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1. Full Text T cells in patients with narcolepsy target self-antigens of hypocretin neurons
by Latorre, Daniela and Kallweit, Ulf and Armentani, Eric and Foglierini, Mathilde and Mele, Federico and Cassotta, Antonino and Jovic, Sandra and Jarrossay, David and Mathis, Johannes and Zellini, Francesco and Becher, Burkhard and Lanzavecchia, Antonio and Khatami, Ramin and Manconi, Mauro and Tafti, Mehdi and Bassetti, Claudio L and Sallusto, Federica
Nature (London), ISSN 0028-0836, 10/2018, Volume 562, Issue 7725, pp. 63 - 68
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Narcolepsy - blood | Autoantigens - metabolism | CD8-Positive T-Lymphocytes - pathology | Humans | Intracellular Signaling Peptides and Proteins - immunology | Intracellular Signaling Peptides and Proteins - metabolism | CD4-Positive T-Lymphocytes - pathology | Narcolepsy - diagnosis | Case-Control Studies | Orthomyxoviridae - immunology | CD4-Positive T-Lymphocytes - immunology | Antigens, Viral | Autoimmunity - immunology | Calcium-Calmodulin-Dependent Protein Kinases - immunology | Neurons - metabolism | Autoimmune Diseases - pathology | Orexins - metabolism | Cell Separation | Autoimmune Diseases - immunology | Neurons - immunology | Autoimmune Diseases - diagnosis | Cross Reactions | Narcolepsy - immunology | Orexins - immunology | Autoantigens - immunology | Narcolepsy - cerebrospinal fluid | Immunologic Memory | CD8-Positive T-Lymphocytes - immunology | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | Care and treatment | Narcolepsy | Genetic aspects | Diagnosis | Research | T cells | Risk factors | CD8 antigen | Vaccination | Homology | Lymphocytes T | Cerebrospinal fluid | Blood | Sleep disorders | Lymphocytes | Antigens | Antigen presentation | Blood & organ donations | Orexins | Neurons | Medical treatment | Autoantigens | T cell receptors | Epitopes | Gene expression | Patients | Screens | CD4 antigen | Sleep | Influenza | Histocompatibility antigen HLA | Diabetes | Index Medicus
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2. Full Text Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2
by Ahmed, Syed Sohail and Volkmuth, Wayne and Duca, José and Corti, Lorenzo and Pallaoro, Michele and Pezzicoli, Alfredo and Karle, Anette and Rigat, Fabio and Rappuoli, Rino and Narasimhan, Vas and Julkunen, Ilkka and Vuorela, Arja and Vaarala, Outi and Nohynek, Hanna and Pasini, Franco Laghi and Montomoli, Emanuele and Trombetta, Claudia and Adams, Christopher M and Rothbard, Jonathan and Steinman, Lawrence
Science translational medicine, ISSN 1946-6234, 07/2015, Volume 7, Issue 294, pp. 294ra105 - 294ra105
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Immunoglobulin G - blood | Humans | Vaccination | Molecular Sequence Data | Immunity | Reassortant Viruses - immunology | Mass Spectrometry | Orexin Receptors - immunology | Influenza, Human - virology | Orexin Receptors - chemistry | Seasons | Child | Amino Acid Sequence | Cell Line | Viral Core Proteins - chemistry | Peptides - chemistry | Peptides - immunology | RNA-Binding Proteins - chemistry | RNA-Binding Proteins - immunology | Cross Reactions - immunology | Narcolepsy - immunology | Sequence Alignment | Influenza Vaccines - immunology | Antibodies, Viral - immunology | Viral Core Proteins - immunology | Influenza, Human - immunology | Index Medicus
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3. Full Text CD4+ T cell autoimmunity to hypocretin/orexin and cross-reactivity to A 2009 h1n1 influenza a epitope in narcolepsy
by De La Herrán-Arita, Alberto K and Kornum, Birgitte Rahbek and Mahlios, Josh and Jiang, Wei and Lin, G and Hou, Tieying and Macaubas, Claudia and Einen, Mali and Plazzi, Giuseppe and Crowe, Catherine and Newell, Evan W and Davis, Mark M and Mellins, Elizabeth D and Mignot, Emmanuel
Science translational medicine, ISSN 1946-6234, 12/2013, Volume 5, Issue 216, pp. 216ra176 - 216ra176
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Influenza A Virus, H1N1 Subtype - immunology | Humans | Middle Aged | Autoimmunity - genetics | Molecular Sequence Data | Epitopes, T-Lymphocyte - genetics | Intracellular Signaling Peptides and Proteins - immunology | Male | HLA-DQ beta-Chains - genetics | Hemagglutinin Glycoproteins, Influenza Virus - immunology | HLA-DQ alpha-Chains - genetics | Narcolepsy - etiology | Case-Control Studies | Hemagglutinin Glycoproteins, Influenza Virus - genetics | CD4-Positive T-Lymphocytes - immunology | Young Adult | Molecular Mimicry - genetics | ADP-ribosyl Cyclase 1 - immunology | Adult | Female | Influenza, Human - virology | Epitopes, T-Lymphocyte - immunology | Membrane Glycoproteins - immunology | Neuropeptides - genetics | Child | Influenza A Virus, H1N1 Subtype - genetics | Intracellular Signaling Peptides and Proteins - genetics | Amino Acid Sequence | Orexins | Lymphocyte Activation | Translational Medical Research | Influenza Vaccines - adverse effects | Molecular Mimicry - immunology | Twins, Monozygotic | Cross Reactions | Narcolepsy - immunology | Sequence Homology, Amino Acid | Narcolepsy - genetics | Influenza Vaccines - immunology | Adolescent | Aged | Neuropeptides - immunology | Interferon-gamma - biosynthesis | Influenza, Human - immunology | Index Medicus
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4. Full Text Elevated Tribbles homolog 2-specific antibody levels in narcolepsy patients
by Cvetkovic-Lopes, Vesna and Bayer, Laurence and Dorsaz, Stéphane and Maret, Stéphanie and Pradervand, Sylvain and Dauvilliers, Yves and Lecendreux, Michel and Lammers, Gert-Jan and Donjacour, Claire E. H. M and Du Pasquier, Renaud A and Pfister, Corinne and Petit, Brice and Hor, Hyun and Mühlethaler, Michel and Tafti, Mehdi
The Journal of clinical investigation, ISSN 0021-9738, 03/2010, Volume 120, Issue 3, pp. 713 - 719
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Neurons - pathology | Narcolepsy - blood | Autoantigens - metabolism | Autoantibodies - blood | Humans | Sleep Initiation and Maintenance Disorders - pathology | Intracellular Signaling Peptides and Proteins - immunology | Male | Intracellular Signaling Peptides and Proteins - metabolism | Autoantigens - genetics | Autoimmune Diseases - genetics | Time Factors | Female | Neurons - metabolism | Neuropeptides - genetics | Autoimmune Diseases - pathology | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Narcolepsy - pathology | Hypothalamus - immunology | Severity of Illness Index | Orexins | Autoimmune Diseases - immunology | Neurons - immunology | Protein-Serine-Threonine Kinases - genetics | Mice, Transgenic | Neuropeptides - metabolism | Hypothalamus - pathology | Calcium-Calmodulin-Dependent Protein Kinases | Sleep Initiation and Maintenance Disorders - blood | Autoimmune Diseases - blood | Narcolepsy - immunology | Narcolepsy - genetics | Autoantibodies - immunology | Animals | Hypothalamus - metabolism | Sleep Initiation and Maintenance Disorders - immunology | Autoantigens - immunology | Sleep Initiation and Maintenance Disorders - genetics | Protein-Serine-Threonine Kinases - immunology | Mice | Neuropeptides - immunology | Usage | Care and treatment | Narcolepsy | Genetic aspects | Research | Gene expression | Enzyme-linked immunosorbent assay | Apoptosis | Index Medicus | Abridged Index Medicus
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5. Full Text Narcolepsy as an autoimmune disease: the role of H1N1 infection and vaccination
by Partinen, Markku, Prof and Kornum, Birgitte Rahbek, PhD and Plazzi, Giuseppe, MD and Jennum, Poul, Prof and Julkunen, Ilkka, Prof and Vaarala, Outi, Prof
Lancet neurology, ISSN 1474-4422, 2014, Volume 13, Issue 6, pp. 600 - 613
Neurology | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Influenza A Virus, H1N1 Subtype - immunology | Humans | Influenza A Virus, H1N1 Subtype - pathogenicity | Influenza, Human - epidemiology | Influenza, Human - complications | Vaccination - adverse effects | Narcolepsy - epidemiology | Narcolepsy - immunology | Autoimmune Diseases of the Nervous System - immunology | Autoimmune Diseases of the Nervous System - virology | Narcolepsy - virology | Autoimmune Diseases of the Nervous System - epidemiology | Influenza, Human - immunology | Virus diseases | Histocompatibility antigens | Sleep | Vaccination | HLA histocompatibility antigens | Narcolepsy | T cells | Health aspects | Sleep disorders | Antigens | Disease | Pathogenesis | Swine flu | Lymphocytes | Infections | Autoimmune diseases | Epidemiology | Age | Index Medicus
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6. Full Text Narcolepsy, 2009 A(H1N1) pandemic influenza, and pandemic influenza vaccinations: What is known and unknown about the neurological disorder, the role for autoimmunity, and vaccine adjuvants
by Ahmed, S. Sohail and Schur, Peter H and MacDonald, Noni E and Steinman, Lawrence
Journal of autoimmunity, ISSN 0896-8411, 2014, Volume 50, pp. 1 - 11
Allergy and Immunology | Adjuvants | Autoimmune disease | Narcolepsy | Molecular mimicry | Vaccines | H1N1 infection | Life Sciences & Biomedicine | Immunology | Science & Technology | Fundamental and applied biological sciences. Psychology | Fundamental immunology | Neurology | Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes | Viral diseases of the respiratory system and ent viral diseases | Infectious diseases | Viral diseases | Biological and medical sciences | Medical sciences | Human viral diseases | Nervous system (semeiology, syndromes) | Autoimmunity | Influenza A Virus, H1N1 Subtype - immunology | alpha-Tocopherol - administration & dosage | Adjuvants, Immunologic - administration & dosage | Polysorbates - chemistry | Humans | Pandemics - prevention & control | Squalene - immunology | Vaccination - adverse effects | Antibodies, Viral - blood | Narcolepsy - physiopathology | Canada - epidemiology | Adjuvants, Immunologic - chemistry | Narcolepsy - chemically induced | Polysorbates - administration & dosage | alpha-Tocopherol - chemistry | Squalene - chemistry | Influenza Vaccines - adverse effects | Europe - epidemiology | Antigens, Viral - chemistry | Influenza A Virus, H1N1 Subtype - pathogenicity | Influenza, Human - epidemiology | Squalene - administration & dosage | Antigens, Viral - immunology | Influenza Vaccines - immunology | Influenza Vaccines - biosynthesis | alpha-Tocopherol - immunology | Influenza, Human - prevention & control | Drug Combinations | Influenza, Human - immunology | Influenza vaccines | Epidemics | Medical colleges | Nervous system diseases | Influenza | Vaccination | Development and progression | Health aspects | Viral antigens | Index Medicus
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7. Full Text Immunohistochemical screening for antibodies in recent onset type 1 narcolepsy and after H1N1 vaccination
by van der Heide, Astrid and Hegeman-Kleinn, Ingrid M and Peeters, Els and Lammers, Gert J and Fronczek, Rolf
Journal of neuroimmunology, ISSN 0165-5728, 2015, Volume 283, pp. 58 - 62
Neurology | Allergy and Immunology | Immunohistochemistry | Narcolepsy type 1 | Autoimmune | Hypothalamus | Cataplexy | Neurosciences | Immunology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Influenza A Virus, H1N1 Subtype - immunology | Autoantibodies - blood | Humans | Middle Aged | Vaccination | Nerve Tissue Proteins - analysis | Child, Preschool | Intracellular Signaling Peptides and Proteins - immunology | Mammillary Bodies - chemistry | Young Adult | Child | Hypothalamus - chemistry | Neuropeptides - analysis | Nerve Tissue Proteins - immunology | Orexins | Intracellular Signaling Peptides and Proteins - analysis | Neurons - immunology | Mammillary Bodies - cytology | Narcolepsy - epidemiology | Narcolepsy - immunology | Autoantibodies - immunology | Influenza Vaccines - immunology | Hypothalamus - cytology | Autoantigens - immunology | Adolescent | Age of Onset | Neuropeptides - immunology | Autoimmunity | Narcolepsy | Index Medicus
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