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1. Full Text Genomic resolution of an aggressive, widespread, diverse and expanding meningococcal serogroup B, C and W lineage
by Lucidarme, Jay and Hill, Dorothea M.C and Bratcher, Holly B and Gray, Steve J and du Plessis, Mignon and Tsang, Raymond S.W and Vazquez, Julio A and Taha, Muhamed-Kheir and Ceyhan, Mehmet and Efron, Adriana M and Gorla, Maria C and Findlow, Jamie and Jolley, Keith A and Maiden, Martin C.J and Borrow, Ray
Journal of Infection, ISSN 0163-4453, 2015, Volume 71, Issue 5, pp. 544 - 552
Summary Objectives Neisseria meningitidis is a leading cause of meningitis and septicaemia. The hyperinvasive ST-11 clonal complex (cc11) caused serogroup C... 
Infectious Disease | Meningococcal | Serogroup C | Genome | ST-11 clonal complex | Serogroup W | INFECTIOUS DISEASES | CLONAL COMPLEX | NEISSERIA-MENINGITIDIS | VACCINE | ET-15 CLONE | EMERGENCE | W135 | DISEASE | OUTBREAK | ET-37/ST-11 | STRAIN | Meningococcal Infections - epidemiology | Humans | Male | Neisseria meningitidis, Serogroup B - genetics | Meningococcal Infections - microbiology | Phylogeny | Multilocus Sequence Typing | Neisseria meningitidis, Serogroup B - isolation & purification | Endemic Diseases | South America - epidemiology | Homosexuality, Male | Disease Outbreaks | Neisseria meningitidis, Serogroup C - classification | Neisseria meningitidis - genetics | Neisseria meningitidis, Serogroup C - isolation & purification | Serotyping | France - epidemiology | Neisseria meningitidis, Serogroup C - genetics | South Africa - epidemiology | Serogroup | Neisseria meningitidis - isolation & purification | Neisseria meningitidis - classification | Neisseria meningitidis, Serogroup B - classification | North America - epidemiology | United Kingdom - epidemiology | Music in education | Epidemics | Respiratory tract diseases | Meningitis | Health aspects | Index Medicus | South America | Biochemistry, Molecular Biology | Genomics | United Kingdom | Neisseria meningitidis | North America | Life Sciences | Neisseria meningitidis, Serogroup C | South Africa | Santé publique et épidémiologie | Neisseria meningitidis, Serogroup B | France | Meningococcal Infections
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2. Full Text Processing-Independent CRISPR RNAs Limit Natural Transformation in Neisseria meningitidis
by Zhang, Yan and Heidrich, Nadja and Ampattu, Biju Joseph and Gunderson, Carl W and Seifert, H. Steven and Schoen, Christoph and Vogel, Jörg and Sontheimer, Erik J
Molecular Cell, ISSN 1097-2765, 05/2013, Volume 50, Issue 4, pp. 488 - 503
CRISPR interference confers adaptive, sequence-based immunity against viruses and plasmids and is specified by CRISPR RNAs (crRNAs) that are transcribed and... 
DEFENSE | IMMUNE-SYSTEM | EVOLUTION | BACTERIOPHAGE | DNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | SEQUENCE | POPULATION-STRUCTURE | INTERFERENCE | GENOME | CELL BIOLOGY | Inverted Repeat Sequences - genetics | Neisseria meningitidis - pathogenicity | Ribonuclease III - metabolism | Genes, Bacterial - genetics | RNA Processing, Post-Transcriptional | Humans | Bacterial Proteins - genetics | Meningococcal Infections - microbiology | Promoter Regions, Genetic - genetics | Sequence Homology, Nucleic Acid | Host-Pathogen Interactions | Transformation, Bacterial | Virulence - genetics | Base Sequence | RNA, Bacterial - genetics | Bacterial Proteins - metabolism | Neisseria meningitidis - genetics | Transcription, Genetic | Models, Genetic | Neisseria meningitidis - physiology | RNA, Bacterial - metabolism | Enzymes | Hydrolases | Biosynthesis | Ribonuclease | Health aspects | Index Medicus | CRISPR | Cas | Neisseria | Type II-C | RNA surveillance system | pathogen | dRNA-seq | Cas9 | RNA processing | crRNA
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3. Full Text Description and nomenclature of Neisseria meningitidis capsule locus
by Harrison, Odile B and Claus, Heike and Jiang, Ying and Bennett, Julia S and Bratcher, Holly B and Jolley, Keith A and Corton, Craig and Care, Rory and Poolman, Jan T and Zollinger, Wendell D and Frasch, Carl E and Stephens, David S and Feavers, Ian and Frosch, Matthias and Parkhill, Julian and Vogel, Ulrich and Quail, Michael A and Bentley, Stephen D and Maiden, Martin C.J
Emerging Infectious Diseases, ISSN 1080-6040, 04/2013, Volume 19, Issue 4, pp. 566 - 573
Pathogenic Neisseria meningitidis isolates contain a polysaccharide capsule that is the main virulence determinant for this bacterium. Thirteen capsular... 
ELUCIDATION | STRUCTURAL DETERMINATION | INFECTIOUS DISEASES | CHEMICAL PROPERTIES | GENETICS | BIOSYNTHESIS | NUCLEAR-MAGNETIC-RESONANCE | MENINGOCOCCAL POLYSACCHARIDES | IMMUNOLOGY | GROUP-B | SEROGROUP-Y | ANTIGEN | Neisseria meningitidis - pathogenicity | Genes, Bacterial | Multigene Family | Magnetic Resonance Spectroscopy | Bacterial Capsules - metabolism | Humans | Virulence | Terminology as Topic | Genetic Loci | Meningococcal Infections - microbiology | Chromosomes, Bacterial | Polysaccharides, Bacterial - biosynthesis | Neisseria meningitidis - isolation & purification | Polysaccharides, Bacterial - genetics | Neisseria meningitidis - classification | Bacterial Capsules - genetics | Polymerase Chain Reaction | Neisseria meningitidis - genetics | Polysaccharides, Bacterial - isolation & purification | Serotyping | Polymerase chain reaction | Usage | Nuclear magnetic resonance spectroscopy | Neisseria meningitidis | Genetic aspects | Research | Identification and classification | Health aspects | Index Medicus | nomenclature | capsule | bacteria | serogroup | China
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4. Full Text Temperature triggers immune evasion by Neisseria meningitidis
by Loh, Edmund and Kugelberg, Elisabeth and Tracy, Alexander and Zhang, Qian and Gollan, Bridget and Ewles, Helen and Chalmers, Ronald and Pelicic, Vladimir and Tang, Christoph M
Nature, ISSN 0028-0836, 2013, Volume 502, Issue 7470, pp. 237 - 240
Neisseria meningitidis has several strategies to evade complement-mediated killing, and these contribute to its ability to cause septicaemic disease and... 
UPPER RESPIRATORY-TRACT | INFLUENZA-A | COMPLEMENT | VIRUS-INFECTION | BIOSYNTHESIS | MULTIDISCIPLINARY SCIENCES | GENES | RESISTANCE | POLYSIALIC ACID CAPSULE | MECHANISMS | EXPRESSION | Meningococcal Infections - immunology | Temperature | Humans | Bacterial Proteins - genetics | Lipopolysaccharides - metabolism | 5' Untranslated Regions - genetics | Meningococcal Infections - microbiology | Immune Evasion - physiology | Thermosensing - genetics | RNA, Bacterial - chemistry | Bacterial Capsules - genetics | Immune Evasion - genetics | RNA, Bacterial - genetics | Bacterial Proteins - metabolism | Neisseria meningitidis - genetics | Gene Expression Regulation, Bacterial | Neisseria meningitidis - physiology | Immune response | Body temperature | Physiological aspects | Development and progression | Neisseria meningitidis | Genetic aspects | Regulation | Research | Proteins | Microbiology | Plasmids | Influenza | Bacteria | Biosynthesis | Index Medicus
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5. Full Text Population Structure and Capsular Switching of Invasive Neisseria meningitidis Isolates in the Pre-Meningococcal Conjugate Vaccine Era—United States, 2000-2005
by Lee H. Harrison and Kathleen A. Shutt and Susanna E. Schmink and Jane W. Marsh and Brian H. Harcourt and Xin Wang and Anne M. Whitney and David S. Stephens and Amanda A. Conn and Nancy E. Messonnier and Leonard W. Mayer
The Journal of Infectious Diseases, ISSN 0022-1899, 4/2010, Volume 201, Issue 8, pp. 1208 - 1224
Background. A quadrivalent meningococcal conjugate vaccine (MCV4) was licensed in the United States in 2005; no serogroup vaccine is available. Neisseria... 
BACTERIA | Conjugate vaccines | Surveillance | Vaccination | Disease outbreaks | Medical genetics | Population structure | Neisseria meningitidis | Preventive medicine | Epidemiology | Genotypes | INFECTIOUS DISEASES | SEROGROUP-C | PREVENTION | MICROBIOLOGY | IMMUNOLOGY | PNEUMONIAE SEROTYPE 19A | FETA | IDENTIFICATION | DISEASE | INFANTS | ZEALANDS EPIDEMIC | INFECTION | STRAIN | Meningococcal Vaccines - genetics | Neisseria meningitidis, Serogroup C - genetics | Neisseria meningitidis, Serogroup W-135 - genetics | Humans | Genotype | Meningococcal Infections - prevention & control | Neisseria meningitidis, Serogroup Y - genetics | Neisseria meningitidis, Serogroup B - genetics | Meningococcal Infections - microbiology | Neisseria meningitidis - isolation & purification | Sequence Analysis, DNA | Bacterial Typing Techniques | Bacterial Capsules - genetics | Neisseria meningitidis - genetics | Meningococcal Vaccines - immunology | Antigenic Variation - genetics | Bacterial Outer Membrane Proteins - genetics | Usage | Physiological aspects | Genetic aspects | Research | Nucleotide sequencing | Membrane proteins | Index Medicus | Abridged Index Medicus | molecular epidemiology | multilocus sequence typing | fetA | population structure | capsular switching | outer membrane proteins | porA | porB | meningococcus, meningococcal | DNA sequencing
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6. Full Text Neisseria meningitidis is structured in clades associated with restriction modification systems that modulate homologous recombination
by Sonia Budroni and Emilio Siena and Julie C. Dunning Hotopp and Kate L. Seib and Davide Serruto and Chiara Nofroni and Maurizio Comanducci and David R. Riley and Sean C. Daugherty and Samuel V. Angiuoli and Antonello Covacci and Mariagrazia Pizza and Rino Rappuoli and E. Richard Moxon and Hervé Tettelin and Duccio Medini
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2011, Volume 108, Issue 11, pp. 4494 - 4499
Molecular data on a limited number of chromosomal loci have shown that the population of Neisseria meningitidis (Nm), a deadly human pathogen, is structured in... 
Biological taxonomies | DNA | Genes | Homologous recombination | Phylogenetics | Population structure | Evolution | Genomes | Neisseria meningitidis | Gene conversion | Population structure and dynamics | Pan-genome | Meningococcus | Phylogenetic clades | TRANSFORMATION | phylogenetic clades | MULTIDISCIPLINARY SCIENCES | pan-genome | population structure and dynamics | VIRULENCE | IDENTIFICATION | EVOLUTION | MICROBIAL PAN-GENOME | SEQUENCE | POPULATION-STRUCTURE | SELECTION | meningococcus | PATHOGENIC BACTERIA | Neisseria meningitidis - pathogenicity | Gene Conversion - genetics | Conserved Sequence - genetics | Genes, Bacterial - genetics | Species Specificity | Humans | Phylogeny | Operon - genetics | Mutagenesis, Insertional - genetics | DNA, Bacterial - genetics | Neisseria meningitidis - classification | Host-Pathogen Interactions - genetics | Recombination, Genetic | Base Sequence | DNA Restriction-Modification Enzymes - genetics | Neisseria meningitidis - genetics | Neisseria meningitidis - growth & development | Chromosome Inversion - genetics | Chromosome Segregation - genetics | Genetic aspects | Research | Genetic recombination | Population genetics | Gram-negative bacteria | Chromosomes | Deoxyribonucleic acid--DNA | Index Medicus | Pathogenicity | Pathogens | Commensals | homologous recombination | Virulence | Data processing | genomics | Biological Sciences
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7. Full Text Whole-genome characterization of epidemic Neisseria meningitidis serogroup C and resurgence of serogroup W, Niger, 2015
by Kretz, Cecilia B and Retchless, Adam C and Sidikou, Fati and Issaka, Bassira and Ousmane, Sani and Schwartz, Stephanie and Tate, Ashley H and Pana, Assimawè and Njanpop-Lafourcade, Berthe-Marie and Nzeyimana, Innocent and Obama Nse, Ricardo and Deghmane, Ala-Eddine and Hong, Eva and Brynildsrud, Ola Brønstad and Novak, Ryan T and Meyer, Sarah A and Oukem-Boyer, Odile Ouwe Missi and Ronveaux, Olivier and Caugant, Dominique A and Taha, Muhamed-Kheir and Wang, Xin and Niger Response Team
Emerging Infectious Diseases, ISSN 1080-6040, 10/2016, Volume 22, Issue 10, pp. 1762 - 1768
In 2015, Niger reported the largest epidemic of Neisseria meningitidis serogroup C (NmC) meningitis in sub-Saharan Africa. The NmC epidemic coincided with... 
AFRICA | INFECTIOUS DISEASES | CARRIAGE | BURKINA-FASO | W135 | MENINGOCOCCAL MENINGITIS | H BINDING-PROTEIN | DISEASE | VACCINE | SUSCEPTIBILITY | DIVERSITY | IMMUNOLOGY | Communicable Diseases, Emerging | Epidemics | Genome, Bacterial | Neisseria meningitidis, Serogroup C - genetics | Niger - epidemiology | Humans | Phylogeny | Antigens, Bacterial - genetics | Neisseria meningitidis - isolation & purification | Sequence Analysis, DNA | Meningitis, Meningococcal - epidemiology | Molecular Typing | DNA, Bacterial | Genetic Variation | Meningitis, Meningococcal - microbiology | Neisseria meningitidis - genetics | Drug Resistance, Bacterial - genetics | Neisseria meningitidis, Serogroup C - isolation & purification | Serotyping | Index Medicus | Neisseria meningitidis/genetics | Neisseria meningitidis, Serogroup C/genetics | Life Sciences | Neisseria meningitidis/isolation & purification | Genetics | Antigens, Bacterial/genetics | Meningitis, Meningococcal/epidemiology | Meningitis, Meningococcal/microbiology | Bacteriology | Human health and pathology | Microbiology and Parasitology | Infectious diseases | Niger/epidemiology | Neisseria meningitidis, Serogroup C/isolation & purification | Drug Resistance, Bacterial/genetics | Santé publique et épidémiologie | Neisseria meningitidis serogroup C | meningitis belt | bacteria | Niger | whole-genome sequencing | Research | Serogroup C and Resurging Serogroup W, Niger, 2015 | Whole-Genome Characterization of Epidemic | Meningococcal meningitis
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8. Full Text DNase H Activity of Neisseria meningitidis Cas9
by Zhang, Yan and Rajan, Rakhi and Seifert, H. Steven and Mondragón, Alfonso and Sontheimer, Erik J
Molecular Cell, ISSN 1097-2765, 10/2015, Volume 60, Issue 2, pp. 242 - 255
Type II CRISPR systems defend against invasive DNA by using Cas9 as an RNA-guided nuclease that creates double-stranded DNA breaks. Dual RNAs (CRISPR RNA... 
ADAPTIVE IMMUNITY | STREPTOCOCCUS-THERMOPHILUS | NATURAL TRANSFORMATION | CRISPR INTERFERENCE | DUAL-RNA | HUMAN-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | RNA-GUIDED ENDONUCLEASE | TARGET DNA | SYSTEMS | PROKARYOTES | CELL BIOLOGY | DNA, Bacterial - metabolism | RNA, Guide - genetics | RNA, Guide - metabolism | DNA, Single-Stranded - metabolism | Bacterial Proteins - genetics | Molecular Sequence Data | DNA, Single-Stranded - genetics | Endodeoxyribonucleases - genetics | DNA, Bacterial - genetics | Nucleotide Motifs | CRISPR-Cas Systems | Clustered Regularly Interspaced Short Palindromic Repeats | Endodeoxyribonucleases - metabolism | Bacterial Proteins - metabolism | Neisseria meningitidis - genetics | Neisseria meningitidis - enzymology | RNA | Enzymes | Genomics | Medical colleges | Nucleases | Therapeutics | Homeopathy | Materia medica and therapeutics | Index Medicus | CRISPR | sgRNA | Cas9 endonucleases | DNA targeting | Neisseria meningitidis | crRNA | NmeCas9 | tracrRNA
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9. Full Text A gene-by-gene population genomics platform: De novo assembly, annotation and genealogical analysis of 108 representative Neisseria meningitidis genomes
by Bratcher, Holly B and Corton, Craig and Jolley, Keith A and Parkhill, Julian and Maiden, Martin
BMC Genomics, ISSN 1471-2164, 12/2014, Volume 15, Issue 1, pp. 1138 - 1138
Background: Highly parallel, 'second generation' sequencing technologies have rapidly expanded the number of bacterial whole genome sequences available for... 
Gene-by-gene analysis | rST | BIGSdb | rMLST | Neisseria meningitidis | cgMLST | de novo assembly | Bacterial population genomics | CARRIAGE | SEROGROUP | RESTRICTION-MODIFICATION SYSTEMS | AMPLIFICATION | KYOTO ENCYCLOPEDIA | BACILLUS-SUBTILIS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CORYNEBACTERIUM-PSEUDOTUBERCULOSIS I19 | GENETICS & HEREDITY | SHORT SEQUENCE READS | MENINGOCOCCAL DISEASE | STRAIN | Genome, Bacterial - genetics | Neisseria meningitidis - genetics | High-Throughput Nucleotide Sequencing | Phylogeny | Genomics - methods | Molecular Sequence Annotation | Genetic research | Genetic aspects | Research | Virulence (Microbiology) | Population genetics | Index Medicus
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10. Full Text Evolutionary events associated with an outbreak of meningococcal disease in men who have sex with men
by Taha, Muhamed-Kheir and Claus, Heike and Lappann, Martin and Veyrier, Frédéric J and Otto, Andreas and Becher, Dörte and Deghmane, Ala-Eddine and Frosch, Matthias and Hellenbrand, Wiebke and Hong, Eva and Parent Du Châtelet, Isabelle and Prior, Karola and Harmsen, Dag and Vogel, Ulrich
PLoS ONE, ISSN 1932-6203, 05/2016, Volume 11, Issue 5, pp. e0154047 - e0154047
Meningococci spread via respiratory droplets, whereas the closely related gonococci are transmitted sexually. Several outbreaks of invasive meningococcal... 
COMPLEMENT | BACTERIA | PROTEIN | DATABASE | MULTIDISCIPLINARY SCIENCES | NEISSERIA-MENINGITIDIS | SEQUENCE | DIVERSITY | BINDING | CLONE | GONORRHOEAE | Complement Factor H - antagonists & inhibitors | Proteome - genetics | Meningitis, Meningococcal - diagnosis | Humans | Male | Phylogeny | Meningitis, Meningococcal - epidemiology | Homosexuality, Male | Urethritis - diagnosis | Disease Outbreaks | Meningitis, Meningococcal - microbiology | Neisseria meningitidis, Serogroup C - classification | Urethritis - pathology | Neisseria meningitidis - genetics | Neisseria meningitidis, Serogroup C - isolation & purification | Neisseria meningitidis - pathogenicity | Nitrite Reductases - genetics | France - epidemiology | Gene Expression | Neisseria meningitidis, Serogroup C - genetics | Bacterial Proteins - genetics | Urethritis - microbiology | Mice, Transgenic | Neisseria meningitidis - isolation & purification | Neisseria meningitidis, Serogroup C - pathogenicity | Germany - epidemiology | Host-Pathogen Interactions | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Complement Factor H - metabolism | Neisseria meningitidis - classification | Bacterial Proteins - metabolism | Mice | Meningitis, Meningococcal - pathology | Complement Factor H - genetics | Urethritis - epidemiology | Proteome - metabolism | Evolution, Molecular | Nitrite Reductases - metabolism | Disease transmission | Gays | Causes of | Meningitis | Development and progression | Genetic aspects | Research | Diseases | Epidemics | Disease | Laboratories | Sex | Outbreaks | Infections | Genomes | Vaccines | Gene sequencing | Proteins | Genotype & phenotype | Invasive meningococcal disease | Complement factor H | Human immunodeficiency virus--HIV | Young adults | Bacterial infections | Nitrite reductase | Cloning | Transgenic mice | Men | Proteomics | Scientific imaging | Mass spectrometry | Urethritis | Hygiene | Meningococcal disease | Reductase | Index Medicus | Life Sciences | Human health and pathology | Infectious diseases | HIV | Human immunodeficiency virus
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11. Full Text Genomic characterization of urethritis-associated Neisseria meningitidis shows that a wide range of N. meningitidis strains can cause urethritis
by Ma, Kevin C and Unemo, Magnus and Jeverica, Samo and Kirkcaldy, Robert D and Takahashi, Hideyuki and Ohnishi, Makoto and Grad, Yonatan H
Journal of Clinical Microbiology, ISSN 0095-1137, 12/2017, Volume 55, Issue 12, pp. 3374 - 3383
Neisseria meningitidis, typically a resident of the oro- or nasopharynx and the causative agent of meningococcal meningitis and meningococcemia, is capable of... 
Neisseria meningitidis | Neisseria gonorrhoeae | Bacterial genomics | Urethritis | CLONAL COMPLEX | urethritis | MICROBIOLOGY | CEPHALOSPORINS | MENINGOCOCCI | EMERGENCE | LOCUS | GONORRHOEAE | bacterial genomics | COLUMBUS | CAPSULE | SEQUENCE | INFECTION | Nitrite Reductases - genetics | Genome, Bacterial | Genomics | Humans | Middle Aged | Bacterial Proteins - genetics | Urethritis - microbiology | Genotype | Male | Antigens, Bacterial - genetics | Neisseria meningitidis - isolation & purification | Genetic Variation | Young Adult | Biosynthetic Pathways - genetics | Neisseria meningitidis - classification | Bacterial Capsules - genetics | Adult | Neisseria meningitidis - genetics | Index Medicus | Bacteriology
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12. Full Text The Neisseria meningitidis CRISPR-Cas9 System Enables Specific Genome Editing in Mammalian Cells
by Lee, Ciaran M and Cradick, Thomas J and Bao, Gang
Molecular Therapy, ISSN 1525-0016, 03/2016, Volume 24, Issue 3, pp. 645 - 654
The clustered regularly-interspaced short palindromic repeats (CRISPR)—CRISPR-associated (Cas) system from has been successfully adapted for RNA-guided genome... 
MEDICINE, RESEARCH & EXPERIMENTAL | MUTAGENESIS | DUAL-RNA | CRYSTAL-STRUCTURE | CRISPR/CAS9 SYSTEMS | NUCLEASES | STAPHYLOCOCCUS-AUREUS CAS9 | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | DNA | OFF-TARGET CLEAVAGE | GENETICS & HEREDITY | RNA-GUIDED ENDONUCLEASE | GENERATION | Gene Targeting | Position-Specific Scoring Matrices | Humans | Substrate Specificity | Genetic Loci | Gene Editing | Nucleotide Motifs | Base Sequence | CRISPR-Cas Systems | Clustered Regularly Interspaced Short Palindromic Repeats | Protein Binding | Neisseria meningitidis - genetics | RNA, Guide | Genome | Binding Sites | Neisseria meningitidis - enzymology | Index Medicus | Original
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