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1. Full Text Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancer
by Conlon, Kevin C and Lugli, Enrico and Welles, Hugh C and Rosenberg, Steven A and Fojo, Antonio Tito and Morris, John C and Fleisher, Thomas A and Dubois, Sigrid P and Perera, Liyanage P and Stewart, Donn M and Goldman, Carolyn K and Bryant, Bonita R and Decker, Jean M and Chen, Jing and Worthy, Tat'Yana A and Figg, William D and Peer, Cody J and Sneller, Michael C and Lane, H. Clifford and Yovandich, Jason L and Creekmore, Stephen P and Roederer, Mario and Waldmann, Thomas A
Journal of clinical oncology, ISSN 0732-183X, 01/2015, Volume 33, Issue 1, pp. 74 - 82
Life Sciences & Biomedicine | Oncology | Science & Technology | Neoplasms - metabolism | Recombinant Proteins - therapeutic use | Nausea - chemically induced | Area Under Curve | Humans | Middle Aged | Male | Metabolic Clearance Rate | Recombinant Proteins - pharmacokinetics | Fever - chemically induced | Dose-Response Relationship, Drug | Young Adult | Neoplasm Metastasis | Aged, 80 and over | Adult | Female | Interleukin-15 - therapeutic use | Neutropenia - chemically induced | Interleukin-15 - adverse effects | Drug Administration Schedule | CD4-Positive T-Lymphocytes - metabolism | Treatment Outcome | Recombinant Proteins - administration & dosage | Neoplasms - drug therapy | Interleukin-15 - genetics | Lymphocyte Activation - drug effects | Neoplasms - immunology | Aged | Cell Proliferation - drug effects | Killer Cells, Natural - drug effects | Infusions, Intravenous | Killer Cells, Natural - metabolism | CD4-Positive T-Lymphocytes - drug effects | Index Medicus | Gdln1 | Mela7 | Faze | To16 | Original Reports | To6 | Bios3 | To21
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2. Full Text The proā€Th2 cytokine ILā€33 directly interacts with invariant NKT and NK cells to induce IFNā€Ī³ production
by Bourgeois, Elvire and Van, Linh Pham and Samson, Michel and Diem, SĆ©verine and Barra, Anne and Roga, StĆ©phane and Gombert, Jeanā€Marc and Schneider, Elke and Dy, Michel and Gourdy, Pierre and Girard, Jeanā€Philippe and Herbelin, AndrĆ©
European journal of immunology, ISSN 0014-2980, 04/2009, Volume 39, Issue 4, pp. 1046 - 1055
Th1/Th2 cells | Inflammation | Natural killer cells | Cytokines | Natural killer T cells | Life Sciences & Biomedicine | Immunology | Science & Technology | Natural Killer T-Cells - drug effects | Spleen - immunology | Humans | Spleen - drug effects | Th2 Cells - immunology | Interferon-gamma - metabolism | Interleukin-4 - agonists | Th2 Cells - drug effects | Liver - immunology | Liver - drug effects | Natural Killer T-Cells - metabolism | Interleukins - immunology | Killer Cells, Natural - immunology | Female | Interleukins - pharmacology | Interleukin-33 | Interleukin-4 - metabolism | Liver - metabolism | Mice, Inbred C57BL | Interleukin-12 - metabolism | Interferon-gamma - agonists | Th2 Cells - metabolism | Mice, Knockout | Interleukin-4 - immunology | Animals | Spleen - metabolism | Interferon-gamma - immunology | Interleukin-12 - immunology | Killer Cells, Natural - drug effects | Mice | Mice, Inbred BALB C | Killer Cells, Natural - metabolism | Natural Killer T-Cells - immunology | Index Medicus
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3. Full Text EZH2 phosphorylation by JAK3 mediates a switch to noncanonical function in natural killer/T-cell lymphoma
by Yan, Junli and Li, Boheng and Lin, Baohong and Lee, Pei Tsung and Chung, Tae-Hoon and Tan, Joy and Bi, Chonglei and Lee, Xue Ting and Selvarajan, Viknesvaran and Ng, Siok-Bian and Yang, Henry and Yu, Qiang and Chng, Wee-Joo
Blood, ISSN 0006-4971, 08/2016, Volume 128, Issue 7, pp. 948 - 958
Life Sciences & Biomedicine | Hematology | Science & Technology | Cell Proliferation - genetics | Enhancer of Zeste Homolog 2 Protein - metabolism | Natural Killer T-Cells - drug effects | Humans | RNA Polymerase II - metabolism | Enzyme Activation - drug effects | Lymphoma, T-Cell - genetics | Protein Subunits - metabolism | Lymphoma, T-Cell - metabolism | Phosphotyrosine - metabolism | Methylation - drug effects | Models, Biological | Natural Killer T-Cells - metabolism | Protein Binding - drug effects | Lymphoma, T-Cell - pathology | Cell Line, Tumor | Cell Proliferation - drug effects | Lysine - metabolism | Protein Kinase Inhibitors - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Histones - metabolism | Phosphorylation - drug effects | Janus Kinase 3 - metabolism | Polycomb Repressive Complex 2 - metabolism | Index Medicus | Abridged Index Medicus
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4. Full Text DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity
by Zhang, Qian and Dove, Christopher G and Hor, Jyh Liang and Murdock, Heardley M and Strauss-Albee, Dara M and Garcia, Jordan A and Mandl, Judith N and Grodick, Rachael A and Jing, Huie and Chandler-Brown, Devon B and Lenardo, Timothy E and Crawford, Greg and Matthews, Helen F and Freeman, Alexandra F and Cornall, Richard J and Germain, Ronald N and Mueller, Scott N and Su, Helen C
The Journal of experimental medicine, ISSN 0022-1007, 2014, Volume 211, Issue 13, pp. 2549 - 2566
Immunology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Index Medicus
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5. Full Text Activation of invariant natural killer T cells impedes liver regeneration by way of both IFNā€Ī³ā€ and ILā€4ā€dependent mechanisms
by Yin, Shi and Wang, Hua and Bertola, Adeline and Feng, Dechun and Xu, Mingā€jiang and Wang, Yan and Gao, Bin
Hepatology (Baltimore, Md.), ISSN 0270-9139, 10/2014, Volume 60, Issue 4, pp. 1356 - 1366
Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Antigens, CD1d - physiology | Hepatocytes - pathology | Male | STAT6 Transcription Factor - genetics | Galactosylceramides - pharmacology | Hepatectomy | Natural Killer T-Cells - physiology | Liver - drug effects | Natural Killer T-Cells - pathology | Antigens, CD1d - genetics | Models, Animal | STAT6 Transcription Factor - physiology | Interferon-gamma - genetics | Interleukin-4 - genetics | Liver - surgery | Interferon-gamma - deficiency | Interleukin-4 - physiology | Hepatocytes - drug effects | Mice, Inbred C57BL | Interferon-gamma - physiology | Interleukin-4 - deficiency | Liver Regeneration - physiology | Mice, Knockout | Animals | STAT6 Transcription Factor - deficiency | Liver - physiology | Cell Proliferation - drug effects | Mice | In Vitro Techniques | Liver Regeneration - drug effects | Index Medicus
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6. Full Text Activation of natural killer T cells by Ī±-galactosylceramide rapidly induces the full maturation of dendritic cells in vivo and thereby acts as an adjuvant for combined CD4 and CD8 T cell immunity to a coadministered protein
by Fujii, Shin-Ichiro and Shimizu, Kanako and Smith, Caroline and Bonifaz, Laura and Steinman, Ralph M
The Journal of experimental medicine, ISSN 0022-1007, 07/2003, Volume 198, Issue 2, pp. 267 - 279
Dendritic cell maturation | Exogenous pathway | Dendritic cells | T cell-mediated immunity | Ī±-galactosylceramide | Immunology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Dendritic Cells - immunology | Mice, Inbred C57BL | Mice, Transgenic | Myeloid Differentiation Factor 88 | Galactosylceramides - pharmacology | Mice, Knockout | CD4-Positive T-Lymphocytes - immunology | Adaptor Proteins, Signal Transducing | Lymphocyte Activation - immunology | Animals | Lymphocyte Activation - drug effects | Killer Cells, Natural - immunology | Dendritic Cells - drug effects | Receptors, Antigen, T-Cell - immunology | Killer Cells, Natural - drug effects | Mice | Receptors, Antigen, T-Cell - genetics | Interferon-gamma - genetics | Receptors, Immunologic - immunology | CD8-Positive T-Lymphocytes - immunology | Antigens, Differentiation - immunology | Index Medicus | exogenous pathway | dendritic cells | dendritic cell maturation | T cellā€“mediated immunity
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7. Full Text Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer T cells: lessons from obesity, diabetes and psoriasis
by Hogan, A E and Tobin, A M and Ahern, T and Corrigan, M A and Gaoatswe, G and Jackson, R and Oā€™Reilly, V and Lynch, L and Doherty, D G and Moynagh, P N and Kirby, B and Oā€™Connell, J and Oā€™Shea, D
Diabetologia, ISSN 0012-186X, 11/2011, Volume 54, Issue 11, pp. 2745 - 2754
Invariant NKT cells | Obesity | Human Physiology | Psoriasis | GLP-1 receptor | Metabolic Diseases | Internal Medicine | Innate immune system | CREB | Medicine & Public Health | GLP-1 analogue | Diabetes | Anti-inflammatory | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Diabetes. Impaired glucose tolerance | Dermatology | Psoriasis. Parapsoriasis. Lichen | Biological and medical sciences | Endocrinopathies | Etiopathogenesis. Screening. Investigations. Target tissue resistance | Metabolic diseases | Medical sciences | Endocrine pancreas. Apud cells (diseases) | Natural Killer T-Cells - drug effects | Cell Count | Humans | Middle Aged | Male | Diabetes Mellitus, Type 2 - metabolism | Molecular Targeted Therapy | RNA, Messenger - metabolism | Psoriasis - complications | Glucagon-Like Peptide 1 - agonists | Natural Killer T-Cells - metabolism | Diabetes Mellitus, Type 2 - immunology | Psoriasis - metabolism | Female | Diabetes Mellitus, Type 2 - complications | Skin - pathology | Natural Killer T-Cells - secretion | Skin - immunology | Hypoglycemic Agents - therapeutic use | Psoriasis - immunology | Receptors, Glucagon - agonists | Receptors, Glucagon - genetics | Severity of Illness Index | Cell Line | Psoriasis - drug therapy | Glucagon-Like Peptide 1 - metabolism | Glucagon-Like Peptide 1 - analogs & derivatives | Obesity - complications | Cytokines - secretion | Glucagon-Like Peptide 1 - pharmacology | Receptors, Glucagon - metabolism | Hypoglycemic Agents - pharmacology | Gene Expression Regulation - drug effects | Glucagon-Like Peptide-1 Receptor | Signal Transduction - drug effects | Immunologic Factors - adverse effects | Diabetes Mellitus, Type 2 - drug therapy | Glucagon-Like Peptide 1 - adverse effects | Hypoglycemic Agents - adverse effects | Immunologic Factors - pharmacology | Liraglutide | Skin - drug effects | Glucagon-Like Peptide 1 - therapeutic use | Immunologic Factors - therapeutic use | Natural Killer T-Cells - immunology | Type 2 diabetes | Peptides | T cells | Emergency medical services | Index Medicus
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8. Full Text A microparticle platform for STING-targeted immunotherapy enhances natural killer cell- and CD8+ T cell-mediated anti-tumor immunity
by Watkins-Schulz, Rebekah and Tiet, Pamela and Gallovic, Matthew D and Junkins, Robert D and Batty, Cole and Bachelder, Eric M and Ainslie, Kristy M and Ting, Jenny P.Y
Biomaterials, ISSN 0142-9612, 06/2019, Volume 205, pp. 94 - 105
Acetalated dextran | STING | Microparticle | CD8+ T cells | Natural killer cells | Immunotherapy | CD8 | T cells | Engineering | Materials Science | Technology | Engineering, Biomedical | Materials Science, Biomaterials | Science & Technology | Dextrans - chemistry | Immunity | Triple Negative Breast Neoplasms - immunology | Microspheres | Neoplasms - therapy | Triple Negative Breast Neoplasms - pathology | Killer Cells, Natural - immunology | Membrane Proteins - metabolism | Acetylation | Disease Models, Animal | Nucleotides, Cyclic - pharmacology | Pathogen-Associated Molecular Pattern Molecules - metabolism | Mice, Inbred C57BL | Hydrodynamics | Melanoma - pathology | Triple Negative Breast Neoplasms - therapy | Animals | Tumor Burden - drug effects | Melanoma - immunology | Neoplasms - immunology | Killer Cells, Natural - drug effects | CD8-Positive T-Lymphocytes - immunology | Melanoma - therapy | Neoplasms - pathology | Index Medicus | Natural Killer cells | CD8+ T Cells | Acetalated Dextran
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9. Full Text Inhibition of type I natural killer T cells by retinoids or following sulfatideā€mediated activation of type II natural killer T cells attenuates alcoholic liver disease in mice
by Maricic, Igor and Sheng, Huiming and Marrero, Idania and Seki, Ekihiro and Kisseleva, Tatiana and Chaturvedi, Som and Molle, Natasha and Mathews, Stephanie A and Gao, Bin and Kumar, Vipin
Hepatology (Baltimore, Md.), ISSN 0270-9139, 04/2015, Volume 61, Issue 4, pp. 1357 - 1369
Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Natural Killer T-Cells - drug effects | Mice, Inbred C57BL | Sulfoglycosphingolipids - therapeutic use | Liver Diseases, Alcoholic - prevention & control | Male | Natural Killer T-Cells - classification | Natural Killer T-Cells - physiology | Animals | Retinoids - therapeutic use | Sulfoglycosphingolipids - pharmacology | Liver Diseases, Alcoholic - immunology | Mice | Retinoids - pharmacology | Antigens | T cell receptors | Liver diseases | Gene expression | Liver cirrhosis | Index Medicus
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