 
Nanodisc | cytochrome b5 | cytochrome P450 | androgen biosynthesis
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3. Full Text The 3.5-Å CryoEM Structure of Nanodisc-Reconstituted Yeast Vacuolar ATPase Vo Proton Channel
by Roh, Soung-Hun and Stam, Nicholas J and Hryc, Corey F and Couoh-Cardel, Sergio and Pintilie, Grigore and Chiu, Wah and Wilkens, Stephan and SLAC National Accelerator Lab., Menlo Park, CA (United States)
Molecular Cell, ISSN 1097-2765, 03/2018, Volume 69, Issue 6, pp. 993 - 1004.e3
The molecular mechanism of transmembrane proton translocation in rotary motor ATPases is not fully understood. Here, we report the 3.5-Å resolution cryoEM... 
Voa1 | reversible disassembly | cryoEM | proton pumping | vacuolar H+-ATPase | Vo proton channel | lipid nanodisc | membrane protein structure | V-ATPase assembly | proton channel | ATPase | vacuolar H | Index Medicus | Vo proton channelcryo | EMlipid nanodisc | BASIC BIOLOGICAL SCIENCES | Vacuolar H+-ATPase
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4. Full Text Influence of Lipid Mimetics on Gating of Ryanodine Receptor
by Willegems, Katrien and Efremov, Rouslan G
Structure, ISSN 0969-2126, 10/2018, Volume 26, Issue 10, pp. 1303 - 1313.e4
Understanding gating principles of ion channels at high resolution is of great importance. Here we investigate the conformational transition from closed to... 
ryanodine receptor | ion channel gating | cryo-EM | lipid mimetic | calcium signaling | lipid nanodiscs | ACTIVATION | CA2+ RELEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANISMS | SARCOPLASMIC-RETICULUM | CELL BIOLOGY | CALCIUM-RELEASE CHANNEL | BIOPHYSICS | STRUCTURAL BASIS | PURIFICATION | MEMBRANE-PROTEINS | RECONSTITUTION | INSIGHTS | Physiological aspects | Membrane lipids | Protein binding
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5. Full Text Colloidal lithography nanostructured Pd/PdO x core-shell sensor for ppb level H2S detection
by Benedict, Samatha and Lumdee, Chatdanai and Dmitriev, Alexandre and Anand, Srinivasan and Bhat, Navakanta
Nanotechnology, ISSN 0957-4484, 04/2018, Volume 29, Issue 25, pp. 255502 - 255502
In this work we report on plasma oxidation of palladium (Pd) to form reliable palladium/palladium oxide (Pd/PdO x ) core-shell sensor for ppb level H2S... 
colloidal lithography | nanodiscs | plasma oxidation
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6. Full Text Cytochrome b5 enhances androgen synthesis by rapidly reducing the CYP17A1 oxy‐complex in the lyase step
by Duggal, Ruchia and Denisov, Ilia G and Sligar, Stephen G
FEBS Letters, ISSN 0014-5793, 07/2018, Volume 592, Issue 13, pp. 2282 - 2288
Cytochrome P450 17A1 ( CYP 17A1) catalyzes the synthesis of androgens from the steroid precursors pregnenolone and progesterone in a two‐step reaction process:... 
Nanodisc | cytochrome b5 | cytochrome P450 | androgen biosynthesis | Index Medicus
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7. Full Text pH resistant monodispersed polymer-lipid nanodiscs
by Ravula, Thirupathi and Hardin, Nathaniel Z and Ramadugu, Sudheer Kumar and Cox, Sarah J and Ramamoorthy, Ayyalusamy
Angewandte Chemie (International ed. in English), ISSN 1433-7851, 1/2018, Volume 57, Issue 5, pp. 1342 - 1345
Polymer lipid nanodiscs have provided an invaluable system for structural and functional studies of membrane proteins in their near-native environment. In... 
magnetic-alignment | SMA | pH tolerance | lipid bilayer | polymer nanodisc
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8. Full Text Cell-Free Synthetic Biology Chassis for Nanocatalytic Photon-to-Hydrogen Conversion
by Wang, Peng and Chang, Angela Y and Novosad, Valentyn and Chupin, Vladimir V and Schaller, Richard D and Rozhkova, Elena A and Argonne National Lab. (ANL), Argonne, IL (United States)
ACS Nano, ISSN 1936-0851, 07/2017, Volume 11, Issue 7, pp. 6739 - 6745
We report on an entirely man-made nano-bio architecture fabricated through noncovalent assembly of a cell-free expressed transmembrane proton pump and TiO2... 
cell-free expression | solar-to-fuel energy conversion | nanoparticles | proton pump | purple membranes | nanodisc TiO | noncovalent assembly | hydrogen | EXCITED-STATE | MATERIALS SCIENCE, MULTIDISCIPLINARY | ISOMERIZATION | FREE PROTEIN-SYNTHESIS | CHEMISTRY, PHYSICAL | PHAGE DISPLAY | NANOSCIENCE & NANOTECHNOLOGY | CHEMISTRY, MULTIDISCIPLINARY | nanodisc TiO2 nanoparticles | NANODISCS | PURPLE MEMBRANE | SPECTROSCOPY | MEMBRANE-PROTEINS | BACTERIORHODOPSIN | WATER | Nanostructures - ultrastructure | Immobilized Proteins - chemistry | Nanotechnology - methods | Titanium - chemistry | Models, Molecular | Photons | Purple Membrane - chemistry | Hydrogen - chemistry | Halobacterium salinarum - chemistry | Quantum Dots - ultrastructure | Quantum Dots - chemistry | Synthetic Biology - methods | Light | Water - chemistry | Nanostructures - chemistry | Catalysis | Bacteriorhodopsins - chemistry | Index Medicus | solar-to-fuel conversion | synthetic biology | NANOSCIENCE AND NANOTECHNOLOGY | cell-free | TiO2
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9. Full Text Interaction of KRas4b with anionic membranes: A special role for PIP2
by Gregory, Michael C and McLean, Mark A and Sligar, Stephen G
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 05/2017, Volume 487, Issue 2, pp. 351 - 355
KRas4b is a small G-protein whose constitutively active oncogenic mutants are present in 90% of pancreatic cancers. Using fully post-translationally modified... 
Nanodisc | Lipid specificity | KRas4b | Cancer signaling | PIP2 | PHOSPHOLIPID-BILAYER NANODISCS | MOLECULAR-DYNAMICS | ACTIVATION | RAS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MIMETIC MODEL | METHYLATED KRAS4B | BIOPHYSICS | STRUCTURAL BASIS | PROTEINS | Index Medicus
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10. Full Text Formation of stable nanodiscs by bihelical apolipoprotein A‐I mimetic peptide
by Kariyazono, Hirokazu and Nadai, Ryo and Miyajima, Rin and Takechi‐Haraya, Yuki and Baba, Teruhiko and Shigenaga, Akira and Okuhira, Keiichiro and Otaka, Akira and Saito, Hiroyuki
Journal of Peptide Science, ISSN 1075-2617, 02/2016, Volume 22, Issue 2, pp. 116 - 122
Nanodiscs are composed of scaffold protein or peptide such as apolipoprotein A‐I (apoA‐I) and phospholipids. Although peptide‐based nanodiscs have an advantage... 
nanodisc scaffold peptide | apoA‐I mimetic peptide | nanodisc | bihelical | apoA-I mimetic peptide | CHEMISTRY, ANALYTICAL | PHOSPHOLIPID-BILAYER NANODISCS | ANALOGS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MEMBRANE SCAFFOLD PROTEINS | NATIVE CHEMICAL LIGATION | SOLUTION NMR | HIGH-DENSITY-LIPOPROTEIN | LIPID INTERACTION | CHOLESTEROL EFFLUX | AMPHIPATHIC HELICAL PEPTIDE | ABCA1 TRANSPORTER | Amino Acid Sequence | Protein Structure, Secondary | Cholic Acid - chemistry | Humans | Molecular Sequence Data | Phosphatidylcholines - chemistry | Particle Size | Molecular Mimicry | Peptide Fragments - chemistry | Nanostructures - chemistry | Protein Stability | Apolipoprotein A-I - chemistry | Dynamic Light Scattering | Peptides | Apolipoproteins | Index Medicus
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11. Full Text NMR analysis of free and lipid nanodisc anchored CEACAM1 membrane proximal peptides with Ca2+/CaM
by Ghazarian, Haike and Hu, Weidong and Mao, Allen and Nguyen, Tung and Vaidehi, Nagarajan and Sligar, Stephen and Shively, John E
BBA - Biomembranes, ISSN 0005-2736, 04/2019, Volume 1861, Issue 4, pp. 787 - 797
CEACAM1, a homotypic transmembrane receptor with 12 or 72 amino acid cytosolic domain isoforms, is converted from inactive -dimers to active -dimers by... 
CEACAM1 | Phosphorylation | NMR | Lipid nanodisc | Calmodulin | C-CAM | CYTOPLASMIC DOMAIN | PHOSPHOLIPID-BILAYER NANODISCS | ACTIN | MOLECULE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-ADHESION | MICELLES | BIOPHYSICS | ACCURATE DOCKING | CALMODULIN-BINDING | PROTEINS
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12. Full Text Molecular mechanism of fusion pore formation driven by the neuronal SNARE complex
by Sharma, Satyan and Lindau, Manfred
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2018, Volume 115, Issue 50, pp. 12751 - 12756
Release of neurotransmitters from synaptic vesicles begins with a narrow fusion pore, the structure of which remains unresolved. To obtain a structural model... 
Molecular dynamics | Transmitter release | Exocytosis | Membrane fusion nanodisc | VESICLE FUSION | MEDIATED FUSION | PHOSPHOLIPID-VESICLES | PROTEIN | MULTIDISCIPLINARY SCIENCES | TRANSMEMBRANE-DOMAIN | molecular dynamics | GRANULES | SYNAPTOBREVIN C-TERMINUS | membrane fusion | MEMBRANE-FUSION | transmitter release | nanodisc | exocytosis | SNAP-25 | Models, Structural | Synaptic Vesicles - metabolism | Neurotransmitter Agents - metabolism | Cytoplasm - metabolism | Mutant Proteins - metabolism | Syntaxin 1 - metabolism | Hydrophobic and Hydrophilic Interactions | Protein Domains | Membrane Proteins - metabolism | Neurons - metabolism | Diaphragm - metabolism | Membrane Fusion - physiology | Vesicle-Associated Membrane Protein 2 - metabolism | SNARE Proteins - metabolism | Physiological aspects | Neurotransmitters | Neural circuitry | Membrane fusion | Computer simulation | Mobility | SNAP receptors | Mutants | Proteins | Synaptobrevin | Domains | Syntaxin | Syntaxin 1 | Synaptic vesicles | Transmembrane domains | Diaphragm | Molecular biology | Fusion protein | Fusion | Pore formation | Bilayers | Index Medicus | Biological Sciences
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13. Full Text Nanodisc-Forming Scaffold Protein Promoted Retardation of Amyloid-Beta Aggregation
by Sahoo, Bikash Ranjan and Genjo, Takuya and Cox, Sarah J and Stoddard, Andrea K and Anantharamaiah, G.M and Fierke, Carol and Ramamoorthy, Ayyalusamy
Journal of Molecular Biology, ISSN 0022-2836, 10/2018, Volume 430, Issue 21, pp. 4230 - 4244
Peptidic nanodiscs are useful membrane mimetic tools for structural and functional studies of membrane proteins, and membrane interacting peptides including... 
beta-amyloid | membrane scaffold protein | Alzheimer's disease | protein aggregation | nanodisc | FIBRIL FORMATION | PHOSPHOLIPID-BILAYER NANODISCS | ALZHEIMERS-DISEASE | NMR-SPECTROSCOPY | MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PARTIALLY FOLDED STRUCTURE | PEPTIDE | FORCE-FIELD | OLIGOMERIZATION | BINDING | Peptides | Hydrogen | Analysis | Molecular dynamics | Fluorescence | Apolipoproteins | Membrane proteins
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14. Full Text Nanodiscs: A Controlled Bilayer Surface for the Study of Membrane Proteins
by McLean, Mark A and Gregory, Michael C and Sligar, Stephen G
Annual Review of Biophysics, ISSN 1936-122X, 5/2018, Volume 47, Issue 1, pp. 107 - 124
The study of membrane proteins and receptors presents many challenges to researchers wishing to perform biophysical measurements to determine the structure,... 
Nanodisc | membrane protein | cancer signaling | integrin activation | blood coagulation | fluorescence | Membrane proteins | Integrins
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15. Full Text The stability and activity of respiratory Complex II is cardiolipin-dependent
by Schwall, Christine T and Greenwood, Victoria L and Alder, Nathan N
BBA - Bioenergetics, ISSN 0005-2728, 09/2012, Volume 1817, Issue 9, pp. 1588 - 1596
Respiratory Complex II of the mitochondrial inner membrane serves as a link between the tricarboxylic acid cycle and the electron transport chain. Complex II... 
Complex II | Nanodisc | Cardiolipin | ROS | PHOSPHOLIPID-BILAYER NANODISCS | OXIDATIVE STRESS | MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SACCHAROMYCES-CEREVISIAE | CHAIN | YEAST MITOCHONDRIA | ELECTRON-TRANSFER | BIOPHYSICS | CYTOCHROME BC COMPLEX | QUINONE-BINDING-SITE | SUCCINATE-UBIQUINONE OXIDOREDUCTASE | Phosphatidylglycerols - physiology | Reactive Oxygen Species - metabolism | Electron Transport Complex II - metabolism | Enzyme Stability | Mitochondria - metabolism | Cardiolipins - physiology | Electron Transport Complex II - chemistry | Enzymes
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16. Full Text Bacterial reaction centers purified with styrene maleic acid copolymer retain native membrane functional properties and display enhanced stability
by Swainsbury, David J K and Scheidelaar, Stefan|info:eu-repo/dai/nl/413333418 and Van Grondelle, Rienk and Killian, J. Antoinette|info:eu-repo/dai/nl/071792317 and Jones, Michael R
Angewandte Chemie - International Edition, ISSN 1433-7851, 10/2014, Volume 53, Issue 44, pp. 11803 - 11807
Integral membrane proteins often present daunting challenges for biophysical characterization, a fundamental issue being how to select a surfactant that will... 
nanodiscs | membrane proteins | reaction centers | detergents | styrene maleic acid | Reaction centers | Styrene maleic acid | Detergents | Membrane proteins | Nanodiscs | THERMAL-STABILITY | PHOTOSYNTHETIC REACTION CENTERS | RHODOBACTER-SPHAEROIDES | CHEMISTRY, MULTIDISCIPLINARY | BIOLOGICAL-MEMBRANES | PHOSPHOLIPID-COMPOSITION | ELECTRON-TRANSFER | RHODOPSEUDOMONAS-SPHAEROIDES | FREE PURIFICATION | PROTEINS | Membrane Proteins - chemistry | Detergents - chemistry | Maleates - chemistry | Electrochemistry | Electrochemical reactions | Lipids | Detergents, Synthetic | Analysis | Aquaporins | Surfactants | Styrene | Index Medicus | Proteins | Membranes | Copolymers | Styrenes | Integrals | Micelles | Bacteria | Communication
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17. Full Text Real-time monitoring of binding events on a thermostabilized human A 2A receptor embedded in a lipid bilayer by surface plasmon resonance
by Bocquet, Nicolas and Kohler, Josiane and Hug, Melanie N and Kusznir, Eric A and Rufer, Arne C and Dawson, Roger J and Hennig, Michael and Ruf, Armin and Huber, Walter and Huber, Sylwia
Biochimica et Biophysica Acta - Biomembranes, ISSN 0005-2736, 2015, Volume 1848, Issue 5, pp. 1224 - 1233
Membrane proteins (MPs) are prevalent drug discovery targets involved in many cell processes. Despite their high potential as drug targets, the study of MPs... 
Surface plasmon resonance | Scintillation proximity assay | Kinetics | GPCRs | Nanodiscs
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18. Full Text Isolation of Single Chain Antibodies Specific to Lysophosphatidic Acid Receptor 1 (LPA1) from a M13 Phage Display Library Using Purified LPA1 Stabilized in Nanodiscs
by Jung, Ji Hae and Han, Seong‐Gu and Ju, Man‐Seok and Jung, Sang Taek and Yu, Yeon Gyu
Bulletin of the Korean Chemical Society, ISSN 1229-5949, 07/2019, Volume 40, Issue 7, pp. 680 - 685
G‐protein coupled receptors (GPCRs) comprise the largest membrane protein family and are involved in various kinds of physiological phenomena. LPA 1 belongs to... 
Agonist | scAb | scFv | GPCR | LPA | Nanodiscs
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