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Oncogene, ISSN 0950-9232, 01/2006, Volume 25, Issue 2, pp. 176 - 185
The induction of senescence-like growth arrest has emerged as a putative contributor to the anticancer effects of chemotherapeutic agents. Clinical trials are... 
Sirt1 | MAPK | Ras | Akt/PKB | Sirtinol | Cellular senescence | TRANSCRIPTION FACTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN DEACETYLASES | TUMOR-CELLS | sirtinol | DEPSIPEPTIDE FR901228 | CELL BIOLOGY | cellular senescence | TERMINAL PROLIFERATION ARREST | HUMAN-FIBROBLASTS | ONCOLOGY | IN-VIVO | GENETICS & HEREDITY | HISTONE DEACETYLASE INHIBITORS | PC12 CELLS | Lung Neoplasms - drug therapy | Receptor, IGF Type 1 - metabolism | Insulin-Like Growth Factor I - pharmacology | Humans | Lung Neoplasms - metabolism | Cellular Senescence - drug effects | Lung Neoplasms - pathology | Phosphatidylinositol 3-Kinases - metabolism | Breast Neoplasms - metabolism | Genes, ras - physiology | Receptor, Epidermal Growth Factor - metabolism | Plasminogen Activator Inhibitor 1 - metabolism | Sirtuin 1 | beta-Galactosidase - metabolism | Benzamides - pharmacology | p38 Mitogen-Activated Protein Kinases - metabolism | Phosphorylation - drug effects | Tumor Cells, Cultured | Proto-Oncogene Proteins c-akt - metabolism | Naphthols - pharmacology | Enzyme Activation - drug effects | Breast Neoplasms - drug therapy | Tyrosine - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Breast Neoplasms - pathology | Histone Deacetylase Inhibitors | Epidermal Growth Factor - pharmacology | Sirtuins - antagonists & inhibitors | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus
Journal Article
Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 07/2012, Volume 16, Issue 7, pp. 1618 - 1628
Sirtuins (a class III histone deacetylase) have emerged as novel targets for cancer therapy. Salermide, a reverse amide compound that inhibits Sirtuin 1... 
Sirt1/2 | death receptor 5 (DR5) | CHOP | salermide | endoplasmic reticulum (ER) stress | ATF3 | ATF4 | Endoplasmic reticulum (ER) stress | Death receptor 5 (DR5) | Salermide | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | MECHANISM | DEATH-RECEPTOR-5 | INVOLVEMENT | ENDOPLASMIC-RETICULUM STRESS | INDUCTION | CELL BIOLOGY | Sirt1 | INHIBITORS | MODULATION | Sirtuin 1 - metabolism | Transcription Factor CHOP - genetics | Up-Regulation | Caspase 9 - genetics | Caspase 9 - metabolism | Apoptosis - drug effects | Humans | Caspase 8 - metabolism | Endoplasmic Reticulum - metabolism | Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism | Sirtuin 1 - genetics | Gene Knockdown Techniques | Sirtuin 2 - metabolism | Caspase 8 - genetics | Endoplasmic Reticulum - drug effects | Caspase 3 | Receptors, TNF-Related Apoptosis-Inducing Ligand - genetics | Gene Expression Regulation, Neoplastic - drug effects | Activating Transcription Factor 3 - genetics | Lung Neoplasms - genetics | Endoplasmic Reticulum - genetics | Signal Transduction | Naphthols - pharmacology | Gene Silencing | Activating Transcription Factor 4 - genetics | Activating Transcription Factor 3 - metabolism | Phenylpropionates - pharmacology | Sirtuin 2 - genetics | Poly(ADP-ribose) Polymerases - metabolism | Poly(ADP-ribose) Polymerases - genetics | Activating Transcription Factor 4 - metabolism | Cell Line, Tumor | Histone Deacetylase Inhibitors - metabolism | Transcription Factor CHOP - metabolism | RNA, Small Interfering - metabolism | Proteins | Gene expression | Lung cancer | Cells | Apoptosis | Index Medicus | 2 | Original
Journal Article
Journal Article
Pharmacological Research, ISSN 1043-6618, 09/2017, Volume 123, pp. 27 - 39
G protein-coupled receptor 35 (GPR35), a receptor for lysophosphatidic acid, is highly expressed in the gastrointestinal tract. Recently, GPR35 has been... 
Inflammatory bowel disease | GPR35 | Colonic epithelial cells | Cell migration | HUMAN FIBRONECTIN | ACTIVATION | ACID | ALPHABETA INTEGRIN | BINDING DOMAIN | PROLIFERATION | ADHESION | IN-VITRO | COLITIS | PHARMACOLOGY & PHARMACY | EXPRESSION | Colon - cytology | Dextran Sulfate | Intestinal Mucosa - metabolism | Epithelial Cells - metabolism | Nitriles - pharmacology | Receptors, G-Protein-Coupled - metabolism | Furans - pharmacology | Colitis - pathology | Male | Extracellular Signal-Regulated MAP Kinases - metabolism | Receptors, G-Protein-Coupled - agonists | RNA, Messenger - metabolism | Integrins - metabolism | Cell Movement - physiology | Epithelial Cells - physiology | Colitis - chemically induced | Colitis - drug therapy | Cytokines - genetics | Cell Line | Colon - pathology | Naphthols - therapeutic use | Mice, Inbred C57BL | Rats | Colon - metabolism | Fibronectins - metabolism | Animals | Colitis - metabolism | Receptors, G-Protein-Coupled - antagonists & inhibitors | Purinones - pharmacology | Wound Healing - physiology | Peroxidase - metabolism | G proteins | Membrane proteins | Immunohistochemistry | Fibronectins | Care and treatment | RNA | Wounds and injuries | Dextran | Epidermal growth factor | Analysis | Gastrointestinal diseases | Gastrointestinal system | Physiological aspects | Colitis | Protein kinases | Integrins | Index Medicus
Journal Article
Cell Death and Disease, ISSN 2041-4889, 07/2015, Volume 6, Issue 7, pp. e1834 - e1834
A number of tumors exhibit an altered expression of sirtuins, including NAD(+)-dependent histone deacetylase silent information regulator 1 (SIRT1) that may... 
P53 ACETYLATION | COLORECTAL-CANCER | ESTROGEN-RECEPTOR-ALPHA | DNA-DAMAGE | B-DEPENDENT TRANSCRIPTION | STROMAL FIBROBLASTS | GENE-EXPRESSION CHANGES | CELL-SURVIVAL | UP-REGULATION | HISTONE DEACETYLASE SIRT1 | CELL BIOLOGY | Sirtuin 1 - metabolism | Receptor, Epidermal Growth Factor - genetics | Receptors, Estrogen - metabolism | Receptors, G-Protein-Coupled - metabolism | Transcription Factor AP-1 - genetics | Humans | Gene Expression Regulation, Neoplastic | Sirtuin 1 - genetics | Transcription Factor AP-1 - metabolism | Quinolines - pharmacology | Breast Neoplasms - metabolism | Receptor, Epidermal Growth Factor - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Female | Benzamides - pharmacology | Estradiol - pharmacology | Fibroblasts - metabolism | Receptors, Estrogen - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Naphthols - pharmacology | Proto-Oncogene Proteins c-fos - metabolism | Etoposide - pharmacology | Signal Transduction - genetics | Cyclopentanes - pharmacology | Fibroblasts - pathology | Breast Neoplasms - drug therapy | Sirtuin 1 - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | Breast Neoplasms - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Breast Neoplasms - pathology | Cell Cycle Checkpoints - drug effects | Mice, Nude | Fibroblasts - drug effects | Cell Line, Tumor | Proto-Oncogene Proteins c-fos - genetics | Cell Proliferation - drug effects | Receptors, G-Protein-Coupled - genetics | Primary Cell Culture | Antineoplastic Agents, Phytogenic - pharmacology | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus | Original
Journal Article
Journal Article
Cytokine, ISSN 1043-4666, 10/2012, Volume 60, Issue 1, pp. 284 - 293
► LPS induces IL-17 and IL-23 expression, and IL-17 secretion. ► LPS increase SIRT1 protein and mRNA levels. ► SIRT1 siRNA and sirtinol blocked LPS-induced... 
P. gingivalis | IL-23 | SIRT1 | LPS | IL-17 | RHEUMATOID-ARTHRITIS | DIFFERENTIAL EXPRESSION | RANKL EXPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | IMMUNOLOGY | CELL BIOLOGY | IN-VITRO | CYTOKINE PRODUCTION | CREVICULAR FLUID | TOLL-LIKE RECEPTORS | GENE-EXPRESSION | HEME OXYGENASE-1 | TNF-ALPHA | Sirtuin 1 - metabolism | RANK Ligand - metabolism | Humans | Alkaline Phosphatase - metabolism | NF-kappa B - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Porphyromonas gingivalis - chemistry | Periodontal Ligament - drug effects | Periodontal Ligament - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Sirtuin 1 - genetics | Interleukin-23 - genetics | Periodontal Ligament - cytology | Antibodies, Neutralizing - immunology | Interleukin-23 - metabolism | RNA Interference | Benzamides - pharmacology | Alkaline Phosphatase - genetics | Naphthols - pharmacology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Interleukin-17 - genetics | Antibodies, Neutralizing - pharmacology | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Sirtuin 1 - antagonists & inhibitors | Toll-Like Receptor 4 - metabolism | Blotting, Western | RANK Ligand - genetics | Interleukin-17 - metabolism | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Signal Transduction - drug effects | Lipopolysaccharides - pharmacology | Toll-Like Receptor 2 - immunology | Mitogen-Activated Protein Kinases - metabolism | Interleukins | Mitogens | Messenger RNA | Index Medicus | Antibodies | Interleukin 23 | periodontal ligament | mRNA | Osteoblasts | phosphoinositides | Lipopolysaccharides | Signal transduction | c-Jun amino-terminal kinase | Toll-like receptors | Bone loss | TRANCE protein | Macrophage colony-stimulating factor | Extracellular signal-regulated kinase | MAP kinase | siRNA | Gene expression | SIRT1 protein | Interleukin 17 | 1-Phosphatidylinositol 3-kinase | Periodontal diseases | NF- Kappa B protein | Molecular modelling | Periodontitis | Osteoclasts | Gingiva
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 09/2008, Volume 28, Issue 9, pp. 1634 - 1639
Journal Article