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Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 12/2010, Volume 335, Issue 3, pp. 735 - 742
Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) (PL) is a naturally occurring yellow pigment found in the plants of the Plumbaginaceae, Droseraceae,... 
APOPTOSIS | TUMOR-NECROSIS-FACTOR | DEPENDENT KINASE | COX-2 | RAT | INFLAMMATION | MACROPHAGES | TRANSCRIPTION | INVOLVEMENT | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | Inflammation - chemically induced | Tumor Necrosis Factor-alpha - metabolism | Analgesics - pharmacology | Abdominal Pain - prevention & control | Gene Expression - drug effects | Magnesium Sulfate - pharmacology | Male | NF-kappa B - metabolism | I-kappa B Proteins - metabolism | Serotonin - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Inflammation - metabolism | Inflammation - drug therapy | Interleukin-1beta - metabolism | Carrageenan - pharmacology | Pain Threshold - drug effects | Foot - pathology | Phosphorylation - drug effects | Interleukin-6 - metabolism | Bradykinin - pharmacology | Edema - prevention & control | Analgesics - therapeutic use | Dinoprostone - pharmacology | Abdominal Pain - chemically induced | NF-KappaB Inhibitor alpha | Histamine - pharmacology | Magnesium Sulfate - administration & dosage | Naphthoquinones - therapeutic use | Acetic Acid - administration & dosage | Rats | Acetic Acid - pharmacology | Naphthoquinones - pharmacology | Edema - drug therapy | Hot Temperature | Rats, Sprague-Dawley | Mice, Inbred ICR | Edema - metabolism | Animals | Transcription Factor RelA - metabolism | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Cyclooxygenase 2 - metabolism | Inflammation - prevention & control | Mice | Edema - chemically induced | Carrageenan - administration & dosage | Nitric Oxide Synthase Type II - metabolism | Index Medicus
Journal Article
Journal Article
Breast Cancer Research, ISSN 1465-5411, 05/2014, Volume 16, Issue 3, pp. R55 - R55
Journal Article
Journal Article
International Journal of Oncology, ISSN 1019-6439, 3/2015, Volume 46, Issue 3, pp. 963 - 972
Journal Article
Journal Article
Journal of Natural Products, ISSN 0163-3864, 09/2010, Volume 73, Issue 9, pp. 1507 - 1511
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 12/2014, Volume 281, Issue 3, pp. 285 - 293
Beta-lapachone (beta-Lp) derived from the Lapacho tree is a potentially novel anticancer agent currently under clinical trials. Previous studies suggested that... 
NQO1 | Beta-lapachone | EPR | Mitochondrial electron transport chain | ROS | Cancer cells | ANION-RADICAL PRODUCTION | OXYGEN SPECIES PRODUCTION | OXIDATIVE STRESS | SUPEROXIDE | B16-F10 MELANOMA | THERAPY | OXIDASE | BIS-N-METHYLACRIDINIUM | LUCIGENIN | SYSTEMS | PHARMACOLOGY & PHARMACY | TOXICOLOGY | Neoplasms - metabolism | Mitochondria - enzymology | Reactive Oxygen Species - metabolism | Humans | Reverse Transcriptase Inhibitors - pharmacology | Neoplasm Proteins - antagonists & inhibitors | Prodrugs - chemistry | Neoplasm Proteins - metabolism | Electron Transport Complex I - metabolism | Prodrugs - metabolism | Reverse Transcriptase Inhibitors - chemistry | Antineoplastic Agents, Phytogenic - antagonists & inhibitors | Oxidation-Reduction - drug effects | Rotenone - pharmacology | Activation, Metabolic - drug effects | Antineoplastic Agents, Phytogenic - metabolism | Electron Transport Complex I - antagonists & inhibitors | Naphthoquinones - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Indolequinones - pharmacology | Neoplasms - enzymology | Naphthoquinones - pharmacology | Mitochondria - metabolism | Mitochondria - drug effects | NAD(P)H Dehydrogenase (Quinone) - antagonists & inhibitors | Neoplasms - drug therapy | Animals | Cell Line, Tumor | NAD(P)H Dehydrogenase (Quinone) - metabolism | Mice | Reverse Transcriptase Inhibitors - metabolism | Antineoplastic Agents, Phytogenic - pharmacology | Naphthoquinones - metabolism | Prodrugs - pharmacology | Antimitotic agents | Oncology, Experimental | Melanoma | Mitochondrial DNA | Research | Antineoplastic agents | Cancer | Index Medicus | ELECTRON SPIN RESONANCE | SUPEROXIDE DISMUTASE | HEPATOMAS | CLINICAL TRIALS | CHEMILUMINESCENCE | MITOCHONDRIA | MELANOMAS | BENZOQUINONES | 60 APPLIED LIFE SCIENCES | OXYGEN | CELL KILLING | PHOSPHATES | RADICALS | OXIDES | PEROXIDASES
Journal Article
Medicinal Chemistry Research, ISSN 1054-2523, 10/2015, Volume 24, Issue 10, pp. 3599 - 3620
In this paper, we present a brief review of quinoid systems, focusing on their chemical synthesis over the last decade. We address not only major methods of... 
Biochemistry, general | Biomedicine | Synthesis | Natural products | Quinone | Redox | Cytotoxicity | Pharmacology | Pharmacology/Toxicology | Cell Biology | OXIDATION | CHEMISTRY, MEDICINAL | REGIOSPECIFIC SYNTHESIS | EXTENDED P-QUINODIMETHANES | O-QUINONES | SUBSTITUTED ANTHRAQUINONES | NAPHTHOQUINONES | FISCHER CARBENE COMPLEXES | REDUCTION | PHENOLS | DERIVATIVES | Antiviral agents
Journal Article