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Oncotarget, ISSN 1949-2553, 2016, Volume 7, Issue 48, pp. 79217 - 79232
Journal Article
International Journal of Nanomedicine, ISSN 1176-9114, 04/2014, Volume 9, Issue 1, pp. 1855 - 1870
Conventional chemotherapy of ovarian cancer often fails because of initiation of drug resistance and/or side effects and trace of untouched remaining cancerous... 
Nanoparticle | Shikonin | Targeted therapy | Nanomedicine | Ovarian cancer | Tumor vasculature | targeted therapy | vasculature | PEGYLATED LIPOSOMAL DOXORUBICIN | MICROARRAY | ovarian cancer | MARKER | NANOCARRIERS | nanomedicine | nanoparticle | NANOSCIENCE & NANOTECHNOLOGY | BIODISTRIBUTION | GENE-EXPRESSION CHANGES | CHEMOTHERAPY | shikonin | TOXICOGENOMICS | tumor | PHARMACOLOGY & PHARMACY | PLGA NANOPARTICLES | Antigens, CD - immunology | Nanocomposites - chemistry | Apoptosis - drug effects | Nanocapsules - administration & dosage | Humans | Antineoplastic Agents - administration & dosage | Nanocapsules - chemistry | Nanocapsules - ultrastructure | Female | Nanocomposites - ultrastructure | Naphthoquinones - administration & dosage | Drugs, Chinese Herbal - administration & dosage | Diffusion | Ovarian Neoplasms - drug therapy | Antibodies, Monoclonal - immunology | Molecular Targeted Therapy - methods | Cell Survival - drug effects | Antigens, Neoplasm - immunology | Treatment Outcome | Antineoplastic Agents - chemistry | Particle Size | Antibodies, Monoclonal - administration & dosage | Drugs, Chinese Herbal - chemistry | Cell Line, Tumor | Naphthoquinones - chemistry | Nanocomposites - administration & dosage | Ovarian Neoplasms - immunology | Nanoparticles | Drugs | Usage | Drug delivery systems | Physiological aspects | Research | Drug therapy | Vehicles | Medical research | Laboratories | Brain cancer | Cytotoxicity | Kinases | Drug resistance | Proteins | Chemotherapy | Acids | Polyethylene glycol | Polyvinyl alcohol | Polymers | Tumors | Apoptosis | tumor vasculature
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 11/2008, Volume 26, Issue 32, pp. 5198 - 5203
Journal Article
Journal Article
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 02/2015, Volume 200, pp. 201 - 211
Lung cancer is one of the most lethal forms of cancer and current chemotherapeutic strategies lack broad specificity and efficacy. Recently, β-lapachone... 
Prodrug therapy | β-Lapachone | Polymeric micelles | Non-small cell lung cancer | Cancer nanomedicine | INDUCED DNA-DAMAGE | NAD(P)H-QUINONE OXIDOREDUCTASE-1 NQO1 | DRUG-DELIVERY | MITOMYCIN-C | PROGRAMMED NECROSIS | TUMOR-CELLS | CHEMISTRY, MULTIDISCIPLINARY | beta-Lapachone | REPAIR | METABOLISM | DT-DIAPHORASE | NANOTHERAPEUTICS | PHARMACOLOGY & PHARMACY | Hemolysis - drug effects | Prodrugs - administration & dosage | Lung Neoplasms - drug therapy | Nanoparticles - chemistry | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Polyethylene Glycols - chemistry | Antineoplastic Agents - therapeutic use | Prodrugs - chemistry | Antineoplastic Agents - administration & dosage | Nanoparticles - therapeutic use | Micelles | Female | Antineoplastic Agents - pharmacology | Naphthoquinones - administration & dosage | Lactates - chemistry | Carcinoma, Non-Small-Cell Lung - pathology | Carcinoma, Non-Small-Cell Lung - metabolism | Naphthoquinones - therapeutic use | Esterases - metabolism | Naphthoquinones - pharmacology | Antineoplastic Agents - chemistry | Mice, SCID | Comet Assay | Erythrocytes - drug effects | Animals | Tumor Burden - drug effects | Cell Line, Tumor | NAD(P)H Dehydrogenase (Quinone) - metabolism | Naphthoquinones - chemistry | Nanoparticles - administration & dosage | Prodrugs - therapeutic use | Carcinoma, Non-Small-Cell Lung - drug therapy | Prodrugs - pharmacology | Index Medicus
Journal Article
Targeted Oncology, ISSN 1776-2596, 12/2015, Volume 10, Issue 4, pp. 523 - 533
After extensive research on radiochemotherapy, 5-year survival rates of children with high risk neuroblastoma still do not exceed 50%, owing to adverse... 
Screening system | Medicine & Public Health | F-box proteins | DNA methyltransferase inhibitors | Oncology | Neuroblastoma | Doxorubicin | Biomedicine general | RNA-interference | APOPTOSIS | TUMOR-SUPPRESSOR GENES | SENSITIVITY | BREAST-CANCER CELLS | GENOMICS | ONCOLOGY | METHYLTRANSFERASES | DRUGS | LEUKEMIA | EXPRESSION | RNA, Small Interfering - genetics | DNA Modification Methylases - antagonists & inhibitors | Humans | Aminoquinolines - administration & dosage | Neuroblastoma - therapy | Tryptophan - administration & dosage | Molecular Targeted Therapy | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Enzyme Inhibitors - administration & dosage | Phthalimides - pharmacology | Phthalimides - administration & dosage | Tryptophan - analogs & derivatives | HEK293 Cells | Naphthoquinones - administration & dosage | Aminoquinolines - pharmacology | Neuroblastoma - pathology | Doxorubicin - administration & dosage | Pyrimidines - administration & dosage | Neuroblastoma - genetics | Enzyme Inhibitors - pharmacology | Naphthoquinones - pharmacology | Pyrimidines - pharmacology | Drug Synergism | Neuroblastoma - drug therapy | Cell Line, Tumor | Cell Proliferation - drug effects | Tryptophan - pharmacology | RNA, Small Interfering - administration & dosage | DNA Methylation - drug effects | F-Box Proteins - genetics | Doxorubicin - pharmacology | Anthracyclines | Chromatin | RNA | Transferases | DNA | Cellular signal transduction | Methylation | Health aspects
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 3/2001, Volume 18, Issue 3, pp. 380 - 388
Purpose. To quantitatively compare in vitro dissolution data in biorelevant and compendial media, to investigate whether in vitro differences are reflected in... 
Biochemistry, general | sanfetrinem cilexetil | troglitazone | Biomedical Engineering | lipophilic drugs | Biomedicine | Pharmacy | atovaquone | prediction | Medical Law | Pharmacology/Toxicology | GV150013X | oral absorption | Oral absorption | Atovaquone | Prediction | Sanfetrinem cilexetil | Lipophilic drugs | Troglitazone | PROGNOSTIC TOOL | BEHAVIOR | SIMULATION-MODELS | CHEMISTRY, MULTIDISCIPLINARY | PHARMACOLOGY & PHARMACY | ABSORPTION | Naphthoquinones - pharmacokinetics | Thiazoles - blood | Anti-Bacterial Agents - blood | Models, Chemical | Humans | Lactams | Thiazoles - administration & dosage | Chromans - blood | Thiazoles - pharmacokinetics | Hypoglycemic Agents - blood | Lipids - chemistry | Chromans - pharmacokinetics | Hypoglycemic Agents - administration & dosage | Adamantane - blood | Antifungal Agents - pharmacokinetics | Chemical Phenomena | Naphthoquinones - blood | Naphthoquinones - administration & dosage | Phenylurea Compounds - pharmacokinetics | Chromans - administration & dosage | Adamantane - pharmacokinetics | Adamantane - analogs & derivatives | Hypoglycemic Agents - pharmacokinetics | Administration, Oral | Solubility | Phenylurea Compounds - blood | Chemistry, Physical | Algorithms | Anti-Bacterial Agents - pharmacokinetics | Pharmaceutical Preparations - chemistry | Pharmacokinetics | Thiazolidinediones | Antifungal Agents - blood
Journal Article
Journal Article
ACS Nano, ISSN 1936-0851, 07/2017, Volume 11, Issue 7, pp. 7259 - 7273
The early detection and thus treatment of breast cancer bone metastasis remain a big challenge clinically. As the most abundant cells within bone tissue,... 
ATP competitiveness | plumbagin | zoledronic acid | breast cancer bone metasatasis | osteocyte-targeting | theranostic | upconversion nanoparticle | SYSTEM | MIGRATION | CELLS | MATERIALS SCIENCE, MULTIDISCIPLINARY | NANOMATERIALS | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | MECHANISMS | CHEMISTRY, MULTIDISCIPLINARY | DELIVERY | PHOSPHATE | BISPHOSPHONATES | OSTEOCLAST FORMATION | IN-VIVO | Osteocytes - drug effects | Luminescent Agents - chemistry | Nanoparticles - chemistry | Zoledronic Acid - therapeutic use | Humans | Bone Neoplasms - secondary | Delayed-Action Preparations - chemistry | Bone Neoplasms - pathology | Drug Delivery Systems | Antineoplastic Agents, Phytogenic - administration & dosage | Theranostic Nanomedicine - methods | Female | Naphthoquinones - administration & dosage | Bone Neoplasms - drug therapy | Antineoplastic Agents, Phytogenic - therapeutic use | Optical Imaging - methods | Bone Neoplasms - diagnostic imaging | Silicon Dioxide - chemistry | Nanoparticles - ultrastructure | Naphthoquinones - therapeutic use | Bone Density Conservation Agents - therapeutic use | Bone Density Conservation Agents - administration & dosage | Zoledronic Acid - administration & dosage | Gadolinium - chemistry | Animals | Breast Neoplasms - pathology | Mice, Nude | Cell Line, Tumor | Osteocytes - pathology | Mice
Journal Article
Journal Article
Drugs, ISSN 0012-6667, 07/2017, Volume 77, Issue 10, pp. 1091 - 1103
Napabucasin (BBI608) is an orally administered small molecule that blocks stem cell activity in cancer cells by targeting the signal transducer and activator... 
GASTROINTESTINAL TOXICITY | BEVACIZUMAB BEV | TARGETED THERAPIES | COLORECTAL-CANCER | PHARMACOLOGY & PHARMACY | TOXICOLOGY |