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2014, 1, Asia : local studies/global themes, ISBN 0520276736, Volume 29, xvii, 304
This trailblazing study examines the history of narcotics in Japan to explain the development of global criteria for political legitimacy in nations and... 
Japan Civilization | Drug abuse | Japan Moral conditions | Social aspects | History | Drug traffic | Civilization | Moral conditions | Japan | 1868
Book
European Journal of Neuroscience, ISSN 0953-816X, 04/2017, Volume 45, Issue 7, pp. 922 - 931
Although certain drugs of abuse are known to disrupt brain glucose metabolism (BGluM), the effects of opiates on BGluM are not well characterized. Moreover,... 
brain imaging | brain energy metabolism | opiate addition | drug self‐administration | drug self-administration | 2-DEOXYGLUCOSE | SMALL ANIMAL PET | NALOXONE | NEUROSCIENCES | ADDICTION | DEPENDENCE | POSITRON-EMISSION-TOMOGRAPHY | NUCLEUS | RECEPTORS | WITHDRAWAL | BRAIN | Anesthetics, Inhalation - pharmacology | Fluorodeoxyglucose F18 - pharmacokinetics | Radiopharmaceuticals - pharmacokinetics | Anesthetics, Inhalation - administration & dosage | Isoflurane - pharmacology | Morphine - pharmacology | Substance Withdrawal Syndrome - etiology | Anesthesia, Intravenous - adverse effects | Analgesics, Opioid - pharmacology | Rats | Isoflurane - adverse effects | Male | Anesthetics, Inhalation - adverse effects | Corpus Striatum - metabolism | Rats, Sprague-Dawley | Positron Emission Tomography Computed Tomography | Analgesics, Opioid - adverse effects | Animals | Analgesics, Opioid - administration & dosage | Corpus Striatum - drug effects | Corpus Striatum - diagnostic imaging | Morphine - administration & dosage | Morphine - adverse effects | Glucose metabolism | Brain research | PET imaging | Physiological aspects | Anesthesia | Morphine | Glucose | Dextrose | Cerebellum | Brain | Cortex (olfactory) | Drug abuse | Basal ganglia | Intravenous administration | Mesencephalon | Emission analysis | Stimulation | Opiates | Hypothalamus | Infusion | Computed tomography | Rodents | Neostriatum | Thalamus | Defecation | Jugular vein | Self-administration | Narcotics | Therapeutic applications | Positron emission | Injection | Metabolism | Isoflurane | Ganglia | Emissions control | Positron emission tomography | Hippocampus
Journal Article
2010, Princeton studies in American politics, ISBN 0691141800, xx, 802
The U.S. Food and Drug Administration is the most powerful regulatory agency in the world. How did the FDA become so influential? And how exactly does it wield... 
Pharmaceutical policy | Drugs | United States. Food and Drug Administration | United States | Research | History | Political Science | Health Sciences | Food and Drug Administration
Book
Journal Article
Journal Article
Journal of General Internal Medicine, ISSN 0884-8734, 6/2018, Volume 33, Issue 6, pp. 818 - 824
Improved understanding of temporal trends in short- and long-term opioid prescribing may inform efforts to curb the opioid epidemic.To characterize the... 
prevalence | Internal Medicine | Medicine & Public Health | veteran | opioid | UNITED-STATES | MEDICINE, GENERAL & INTERNAL | PAIN | HEALTH CARE SCIENCES & SERVICES | GUIDELINE | Usage | Prescription writing | Veterans | Opioids | Health care | Epidemics | Trends | Narcotics | Patients | Original Research
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 07/2009, Volume 157, Issue 5, pp. 831 - 843
Background and purpose:  Buprenorphine displays attributes of opioids, but also some features distinct from them. We examined spinal and supraspinal signal... 
mechanism of action | supraspinal | buprenorphine | analgesia (antinociception) | Supraspinal | Analgesia (antinociception) | Buprenorphine | Mechanism of action | MOLECULAR REARRANGEMENTS | OKADAIC-ACID | ANTISENSE OLIGODEOXYNUCLEOTIDES | MU-OPIOID RECEPTOR | INTRINSIC EFFICACY | SERINE/THREONINE PROTEIN PHOSPHATASES | PARTIAL AGONIST | PHARMACOLOGY & PHARMACY | MORPHINE-THEBAINE GROUP | TAIL-FLICK TEST | INDUCED ANTINOCICEPTION | Fentanyl - administration & dosage | Piperazines - administration & dosage | Narcotic Antagonists - administration & dosage | Serotonin Antagonists - administration & dosage | Phosphoprotein Phosphatases - metabolism | Aminoquinolines - administration & dosage | Injections, Intraventricular | Oligonucleotides, Antisense - metabolism | Male | Opioid Peptides - administration & dosage | Pain - chemically induced | Adrenergic alpha-Antagonists - administration & dosage | Pain - metabolism | GTP-Binding Proteins - genetics | Okadaic Acid - administration & dosage | Brain - metabolism | Dose-Response Relationship, Drug | Enzyme Inhibitors - administration & dosage | Benzamides - administration & dosage | Pain Threshold - drug effects | Anesthetics, Local - administration & dosage | Pertussis Toxin - administration & dosage | Receptor, Serotonin, 5-HT1A - metabolism | Disease Models, Animal | Receptors, Opioid - metabolism | Injections, Spinal | Pyridines - administration & dosage | Pain - prevention & control | Phosphoprotein Phosphatases - antagonists & inhibitors | Yohimbine - administration & dosage | Brain - drug effects | Buprenorphine - administration & dosage | Animals | Signal Transduction - drug effects | Analgesics, Opioid - administration & dosage | Acetylcholine | Mice | Naloxone - administration & dosage | Pain Measurement | Morphine - administration & dosage | Receptors, Opioid - drug effects | Serotonin 5-HT1 Receptor Antagonists | GTP-Binding Proteins - metabolism | Index Medicus | Research Papers
Journal Article
Brain, Behavior, and Immunity, ISSN 0889-1591, 2015, Volume 51, pp. 204 - 211
Highlights • Endocannabinoids participate in the fever induced by TNF, IL-1β, IL-6, CRF and ET-1. • Endocannabinoids are not involved in the fever induced by... 
Psychiatry | Allergy and Immunology | Prostaglandins | Cytokines | β-Endorphin | Fever | Endocannabinoids | Anandamide | SYSTEM | ENDOGENOUS CANNABINOIDS | RECEPTOR-SELECTIVE ANTAGONIST | RATS | IMMUNOLOGY | NEUROSCIENCES | beta-Endorphin | ENDOTHELIAL-CELLS | INDEPENDENT FEVER | ANXIETY-LIKE | CANNABINOID 1 RECEPTORS | CB1 RECEPTORS | Narcotic Antagonists - administration & dosage | Rats, Wistar | Body Temperature - drug effects | Male | Fever - chemically induced | Cytokines - physiology | Fever - physiopathology | Receptor, Cannabinoid, CB1 - physiology | Endocannabinoids - physiology | Arachidonic Acids - administration & dosage | Interleukin-6 - physiology | Corticotropin-Releasing Hormone - administration & dosage | Interleukin-6 - administration & dosage | Arachidonic Acids - physiology | Interleukin-1beta - physiology | Piperidines - administration & dosage | beta-Endorphin - cerebrospinal fluid | Endothelin-1 - administration & dosage | Rats | Cytokines - administration & dosage | Polyunsaturated Alkamides - administration & dosage | Prostaglandins - physiology | Pyrazoles - administration & dosage | Animals | Endocannabinoids - administration & dosage | Interleukin-1beta - administration & dosage | Tumor Necrosis Factor-alpha - physiology | Tumor Necrosis Factor-alpha - administration & dosage | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Naloxone - administration & dosage | Prostaglandins - administration & dosage
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 2004, Volume 201, Issue 3, pp. 226 - 294
Experience with dose response and mechanisms of toxicity has shown that multiple mechanisms may exist for a single agent along the continuum of the full... 
Mechanisms of toxicity | Dose response | Formaldehyde | Zinc | Progesterone/hydroxyflutamide | Propylene oxide | Dose-dependent transitions | Peroxisome proliferator-activated receptor | Acetaminophen | Vinylidene chloride | Butadiene, ethylene glycol | Methylene chloride | Vinyl acetate | Vinyl chloride | Manganese | Progesterone/ hydroxyflutamide | ACETAMINOPHEN-INDUCED HEPATOTOXICITY | propylene oxide | ACTIVATED RECEPTOR-GAMMA | dose-dependent transitions | mechanisms of toxicity | vinylidene chloride | manganese | butadiene | INDUCED HEPATIC-NECROSIS | dose response | ethylene glycol | methylene chloride | PHARMACOLOGY & PHARMACY | TOXICOLOGY | peroxisome proliferator-activated receptor | vinyl acetate | zinc | SISTER-CHROMATID EXCHANGES | SPRAGUE-DAWLEY RATS | MANGANESE OXIDE AEROSOL | formaldehyde | CHRONIC INHALATION TOXICITY | PROTEIN CROSS-LINKS | acetaminophen | vinyl chloride | GLUTATHIONE-S-TRANSFERASE | PARA-BENZOQUINONE IMINE | progesterone/hydroxyflutamide | Analgesics, Non-Narcotic - pharmacokinetics | Progesterone - administration & dosage | Humans | Acetaminophen - administration & dosage | Epoxy Compounds - pharmacokinetics | Dichloroethylenes - toxicity | Manganese - pharmacokinetics | Methylene Chloride - administration & dosage | Analgesics, Non-Narcotic - toxicity | Manganese - administration & dosage | Dichloroethylenes - pharmacokinetics | Dichloroethylenes - administration & dosage | Formaldehyde - toxicity | Androgen Antagonists - toxicity | Ethylene Glycol - toxicity | Butadienes - toxicity | Androgen Antagonists - pharmacokinetics | Progesterone - pharmacokinetics | Oxidation-Reduction | Acetaminophen - toxicity | Vinyl Compounds - administration & dosage | Zinc - toxicity | Androgen Antagonists - administration & dosage | Flutamide - administration & dosage | Vinyl Compounds - toxicity | Zinc - administration & dosage | Peroxisome Proliferator-Activated Receptors - physiology | Drug-Related Side Effects and Adverse Reactions - chemically induced | Flutamide - toxicity | Drug-Related Side Effects and Adverse Reactions - metabolism | Vinyl Compounds - pharmacokinetics | Dose-Response Relationship, Drug | Methylene Chloride - toxicity | Zinc - pharmacokinetics | Epoxy Compounds - administration & dosage | Formaldehyde - administration & dosage | Ethylene Glycol - administration & dosage | Formaldehyde - pharmacokinetics | Ethylene Glycol - pharmacokinetics | Butadienes - pharmacokinetics | Flutamide - analogs & derivatives | Analgesics, Non-Narcotic - administration & dosage | Epoxy Compounds - toxicity | Animals | Butadienes - administration & dosage | Progesterone - toxicity | Methylene Chloride - pharmacokinetics | Acetaminophen - pharmacokinetics | Flutamide - pharmacokinetics | Manganese Poisoning - metabolism
Journal Article