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Journal of Clinical Investigation, ISSN 0021-9738, 12/2009, Volume 119, Issue 12, pp. 3626 - 3636
The polycomb group protein B lymphoma Mo-MLV insertion region 1 homolog (Bmi-1) is dysregulated in various cancers, and its upregulation strongly correlates... 
MEDICINE, RESEARCH & EXPERIMENTAL | BREAST-CANCER CELLS | DEVELOPMENTAL REGULATORS | CELLULAR MEMORY | E-CADHERIN EXPRESSION | HEMATOPOIETIC STEM-CELLS | PROSTATE-CANCER | MYC TRANSGENIC MICE | SELF-RENEWAL | NF-KAPPA-B | TRANSCRIPTION FACTOR | Nasopharyngeal Neoplasms - genetics | Neoplasm Transplantation | Nasopharyngeal Neoplasms - metabolism | Epithelial Cells - metabolism | Cadherins - metabolism | Humans | Glycogen Synthase Kinase 3 beta | Transplantation, Heterologous | Phosphatidylinositol 3-Kinases - metabolism | Mesoderm - cytology | Repressor Proteins - antagonists & inhibitors | Nasopharyngeal Neoplasms - pathology | Cadherins - genetics | Epithelial Cells - cytology | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Nasopharyngeal Neoplasms - etiology | Snail Family Transcription Factors | Nasopharynx - metabolism | Repressor Proteins - metabolism | Proto-Oncogene Proteins - metabolism | PTEN Phosphohydrolase - genetics | Proto-Oncogene Proteins - antagonists & inhibitors | Signal Transduction | Neoplasm Invasiveness | Down-Regulation | Gene Silencing | PTEN Phosphohydrolase - metabolism | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Glycogen Synthase Kinase 3 - metabolism | Transcription Factors - metabolism | Animals | Polycomb Repressive Complex 1 | Mice, Nude | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Mesoderm - metabolism | Mice | Nasopharynx - cytology | Chromatin | Care and treatment | Lymphomas | Research | Analysis | Cancer | Index Medicus | Abridged Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 04/2013, Volume 73, Issue 7, pp. 2322 - 2332
Tumor-initiating cells (TIC), also known as cancer stem cells, are regarded widely as a specific subpopulation of cells needed for cancer initiation and... 
SURVIVAL | NASOPHARYNGEAL CARCINOMA | STEM-CELLS | SUPPRESSOR GENE | ANGIOGENESIS | ONCOLOGY | GROWTH | SELF-RENEWAL | ETS-1 | IDENTIFICATION | EXPRESSION | Liver Neoplasms, Experimental - secondary | RNA, Small Interfering - genetics | Cell Proliferation | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Humans | Lung Neoplasms - metabolism | Middle Aged | Male | Gene Expression Profiling | Immunoenzyme Techniques | Esophageal Neoplasms - pathology | Liver Neoplasms, Experimental - metabolism | Flow Cytometry | Lung Neoplasms - secondary | Neoplastic Stem Cells - metabolism | Esophageal Neoplasms - metabolism | Thy-1 Antigens - genetics | Epithelial-Mesenchymal Transition | Biomarkers, Tumor - metabolism | Neoplastic Stem Cells - pathology | Female | Cell Differentiation | Liver Neoplasms, Experimental - genetics | Real-Time Polymerase Chain Reaction | Thy-1 Antigens - chemistry | Lung Neoplasms - genetics | Signal Transduction | RNA, Messenger - genetics | Lymphatic Metastasis | Mice, SCID | Reverse Transcriptase Polymerase Chain Reaction | Cell Adhesion | Blotting, Western | Disease Progression | Thy-1 Antigens - metabolism | Animals | Esophageal Neoplasms - genetics | Carcinoma, Squamous Cell - secondary | Mice, Inbred NOD | Biomarkers, Tumor - genetics | Mice | Neoplasm Staging | Apoptosis | Cell Movement | Index Medicus
Journal Article
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2012, Volume 82, Issue 1, pp. 299 - 307
To correlate proton magnetic resonance spectroscopy ( H-MRS), dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), and F-labeled fluorodeoxyglucose... 
Proton magnetic resonance spectroscopy | Dynamic contrast-enhanced MRI | Head and neck squamous cell carcinoma | Short-term treatment response | [ 18F]FDG-PET | F]FDG-PET | Choline - metabolism | Fluorodeoxyglucose F18 - pharmacokinetics | Nasopharyngeal Neoplasms - metabolism | Prospective Studies | Carcinoma, Squamous Cell - metabolism | Humans | Middle Aged | Magnetic Resonance Imaging - methods | Male | Antineoplastic Agents - therapeutic use | Head and Neck Neoplasms - metabolism | Bevacizumab | Feasibility Studies | Nasopharyngeal Neoplasms - pathology | Tonsillar Neoplasms - metabolism | Diagnostic Imaging - methods | Fluorouracil - therapeutic use | Extracellular Space - metabolism | Statistics, Nonparametric | Adult | Female | Tonsillar Neoplasms - therapy | Tongue Neoplasms - metabolism | Tonsillar Neoplasms - pathology | Chemoradiotherapy - methods | Antibodies, Monoclonal, Humanized - therapeutic use | Magnetic Resonance Spectroscopy - methods | Radiopharmaceuticals - pharmacokinetics | Tongue Neoplasms - therapy | Nasopharyngeal Neoplasms - therapy | Head and Neck Neoplasms - therapy | Carcinoma, Squamous Cell - therapy | Lymphatic Metastasis | Positron-Emission Tomography - methods | Tongue Neoplasms - pathology | Head and Neck Neoplasms - pathology | Regression Analysis | Contrast Media | Cisplatin - therapeutic use | Glucose - metabolism | Glycolysis | Carcinoma, Squamous Cell - secondary | Aged | Gadolinium DTPA | Index Medicus
Journal Article
Oncogene, ISSN 0950-9232, 04/2015, Volume 34, Issue 17, pp. 2156 - 2166
The epithelial-mesenchymal transition (EMT) is crucial to cancer progression and metastasis. Although multiple cellular miRNAs have been identified to regulate... 
PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | E-CADHERIN | CANCER STEM-CELLS | ENCODED MICRORNAS | CELL BIOLOGY | EPITHELIAL-MESENCHYMAL TRANSITION | LUNG-CANCER | INVASION | ONCOLOGY | TARGETING PTEN | GENETICS & HEREDITY | EXPRESSION | EPSTEIN-BARR-VIRUS | Nasopharyngeal Neoplasms - genetics | Nasopharyngeal Neoplasms - metabolism | Carcinoma | Herpesvirus 4, Human - genetics | Humans | Nasopharyngeal Neoplasms - virology | Glycogen Synthase Kinase 3 beta | Phosphatidylinositol 3-Kinases - metabolism | RNA, Neoplasm - metabolism | Proto-Oncogene Proteins c-akt - genetics | Nasopharyngeal Neoplasms - pathology | Neoplasm Metastasis | Cell Nucleus - metabolism | RNA, Viral - genetics | Cell Nucleus - pathology | Epithelial-Mesenchymal Transition | Epstein-Barr Virus Infections - genetics | Female | RNA, Viral - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Cell Line | PTEN Phosphohydrolase - genetics | Nasopharyngeal Carcinoma | Neoplasm Invasiveness | PTEN Phosphohydrolase - biosynthesis | Signal Transduction - genetics | Glycogen Synthase Kinase 3 - metabolism | Epstein-Barr Virus Infections - pathology | Phosphatidylinositol 3-Kinases - genetics | Cell Nucleus - genetics | Glycogen Synthase Kinase 3 - genetics | RNA, Neoplasm - genetics | Herpesvirus 4, Human - metabolism | Epstein-Barr Virus Infections - metabolism | MicroRNA | Biological products | Innovations | Development and progression | Epstein-Barr virus | Genetic aspects | Nasopharyngeal cancer | Gene expression | Health aspects | Cellular biology | Metastasis | Cancer | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 04/2016, Volume 7, Issue 1, pp. 11309 - 11309
The biological role of miR-3188 has not yet been reported in the context of cancer. In this study, we observe that miR-3188 not only reduces cell-cycle... 
EPITHELIAL-MESENCHYMAL TRANSITION | CANCER-CELLS | BREAST-CANCER | FORKHEAD TRANSCRIPTION FACTOR | SIGNALING PATHWAY | MULTIDISCIPLINARY SCIENCES | SQUAMOUS-CELL CARCINOMA | C-MYC | TUMOR-SUPPRESSOR | CISPLATIN RESISTANCE | PROMOTES | Nasopharyngeal Neoplasms - genetics | Neoplasm Transplantation | Nasopharyngeal Neoplasms - metabolism | Carcinoma | Prognosis | TOR Serine-Threonine Kinases - metabolism | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | JNK Mitogen-Activated Protein Kinases - metabolism | Male | MicroRNAs - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Proto-Oncogene Proteins c-akt - genetics | Nasopharyngeal Neoplasms - pathology | TOR Serine-Threonine Kinases - genetics | Cell Transformation, Neoplastic - genetics | Forkhead Transcription Factors - metabolism | Aged, 80 and over | Adult | Female | JNK Mitogen-Activated Protein Kinases - genetics | Proto-Oncogene Proteins c-akt - metabolism | Nasopharyngeal Neoplasms - diagnosis | Nasopharyngeal Carcinoma | Signal Transduction | Forkhead Transcription Factors - genetics | Cell Transformation, Neoplastic - metabolism | Phosphatidylinositol 3-Kinases - genetics | Drug Resistance, Neoplasm - genetics | Feedback, Physiological | Animals | Survival Analysis | Cell Line, Tumor | Aged | Forkhead Box Protein O1 | Mice | MicroRNAs - genetics | Cell Transformation, Neoplastic - pathology | Neoplasm Staging | Index Medicus
Journal Article
The Journal of Pathology, ISSN 0022-3417, 06/2016, Volume 239, Issue 2, pp. 186 - 196
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 10/2017, Volume 118, Issue 10, pp. 3349 - 3358
Our findings will shed light on the role and mechanism of XIST/miR‐133a/EGFR in regulating PC cells proliferation. XIST may serve as a potential therapeutic... 
PROLIFERATION | XIST | miR‐133a | EGFR | PANCREATIC CANCER (PC) | miR-133a | BLADDER-CANCER | MIRNA-MESSENGER-RNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | EPITHELIAL-MESENCHYMAL TRANSITION | CELL LUNG-CANCER | NASOPHARYNGEAL CARCINOMA | LONG NONCODING RNA | GASTRIC-CANCER | TUMOR-SUPPRESSOR | EXERTS ONCOGENIC FUNCTIONS | KIDNEY CANCER | Receptor, Epidermal Growth Factor - genetics | Up-Regulation | Receptor, Epidermal Growth Factor - biosynthesis | Cell Proliferation | Pancreatic Neoplasms - metabolism | Neoplasm Proteins - biosynthesis | Humans | Pancreatic Neoplasms - pathology | Gene Expression Regulation, Neoplastic | Male | MicroRNAs - metabolism | Pancreatic Neoplasms - genetics | RNA, Long Noncoding - genetics | RNA, Neoplasm - metabolism | Cell Line, Tumor | RNA, Neoplasm - genetics | Female | MicroRNAs - genetics | Neoplasm Proteins - genetics | RNA, Long Noncoding - metabolism | Development and progression | RNA | Web sites | Pancreatic cancer | Cell proliferation | Biotechnology | Cell survival | Transcription | Epidermal growth factor receptors | MiRNA | Tumor cell lines | Tissues | Biological activity | Lymph nodes | Cell growth | Reporter gene | Ribonucleic acids | 3' Untranslated regions | Medical prognosis | Pheochromocytoma cells | Inhibition | Non-coding RNA | Tumors | Cancer | Lymph | Index Medicus
Journal Article
British Journal of Cancer, ISSN 0007-0920, 01/2018, Volume 118, Issue 2, pp. 233 - 247
Background: Bactericidal/Permeability-increasing-fold-containing family B member 1 (BPIFB1, previously termed LPLUNC1) is highly expressed in the nasopharynx,... 
CELLS | nasopharyngeal carcinoma | PROTEIN | VIRUS | VITRONECTIN | EPITHELIAL-MESENCHYMAL TRANSITION | VTN | BPIFB1 | VIMENTIN | ONCOLOGY | metastasis | INTEGRINS | POOR-PROGNOSIS | NASAL EPITHELIUM | LPLUNC1 | VIM | EXPRESSION | Nasopharyngeal Neoplasms - metabolism | Autoantigens - metabolism | Autoantigens - biosynthesis | Vimentin - metabolism | Humans | Lung Neoplasms - metabolism | Male | Vitronectin - antagonists & inhibitors | Cell Movement - physiology | MAP Kinase Signaling System | Nasopharyngeal Neoplasms - pathology | Lung Neoplasms - secondary | src-Family Kinases - metabolism | Focal Adhesion Kinase 1 - metabolism | Vimentin - biosynthesis | Neoplasm Invasiveness | Nasopharyngeal Carcinoma - metabolism | Vitronectin - metabolism | Animals | Proteins - metabolism | Mice, Nude | Nasopharyngeal Carcinoma - pathology | Cell Line, Tumor | Mice | Vitronectin - biosynthesis | Vimentin - antagonists & inhibitors | Vimentin | Immunohistochemistry | Immunoprecipitation | Mesenchyme | Lung | Vitronectin | Nasopharynx | Metastasis | Western blotting | Metastases | Cell adhesion & migration | Proteins | Nasopharyngeal carcinoma | Signal transduction | Inhibition | Extracellular signal-regulated kinase | Mass spectroscopy | Permeability | Signaling | Molecular modelling | In vivo methods and tests | Focal adhesion kinase | Immunofluorescence | Mass spectrometry | Cell migration | Index Medicus | Molecular Diagnostics
Journal Article
Cancer Science, ISSN 1347-9032, 12/2013, Volume 104, Issue 12, pp. 1675 - 1682
Journal Article
Molecular Therapy, ISSN 1525-0016, 01/2017, Volume 25, Issue 1, pp. 249 - 258
The adoptive transfer of T cells redirected to tumor-associated antigens via transgenic expression of chimeric antigen receptors (CARs) has produced tumor... 
pancreatic cancer | IL-7R | T cell therapy | PSCA | CAR | inverted cytokine receptor | IL-4 | inhibitory cytokines | ICR | chimeric antigen receptor | tumor microenvironment | IL-4R | TARGET | MEDICINE, RESEARCH & EXPERIMENTAL | ADENOCARCINOMA | ANTITUMOR-ACTIVITY | TRIAL | NASOPHARYNGEAL CARCINOMA | IMMUNOTHERAPY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PROSTATE-CANCER | GROWTH | GENETICS & HEREDITY | LEUKEMIA | LYMPHOCYTES | Pancreatic Neoplasms - metabolism | Humans | Recombinant Fusion Proteins - metabolism | Lymphocyte Subsets - immunology | Lymphocyte Subsets - metabolism | Interleukin-4 - pharmacology | Lymphocyte Activation - immunology | Disease Models, Animal | Immunotherapy, Adoptive - adverse effects | Antigens, Neoplasm - genetics | Gene Expression | Immunotherapy, Adoptive - methods | Cytokines - metabolism | Receptors, Antigen, T-Cell - metabolism | Antigens, Neoplasm - immunology | Lymphocyte Subsets - drug effects | Interleukin-4 - metabolism | Pancreatic Neoplasms - pathology | Tumor Microenvironment - immunology | Animals | Pancreatic Neoplasms - immunology | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | Cell Proliferation - drug effects | Mice | Receptors, Antigen, T-Cell - genetics | Cytotoxicity, Immunologic | Pancreatic Neoplasms - therapy | Cell proliferation | Medical research | Flow cytometry | Antigens | Cytokines | Lymphocytes T | Cancer therapies | Adoptive transfer | Interleukin 7 | Cell growth | Interleukin 4 | Lymphocytes | Pancreatic cancer | Antigen (tumor-associated) | Lysis | Stem cells | Antitumor activity | Prostate | Tumors | Index Medicus | Original
Journal Article
Cancer, ISSN 0008-543X, 05/2017, Volume 123, Issue 10, pp. 1778 - 1790
Human papillomavirus‐associated head and neck cancer tends to respond better to treatment compared with tobacco‐associated tumors; however, patients suffer... 
human papillomavirus (HPV) | tumor necrosis factor receptor‐associated factor 3 (TRAF3) | prognosis | nuclear factor κB (NF‐κB) | head and neck squamous cell carcinoma | nuclear factor κB (NF-κB) | tumor necrosis factor receptor-associated factor 3 (TRAF3) | nuclear factor B (NF-B) | MULTIPLE-MYELOMA | IMMUNE-RESPONSE | VIRAL INTEGRATION | CERVICAL-CANCER | ANTIVIRAL RESPONSE | NASOPHARYNGEAL CARCINOMA | ONCOLOGY | OROPHARYNGEAL CANCER | DNA-REPAIR | NF-KAPPA-B | INNATE IMMUNITY | Oropharyngeal Neoplasms - genetics | Papillomavirus Infections - complications | Head and Neck Neoplasms - virology | Prognosis | Deubiquitinating Enzyme CYLD | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - virology | Humans | NF-kappa B - metabolism | Oropharyngeal Neoplasms - virology | Head and Neck Neoplasms - metabolism | Oropharyngeal Neoplasms - complications | Papillomavirus Infections - genetics | Squamous Cell Carcinoma of Head and Neck | Papillomavirus Infections - metabolism | TNF Receptor-Associated Factor 3 - genetics | Carcinoma, Squamous Cell - complications | Tumor Suppressor Proteins - genetics | Oropharyngeal Neoplasms - metabolism | Head and Neck Neoplasms - complications | Head and Neck Neoplasms - genetics | Papillomaviridae | Databases, Factual | Complications and side effects | Chemotherapy | Usage | Head and neck cancer | Diagnosis | Radiotherapy | Papillomavirus infections | Health aspects | Risk factors | Smoking | Cancer | Epidemics | Correlation | Genes | Radiation | Medical services | Clinical trials | Genomes | Activation | Cancer therapies | Carcinogenesis | Defects | Incidence | Metastases | Carcinogens | Human papillomavirus | Etiology | Transcription activation | Tumorigenesis | Bioindicators | Neck | Medical research | Integration | Head | Squamous cell carcinoma | Data processing | Oropharynx | Radiation therapy | Patients | Survival | Morbidity | Radiation dosage | Side effects | Tobacco | Lysine | Medical prognosis | Biomarkers | Head & neck cancer | Mutation | Cervical cancer | Tumors | Index Medicus | Abridged Index Medicus | Original
Journal Article