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Hepatology (Baltimore, Md.), ISSN 0270-9139, 2012, Volume 56, Issue 6, pp. 2255 - 2267
...) in diethylnitrosamine (DEN)‐induced rat hepatocarcinogenesis and cirrhotic livers of HCC patients. Using several experimental approaches, including 2... 
PROGENITOR CELLS | STEM-CELLS | HEPATOCELLULAR-CARCINOMA | HEPATOCYTES | TGF-BETA | EPIGENETIC REGULATION | PTEN | SELF-RENEWAL | TUMORIGENICITY | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | Rats, Wistar | TOR Serine-Threonine Kinases - metabolism | Humans | Glycoproteins - metabolism | Liver Neoplasms, Experimental - chemically induced | Male | MicroRNAs - metabolism | Proto-Oncogene Proteins c-akt - genetics | Antigens, CD - metabolism | Epithelial Cell Adhesion Molecule | Pluripotent Stem Cells - pathology | Liver Neoplasms, Experimental - metabolism | Peptides - metabolism | Neoplastic Stem Cells - metabolism | Diethylnitrosamine | Liver Cirrhosis - metabolism | Antigens, Neoplasm - metabolism | Biomarkers, Tumor - metabolism | Antigens, Differentiation - metabolism | Liver Neoplasms, Experimental - pathology | Proto-Oncogene Proteins c-akt - metabolism | STAT3 Transcription Factor - metabolism | Liver - metabolism | Mice, Inbred C57BL | PTEN Phosphohydrolase - metabolism | Rats | Mice, SCID | AC133 Antigen | Cell Adhesion Molecules - metabolism | Cell Transformation, Neoplastic - metabolism | Pluripotent Stem Cells - metabolism | Thy-1 Antigens - metabolism | Transforming Growth Factor beta - pharmacology | Animals | Pluripotent Stem Cells - drug effects | Liver Cirrhosis - pathology | Mice, Inbred NOD | Mice | Cell Transformation, Neoplastic - pathology | Transforming Growth Factor beta - metabolism | Proteins | Liver cancer | Liver cirrhosis | Hepatology
Journal Article
Cell (Cambridge), ISSN 0092-8674, 2007, Volume 130, Issue 6, pp. 1120 - 1133
Coordination of cell proliferation and cell death is essential to attain proper organ size during development and for maintaining tissue homeostasis throughout... 
DEVBIO | SIGNALING | YES-ASSOCIATED PROTEIN | WW | APOPTOSIS | DOMAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | TUMOR-SUPPRESSOR | YAP | MICE | CELL | CANCER | CELL BIOLOGY | Protein Kinases - metabolism | Phosphorylation | Cell Proliferation | Large Neutral Amino Acid-Transporter 1 - metabolism | Humans | Liver Neoplasms, Experimental - chemically induced | Homeostasis | Cytoplasm - metabolism | Drosophila Proteins - metabolism | Doxorubicin | Drosophila - enzymology | Liver Neoplasms, Experimental - metabolism | Cell Nucleus - metabolism | Transfection | Trans-Activators - genetics | Active Transport, Cell Nucleus | Liver Neoplasms, Experimental - pathology | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Drosophila - genetics | Cell Line | Mammals - metabolism | Mammals - growth & development | Signal Transduction | Mice, Inbred C57BL | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Intracellular Signaling Peptides and Proteins | Organ Size | Drosophila - cytology | Mice, Transgenic | Nuclear Proteins - metabolism | Transcription Factors - genetics | Serine - metabolism | Transcription Factors - metabolism | Animals | Liver Neoplasms, Experimental - enzymology | Trans-Activators - metabolism | Drosophila - growth & development | Mice | Drosophila - metabolism | Drosophila Proteins - genetics | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Apoptosis | Drosophila | Knowledge-based systems
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2012, Volume 122, Issue 8, pp. 2884 - 2897
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 01/2008, Volume 118, Issue 1, pp. 79 - 88
Despite great interest in cancer chemoprevention, effective agents are few. Here we show that chloroquine, a drug that activates the stress-responsive Atm-p53... 
MEDICINE, RESEARCH & EXPERIMENTAL | BCL-X-L | SIGNALING PATHWAYS | INDUCED APOPTOSIS | PHOSPHORYLATION | ATM | AUTOPHAGY | CYTOCHROME-C RELEASE | MYC-INDUCED LYMPHOMAGENESIS | TRANSGENIC MICE | P53 | Apoptosis - drug effects | Humans | Apoptosis - genetics | Male | Autophagy - drug effects | Burkitt Lymphoma - pathology | Neoplasms, Experimental - pathology | Chloroquine - pharmacology | Cell Transformation, Neoplastic - genetics | Autophagy - genetics | B-Lymphocytes - pathology | B-Lymphocytes - metabolism | Protein-Serine-Threonine Kinases - metabolism | Fibroblasts - metabolism | Tumor Suppressor Proteins - metabolism | Embryo, Mammalian - pathology | Cell Cycle Proteins - metabolism | Neoplasms, Experimental - prevention & control | bcl-2-Associated X Protein - metabolism | Ataxia Telangiectasia Mutated Proteins | Fibroblasts - pathology | Ataxia Telangiectasia - pathology | Ataxia Telangiectasia - genetics | Mice | Proto-Oncogene Proteins c-myc - genetics | Neoplasms, Experimental - metabolism | bcl-2 Homologous Antagonist-Killer Protein - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Embryo, Mammalian - metabolism | Tumor Suppressor Protein p53 - genetics | DNA-Binding Proteins - metabolism | Caspases - metabolism | Lysosomes - metabolism | Burkitt Lymphoma - prevention & control | Mice, Mutant Strains | Tumor Suppressor Proteins - genetics | Neoplasms, Experimental - genetics | Burkitt Lymphoma - genetics | Cell Cycle Proteins - genetics | Female | Lysosomes - pathology | Antirheumatic Agents - pharmacology | bcl-2-Associated X Protein - genetics | Antirheumatic Agents - therapeutic use | Ataxia Telangiectasia - prevention & control | Caspases - genetics | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Tumor Suppressor Protein p53 - metabolism | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Burkitt Lymphoma - metabolism | Chloroquine - therapeutic use | Ataxia Telangiectasia - metabolism | DNA-Binding Proteins - genetics | Cell Transformation, Neoplastic - metabolism | Proto-Oncogene Proteins c-myc - metabolism | Animals | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Cell Transformation, Neoplastic - pathology | Prevention | Chloroquine | Lysosomes | Dosage and administration | Research | Drug therapy | Health aspects | Cancer
Journal Article
PloS one, ISSN 1932-6203, 2010, Volume 5, Issue 11, p. e14062
Background: The cancer stem cell theory hypothesizes that cancers are perpetuated by cancer stem cells (CSC) or tumor initiating cells (TIC) possessing... 
COLON-CANCER | INITIATING CELLS | POPULATION | MARKER | MULTIDISCIPLINARY SCIENCES | TUMOR | HYALURONAN | CHEMORESISTANCE | FLOW-CYTOMETRY | IDENTIFICATION | LINES | Immunohistochemistry | Humans | Lung Neoplasms - metabolism | Middle Aged | Glycoproteins - metabolism | Peptides - genetics | Immunoblotting | Lung Neoplasms - pathology | Male | Transplantation, Heterologous | Gene Expression Profiling | Antigens, CD - genetics | Antigens, CD - metabolism | Neoplasms, Experimental - pathology | Octamer Transcription Factor-3 - genetics | Flow Cytometry | Peptides - metabolism | Neoplastic Stem Cells - metabolism | Hyaluronan Receptors - metabolism | Neoplasms, Experimental - genetics | Neoplastic Stem Cells - pathology | Female | Nuclear Proteins - genetics | Repressor Proteins - metabolism | Carcinoma, Non-Small-Cell Lung - pathology | Glycoproteins - genetics | Lung Neoplasms - genetics | Proto-Oncogene Proteins - metabolism | Carcinoma, Non-Small-Cell Lung - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | AC133 Antigen | Hyaluronan Receptors - genetics | Animals | Polycomb Repressive Complex 1 | Mice, Nude | Octamer Transcription Factor-3 - metabolism | Cell Line, Tumor | Aged | Mice | Neoplasms, Experimental - metabolism | Squamous cell carcinoma | Lung cancer, Non-small cell | Analysis | Stem cells | Flow cytometry | Biotechnology | Laboratories | Heart surgery | Oct-4 protein | Lung cancer | Colorectal cancer | Stem cell transplantation | Proteins | Allografts | Epidermal growth factor | CD44 antigen | Xenografts | Cell cycle | CD34 antigen | Subpopulations | Cell survival | Tumor cells | Non-small cell lung carcinoma | Tumor cell lines | Cisplatin | Studies | Polymerase chain reaction | Pathology | Cytometry | Properties (attributes) | Medical prognosis | Biomarkers | In vivo methods and tests | Pluripotency | Tumors | Apoptosis | Cancer
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2012, Volume 122, Issue 8, pp. 2911 - 2915
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 2014, Volume 211, Issue 7, pp. 1379 - 1391
Journal Article
Nature communications, ISSN 2041-1723, 2017, Volume 8, Issue 1, pp. 2256 - 13
...ARTICLE TNFα blockade overcomes resistance to anti-PD-1 in experimental melanoma Florie Bertrand1,2, Anne Montfort1,2, Elie Marcheteau1,2,3,4, Caroline... 
UNTREATED MELANOMA | REGULATORY-CELLS | LUNG-CANCER | TUMOR-NECROSIS-FACTOR | PD-1 BLOCKADE | MULTIDISCIPLINARY SCIENCES | ADAPTIVE RESISTANCE | T-CELL DYSFUNCTION | ANTITUMOR IMMUNITY | TIM-3 | UP-REGULATION | Tumor Necrosis Factor-alpha - metabolism | Hepatitis A Virus Cellular Receptor 2 - drug effects | Humans | Melanoma, Experimental - drug therapy | Hepatitis A Virus Cellular Receptor 2 - metabolism | Antibodies, Monoclonal - therapeutic use | Melanoma, Experimental - metabolism | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Melanoma - genetics | Ipilimumab - therapeutic use | Female | Mammary Neoplasms, Animal - genetics | Melanoma - metabolism | Lymphocytes, Tumor-Infiltrating - drug effects | Receptors, Tumor Necrosis Factor, Type I - antagonists & inhibitors | Antineoplastic Agents, Immunological - pharmacology | Skin Neoplasms - metabolism | B7-H1 Antigen - drug effects | Drug Synergism | B7-H1 Antigen - metabolism | Animals | Melanoma, Experimental - genetics | Antineoplastic Agents, Immunological - therapeutic use | CD8-Positive T-Lymphocytes - drug effects | Mammary Neoplasms, Animal - metabolism | Skin Neoplasms - genetics | Cell Line, Tumor | Mice | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Drug Resistance, Neoplasm - drug effects | Tumor necrosis factor receptors | Immunoglobulins | Immune response | PD-1 protein | CD8 antigen | Melanoma | Antibodies | Lymphocytes T | Tumor necrosis factor-α | Patients | Signaling | Lymphocytes | Cell death | PD-L1 protein | Tumor necrosis factor-TNF | Cancer | Apoptosis | Immune system
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 08/2012, Volume 122, Issue 8, pp. 2871 - 2883
miR-122, an abundant liver-specific microRNA (miRNA), regulates cholesterol metabolism and promotes hepatitis C virus (HCV) replication... 
MICRORNA BINDING | MEDICINE, RESEARCH & EXPERIMENTAL | HEPATOCELLULAR-CARCINOMA | LIPID-METABOLISM | IN-VIVO | GENE-EXPRESSION | MICE | STEATOHEPATITIS | DIFFERENTIATION | HEPATIC STEATOSIS | CANCER | MicroRNAs - therapeutic use | Liver - pathology | Cell Proliferation | MicroRNAs - antagonists & inhibitors | Fatty Liver - pathology | Humans | Cell Survival - genetics | MicroRNAs - metabolism | Liver Neoplasms - therapy | Monocytes - immunology | Genes, myc | Mice, 129 Strain | RNA, Neoplasm - metabolism | Liver Neoplasms, Experimental - metabolism | Liver - immunology | Base Sequence | Carcinoma, Hepatocellular - genetics | Lipids - blood | Monocytes - pathology | Lipid Metabolism - genetics | Liver Neoplasms, Experimental - genetics | 3' Untranslated Regions | Genes, Tumor Suppressor | Neutrophils - pathology | Fatty Liver - genetics | Gene Expression | Fatty Liver - metabolism | Liver Neoplasms - genetics | Liver - metabolism | Neutrophils - immunology | Liver Neoplasms, Experimental - etiology | Mice, Knockout | Animals | Liver Neoplasms - metabolism | RNA, Neoplasm - genetics | Carcinoma, Hepatocellular - therapy | Mice | MicroRNAs - genetics | Cytokines - biosynthesis | Carcinoma, Hepatocellular - metabolism | Fatty Liver - etiology | Liver diseases | MicroRNA | Anti-inflammatory drugs | Tumor necrosis factor | Physiological aspects | Hepatitis C virus | Cholesterol | Tumors
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2014, Volume 124, Issue 7, pp. 3093 - 3106
Dysregulation of epigenetic controls is associated with tumorigenesis in response to microenvironmental stimuli; however, the regulatory pathways involved in... 
EPITHELIAL-MESENCHYMAL TRANSITION | BREAST-CANCER | MEDICINE, RESEARCH & EXPERIMENTAL | DIVISIONS | NOTCH | MIR-205 | SLUG | ESTROGEN-RECEPTOR | GLAND | Cell Polarity | Transcription Factor HES-1 | Cell Proliferation | MicroRNAs - antagonists & inhibitors | Epigenesis, Genetic | Homeodomain Proteins - metabolism | Humans | Gene Expression Regulation, Neoplastic | Tumor Microenvironment | MicroRNAs - metabolism | Mammary Neoplasms, Experimental - metabolism | RNA, Neoplasm - metabolism | Mammary Neoplasms, Experimental - genetics | Breast Neoplasms - metabolism | Gene Knockdown Techniques | Intercellular Signaling Peptides and Proteins - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Neoplastic Stem Cells - metabolism | Kruppel-Like Transcription Factors - metabolism | Serrate-Jagged Proteins | Epithelial-Mesenchymal Transition | Mammary Neoplasms, Experimental - pathology | Neoplastic Stem Cells - pathology | Female | Membrane Proteins - metabolism | Jagged-1 Protein | Calcium-Binding Proteins - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Signal Transduction | Membrane Proteins - genetics | Carcinogenesis - genetics | Intercellular Signaling Peptides and Proteins - genetics | Receptor, Notch2 - metabolism | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Cell Line, Tumor | RNA, Neoplasm - genetics | Mice | MicroRNAs - genetics | Calcium-Binding Proteins - genetics | Zinc Finger E-box-Binding Homeobox 1 | MicroRNA | Oncology, Experimental | Stem cells | Genetic research | Genetic aspects | Research | Genetic regulation | Properties | Carcinogenesis | Cancer | Medical research | Breast cancer | Rodents
Journal Article