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by Morrissy, A. Sorana and Garzia, Livia and Shih, David J. H and Zuyderduyn, Scott and Huang, Xi and Skowron, Patryk and Remke, Marc and Cavalli, Florence M. G and Ramaswamy, Vijay and Lindsay, Patricia E and Jelveh, Salomeh and Donovan, Laura K and Wang, Xin and Luu, Betty and Zayne, Kory and Li, Yisu and Mayoh, Chelsea and Thiessen, Nina and Mercier, Eloi and Mungall, Karen L and Ma, Yusanne and Tse, Kane and Zeng, Thomas and Shumansky, Karey and Roth, Andrew J. L and Shah, Sohrab and Farooq, Hamza and Kijima, Noriyuki and Holgado, Borja L and Lee, John J. Y and Matan-Lithwick, Stuart and Liu, Jessica and Mack, Stephen C and Manno, Alex and Michealraj, K. A and Nor, Carolina and Peacock, John and Qin, Lei and Reimand, Juri and Rolider, Adi and Thompson, Yuan Y and Wu, Xiaochong and Pugh, Trevor and Ally, Adrian and Bilenky, Mikhail and Butterfield, Yaron S. N and Carlsen, Rebecca and Cheng, Young and Chuah, Eric and Corbett, Richard D and Dhalla, Noreen and He, An and Lee, Darlene and Li, Haiyan I and Long, William and Mayo, Michael and Plettner, Patrick and Qian, Jenny Q and Schein, Jacqueline E and Tam, Angela and Wong, Tina and Birol, Inanc and Zhao, Yongjun and Faria, Claudia C and Pimentel, José and Nunes, Sofia and Shalaby, Tarek and Grotzer, Michael and Pollack, Ian F and Hamilton, Ronald L and Li, Xiao-Nan and Bendel, Anne E and Fults, Daniel W and Walter, Andrew W and Kumabe, Toshihiro and Tominaga, Teiji and Collins, V. Peter and Cho, Yoon-Jae and Hoffman, Caitlin and Lyden, David and Wisoff, Jeffrey H and Garvin, James H and Stearns, Duncan S and Massimi, Luca and Schüller, Ulrich and Sterba, Jaroslav and Zitterbart, Karel and Puget, Stephanie and Ayrault, Olivier and Dunn, Sandra E and Tirapelli, Daniela P. C and Carlotti, Carlos G and Wheeler, Helen and Hallahan, Andrew R and Ingram, Wendy and MacDonald, Tobey J and Olson, Jeffrey J and Van Meir, Erwin G and Lee, Ji-Yeoun and Wang, Kyu-Chang and ...
Nature (London), ISSN 1476-4687, 2016, Volume 529, Issue 7586, pp. 351 - 357
... (microneurosurgical tumour resection followed by multi-fractionated, image-guided radiotherapy). Genetic events in recurrent murine medulloblastoma exhibit a very poor overlap with those in matched murine diagnostic samples (<5... 
HETEROGENEITY | CANCER EVOLUTION | CELLS | IMPACT | MULTIDISCIPLINARY SCIENCES | SUBGROUP MEDULLOBLASTOMA | DYNAMICS | MUTATIONS | SEQUENCING DATA | LYMPHOBLASTIC-LEUKEMIA | GENOME | Clone Cells - drug effects | Humans | Male | Medulloblastoma - therapy | Radiotherapy, Image-Guided | Selection, Genetic - drug effects | Drosophila melanogaster - genetics | Neoplasm Recurrence, Local - pathology | Medulloblastoma - radiotherapy | DNA Mutational Analysis | Medulloblastoma - pathology | Female | Medulloblastoma - surgery | Cerebellar Neoplasms - pathology | Medulloblastoma - genetics | Molecular Targeted Therapy - methods | Disease Models, Animal | Signal Transduction | Neoplasm Recurrence, Local - therapy | Drosophila melanogaster - cytology | Cerebellar Neoplasms - genetics | Clone Cells - metabolism | Genome, Human - genetics | Xenograft Model Antitumor Assays | Animals | Clone Cells - pathology | Craniospinal Irradiation | Neoplasm Recurrence, Local - genetics | Mice | Cerebellar Neoplasms - therapy | Cerebellar Neoplasms - surgery | Cerebellar Neoplasms - radiotherapy | Clonal selection theory | Care and treatment | Medulloblastoma | Oncology, Experimental | Genetic aspects | Research | Cancer | Genes | Cloning | Clinical trials | Cytotoxicity | Genomes | Radiation therapy | Metastasis | Cancer therapies | Rodents | Medical prognosis | Mutation | Tumors | Index Medicus
Journal Article
JNCI : Journal of the National Cancer Institute, ISSN 1460-2105, 2015, Volume 108, Issue 5, p. djv377
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2013, Volume 343, Issue 6167, pp. 189 - 193
Tumor recurrence is a leading cause of cancer mortality. Therapies for recurrent disease may fail, at least in part, because the genomic alterations driving the growth of recurrences are distinct from those in the initial tumor... 
Geography | Glioma | REPORTS | Medical genetics | Evolution | Evolutionary genetics | Genomes | Genetic mutation | Genetic heterogeneity | Cancer | Tumors | RETINOBLASTOMA | IDH1 MUTATIONS | MULTIDISCIPLINARY SCIENCES | INTRATUMOR HETEROGENEITY | GROWTH | CLONAL EVOLUTION | MSH6 MUTATIONS | IDENTIFICATION | HUMAN CANCER | HUMAN-MALIGNANT GLIOMAS | TEMOZOLOMIDE | Dacarbazine - adverse effects | Dacarbazine - therapeutic use | Humans | Brain Neoplasms - pathology | Neoplasm Recurrence, Local - drug therapy | X-linked Nuclear Protein | Mutagenesis - drug effects | Proto-Oncogene Proteins c-akt - genetics | Tumor Suppressor Protein p53 - genetics | Glioma - genetics | Neoplasm Grading | TOR Serine-Threonine Kinases - genetics | DNA Mutational Analysis | Glioma - pathology | Dacarbazine - analogs & derivatives | Nuclear Proteins - genetics | DNA Helicases - genetics | Brain Neoplasms - genetics | Transcription Factors - genetics | Brain Neoplasms - drug therapy | Antineoplastic Agents, Alkylating - therapeutic use | Brain - drug effects | Proto-Oncogene Proteins B-raf - genetics | Neoplasm Recurrence, Local - chemically induced | Brain - pathology | Neoplasm Recurrence, Local - genetics | Antineoplastic Agents, Alkylating - adverse effects | Glioma - drug therapy | Care and treatment | Gene mutations | Gliomas | Physiological aspects | Genetic aspects | Research | Methods | Studies | Brain surgery | Mutagenesis | Brain cancer | Clinical outcomes | Index Medicus
Journal Article
Journal Article
Clinical cancer research, ISSN 1557-3265, 2018, Volume 24, Issue 15, pp. 3593 - 3601
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 07/2017, Volume 23, Issue 14, pp. 3769 - 3780
Journal Article
Cancer Letters, ISSN 0304-3835, 2016, Volume 375, Issue 1, pp. 47 - 50
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2013, Volume 110, Issue 43, pp. 17426 - 17431
The telomerase reverse transcriptase (TERT) promoter, an important element of telomerase expression, has emerged as a target of cancer-specific mutations.... 
Relapse | Urinary bladder neoplasms | Carcinoma | Urinary bladder | Alleles | Cell lines | Genetic mutation | Binding sites | Tumors | Cancer | Cancer genetics | Transcription factors | Noncoding mutations | TERT mutations | Reporter assays | noncoding mutations | WILD-TYPE P53 | CELLS | transcription factors | MULTIDISCIPLINARY SCIENCES | TUMOR | RISK | BREAST | reporter assays | cancer genetics | GENE-EXPRESSION | TRANSCRIPTIONAL REGULATION | EPIDEMIOLOGY | TELOMERE LENGTH | Luciferases - metabolism | Prognosis | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Molecular Sequence Data | Male | Promoter Regions, Genetic - genetics | Luciferases - genetics | Telomerase - genetics | Urinary Bladder Neoplasms - genetics | Base Sequence | DNA Mutational Analysis - statistics & numerical data | Urinary Bladder Neoplasms - pathology | Aged, 80 and over | Female | Carcinoma, Transitional Cell - genetics | Kaplan-Meier Estimate | Neoplasm Recurrence, Local | Proportional Hazards Models | Carcinoma, Transitional Cell - pathology | Cell Line, Tumor | Biomarkers, Tumor - genetics | Polymorphism, Single Nucleotide | Mutation | Promoters (Genetics) | Gene mutations | Patient outcomes | Physiological aspects | Genetic aspects | Research | Bladder cancer | Genetic polymorphisms | Biological Sciences | Cancer and Oncology | Cancer och onkologi
Journal Article
International journal of cancer, ISSN 0020-7136, 2014, Volume 135, Issue 3, pp. 598 - 610
Thyroid cancer is a heterogeneous disease with several subtypes characterized by cytological, histological and genetic alterations, but the involvement of epigenetics is not well understood... 
BRAF | well‐differentiated thyroid cancer | prognostic markers | RAS | methylation | Prognostic markers | Methylation | Well-differentiated thyroid cancer | PROMOTER METHYLATION | OVERACTIVATION | WT1 GENE-EXPRESSION | BRAF V600E MUTATION | CHROMOSOMAL INSTABILITY | ABERRANT METHYLATION | ONCOLOGY | well-differentiated thyroid cancer | POOR-PROGNOSIS | SENESCENCE | PAPILLARY | CARCINOMA | ras Proteins - genetics | Carcinoma, Papillary - genetics | Prognosis | Adenoma - genetics | Adenoma - mortality | DNA Fingerprinting | Epigenesis, Genetic | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | Neoplasm Recurrence, Local - mortality | Promoter Regions, Genetic - genetics | Neoplasm Recurrence, Local - pathology | Young Adult | DNA Methylation | Aged, 80 and over | Adult | Female | WT1 Proteins - genetics | Thyroid Neoplasms - mortality | Survival Rate | Mutation - genetics | Carcinoma, Papillary - pathology | Carcinoma, Papillary - mortality | Thyroid Neoplasms - genetics | Proto-Oncogene Proteins B-raf - genetics | Adolescent | Adenoma - pathology | Neoplasm Recurrence, Local - genetics | Aged | Biomarkers, Tumor - genetics | Neoplasm Staging | Thyroid Gland - metabolism | Thyroid Neoplasms - pathology | Relapse | Thyroid cancer | DNA | Genetic aspects | Diseases | Cancer | DNA methylation | Epigenetics | Genomes | Mutation | Deoxyribonucleic acid--DNA | Tumors | Index Medicus
Journal Article