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1. Full Text Opioids in Gastroenterology: Treating Adverse Effects and Creating Therapeutic Benefits
by Camilleri, Michael and Lembo, Anthony and Katzka, David A
Clinical Gastroenterology and Hepatology, ISSN 1542-3565, 2017, Volume 15, Issue 9, pp. 1338 - 1349
Abstract The use of opioid medications on both an acute and chronic basis is ubiquitous in the U.S. As opioid receptors densely populate the gastrointestinal... 
Gastroenterology and Hepatology | Narcotic | Opiates | Motility | PROLONGED-RELEASE OXYCODONE | TAPENTADOL EXTENDED-RELEASE | INDUCED CONSTIPATION | CONTROLLED PHASE-III | GASTROINTESTINAL TRANSIT | SUBCUTANEOUS METHYLNALTREXONE | DOUBLE-BLIND | PLACEBO-CONTROLLED TRIAL | GASTROENTEROLOGY & HEPATOLOGY | IRRITABLE-BOWEL-SYNDROME | CHRONIC NONCANCER PAIN | Analgesics, Opioid - adverse effects | United States | Gastrointestinal Diseases - drug therapy | Humans | Analgesics, Opioid - therapeutic use | Gastroenterology - methods | Gastrointestinal Diseases - chemically induced | Complications and side effects | Gastrointestinal system | Opioids | Irritable bowel syndrome | Physiological aspects | Nausea | Epidemiology | Diarrhea
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2. Respiratory adverse effects of opioids for breathlessness: a systematic review and meta-analysis
by Verberkt, Cindy A and van den Beuken-van Everdingen, Marieke H J and Schols, Jos M G A and Datla, Sushma and Dirksen, Carmen D and Johnson, Miriam J and van Kuijk, Sander M J and Wouters, Emiel F M and Janssen, Daisy J A
The European respiratory journal, ISSN 0903-1936, 11/2017, Volume 50, Issue 5, pp. 1701153 - 1701153
Previous studies have shown that opioids can reduce chronic breathlessness in advanced disease. However, physicians remain reluctant to prescribe opioids for... 
CHRONIC HEART-FAILURE | REFRACTORY DYSPNEA | SUSTAINED-RELEASE MORPHINE | CANCER-PATIENTS | TRANSMUCOSAL FENTANYL CITRATE | RESPIRATORY SYSTEM | LOW-DOSE DIAMORPHINE | EXERCISE TOLERANCE | TERMINALLY-ILL PATIENTS | NEBULIZED MORPHINE | PALLIATIVE CARE PATIENTS | Analgesics, Opioid - adverse effects | Humans | Pain Management | Analgesics, Opioid - therapeutic use | Dyspnea - drug therapy | Morphine - adverse effects | Morphine - therapeutic use | Randomized Controlled Trials as Topic | Narcotics | Carbon dioxide | Clinical trials | Data processing | Population studies | Systematic review | Morphine | Studies | Side effects | Pain | Opioids | Oxygen tension | Cancer
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3. Full Text Polymorphisms associated with fentanyl pharmacokinetics, pharmacodynamics and adverse effects
by Saiz‐Rodríguez, Miriam and Ochoa, Dolores and Herrador, Coral and Belmonte, Carmen and Román, Manuel and Alday, Enrique and Koller, Dora and Zubiaur, Pablo and Mejía, Gina and Hernández‐Martínez, María and Abad‐Santos, Francisco
Basic & Clinical Pharmacology & Toxicology, ISSN 1742-7835, 03/2019, Volume 124, Issue 3, pp. 321 - 329
Fentanyl is an agonist of the μ‐opioid receptor commonly used in the treatment of moderate‐severe pain. In order to study whether pharmacogenetics explains... 
ALLELE | CYP3A4-ASTERISK-20 | LIGANDS | MORPHINE | TRANSDERMAL FENTANYL | OPIOIDS | PHARMACOLOGY & PHARMACY | PHARMACOGENETICS | TOXICOLOGY | CYP3A4 | IDENTIFICATION | VARIANT | Fentanyl - adverse effects | Humans | Middle Aged | Analgesics, Opioid - pharmacology | Cytochrome P-450 Enzyme System - metabolism | Fentanyl - pharmacokinetics | Male | Fentanyl - pharmacology | Naltrexone - antagonists & inhibitors | Catechol O-Methyltransferase - genetics | Young Adult | Catechol O-Methyltransferase - metabolism | Analgesics, Opioid - adverse effects | Fentanyl - blood | Adult | Female | ATP Binding Cassette Transporter, Subfamily B - genetics | Pharmacogenetics | Analgesics, Opioid - blood | Receptors, Opioid, mu - metabolism | Gene Frequency | Genotype | Receptors, Adrenergic, beta-1 - metabolism | ATP Binding Cassette Transporter, Subfamily B - metabolism | Polymorphism, Genetic | Cross-Over Studies | Adolescent | Analgesics, Opioid - pharmacokinetics | Cytochrome P-450 Enzyme System - genetics | Receptors, Adrenergic, beta-1 - genetics | Receptors, Opioid, mu - genetics | Complications and side effects | Central nervous system depressants | Cytochrome P-450 | Fentanyl | Genetic aspects | Liquid chromatography | Mass spectrometry | Cytochrome | Methyltransferase | Opioid receptors (type mu) | Catechol O-methyltransferase | Naltrexone | Risk factors | Receptors | Pain | Blood pressure | Cytochromes P450 | Enzymes | Pharmacodynamics | Narcotics | Cytochrome P450 | Mass spectroscopy | Pharmacology | Catechol | Risk analysis | Gene expression | Carriers | Alleles | Adrenergic receptors | Pharmacokinetics | Index Medicus
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4. Full Text Comparative Rates of Mortality and Serious Adverse Effects Among Commonly Prescribed Opioid Analgesics
by Murphy, David L and Lebin, Jacob A and Severtson, Stevan G and Olsen, Heather A and Dasgupta, Nabarun and Dart, Richard C
Drug Safety, ISSN 0114-5916, 8/2018, Volume 41, Issue 8, pp. 787 - 795
The epidemic of prescription opioid overdose and mortality parallels the dispensing rates of prescription opioids, and the availability of increasingly potent... 
Medicine & Public Health | Drug Safety and Pharmacovigilance | Pharmacology/Toxicology | UNITED-STATES | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | CHRONIC PAIN | AMERICAN ASSOCIATION | ABUSE | OVERDOSE | PHARMACOLOGY & PHARMACY | TOXICOLOGY | PRESCRIPTIONS | Epidemics | Drug abuse | Tablets | Narcotics | Abuse | Mortality | Oxycodone | Dispensing | Morphine | Exposure | Drug overdose | Analgesics | Addiction | Tramadol | Opioids | Overdose | Poisoning | Drug stores | Public health | Index Medicus
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5. Full Text Strategies to Manage the Adverse Effects of Oral Morphine: An Evidence-Based Report
by Nathan Cherny and Carla Ripamonti and Jose Pereira and Carol Davis and Marie Fallon and Henry McQuay and Sebastiano Mercadante and Gavril Pasternak and Vittorio Ventafridda and for the Expert Working Group of the European Association of Palliative Care Network and European Assoc Palliative Care Net and Expert Working Group of the European Association of Palliative Care Network and for the Expert Working Group of the European Association of Palliative Care Network
Journal of Clinical Oncology, ISSN 0732-183X, 05/2001, Volume 19, Issue 9, pp. 2542 - 2554
Successful pain management with opioids requires that adequate analgesia be achieved without excessive adverse effects. By these criteria, a substantial... 
CONTROLLED-RELEASE MORPHINE | HEALTH-ORGANIZATION GUIDELINES | ONCOLOGY | BONE METASTASES | ENHANCED BIOAVAILABILITY | TRANSDERMAL FENTANYL | MOR-1 OPIOID RECEPTOR | NAIVE CANCER-PATIENTS | DOUBLE-BLIND | SUBCUTANEOUS MORPHINE | CONTINUOUS-INFUSION | Diagnosis, Differential | Administration, Oral | Cognition Disorders - chemically induced | Humans | Myoclonus - chemically induced | Narcotics - adverse effects | Constipation - chemically induced | Vomiting - chemically induced | Animals | Drug Interactions | Constipation - therapy | Vomiting - therapy | Cognition Disorders - therapy | Morphine - administration & dosage | Myoclonus - therapy | Morphine - adverse effects
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6. Full Text Putative Kappa Opioid Heteromers As Targets for Developing Analgesics Free of Adverse Effects
by Le Naour, Morgan and Lunzer, Mary M and Powers, Michael D and Kalyuzhny, Alexander E and Benneyworth, Michael A and Thomas, Mark J and Portoghese, Philip S
Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2014, Volume 57, Issue 15, pp. 6383 - 6392
It is now generally recognized that upon activation by an agonist, β-arrestin associates with G protein-coupled receptors and acts as a scaffold in creating a... 
CHEMISTRY, MEDICINAL | NARCOTIC ANTAGONISTS | NOR-BINALTORPHIMINE | MORPHINE-TOLERANCE | CONDITIONED PLACE PREFERENCE | NAPHTHOYL-BETA-NALTREXAMINE | PROTEIN-COUPLED RECEPTORS | FUNCTIONAL SELECTIVITY | SALVINORIN-A | 6'-GUANIDINONALTRINDOLE 6'-GNTI | ANTINOCICEPTIVE TOLERANCE | Naltrexone - analogs & derivatives | Receptors, Opioid, delta - metabolism | Analgesics - pharmacology | Calcium - metabolism | Stereoisomerism | Humans | Protein Multimerization | Naltrexone - chemistry | Structure-Activity Relationship | Receptors, Opioid, mu - agonists | Arrestins - metabolism | Naltrexone - pharmacology | HEK293 Cells | Indoles - pharmacology | Analgesics - adverse effects | Substance-Related Disorders - etiology | Receptors, Opioid, mu - metabolism | Receptors, Opioid, kappa - agonists | Drug Tolerance | Receptors, Opioid, kappa - metabolism | Animals | Indoles - adverse effects | Analgesics - chemistry | beta-Arrestins | Avoidance Learning - drug effects | Mice | Naltrexone - adverse effects | Indoles - chemistry | Receptors, Opioid, delta - agonists
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7. Safe Opioid Use: Management of Opioid-Related Adverse Effects and Aberrant Behaviors
by Arthur, Joseph and Hui, David
Hematology/Oncology Clinics of North America, ISSN 0889-8588, 06/2018, Volume 32, Issue 3, pp. 387 - 403
Opioids are highly effective for cancer pain but are associated with multiple adverse effects and risk of addiction. This article provides a synopsis on the... 
Aberrant behavior | Opioid | Tolerance | Nausea | Adverse effects | Sedation | Constipation | Cancer | SUBSTANCE-ABUSE | INDUCED PRURITUS | INDUCED CONSTIPATION | RISK TOOL | ORAL MORPHINE | CANCER-PATIENTS | THERAPY | ONCOLOGY | PART 1 | DRUG-RELATED BEHAVIOR | HEMATOLOGY | CHRONIC NONCANCER PAIN | Analgesics, Opioid - adverse effects | Mental Disorders - chemically induced | Pain - drug therapy | Pain - physiopathology | Humans | Mental Disorders - prevention & control | Analgesics, Opioid - therapeutic use | Narcotics - therapeutic use | Opioid-Related Disorders - prevention & control | Neoplasms - physiopathology | Narcotics - adverse effects | Neoplasms - drug therapy
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8. Full Text Nor-Binaltorphimine Blocks the Adverse Effects of Morphine after Spinal Cord Injury
by Aceves, Miriam and Bancroft, Eric A and Aceves, Alejandro R and Hook, Michelle A
Journal of Neurotrauma, ISSN 0897-7151, 03/2017, Volume 34, Issue 6, pp. 1164 - 1174
Opioids are frequently used for the treatment of pain following spinal cord injury (SCI). Unfortunately, we have shown that morphine administered in the acute... 
Original Articles | SCI | recovery | sensory function | receptors | locomotor function | PREEMPTIVE ANALGESIA | ACTIVATED PROTEIN-KINASE | INTRATHECAL MORPHINE | TRAUMATIC INJURY | P38 MAPK | GLIAL-CELLS | NEUROSCIENCES | CLINICAL NEUROLOGY | NEUROPATHIC PAIN | DYNORPHIN IMMUNOREACTIVITY | NERVE LIGATION | POSTOPERATIVE PAIN | CRITICAL CARE MEDICINE | Naltrexone - analogs & derivatives | Narcotic Antagonists - administration & dosage | Receptors, Opioid, kappa - antagonists & inhibitors | Drug-Related Side Effects and Adverse Reactions - prevention & control | Spinal Cord Injuries - drug therapy | Morphine - pharmacology | Recovery of Function - drug effects | Motor Activity - drug effects | Rats | Male | Rats, Sprague-Dawley | Narcotics - adverse effects | Narcotics - administration & dosage | Naltrexone - pharmacology | Animals | Narcotic Antagonists - pharmacology | Nociception - drug effects | Narcotics - pharmacology | Morphine - administration & dosage | Naltrexone - administration & dosage | Morphine - adverse effects | Disease Models, Animal | Morphine | Care and treatment | Dosage and administration | Spinal cord injuries | Safety and security measures | Drug therapy | Side effects | Narcotics | Rodents | Pain management | Original
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9. Full Text Gene expression profiling of rat livers reveals indicators of potential adverse effects
by Heinloth, Alexandra N and Irwin, Richard D and Boorman, Gary A and Nettesheim, Paul and Fannin, Rickie D and Sieber, Stella O and Snell, Michael L and Tucker, Charles J and Li, Leping and Travlos, Gregory S and Vansant, Gordon and Blackshear, Pamela E and Tennant, Raymond W and Cunningham, Michael L and Paules, Richard S
Toxicological Sciences, ISSN 1096-6080, 07/2004, Volume 80, Issue 1, pp. 193 - 202
This study tested the hypothesis that gene expression profiling can reveal indicators of subtle injury to the liver induced by a low dose of a substance that... 
Mitochondrial toxicity | Acetaminophen | Hepatotoxicity | Toxicogenomics | METALLOTHIONEIN | toxicogenomics | PROTECTION | PHOSPHORYLATION | PROTEIN-KINASE | INJURY | TOXICITY | INDUCTION | ACETAMINOPHEN HEPATOTOXICITY | acetaminophen | GLUTATHIONE | hepatotoxicity | TOXICOLOGY | mitochondrial toxicity | PROTEOMICS | Acetaminophen - adverse effects | Liver - pathology | Administration, Oral | Mitochondria, Liver - metabolism | Liver - metabolism | Rats, Inbred F344 | Acetaminophen - administration & dosage | Rats | Male | Analgesics, Non-Narcotic - administration & dosage | Gene Expression Profiling | Dose-Response Relationship, Drug | Animals | Liver - drug effects | Chemical and Drug Induced Liver Injury - metabolism | Microarray Analysis | Adenosine Triphosphate - metabolism | Analgesics, Non-Narcotic - adverse effects | Mitochondria, Liver - ultrastructure | Toxicity Tests - methods | Chemical and Drug Induced Liver Injury - pathology | Chemical and Drug Induced Liver Injury - etiology
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10. Exposure to crack cocaine causes adverse effects on marine mussels Perna perna
by LA Maranho and MK Fontes and ASS Kamimura and CR Nobre and BB Moreno and FH Pusceddu and FS Cortez and DT Lebre and JR Marques and DMS Abessa and DA Ribeiro and CDS Pereira
Marine Pollution Bulletin, ISSN 0025-326X, 10/2017, Volume 123, Issue 1/2, p. 410
Our study aimed to evaluate crack cocaine effects in different life stages of the marine mussel Perna perna. For this purpose, fertilization rate,... 
Gametes | Drugs | Drug abuse | Toxicity | Ecosystems | DNA damage | Genotoxicity | Mollusks | Coastal ecosystems | Marine molluscs | Deoxyribonucleic acid--DNA | Stability | Narcotics | Fertilization | Stability analysis | Biological assays | Embryos | Contaminants | Mussels | DNA | Biological fertilization | Marine organisms | Cocaine | Freshwater molluscs | Larval development | Acute toxicity
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11. Full Text Characterization of the Adverse Effects Induced by Acetaminophen and Nonsteroidal Anti-Inflammatory Drugs Based on the Analysis of the Japanese Adverse Drug Event Report Database
by Nagai, Junko and Uesawa, Yoshihiro and Shimamura, Ryotaro and Kagaya, Hajime
Clinical Journal of Pain, ISSN 0749-8047, 2017, Volume 33, Issue 8, pp. 667 - 675
Objectives:Acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs) are antipyretic analgesics with established adverse effects (AEs); however, only a... 
nonsteroidal anti-inflammatory drugs | acetaminophen (paracetamol) | adverse effects | Japanese Adverse Drug Event Report (JADER) database | principal component analysis | MYOCARDIAL-INFARCTION | PARACETAMOL | RISK | TOXICITY | CLINICAL NEUROLOGY | GENERAL-POPULATION | SIGNAL-DETECTION | SYSTEMS | ANESTHESIOLOGY | INHIBITORS | HEALTH | Acetaminophen - adverse effects | Databases, Pharmaceutical | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Analgesics, Non-Narcotic - adverse effects | Humans | Japan | Acetaminophen - therapeutic use | Analgesics, Non-Narcotic - therapeutic use | Principal Component Analysis | Original
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12. Reactions weekly
Reactions weekly, ISSN 0114-9954, 1990
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13. Full Text Ephedrine Alkaloids-Free Ephedra Herb Extract, EFE, Has No Adverse Effects Such as Excitation, Insomnia, and Arrhythmias
by Takemoto, Hiroaki and Takahashi, Jun and Hyuga, Sumiko and Odaguchi, Hiroshi and Uchiyama, Nahoko and Maruyama, Takuro and Yamashita, Tadatoshi and Hyuga, Masashi and Oshima, Naohiro and Amakura, Yoshiaki and Hakamatsuka, Takashi and Goda, Yukihiro and Hanawa, Toshihiko and Kobayashi, Yoshinori
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2018, Volume 41, Issue 2, pp. 247 - 253
Ephedrine alkaloids-free Ephedra Herb extract (EFE) has been developed to eliminate the adverse effects caused by ephedrine alkaloid-induced sympathetic... 
adverse effect | ephedrine alkaloid-free | Ephedra Herb | ephedrine alkaloid | Ephedrine alkaloid-free | Ephedrine alkaloid | Adverse effect | SYSTEM | DRUG INTERACTIONS | SLEEP | ADENOSINE | RATS | RECEPTOR | MECHANISMS | INDUCED ATRIAL-FIBRILLATION | NARDOSTACHYS-CHINENSIS | PHARMACOLOGY & PHARMACY | MICE | Plant Extracts - chemistry | Arrhythmias, Cardiac - chemically induced | Food Contamination | Caffeine - poisoning | Pentobarbital - pharmacology | Male | Anxiety - prevention & control | Dietary Supplements - analysis | Ephedrine - administration & dosage | Sleep Initiation and Maintenance Disorders - chemically induced | Sleep Initiation and Maintenance Disorders - prevention & control | Behavior, Animal | Plant Extracts - administration & dosage | Analgesics, Non-Narcotic - adverse effects | Alkaloids - analysis | Animals, Outbred Strains | Plant Stems - chemistry | Dietary Supplements - adverse effects | Ephedra - chemistry | Ephedrine - adverse effects | Arrhythmias, Cardiac - prevention & control | Alkaloids - toxicity | Sleep Initiation and Maintenance Disorders - etiology | Anxiety - blood | Japan | Analgesics, Non-Narcotic - administration & dosage | Arrhythmias, Cardiac - etiology | Sleep Initiation and Maintenance Disorders - blood | Ephedrine - chemistry | Animals | Central Nervous System Stimulants - poisoning | Potassium - blood | Anxiety - chemically induced | Arrhythmias, Cardiac - blood | Hypnotics and Sedatives - pharmacology | Mice | Analgesics, Non-Narcotic - chemistry | Anxiety - etiology | Plant Extracts - adverse effects | Heart | Cardiac arrhythmia | P waves | Ephedrine | Electrophysiology | Metastases | Alkaloids | Sleep disorders | Receptors | Fibrillation | Field tests | Electrocardiography | Hypokalemia | Excitation | Locomotor activity | Open-field behavior | Herbs | Epinephrine | Side effects | Sleep | Insomnia | Pentobarbital | Influenza | Bans
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14. Full Text Adverse effects induced by ecgonine methyl ester to the zebra mussel: A comparison with the benzoylecgonine
by Parolini, Marco and Binelli, Andrea
Environmental Pollution, ISSN 0269-7491, 11/2013, Volume 182, pp. 371 - 378
Cocaine and its metabolites are the prevalent psychotropic substances in aquatic environment. However, to date the knowledge on their adverse effects to... 
Ecgonine methyl ester | Biomarkers | Illicit drugs | Dreissena polymorpha | Cocaine metabolites | ANTIOXIDANT RESPONSES | LYSOSOMAL MEMBRANE DAMAGE | URBAN WASTE-WATER | ENVIRONMENTAL RISK-ASSESSMENT | MYTILUS-GALLOPROVINCIALIS | EXPERT-SYSTEM | ENVIRONMENTAL SCIENCES | MARINE MUSSELS | INDUCED STRESS SYNDROME | Biomarkers - metabolism | Glutathione Peroxidase - metabolism | Cocaine - metabolism | Glutathione Transferase - metabolism | Dreissena - drug effects | Cocaine - analogs & derivatives | Catalase - metabolism | Animals | Dreissena - physiology | Cocaine - toxicity | DNA Fragmentation | Lipid Peroxidation - drug effects | Superoxide Dismutase - metabolism | Enzymes | Complications and side effects | Cocaine | Metabolites | Analysis | Index Medicus | Narcotics | Mussels | Toxicity | Biocompatibility | Esters
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