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Natural product reports, ISSN 1460-4752, 2012, Volume 29, Issue 2, pp. 264 - 325
Journal Article
International Journal of Oncology, ISSN 1019-6439, 03/2015, Volume 46, Issue 3, pp. 963 - 972
Journal Article
Breast Cancer Research, ISSN 1465-5411, 05/2014, Volume 16, Issue 3, pp. R55 - R55
Journal Article
Medicinal research reviews, ISSN 0198-6325, 2012, Volume 32, Issue 3, pp. 459 - 517
Diabetes mellitus is a systemic disease responsible for morbidity in the western world and is gradually becoming prevalent in developing countries too. The... 
metabolism | insulin | diabetes | protein tyrosine phosphatase 1B (PTP 1B) | obesity | Obesity | Diabetes | Metabolism | Insulin | Protein Tyrosine Phosphatase 1B (PTP 1B) | PTP1B INHIBITORS | PYRIDAZINE ANALOGS | CHEMISTRY, MEDICINAL | COMPETITIVE INHIBITOR | ISOPRENYLATED FLAVONOIDS | GLUCOSE-TRANSPORT | FORMYLCHROMONE DERIVATIVES | SIGNAL-TRANSDUCTION | SELECTIVE INHIBITORS | PHARMACOLOGY & PHARMACY | INCREASED INSULIN SENSITIVITY | STRUCTURE-BASED DESIGN | Catalytic Domain - drug effects | Humans | Benzofurans - pharmacology | Pyridazines - pharmacology | Biphenyl Compounds - pharmacology | Insulin Resistance - physiology | Janus Kinase 2 - metabolism | Acetophenones - pharmacology | Vanadium Compounds - pharmacology | Catechols - pharmacology | Chromones - pharmacology | Thiazolidinediones - pharmacology | Insulin Secretion | Phosphates - pharmacology | Amino Acid Sequence | Peptidomimetics - pharmacology | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors | Models, Molecular | Thiophenes - pharmacology | Naphthoquinones - pharmacology | Enzyme Inhibitors - therapeutic use | Fluorides - pharmacology | Insulin - metabolism | Animals | STAT3 Transcription Factor - drug effects | Benzoates - pharmacology | Receptor, Insulin - drug effects | Receptor, Insulin - metabolism | Signal Transduction - physiology | Thiazoles - pharmacology | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy
Journal Article
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 12/2014, Volume 281, Issue 3, pp. 285 - 293
Beta-lapachone (beta-Lp) derived from the Lapacho tree is a potentially novel anticancer agent currently under clinical trials. Previous studies suggested that... 
NQO1 | Beta-lapachone | EPR | Mitochondrial electron transport chain | ROS | Cancer cells | ANION-RADICAL PRODUCTION | OXYGEN SPECIES PRODUCTION | OXIDATIVE STRESS | SUPEROXIDE | B16-F10 MELANOMA | THERAPY | OXIDASE | BIS-N-METHYLACRIDINIUM | LUCIGENIN | SYSTEMS | PHARMACOLOGY & PHARMACY | TOXICOLOGY | Neoplasms - metabolism | Mitochondria - enzymology | Reactive Oxygen Species - metabolism | Humans | Reverse Transcriptase Inhibitors - pharmacology | Neoplasm Proteins - antagonists & inhibitors | Prodrugs - chemistry | Neoplasm Proteins - metabolism | Electron Transport Complex I - metabolism | Prodrugs - metabolism | Reverse Transcriptase Inhibitors - chemistry | Antineoplastic Agents, Phytogenic - antagonists & inhibitors | Oxidation-Reduction - drug effects | Rotenone - pharmacology | Activation, Metabolic - drug effects | Antineoplastic Agents, Phytogenic - metabolism | Electron Transport Complex I - antagonists & inhibitors | Naphthoquinones - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Indolequinones - pharmacology | Neoplasms - enzymology | Naphthoquinones - pharmacology | Mitochondria - metabolism | Mitochondria - drug effects | NAD(P)H Dehydrogenase (Quinone) - antagonists & inhibitors | Neoplasms - drug therapy | Animals | Cell Line, Tumor | NAD(P)H Dehydrogenase (Quinone) - metabolism | Mice | Reverse Transcriptase Inhibitors - metabolism | Antineoplastic Agents, Phytogenic - pharmacology | Naphthoquinones - metabolism | Prodrugs - pharmacology | Antimitotic agents | Oncology, Experimental | Melanoma | Mitochondrial DNA | Research | Antineoplastic agents | Cancer | ELECTRON SPIN RESONANCE | SUPEROXIDE DISMUTASE | HEPATOMAS | CLINICAL TRIALS | CHEMILUMINESCENCE | MITOCHONDRIA | MELANOMAS | BENZOQUINONES | 60 APPLIED LIFE SCIENCES | OXYGEN | CELL KILLING | PHOSPHATES | RADICALS | OXIDES | PEROXIDASES
Journal Article
Blood, ISSN 1528-0020, 2015, Volume 126, Issue 3, pp. 363 - 372
Mcl-1 inhibition by pan-active Bcl-2 inhibitor (–)BI97D6 kills AML cells via induction of mitochondrial apoptosis. Mcl-1 inhibition by (–)BI97D6 overcomes... 
SURVIVAL | ANTI-APOPTOTIC MCL-1 | POTENT | BIM | BAX | ANTITUMOR-ACTIVITY | PROTEINS | CLEAVAGE | HEMATOLOGY | BCL-2 FAMILY | CELL-DEATH | Immunoprecipitation | Apoptosis - drug effects | Neoplastic Stem Cells - drug effects | Humans | Leukemia, Myeloid, Acute - metabolism | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | Stem Cells - cytology | Stem Cells - metabolism | Immunoenzyme Techniques | Proto-Oncogene Proteins c-bcl-2 - metabolism | Flow Cytometry | Biphenyl Compounds - pharmacology | Neoplastic Stem Cells - metabolism | Nitrophenols - pharmacology | Mesenchymal Stem Cells - cytology | Mesenchymal Stem Cells - drug effects | Leukemia, Myeloid, Acute - drug therapy | Neoplastic Stem Cells - pathology | Female | Tumor Cells, Cultured | Mesenchymal Stem Cells - metabolism | Myeloid Cell Leukemia Sequence 1 Protein - antagonists & inhibitors | Leukemia, Myeloid, Acute - pathology | Naphthoquinones - pharmacology | Mice, SCID | Sulfonamides - pharmacology | Piperazines - pharmacology | Blotting, Western | Xenograft Model Antitumor Assays | Gossypol - pharmacology | Animals | Gossypol - analogs & derivatives | Stem Cells - drug effects | Mice, Inbred NOD | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Cell Proliferation - drug effects | Mice | Drug Resistance, Neoplasm - drug effects | Myeloid Neoplasia
Journal Article