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Nature Cell Biology, ISSN 1465-7392, 09/2010, Volume 12, Issue 9, pp. 863 - 875
Accumulation of unwanted/misfolded proteins in aggregates has been observed in airways of patients with cystic fibrosis (CF), a life-threatening genetic... 
APOPTOSIS | UNFOLDED PROTEIN RESPONSE | BECLIN 1 | DOWN-REGULATION | ENDOPLASMIC-RETICULUM | MICE | GENE-TRANSFER | TISSUE TRANSGLUTAMINASE | NEURODEGENERATIVE DISEASES | CELL-DEATH | CELL BIOLOGY | Reactive Oxygen Species - metabolism | Respiratory Mucosa - drug effects | Sequestosome-1 Protein | Humans | Transglutaminases - genetics | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Autophagy - drug effects | Young Adult | Cystamine - therapeutic use | Inflammation - metabolism | Autophagy - genetics | Nasal Polyps - metabolism | Mice, Inbred CFTR | Respiratory Mucosa - cytology | Cystic Fibrosis - metabolism | Membrane Proteins - genetics | Mice, Transgenic | Protein Transport - genetics | Apoptosis Regulatory Proteins - metabolism | Reactive Oxygen Species - antagonists & inhibitors | Models, Biological | Cystic Fibrosis - genetics | Transglutaminases - metabolism | Adolescent | Cystic Fibrosis Transmembrane Conductance Regulator - genetics | Mice | GTP-Binding Proteins | Cystic Fibrosis - drug therapy | Protein Binding - physiology | Microtubule-Associated Proteins - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Salicylates - pharmacology | Epithelial Sodium Channels - genetics | Apoptosis Regulatory Proteins - genetics | Adult | Cystamine - pharmacology | Membrane Proteins - metabolism | Acetylcysteine - therapeutic use | Beclin-1 | Cystic Fibrosis Transmembrane Conductance Regulator - antagonists & inhibitors | Cell Line | Small Ubiquitin-Related Modifier Proteins - metabolism | Heat-Shock Proteins - metabolism | Cystic Fibrosis Transmembrane Conductance Regulator - metabolism | Antioxidants - pharmacology | Mice, Inbred Strains | Nasal Polyps - drug therapy | Antioxidants - therapeutic use | Animals | Acetylcysteine - pharmacology | Adaptor Proteins, Signal Transducing - genetics | Respiratory Mucosa - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Organometallic Compounds - pharmacology | Complications and side effects | Active oxygen | Gene mutations | Lung diseases | Physiological aspects | Cystic fibrosis | Genetic aspects | Research | Health aspects | Risk factors | Index Medicus
Journal Article
European Journal of Pharmaceutical Sciences, ISSN 0928-0987, 01/2013, Volume 48, Issue 1-2, pp. 195 - 201
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2016, Volume 11, Issue 2, pp. e0147778 - e0147778
Background Recently, academic studies suggest that global growth of airway allergic disease has a close association with dietary changes including reduced... 
RHINITIS | TH2 RESPONSES | HYGIENE HYPOTHESIS | DISEASES | HEALTH-BENEFITS | MULTIDISCIPLINARY SCIENCES | PULMONARY INFLAMMATION | ASTHMA | MECHANISMS | UPDATE | GUT MICROBIOTA | Intestines - drug effects | Lactobacillus - growth & development | Eosinophils - drug effects | Humans | Immunoglobulin E - biosynthesis | Goblet Cells - drug effects | Cellulose - administration & dosage | Bifidobacterium - growth & development | Eosinophils - immunology | Intestines - immunology | Goblet Cells - immunology | Feces - microbiology | Dietary Fiber - therapeutic use | Lactobacillus - drug effects | Female | Th1-Th2 Balance - drug effects | Nasal Mucosa - drug effects | Disease Models, Animal | Ovalbumin | Respiratory Hypersensitivity - chemically induced | Bacteroidetes - drug effects | Inflammation | Respiratory Hypersensitivity - microbiology | Respiratory Hypersensitivity - immunology | Proteobacteria - drug effects | Pectins - administration & dosage | Bifidobacterium - drug effects | Animals | Gastrointestinal Microbiome - drug effects | Intestines - microbiology | Nasal Mucosa - immunology | Lung - drug effects | RNA, Ribosomal, 16S - genetics | Bacteroidetes - growth & development | Mice | Mice, Inbred BALB C | Proteobacteria - growth & development | Gastrointestinal Microbiome - immunology | Lung - immunology | Respiratory Hypersensitivity - diet therapy | Control methods | Laboratories | Mucosa | Body weight | Lung | Cellulose | Immunoglobulin E | Otolaryngology | Inflammatory response | Microflora | Lymphocytes T | Immunity | Respiratory tract | Sneezing | E coli | Intestine | Surgery | Bacteria | Respiratory tract diseases | Qualitative analysis | Supplementation | Intestinal microflora | Enzyme-linked immunosorbent assay | Deoxyribonucleic acid--DNA | Food allergies | Cytokines | Rubbing | Hypersensitivity | Dietary supplements | Pectin | Dietary intake | Prebiotics | Asthma | Disease prevention | Metaplasia | Probiotics | Otology | Diet | γ-Interferon | Interferon | Infiltration | Dietary fiber | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Regulatory Toxicology and Pharmacology, ISSN 0273-2300, 11/2016, Volume 81, pp. S123 - S138
Modified risk tobacco products (MRTPs) are being developed with the aim of reducing smoking-related health risks. The Tobacco Heating System 2.2 (THS2.2) is a... 
Lipidomics | Subchronic inhalation toxicity | Transcriptomics | Systems toxicology | Modified risk tobacco product | Proteomics | NASAL-MUCOSA | MEDICINE, LEGAL | TISSUE-REPAIR | NONDISEASED PULMONARY | ENDOPLASMIC-RETICULUM STRESS | NETWORK MODEL | EPITHELIAL DIFFERENTIATION | UNFOLDED-PROTEIN-RESPONSE | INHALATION TOXICOLOGY | RAT RESPIRATORY-TRACT | PHARMACOLOGY & PHARMACY | TOXICOLOGY | CYTOKERATIN EXPRESSION PATTERNS | Smoking - adverse effects | Humans | Pneumonia - pathology | Pneumonia - prevention & control | Male | Tobacco Products - analysis | Gene Expression Profiling | Nasal Mucosa - pathology | Tobacco Products - toxicity | Tobacco Industry | Equipment Design | Systems Biology | Dose-Response Relationship, Drug | Time Factors | Pneumonia - chemically induced | Toxicogenetics | Inhalation Exposure - adverse effects | Smoke - analysis | Female | Toxicity Tests - methods | Lung - metabolism | Nasal Mucosa - metabolism | Menthol - toxicity | Nasal Mucosa - drug effects | Pneumonia - genetics | Lung - pathology | Risk Assessment | Smoke - adverse effects | Consumer Product Safety | Electronic Nicotine Delivery Systems - adverse effects | Smoking - genetics | Transcriptome - drug effects | Genetic Markers | Hot Temperature | Rats, Sprague-Dawley | Gene Expression Regulation - drug effects | Animals | Harm Reduction | Lung - drug effects | Aerosols | Menthol - analysis | Comparative analysis | Smoking | Inflammation | Index Medicus
Journal Article
Journal Article