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Nature, ISSN 0028-0836, 10/2018, Volume 562, Issue 7725, pp. 63 - 68
Narcolepsy is a chronic sleep disorder caused by the loss of neurons that produce hypocretin. The close association with HLA-DQB1*06: 02, evidence for immune... 
AUTOANTIBODIES | PEPTIDES | MEMORY | MULTIDISCIPLINARY SCIENCES | VACCINATION | CATAPLEXY | ABSENCE | DONORS | TYPE-1 | NAIVE | LOCUS | Narcolepsy - blood | Autoantigens - metabolism | CD8-Positive T-Lymphocytes - pathology | Humans | Intracellular Signaling Peptides and Proteins - immunology | Intracellular Signaling Peptides and Proteins - metabolism | CD4-Positive T-Lymphocytes - pathology | Narcolepsy - diagnosis | Case-Control Studies | Orthomyxoviridae - immunology | CD4-Positive T-Lymphocytes - immunology | Antigens, Viral | Autoimmunity - immunology | Calcium-Calmodulin-Dependent Protein Kinases - immunology | Neurons - metabolism | Autoimmune Diseases - pathology | Orexins - metabolism | Cell Separation | Autoimmune Diseases - immunology | Neurons - immunology | Autoimmune Diseases - diagnosis | Cross Reactions | Narcolepsy - immunology | Orexins - immunology | Autoantigens - immunology | Narcolepsy - cerebrospinal fluid | Immunologic Memory | CD8-Positive T-Lymphocytes - immunology | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | Care and treatment | Narcolepsy | Genetic aspects | Diagnosis | Research | T cells | Risk factors | CD8 antigen | Vaccination | Homology | Lymphocytes T | Cerebrospinal fluid | Blood | Sleep disorders | Lymphocytes | Antigens | Antigen presentation | Blood & organ donations | Orexins | Neurons | Medical treatment | Autoantigens | T cell receptors | Epitopes | Gene expression | Patients | Screens | CD4 antigen | Sleep | Influenza | Histocompatibility antigen HLA | Diabetes
Journal Article
Science Translational Medicine, ISSN 1946-6234, 07/2015, Volume 7, Issue 294, pp. 294ra105 - 294ra105
Journal Article
Science Translational Medicine, ISSN 1946-6234, 12/2013, Volume 5, Issue 216, pp. 216ra176 - 216ra176
Narcolepsy, a disorder strongly associated with human leukocyte antigen (HLA)-DQA1*01:02/DQB1*06:02 (DQ0602), is characterized by excessive daytime sleepiness,... 
ANTIBODIES | MEDICINE, RESEARCH & EXPERIMENTAL | SUSCEPTIBILITY | VACCINATION | NEURONS | CATAPLEXY | RISK | ASSOCIATION | ONSET | CHILDREN | CELL BIOLOGY | Influenza A Virus, H1N1 Subtype - immunology | Humans | Middle Aged | Autoimmunity - genetics | Molecular Sequence Data | Epitopes, T-Lymphocyte - genetics | Intracellular Signaling Peptides and Proteins - immunology | Male | HLA-DQ beta-Chains - genetics | Hemagglutinin Glycoproteins, Influenza Virus - immunology | HLA-DQ alpha-Chains - genetics | Narcolepsy - etiology | Case-Control Studies | Hemagglutinin Glycoproteins, Influenza Virus - genetics | CD4-Positive T-Lymphocytes - immunology | Young Adult | Molecular Mimicry - genetics | ADP-ribosyl Cyclase 1 - immunology | Adult | Female | Influenza, Human - virology | Epitopes, T-Lymphocyte - immunology | Membrane Glycoproteins - immunology | Neuropeptides - genetics | Child | Influenza A Virus, H1N1 Subtype - genetics | Intracellular Signaling Peptides and Proteins - genetics | Amino Acid Sequence | Orexins | Lymphocyte Activation | Translational Medical Research | Influenza Vaccines - adverse effects | Molecular Mimicry - immunology | Twins, Monozygotic | Cross Reactions | Narcolepsy - immunology | Sequence Homology, Amino Acid | Narcolepsy - genetics | Influenza Vaccines - immunology | Adolescent | Aged | Neuropeptides - immunology | Interferon-gamma - biosynthesis | Influenza, Human - immunology
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 03/2010, Volume 120, Issue 3, pp. 713 - 719
Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness and attacks of muscle atonia triggered by strong emotions (cataplexy). Narcolepsy... 
MEDICINE, RESEARCH & EXPERIMENTAL | PEPTIDES | NEURONS | UVEITIS | CATAPLEXY | MICE | NORMALIZATION | AUTOANTIBODY | ONSET | HYPOCRETIN OREXIN | Neurons - pathology | Narcolepsy - blood | Autoantigens - metabolism | Autoantibodies - blood | Humans | Sleep Initiation and Maintenance Disorders - pathology | Intracellular Signaling Peptides and Proteins - immunology | Male | Intracellular Signaling Peptides and Proteins - metabolism | Autoantigens - genetics | Autoimmune Diseases - genetics | Time Factors | Female | Neurons - metabolism | Neuropeptides - genetics | Autoimmune Diseases - pathology | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Narcolepsy - pathology | Hypothalamus - immunology | Severity of Illness Index | Orexins | Autoimmune Diseases - immunology | Neurons - immunology | Protein-Serine-Threonine Kinases - genetics | Mice, Transgenic | Neuropeptides - metabolism | Hypothalamus - pathology | Calcium-Calmodulin-Dependent Protein Kinases | Sleep Initiation and Maintenance Disorders - blood | Autoimmune Diseases - blood | Narcolepsy - immunology | Narcolepsy - genetics | Autoantibodies - immunology | Animals | Hypothalamus - metabolism | Sleep Initiation and Maintenance Disorders - immunology | Autoantigens - immunology | Sleep Initiation and Maintenance Disorders - genetics | Protein-Serine-Threonine Kinases - immunology | Mice | Neuropeptides - immunology | Usage | Care and treatment | Narcolepsy | Genetic aspects | Research | Gene expression | Enzyme-linked immunosorbent assay | Apoptosis
Journal Article
Journal Article
Journal of Autoimmunity, ISSN 0896-8411, 2014, Volume 50, pp. 1 - 11
Abstract The vaccine safety surveillance system effectively detected a very rare adverse event, narcolepsy, in subjects receiving AS03-adjuvanted A(H1N1)... 
Allergy and Immunology | Adjuvants | Autoimmune disease | Narcolepsy | Molecular mimicry | Vaccines | H1N1 infection | SYSTEMIC-LUPUS-ERYTHEMATOSUS | BELLS-PALSY | GUILLAIN-BARRE-SYNDROME | ELDERLY-PEOPLE | IMMUNOLOGY | MF59-ADJUVANTED VACCINE | LYME ARTHRITIS | ENCEPHALITIS LETHARGICA | MULTIPLE-SCLEROSIS | DNA VACCINES | SEASONAL INFLUENZA | Autoimmunity | Influenza A Virus, H1N1 Subtype - immunology | alpha-Tocopherol - administration & dosage | Adjuvants, Immunologic - administration & dosage | Polysorbates - chemistry | Humans | Pandemics - prevention & control | Squalene - immunology | Vaccination - adverse effects | Antibodies, Viral - blood | Narcolepsy - physiopathology | Canada - epidemiology | Adjuvants, Immunologic - chemistry | Narcolepsy - chemically induced | Polysorbates - administration & dosage | alpha-Tocopherol - chemistry | Squalene - chemistry | Influenza Vaccines - adverse effects | Europe - epidemiology | Antigens, Viral - chemistry | Influenza A Virus, H1N1 Subtype - pathogenicity | Influenza, Human - epidemiology | Squalene - administration & dosage | Antigens, Viral - immunology | Influenza Vaccines - immunology | Influenza Vaccines - biosynthesis | alpha-Tocopherol - immunology | Influenza, Human - prevention & control | Drug Combinations | Influenza, Human - immunology | Influenza vaccines | Epidemics | Medical colleges | Nervous system diseases | Influenza | Vaccination | Development and progression | Health aspects | Viral antigens
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2014, Volume 9, Issue 12, p. e114361
Background: Narcolepsy results from immune-mediated destruction of hypocretin secreting neurons in hypothalamus, however the triggers and disease mechanisms... 
ANTIBODIES | VACCINATION | CELLS | PROTEIN | MULTIDISCIPLINARY SCIENCES | CHILDREN | HLA-DQ beta-Chains - immunology | Influenza A Virus, H1N1 Subtype - immunology | Orthomyxoviridae Infections - prevention & control | Humans | Antigens, Viral - adverse effects | Child, Preschool | HLA-DQ beta-Chains - genetics | Narcolepsy - etiology | Orthomyxoviridae Infections - genetics | Immunoglobulin G - immunology | Child | Antigens, Viral - analysis | Influenza Vaccines - adverse effects | Influenza Vaccines - analysis | Narcolepsy - immunology | Antigens, Viral - immunology | Narcolepsy - genetics | Animals | Influenza Vaccines - immunology | Influenza, Human - genetics | Adolescent | Alleles | Antibody Formation | Mice, Inbred NOD | Influenza, Human - prevention & control | Orthomyxoviridae Infections - immunology | Influenza, Human - immunology | Pediatrics | Pandemics | Peptides | Immunoglobulin G | Vaccination | Antibodies | Risk | Biochemistry | Vaccines | Hypothalamus | Quantitation | Antibody response | Proteins | Sleep disorders | Immunology | Hemagglutinins | Influenza A | Electrophoresis | Narcolepsy | Teenagers | Children | Antigens | Immunization | Orexins | Gel electrophoresis | Developmental biology | Health risks | Transgenic mice | Mass spectroscopy | Bacteriology | Hypotheses | Hospitals | Infectious diseases | Surveillance | Swine flu | Proteomics | Web sites | Mass spectrometry
Journal Article
New England Journal of Medicine, ISSN 0028-4793, 09/2000, Volume 343, Issue 11, pp. 782 - 786
This article presents a genetic analysis and structural aspects of the histocompatibility complex system in relation to molecular deficiencies, HLA genes'... 
Immunology | Hemochromatosis | Blood platelets | Cell surface antigens | HLA histocompatibility antigens | Causes of | Physiological aspects | Transplantation of organs, tissues, etc | Genetic aspects | Narcolepsy | Autoimmune diseases | Cancer
Journal Article