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European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2019, Volume 164, pp. 499 - 516
Allosteric modulators of G-protein-coupled receptors have lately gained significant traction in drug discovery. Recent studies have shown that allosteric... 
Anti-obesity | Serotonin | Negative allosteric modulator | Food intake | Positive allosteric modulator | 5-HT2C receptor | 5-HT2B receptor | DESIGN | CHEMISTRY, MEDICINAL | AGONISTS | DISCOVERY | (2-PHENYLCYCLOPROPYL)METHYLAMINES | POTENT | INHIBITORS
Journal Article
BBA - General Subjects, ISSN 0304-4165, 03/2014, Volume 1840, Issue 3, pp. 1194 - 1203
Among adenosine receptors (ARs) the A subtype exhibits low affinity for the endogenous agonist compared with the A , A , and A subtypes and is therefore... 
1-Benzyl-3-ketoindole derivatives | Positive allosteric modulators | GPCR allosteric modulators | A2B adenosine receptor | Negative allosteric modulators | Ligand–receptor interaction | adenosine receptor | Ligand-receptor interaction
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2019, pp. 499 - 516
Allosteric modulators of G-protein-coupled receptors have lately gained significant traction in drug discovery. Recent studies have shown that allosteric... 
receptor | Anti-obesity | Negative allosteric modulator | Serotonin | Food intake | Positive allosteric modulator | 5-HT
Journal Article
Current Topics in Medicinal Chemistry, ISSN 1568-0266, 2013, Volume 13, Issue 1, pp. 26 - 54
Schizophrenia is a highly debilitating mental disorder which afflicts approximately 1% of the global population. Cognitive and negative deficits account for... 
PAMS | AMPA | Allosterism | NMDA | Schizophrenia | Glutamate | Glycine | NAMS | CHEMISTRY, MEDICINAL | NEGATIVE SYMPTOMS | PROTEIN-COUPLED RECEPTORS | schizophrenia | GLYCINE TRANSPORTER | D-ASPARTATE RECEPTOR | SYNAPTIC PLASTICITY | NR2B-CONTAINING NMDA RECEPTORS | D-SERINE | glycine | DOUBLE-BLIND | CENTRAL-NERVOUS-SYSTEM | LONG-TERM POTENTIATION | glutamate
Journal Article
by Sun, B and Chen, LH and Liu, L and Xia, ZX and Pin, JP and Nan, FJ and Liu, JF
BIOCHEMICAL JOURNAL, ISSN 0264-6021, 03/2016, Volume 473, pp. 779 - 787
An gamma-aminobutyric acid type B (GABA(B))-receptor mediates slow and prolonged synaptic inhibition in the central nervous system, which represents an... 
negative allosteric modulator | GAMMA | ACID(B) RECEPTORS | C-TERMINI | ACTIVATION | GABA-B RECEPTORS | ANTAGONIST | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHARMACOLOGY | GLUTAMATE | N,N'-DICYCLOPENTYL-2-METHYLSULFANYL-5-NITRO-PYRIMIDINE-4,6-DIAMINE GS39783 | cerebellar granular neurons | heptahelical domain | GABA(B)-receptor
Journal Article
EXPERT OPINION ON THERAPEUTIC PATENTS, ISSN 1354-3776, 04/2013, Volume 23, Issue 4, pp. 393 - 408
Journal Article
Pain, ISSN 0304-3959, 2015, Volume 156, Issue 6, pp. 1060 - 1073
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 09/2016, Volume 26, Issue 18, pp. 4403 - 4407
Existing CB1 negative allosteric modulators (NAMs) fall into a limited range of structural classes. In spite of the theoretical potential of CB1 NAMs,... 
Negative allosteric modulator | Cannabinoid | Indole sulfonamide | CB1 NAM | SYSTEM | OBESITY | CHEMISTRY, MEDICINAL | ANTAGONIST | INDOLE-2-CARBOXAMIDES | CHEMISTRY, ORGANIC | CB1 RECEPTOR | Cannabinoid Receptor Modulators - pharmacology | Indoles - pharmacology | Sulfonamides - pharmacology | Allosteric Regulation | Humans | Sulfonamides | Index Medicus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2016, Volume 11, Issue 3, p. e0148737
Knowledge about the neural underpinnings of the negative blood oxygen level dependent (BOLD) responses in functional magnetic resonance imaging (fMRI) is still... 
NEURONAL-ACTIVITY | BRAIN ACTIVITY | NEGATIVE BOLD | DIAZEPAM | INHIBITION | MEMORY | MULTIDISCIPLINARY SCIENCES | DEPENDENT FMRI SIGNALS | BENZODIAZEPINE-RECEPTORS | DEFAULT-MODE NETWORK | CEREBRAL-BLOOD-FLOW | Double-Blind Method | Gyrus Cinguli - blood supply | Allosteric Regulation | Humans | GABA Modulators - pharmacokinetics | Male | Diazepam - pharmacokinetics | Oxygen - blood | Diazepam - pharmacology | Dose-Response Relationship, Drug | Young Adult | Magnetic Resonance Imaging | GABA Modulators - pharmacology | Adult | Female | Gyrus Cinguli - physiology | Gyrus Cinguli - drug effects | GABA | Physiological aspects | Genetic aspects | Research | Cingulate cortex | Neuroimaging | Health sciences | Correlation | Cortex (cingulate) | Nuclear magnetic resonance--NMR | Memory | Mental task performance | Pharmacology | Blood | Blood levels | Studies | γ-Aminobutyric acid | Allosteric properties | Magnetic resonance imaging | Functional magnetic resonance imaging | Attenuation | Adults | Short term memory | Drug dosages | Diazepam | Basic Medicine | Neurosciences | quantitative magnetic resonance imaging; brain tissue modeling; myelin; edema; T-1 relaxation; T-2 relaxation; proton density | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Neurovetenskaper | NMR | Nuclear magnetic resonance
Journal Article
Neuropharmacology, ISSN 0028-3908, 07/2014, Volume 82, pp. 161 - 173
Previous work has suggested that activation of mGlu5 receptor augments NMDA receptor function and thereby may constitute a rational approach addressing... 
Schizophrenia | Positive allosteric modulator | Neurotoxicity | Metabotropic glutamate receptor | Antipsychotic activity | METABOTROPIC GLUTAMATE-RECEPTOR | PROTEIN-KINASE-C | NEGATIVE SYMPTOMS | FRAGILE-X | NEUROSCIENCES | PREFRONTAL CORTEX | D-SERINE | PHARMACOLOGY & PHARMACY | LONG-TERM POTENTIATION | BINDING-SITES | ACUTE STRESS | METHYL-D-ASPARTATE | Antipsychotic Agents - toxicity | Neurons - pathology | Cricetulus | Rats, Wistar | Benzamides - pharmacokinetics | Allosteric Regulation | Humans | Male | Excitatory Amino Acid Agents - pharmacokinetics | Mice, 129 Strain | Necrosis - pathology | Excitatory Amino Acid Agents - chemistry | Oxadiazoles - toxicity | Receptor, Metabotropic Glutamate 5 - genetics | Necrosis - physiopathology | Neurotoxicity Syndromes - pathology | Neurons - physiology | Female | Cell Death - drug effects | Neurons - drug effects | Oxadiazoles - chemistry | Oxadiazoles - pharmacokinetics | Benzamides - chemistry | CHO Cells | Benzamides - toxicity | Brain - physiopathology | Cells, Cultured | Antipsychotic Agents - pharmacokinetics | Receptor, Metabotropic Glutamate 5 - metabolism | Rats, Sprague-Dawley | Mice, Knockout | Brain - drug effects | Excitatory Amino Acid Agents - toxicity | Animals | Antipsychotic Agents - chemistry | Cell Death - physiology | Neurotoxicity Syndromes - physiopathology | Brain - pathology | Methyl aspartate | Antipsychotic drugs | Glutamate | Index Medicus
Journal Article
Journal Article
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, ISSN 0304-4165, 03/2014, Volume 1840, Issue 3, pp. 1194 - 1203
Journal Article
EXPERT OPINION ON THERAPEUTIC PATENTS, ISSN 1354-3776, 2017, Volume 27, Issue 6, pp. 691 - 706
Journal Article