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Current Pharmaceutical Design, ISSN 1381-6128, 01/2007, Volume 13, Issue 3, pp. 333 - 346
The matrix metalloproteinase family of enzymes has been a pharmaceutical target for over 20 years. In that time, many drugs have been developed but none have... 
Cardiovascular disease | Inflammation | Topical | Acute therapy | Remodeling | SMOKE-INDUCED EMPHYSEMA | cardiovascular disease | remodeling | topical | ABDOMINAL AORTIC-ANEURYSMS | HEART-FAILURE | BLOOD-BRAIN-BARRIER | RESPIRATORY-DISTRESS-SYNDROME | MUSCLE-CELL-MIGRATION | OBSTRUCTIVE PULMONARY-DISEASE | TISSUE-PLASMINOGEN-ACTIVATOR | inflammation | acute therapy | MACROPHAGE ELASTASE MMP-12 | PHARMACOLOGY & PHARMACY | PREVENTS CARDIAC RUPTURE | Hypertrophy, Left Ventricular - enzymology | Humans | Eye Diseases - enzymology | Protease Inhibitors - pharmacology | Atherosclerosis - enzymology | Drug Design | Hypertrophy, Left Ventricular - drug therapy | Protease Inhibitors - therapeutic use | Vascular Diseases - drug therapy | Extracellular Matrix Proteins - metabolism | Myocardial Infarction - enzymology | Atherosclerosis - drug therapy | Heart Rupture, Post-Infarction - enzymology | Neoplasms - enzymology | Skin Diseases - drug therapy | Stroke - drug therapy | Respiratory Distress Syndrome, Adult - drug therapy | Vascular Diseases - enzymology | Arthritis - enzymology | Neoplasms - drug therapy | Pulmonary Disease, Chronic Obstructive - enzymology | Stroke - enzymology | Animals | Myocardial Infarction - drug therapy | Eye Diseases - drug therapy | Arthritis - drug therapy | Matrix Metalloproteinase Inhibitors | Matrix Metalloproteinases - metabolism | Heart Rupture, Post-Infarction - drug therapy | Respiratory Distress Syndrome, Adult - enzymology | Skin Diseases - enzymology | Pulmonary Disease, Chronic Obstructive - drug therapy
Journal Article
World Journal of Gastroenterology, ISSN 1007-9327, 11/2013, Volume 19, Issue 41, pp. 6969 - 6978
The 148 Isoleucine to Methionine protein variant (I148M) of patatin-like phospholipase domain-containing 3 (PNPLA3), a protein is expressed in the liver and is... 
Liver disease | Patatin-like phospholipase domain-containing 3 | Chronic hepatitis C virus hepatitis | Genetics | Hepatocellular carcinoma | Nonalcoholic fatty liver disease | Single nucleotide polymorphism | Fibrogenesis | Alcoholic liver disease | Steatosis | CHRONIC HEPATITIS-C | NONALCOHOLIC STEATOHEPATITIS | GREATER-THAN-G | B-VIRUS INFECTION | HEPATOCELLULAR-CARCINOMA | INSULIN-RESISTANCE | FATTY LIVER | DOMAIN-CONTAINING 3 | GENETIC VARIANT | GASTROENTEROLOGY & HEPATOLOGY | GENOME-WIDE ASSOCIATION | Cholangitis, Sclerosing - enzymology | Hepatitis C, Chronic - pathology | Fatty Liver - pathology | Humans | Cholangitis, Sclerosing - genetics | Fatty Liver - complications | Hepatitis B, Chronic - enzymology | Hepatitis C, Chronic - complications | Liver Cirrhosis - enzymology | Hemochromatosis - pathology | Fatty Liver, Alcoholic - genetics | Hepatitis B, Chronic - genetics | Liver Cirrhosis, Alcoholic - enzymology | Hepatitis C, Chronic - enzymology | Fatty Liver - enzymology | Non-alcoholic Fatty Liver Disease | Liver Neoplasms - pathology | Fatty Liver, Alcoholic - pathology | Liver Neoplasms - enzymology | Fatty Liver, Alcoholic - enzymology | Hepatitis B, Chronic - pathology | Liver Cirrhosis - genetics | Hemochromatosis - genetics | Fatty Liver - genetics | Genetic Predisposition to Disease | Liver Neoplasms - genetics | Liver Cirrhosis, Alcoholic - pathology | Membrane Proteins - genetics | Risk Factors | Hemochromatosis - enzymology | Disease Progression | Polymorphism, Genetic | Cholangitis, Sclerosing - pathology | Fatty Liver, Alcoholic - complications | Liver Cirrhosis, Alcoholic - genetics | Phenotype | Liver Cirrhosis - pathology | Carcinoma, Hepatocellular | Hepatitis C, Chronic - genetics | Lipase - genetics | Review | Gastroenterologi | Hepatocellular | Gastroenterology and Hepatology
Journal Article
Cancer Research, ISSN 0008-5472, 10/2009, Volume 69, Issue 20, pp. 8208 - 8215
Journal Article
Cancer prevention research (Philadelphia, Pa.), ISSN 1940-6215, 2011, Volume 4, Issue 7, pp. 1021 - 1029
Journal Article
Annual review of physiology, ISSN 1545-1585, 2011, Volume 73, Issue 1, pp. 479 - 501
Journal Article
Genes and Development, ISSN 0890-9369, 06/2006, Volume 20, Issue 12, pp. 1569 - 1574
The tumor suppressor PTEN is frequently inactivated in human cancers. A major downstream effector of PTEN is Akt, which is hyperactivated via PTEN... 
Intestinal polyps | PIN | Endometrium carcinoma | Thyroid and adrenal tumors | Cancer therapy | AKT/PKB | GENETICALLY-ENGINEERED MICE | PTEN | DEVELOPMENTAL BIOLOGY | PHOSPHOINOSITIDE 3-KINASE | CANCER | CELL BIOLOGY | cancer therapy | PATHWAY | thyroid and adrenal tumors | NEOPLASIA | RELEVANCE | intestinal polyps | MUTATION | GENETICS & HEREDITY | endometrium carcinoma | Prostatic Intraepithelial Neoplasia - pathology | Thyroid Neoplasms - enzymology | Proto-Oncogene Proteins c-akt - deficiency | Male | Intestinal Polyps - enzymology | Proto-Oncogene Proteins c-akt - genetics | Adrenal Gland Neoplasms - enzymology | Prostatic Neoplasms - genetics | Endometrial Neoplasms - genetics | Neoplasms - genetics | Female | Pseudolymphoma - genetics | Pseudolymphoma - enzymology | Adrenal Gland Neoplasms - pathology | PTEN Phosphohydrolase - genetics | Prostatic Neoplasms - pathology | Endometrial Neoplasms - enzymology | Neoplasms - enzymology | PTEN Phosphohydrolase - metabolism | Pseudolymphoma - pathology | Thyroid Neoplasms - genetics | Animals | Prostatic Intraepithelial Neoplasia - enzymology | Intestinal Polyps - pathology | Prostatic Neoplasms - enzymology | Endometrial Neoplasms - pathology | Heterozygote | Mice | Prostatic Intraepithelial Neoplasia - genetics | Neoplasms - pathology | Adrenal Gland Neoplasms - genetics | Thyroid Neoplasms - pathology | Research Communication
Journal Article
Journal Article
Cell stem cell, ISSN 1934-5909, 2012, Volume 11, Issue 3, pp. 401 - 414
The integrity of the epidermis and mucosal epithelia is highly dependent on resident self-renewing stem cells, which makes them vulnerable to physical and... 
MAMMALIAN TARGET | CANCER PATIENTS | RAPAMYCIN | HEAD | AGING PHENOTYPES | MANGANESE SUPEROXIDE-DISMUTASE | STRESS-RESPONSE | TUMOR | NECK | SKIN | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Cell Death - radiation effects | TOR Serine-Threonine Kinases - metabolism | Keratinocytes - radiation effects | Carcinoma, Squamous Cell - pathology | Epithelial Cells - drug effects | Humans | Cellular Senescence - drug effects | Cell Compartmentation - radiation effects | Mucositis - prevention & control | Mouth Mucosa - drug effects | TOR Serine-Threonine Kinases - antagonists & inhibitors | Mouth Mucosa - radiation effects | Mucositis - pathology | Stem Cells - enzymology | Mucositis - enzymology | Cellular Senescence - radiation effects | Cytoprotection - drug effects | Clone Cells | Oxidative Stress - radiation effects | Cell Death - drug effects | Head and Neck Neoplasms - enzymology | Mouth Mucosa - pathology | Keratinocytes - enzymology | Superoxide Dismutase - metabolism | Radiation, Ionizing | Carcinoma, Squamous Cell - enzymology | Epithelial Cells - radiation effects | Cells, Cultured | Stem Cells - radiation effects | Epithelial Cells - pathology | Radiation Injuries - enzymology | Sirolimus - pharmacology | Head and Neck Neoplasms - pathology | Keratinocytes - pathology | Animals | Keratinocytes - drug effects | Radiation Injuries - prevention & control | Epithelial Cells - enzymology | Cell Compartmentation - drug effects | Stem Cells - drug effects | Stem Cells - pathology | Radiation Injuries - pathology | Cell Proliferation - drug effects | Mice | Oxidative Stress - drug effects | Cytoprotection - radiation effects | Cell Proliferation - radiation effects
Journal Article
Biochemical journal, ISSN 1470-8728, 2004, Volume 381, Issue 3, pp. 761 - 767
An important regulator involved in oxygen-dependent gene expression is the transcription factor HIF (hypoxia-inducible factor), which is composed of an... 
Post-translational modification | Hypoxia-inducible factor | Protein degradation | Oxygen sensing | Prolyl hydroxylation | Von-Hippel-Lindau protein | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | ALPHA | hypoxia-inducible factor | oxygen sensing | post-translational modification | von-Hippel-Lindau protein | HYDROXYLASES | DESTRUCTION | FACTOR-1-ALPHA | GENES | HIF-1-ALPHA | VHL | protein degradation | PROLYL | prolyl hydroxylation | Humans | Half-Life | Kidney Neoplasms - metabolism | Ubiquitin-Protein Ligases - physiology | Bone Neoplasms - pathology | Hypoxia-Inducible Factor 1, alpha Subunit | RNA, Messenger - biosynthesis | Liver Neoplasms - pathology | Liver Neoplasms - enzymology | Kidney Tubules, Proximal - cytology | DNA-Binding Proteins - physiology | Hypoxia - enzymology | Hydroxylation | Hypoxia-Inducible Factor 1 | Immediate-Early Proteins - biosynthesis | Carcinoma, Hepatocellular - enzymology | Tumor Suppressor Proteins - physiology | Epithelial Cells - enzymology | Liver Neoplasms - metabolism | Cell Line, Tumor | Von Hippel-Lindau Tumor Suppressor Protein | Enzyme Induction - physiology | Osteosarcoma - pathology | Carcinoma, Hepatocellular - metabolism | Epithelial Cells - metabolism | Gene Expression Regulation, Enzymologic - physiology | Oxygen - metabolism | Procollagen-Proline Dioxygenase - biosynthesis | Bone Neoplasms - metabolism | Procollagen-Proline Dioxygenase - metabolism | DNA-Binding Proteins - metabolism | Kidney Tubules, Proximal - enzymology | Gene Expression Regulation, Neoplastic - physiology | Osteosarcoma - metabolism | Cell Line | Transcription Factors - physiology | Bone Neoplasms - enzymology | Osteosarcoma - enzymology | Adenocarcinoma, Clear Cell - metabolism | Nuclear Proteins - metabolism | Hypoxia-Inducible Factor-Proline Dioxygenases | Dioxygenases | Transcription Factors - metabolism | Kidney Neoplasms - enzymology | Carcinoma, Hepatocellular - pathology | Kidney Tubules, Proximal - metabolism | Kidney Neoplasms - pathology | Adenocarcinoma, Clear Cell - pathology | Nuclear Proteins - physiology | Adenocarcinoma, Clear Cell - enzymology | DNA-Binding Proteins - biosynthesis | ODD, oxygen-dependent degradation domain | aRP, acidic ribosomal protein | RNAi, RNA interference | pVHL, von-Hippel-Lindau protein | EGLN, egg-laying deficient nine-like protein | HIF, hypoxia-inducible factor | siRNA, small interfering RNA | IVTT, in vitro transcription | PHD, prolyl hydroxylase domain containing protein | translation | RT, reverse transcriptase | RPTEC, human renal proximal tubular epithelial cells
Journal Article
Current Pharmaceutical Design, ISSN 1381-6128, 2013, Volume 19, Issue 14, pp. 2574 - 2593
Journal Article
Cancer cell, ISSN 1535-6108, 2008, Volume 13, Issue 3, pp. 193 - 205
Tumor vasculature is derived from sprouting of local vessels (angiogenesis) and bone marrow (BM)-derived circulating cells (vasculogenesis). By using a model... 
CELLCYCLE | BREAST-CANCER | ENDOTHELIAL PROGENITOR CELLS | RECTAL-CANCER | MAMMARY-TUMORS | ONCOLOGY | HEMATOPOIETIC STEM-CELLS | IN-VIVO | GROWTH-FACTOR | PRECURSOR CELLS | CANCER-THERAPY | RADIATION-THERAPY | CELL BIOLOGY | Myeloid Cells - enzymology | Bone Marrow Cells - enzymology | Neoplasms, Experimental - enzymology | Antineoplastic Agents - therapeutic use | Monocytes - immunology | Subcutaneous Tissue - surgery | Neovascularization, Pathologic - pathology | Neoplasms, Experimental - pathology | Neovascularization, Pathologic - enzymology | Protease Inhibitors - pharmacology | Matrix Metalloproteinase 9 - metabolism | Monocytes - transplantation | Melanoma, Experimental | Stem Cells - enzymology | Time Factors | Matrix Metalloproteinase 9 - genetics | Myeloid Cells - immunology | Bone Marrow Cells - immunology | Bone Marrow Transplantation | Diphosphonates - therapeutic use | Bone Marrow Cells - drug effects | Myeloid Cells - drug effects | Neovascularization, Pathologic - prevention & control | Antineoplastic Agents - pharmacology | Imidazoles - therapeutic use | Protease Inhibitors - therapeutic use | Signal Transduction | Mice, Inbred C57BL | Imidazoles - pharmacology | Matrix Metalloproteinase 9 - deficiency | Neoplasms, Experimental - radiotherapy | Mice, Inbred C3H | Mice, Knockout | Monocytes - drug effects | Monocytes - enzymology | Subcutaneous Tissue - radiation effects | Animals | Subcutaneous Tissue - blood supply | Matrix Metalloproteinase Inhibitors | Myeloid Cells - transplantation | Mice | CD11b Antigen - metabolism | Endothelial Cells - enzymology | Neoplasms, Experimental - drug therapy | Diphosphonates - pharmacology | Neoplasms, Experimental - blood supply | Neovascularization | Nuclear radiation | Analysis | Tumors
Journal Article