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1. Full Text Metformin for chemoprevention of metachronous colorectal adenoma or polyps in post-polypectomy patients without diabetes: a multicentre double-blind, placebo-controlled, randomised phase 3 trial
by Higurashi, Takuma, MD and Hosono, Kunihiro, MD and Takahashi, Hirokazu, MD and Komiya, Yasuhiko, MD and Umezawa, Shotaro, MD and Sakai, Eiji, MD and Uchiyama, Takashi, MD and Taniguchi, Leo, MD and Hata, Yasuo, MD and Uchiyama, Shiori, MD and Hattori, Akiko, MD and Nagase, Hajime, MD and Kessoku, Takaomi, MD and Arimoto, Jun, MD and Matsuhashi, Nobuyuki, MD and Inayama, Yoshiaki, MD and Yamanaka, Shoji, MD and Taguri, Masataka, PhD and Nakajima, Atsushi, Prof
Lancet Oncology, The, ISSN 1470-2045, 2016, Volume 17, Issue 4, pp. 475 - 483
Summary Background The prevalence of, and mortality from, colorectal cancer is increasing worldwide, and new strategies for prevention are needed to reduce the... 
Hematology, Oncology and Palliative Medicine | COLONOSCOPY | POPULATION | METAANALYSIS | ONCOLOGY | KINASE | GROWTH | CANCER-RISK | PREVENTION | COHORT | COLON | ABERRANT CRYPT FOCI | Double-Blind Method | Chemoprevention | Colonic Polyps - pathology | Humans | Japan | Middle Aged | Male | Metformin - adverse effects | Neoplasm Recurrence, Local - pathology | Colonoscopy | Colorectal Neoplasms - drug therapy | Adenoma - drug therapy | Adenoma - pathology | Aged, 80 and over | Colonic Polyps - drug therapy | Adult | Female | Aged | Metformin - administration & dosage | Colorectal Neoplasms - pathology | Neoplasms, Second Primary - drug therapy | Neoplasms, Second Primary - pathology | Prevention | Medical colleges | Mortality | Colorectal cancer | Clinical trials | Product development | Metformin | Adenoma | Diabetes therapy | Cancer | Medical research | Diabetics | Polyps (Pathology) | Analysis | Medicine, Experimental
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2. Full Text Current and emerging therapies in metastatic pancreatic cancer
by Manji, Gulam Abbas and Olive, Kenneth P and Saenger, Yvonne M and Oberstein, Paul
Clinical Cancer Research, ISSN 1078-0432, 04/2017, Volume 23, Issue 7, pp. 1670 - 1678
Targeted therapies and immunotherapy have changed the face of multiple solid malignancies, including metastatic melanoma and lung cancer, but no such therapies... 
PHASE-III TRIAL | ONCOLOGY | NAB-PACLITAXEL | IMMUNOTHERAPY | TUMOR-INFILTRATING MACROPHAGES | OPEN-LABEL | OXALIPLATIN | FOLINIC ACID | 1ST-LINE THERAPY | COMBINATION | GEMCITABINE | Adenocarcinoma - pathology | Humans | Clinical Trials as Topic | Adenocarcinoma - drug therapy | Carcinoma, Pancreatic Ductal - pathology | Carcinoma, Pancreatic Ductal - genetics | Carcinoma, Pancreatic Ductal - drug therapy | Neoplasm Metastasis | Tumor Microenvironment - genetics | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Immunotherapy | Adenocarcinoma - genetics | Neoplasms, Second Primary - genetics | Neoplasms, Second Primary - drug therapy | Neoplasms, Second Primary - pathology | Precision Medicine | Adenocarcinoma | Medical research | Lung cancer | Melanoma | Clinical trials | Stroma | Metastasis | Metastases | Chemotherapy | Immunosuppression | Pathways | Pancreatic cancer | Biomarkers | Bioindicators | Mutation | Cancer
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3. Full Text IMRT Reirradiation of Head and Neck Cancer—Disease Control and Morbidity Outcomes
by Sulman, Erik P., M.D., Ph.D and Schwartz, David L., M.D and Le, Thuy T and Ang, K. Kian, M.D., Ph.D and Morrison, William H., M.D and Rosenthal, David I., M.D and Ahamad, Anesa, M.D and Kies, Merril, M.D and Glisson, Bonnie, M.D and Weber, Randal, M.D., F.A.C.S and Garden, Adam S., M.D
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2009, Volume 73, Issue 2, pp. 399 - 409
Purpose Institutional and cooperative group experience has demonstrated the feasibility of reirradiation for head and neck cancer. Limited data are available... 
Radiology | Hematology, Oncology and Palliative Medicine | reirradiation | radiotherapy | IMRT | head and neck cancer | salvage | ONCOLOGY-GROUP | PROGNOSTIC-FACTORS | MODULATED RADIATION-THERAPY | NASOPHARYNGEAL CARCINOMA | ONCOLOGY | FULL-DOSE REIRRADIATION | UNRESECTABLE HEAD | RECURRENT HEAD | SQUAMOUS-CELL CARCINOMA | SALVAGE SURGERY | CISPLATIN PLUS FLUOROURACIL | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Neoplasm Recurrence, Local - radiotherapy | Humans | Middle Aged | Salvage Therapy | Neoplasm Recurrence, Local - drug therapy | Carcinoma, Squamous Cell - surgery | Male | Carcinoma, Squamous Cell - radiotherapy | Neoplasm Recurrence, Local - mortality | Neoplasms, Second Primary - radiotherapy | Neoplasms, Second Primary - surgery | Neoplasm Recurrence, Local - surgery | Young Adult | Aged, 80 and over | Adult | Female | Retrospective Studies | Radiotherapy, Intensity-Modulated - mortality | Radiotherapy Dosage | Radiotherapy, Intensity-Modulated - methods | Head and Neck Neoplasms - drug therapy | Radiation Dosage | Head and Neck Neoplasms - radiotherapy | Carcinoma, Squamous Cell - drug therapy | Analysis of Variance | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Aged | Head and Neck Neoplasms - mortality | Neoplasms, Second Primary - drug therapy | Head and Neck Neoplasms - surgery | Retreatment - adverse effects | Head and neck cancer | Diagnostic imaging | Radiotherapy | Radiation | Index Medicus | SURGERY | HEAD | PATIENTS | DISEASE INCIDENCE | DEATH | RADIATION DOSES | TOXICITY | CHEMOTHERAPY | IRRADIATION | CARCINOMAS | RADIOLOGY AND NUCLEAR MEDICINE | NECK | RADIOTHERAPY
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4. Full Text ACR appropriateness criteria® retreatment of recurrent head and neck cancer after prior definitive radiation: Expert panel on radiation oncology-head and neck cancer
by McDonald, Mark W and Lawson, Joshua and Garg, Madhur Kumar and Quon, Harry and Ridge, John A and Saba, Nabil and Salama, Joseph K and Smith, Richard V and Yeung, Anamaria Reyna and Yom, Sue S and Beitler, Jonathan J and Expert Panel on Radiation Oncology-Head and Neck Cancer
International Journal of Radiation Oncology Biology Physics, ISSN 0360-3016, 08/2011, Volume 80, Issue 5, pp. 1292 - 1298
Recurrent and second primary head-and-neck squamous cell carcinomas arising within or in close proximity to previously irradiated fields are a common clinical... 
Appropriateness criteria | Head-and-neck cancer | Reirradiation | Salvage therapy | Neoplasm Recurrence, Local - radiotherapy | Organs at Risk - radiation effects | Neoplasms, Squamous Cell - surgery | United States | Humans | Radiation Tolerance | Neoplasm Recurrence, Local - drug therapy | Male | Neoplasms, Second Primary - radiotherapy | Neoplasms, Second Primary - surgery | Neoplasm Recurrence, Local - surgery | Patient Selection | Neoplasm, Residual | Nasopharyngeal Neoplasms - radiotherapy | Squamous Cell Carcinoma of Head and Neck | Neoplasms, Squamous Cell - drug therapy | Neoplasms, Squamous Cell - radiotherapy | Female | Retreatment - standards | Nasopharyngeal Neoplasms - surgery | Cancer Care Facilities - standards | Carcinoma - drug therapy | Carcinoma - surgery | Head and Neck Neoplasms - drug therapy | Carcinoma - radiotherapy | Carcinoma, Squamous Cell | Head and Neck Neoplasms - radiotherapy | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Neoplasms, Second Primary - drug therapy | Head and Neck Neoplasms - surgery | Salvage Therapy - methods | Radiation Oncology - standards | Index Medicus
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5. Full Text MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation
by Figueroa, Maria E and Skrabanek, Lucy and Li, Yushan and Jiemjit, Anchalee and Fandy, Tamer E and Paietta, Elisabeth and Fernandez, Hugo and Tallman, Martin S and Greally, John M and Carraway, Hetty and Licht, Jonathan D and Gore, Steven D and Melnick, Ari
Blood, ISSN 0006-4971, 2009, Volume 114, Issue 16, pp. 3448 - 3458
Increasing evidence shows aberrant hypermethylation of genes occurring in and potentially contributing to pathogenesis of myeloid malignancies. Several of... 
LEUKEMIA GROUP-B | PROMOTER HYPERMETHYLATION | 5-AZA-2'-DEOXYCYTIDINE | HISTONE DEACETYLASE INHIBITION | POOR-PROGNOSIS | GENE-EXPRESSION | MYELOID-LEUKEMIA | HEMATOLOGY | MYELODYSPLASTIC SYNDROME | CANCER | CYTOSINE METHYLATION | Antigens, CD34 | Promoter Regions, Genetic | Myelodysplastic Syndromes - metabolism | DNA, Neoplasm - metabolism | Humans | Leukemia, Myeloid, Acute - metabolism | Histone Deacetylases - metabolism | Male | Wnt Proteins - metabolism | Enzyme Inhibitors - administration & dosage | Neoplasms, Second Primary - metabolism | MAP Kinase Signaling System - drug effects | Time Factors | Leukemia, Myeloid, Acute - drug therapy | Female | Histone Deacetylase Inhibitors | Neoplasms, Second Primary - drug therapy | DNA Methylation - drug effects | Bone Marrow Cells - metabolism | Myelodysplastic Syndromes - drug therapy | Azacitidine - administration & dosage | Myeloid Neoplasia
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6. Full Text Long-term outcome of concurrent chemotherapy and reirradiation for recurrent and second primary head-and-neck squamous cell carcinoma
by Salama, Joseph K and Vokes, Everett E and Chmura, Steven J and Milano, Michael T and Kao, Johnny and Stenson, Kirsten M and Witt, Mary Ellyn and Haraf, Daniel J
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2006, Volume 64, Issue 2, pp. 382 - 391
To define favorable pretreatment characteristics for overall survival (OS), progression-free survival (PFS), locoregional control, and freedom from distant... 
Reirradiation | Head-and-neck cancer | Chemoradiotherapy | reirradiation | POOR-PROGNOSIS HEAD | HYDROXYUREA | chemoradiotherapy | CONCOMITANT CHEMORADIOTHERAPY | CANCER | STIMULATING FACTOR SUPPORT | RADIATION-THERAPY | head-and-neck cancer | ONCOLOGY | FULL-DOSE REIRRADIATION | UNRESECTABLE HEAD | SALVAGE SURGERY | PHASE-I | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Neoplasm Recurrence, Local - radiotherapy | Prognosis | Humans | Middle Aged | Neoplasm Recurrence, Local - drug therapy | Carcinoma, Squamous Cell - surgery | Male | Mandibular Diseases - surgery | Carcinoma, Squamous Cell - radiotherapy | Neoplasms, Second Primary - radiotherapy | Neoplasms, Second Primary - surgery | Osteoradionecrosis - surgery | Neoplasm Recurrence, Local - surgery | Cisplatin - administration & dosage | Fluorouracil - administration & dosage | Treatment Failure | Aged, 80 and over | Adult | Camptothecin - administration & dosage | Female | Paclitaxel - administration & dosage | Camptothecin - analogs & derivatives | Radiotherapy Dosage | Deoxycytidine - administration & dosage | Head and Neck Neoplasms - drug therapy | Hydroxyurea - administration & dosage | Treatment Outcome | Combined Modality Therapy | Head and Neck Neoplasms - radiotherapy | Carcinoma, Squamous Cell - drug therapy | Aged | Neoplasms, Second Primary - drug therapy | Deoxycytidine - analogs & derivatives | Head and Neck Neoplasms - surgery | Medical colleges | Chemotherapy | Squamous cell carcinoma | Oncology, Experimental | Analysis | Radiation | Hydroxyurea | Metastasis | Research | Health aspects | Fluorouracil | Cancer
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7. Full Text Effect of first-line treatment on second primary malignancies and Richter's transformation in patients with CLL
by Maurer, C and Langerbeins, P and Bahlo, J and Cramer, P and Fink, A.M and Pflug, N and Engelke, A and Von Tresckow, J and Kovacs, G and Stilgenbauer, S and Wendtner, C.-M and Müller, L and Ritgen, M and Seiler, T and Fischer, K and Hallek, M and Eichhorst, B and German CLL Study Grp
Leukemia, ISSN 0887-6924, 10/2016, Volume 30, Issue 10, pp. 2019 - 2025
This study aimed to assess the frequency of and the contributing factors for second primary malignancies (SPMs) and Richter's transformations (RTs) following... 
HAIRY-CELL LEUKEMIA | THERAPY | ONCOLOGY | IMMUNOSUPPRESSION | CHRONIC LYMPHOCYTIC-LEUKEMIA | CLINICAL CHARACTERISTICS | LYMPHOMA | SINGLE-INSTITUTION | HEMATOLOGY | CANCER | FLUDARABINE | CHLORAMBUCIL | Bendamustine Hydrochloride - therapeutic use | Cyclophosphamide - administration & dosage | Chlorambucil - therapeutic use | Humans | Middle Aged | Male | Neoplasms, Second Primary - mortality | Cell Transformation, Neoplastic - chemically induced | Case-Control Studies | Cyclophosphamide - therapeutic use | Bendamustine Hydrochloride - administration & dosage | Aged, 80 and over | Adult | Female | Registries | Chlorambucil - administration & dosage | Risk Assessment | Risk Factors | Vidarabine - analogs & derivatives | Vidarabine - therapeutic use | Disease-Free Survival | Aged | Leukemia, Lymphocytic, Chronic, B-Cell - mortality | Vidarabine - administration & dosage | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Neoplasms, Second Primary - drug therapy | Germany | Chlorambucil | Chronic lymphocytic leukemia | Care and treatment | Immunosuppression | Dosage and administration | Diagnosis
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8. Full Text Changes in PIK3CA mutation status are not associated with recurrence, metastatic disease or progression in endocrine-treated breast cancer
by Arthur, L M and Turnbull, A K and Renshaw, L and Keys, J and Thomas, J S and Wilson, T R and Lackner, M R and Sims, A H and Dixon, J M
Breast Cancer Research and Treatment, ISSN 0167-6806, 8/2014, Volume 147, Issue 1, pp. 211 - 219
The phosphatidylinositol-3-kinase pathway plays an important role in proliferation, migration and survival in breast cancer and may play a role in resistance... 
Resistance | Medicine & Public Health | PIK3CA | PTEN | Oncology | Endocrine | Breast cancer | Mutation | PTEN LOSS | ACTIVATION | BIOMARKER | SIGNATURE | GENE | ONCOLOGY | PATHWAY | ESTROGEN-RECEPTOR-ALPHA | EXPRESSION | CARCINOMA | CORRELATE | Neoplasms, Hormone-Dependent - mortality | Follow-Up Studies | Humans | Middle Aged | Neoplasms, Second Primary - mortality | Carcinoma, Intraductal, Noninfiltrating - genetics | Neoplasms, Hormone-Dependent - genetics | Neoplasm Recurrence, Local - pathology | Carcinoma, Ductal, Breast - drug therapy | Carcinoma, Lobular - genetics | Aged, 80 and over | Neoplasms, Second Primary - genetics | Carcinoma, Ductal, Breast - secondary | Carcinoma, Lobular - secondary | PTEN Phosphohydrolase - genetics | Survival Rate | Mutation - genetics | Adenocarcinoma - drug therapy | Breast Neoplasms - drug therapy | Adenocarcinoma - secondary | Disease Progression | Neoplasms, Second Primary - secondary | Breast Neoplasms - genetics | Class I Phosphatidylinositol 3-Kinases | Neoplasms, Second Primary - drug therapy | Cohort Studies | Carcinoma, Ductal, Breast - genetics | Prognosis | Neoplasm Recurrence, Local - drug therapy | Neoplasms, Hormone-Dependent - secondary | Neoplasm Recurrence, Local - mortality | Carcinoma, Ductal, Breast - mortality | Carcinoma, Intraductal, Noninfiltrating - mortality | Carcinoma, Lobular - mortality | Antineoplastic Agents, Hormonal - therapeutic use | Adult | Female | Adenocarcinoma - genetics | Neoplasm Invasiveness | Carcinoma, Intraductal, Noninfiltrating - drug therapy | Phosphatidylinositol 3-Kinases - genetics | Phosphatidylinositol 3-Kinase - genetics | Breast Neoplasms - pathology | Breast Neoplasms - mortality | Neoplasm Recurrence, Local - genetics | Aged | Carcinoma, Lobular - drug therapy | Neoplasms, Hormone-Dependent - drug therapy | Neoplasm Staging | Carcinoma, Intraductal, Noninfiltrating - secondary | Adenocarcinoma - mortality | Immunohistochemistry | Care and treatment | Relapse | Genetic aspects | Metastasis | Diseases | Development and progression
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9. Full Text Circulating tumour DNA predicts response to anti-PD1 antibodies in metastatic melanoma
by Lee, J.H and Long, G.V and Boyd, S and Lo, S and Menzies, A.M and Tembe, V and Guminski, A and Jakrot, V and Scolyer, R.A and Mann, G.J and Kefford, R.F and Carlino, M.S and Rizos, H
Annals of oncology : official journal of the European Society for Medical Oncology, ISSN 0923-7534, 05/2017, Volume 28, Issue 5, pp. 1130 - 1136
Background: Programmed death 1 (PD1) inhibitors are now a foundation of medical management of metastatic melanoma. This study sought to determine whether... 
melanoma | PD1 antibodies | circulating tumour DNA | biomarkers | immunotherapy | CRITERIA | CHEMOTHERAPY | UNTREATED MELANOMA | TRIAL | DROPLET DIGITAL PCR | PEMBROLIZUMAB | ONCOLOGY | MUTATION | RESISTANCE | NIVOLUMAB | IPILIMUMAB | Melanoma - blood | Prognosis | Humans | Middle Aged | Antibodies, Anti-Idiotypic - immunology | Male | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Melanoma - pathology | Biomarkers, Tumor - blood | Disease-Free Survival | Antibodies, Anti-Idiotypic - administration & dosage | Neoplasm Metastasis | Neoplasms, Second Primary - blood | Melanoma - drug therapy | Female | Aged | Circulating Tumor DNA - blood | Programmed Cell Death 1 Receptor - immunology | Neoplasm Staging | Neoplasms, Second Primary - drug therapy | Ipilimumab - administration & dosage
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10. Full Text Is perioperative chemotherapy useful for solitary, metachronous, colorectal liver metastases?
by Adam, Rene and Bhangui, Prashant and Poston, Graeme and Mirza, Darius and Nuzzo, Gennaro and Barroso, Eduardo and Ijzermans, Jan and Hubert, Catherine and Ruers, Theo and Capussotti, Lorenzo and Ouellet, Jean-Francois and Laurent, Christophe and Cugat, Esteban and Colombo, Pierre Emmanuel and Milicevic, Miroslav
Annals of Surgery, ISSN 0003-4932, 11/2010, Volume 252, Issue 5, pp. 774 - 785
Background: Chemotherapy is increasingly used in colorectal liver metastases (CRLMs) even when they are initially resectable. The aim of our study was to... 
SURVIVAL | SURGERY | PREOPERATIVE CHEMOTHERAPY | THERAPY | NEOADJUVANT CHEMOTHERAPY | SYSTEMIC CHEMOTHERAPY | PATHOLOGICAL RESPONSE | OXALIPLATIN | OUTCOMES | HEPATIC RESECTION | CANCER | Prognosis | Humans | Biomarkers - analysis | Liver Neoplasms - drug therapy | Proportional Hazards Models | Liver Neoplasms - surgery | Male | Survival Rate | Combined Modality Therapy | Chi-Square Distribution | Neoplasms, Second Primary - surgery | Carcinoembryonic Antigen - analysis | Hepatectomy | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Female | Registries | Aged | Colorectal Neoplasms - pathology | Liver Neoplasms - secondary | Neoplasms, Second Primary - drug therapy | Postoperative Complications
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11. Full Text Outcomes in stage I testicular seminoma: A population‐based study of 9193 patients
by Beard, Clair J and Travis, Lois B and Chen, Ming‐Hui and Arvold, Nils D and Nguyen, Paul L and Martin, Neil E and Kuban, Deborah A and Ng, Andrea K and Hoffman, Karen E
Cancer, ISSN 0008-543X, 08/2013, Volume 119, Issue 15, pp. 2771 - 2777
Despite high cure rates following treatment for stage I testicular seminoma, survivors experience increased all‐cause mortality and mortality from second... 
testicular cancer | cardiovascular disease | suicide | radiotherapy | all‐cause mortality | seminoma | second malignant neoplasm | survivor | all-cause mortality | MORTALITY | LONG-TERM SURVIVORS | GERM-CELL TUMORS | 2ND CANCERS | CHEMOTHERAPY | CANCER-PATIENTS | ONCOLOGY | CARDIOVASCULAR-DISEASE | SURVEILLANCE | LIFE | United States - epidemiology | Testicular Neoplasms - mortality | Humans | Middle Aged | Male | Neoplasms, Second Primary - mortality | Neoplasms, Second Primary - radiotherapy | Testicular Neoplasms - pathology | Young Adult | Testicular Neoplasms - radiotherapy | Seminoma - radiotherapy | Cardiovascular Diseases - epidemiology | Adult | SEER Program | Seminoma - drug therapy | Risk Factors | Proportional Hazards Models | Treatment Outcome | Seminoma - mortality | Testicular Neoplasms - drug therapy | Adolescent | Aged | Neoplasm Staging | Neoplasms, Second Primary - drug therapy | Neoplasms, Second Primary - pathology | Seminoma - pathology | Usage | Demographic aspects | Patient outcomes | Diagnosis | Cardiovascular diseases | Radiotherapy | Testicular cancer | Risk factors
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12. Full Text The Role of Previous Therapies and Sites of Metastasis as Influencing Factors on Discordance of ER, PR and HER2 Status Between Primary and Metastasized Breast Cancer
by Vogel, Constanze and Malter, Wolfram and Morgenstern, Bernd and Ludwig, Sebastian and Vehreschild, Jörg Janne and Hamacher, Stefanie and Mallmann, Peter and Kirn, Verena and Thangarajah, Fabinshy
Anticancer research, ISSN 0250-7005, 05/2019, Volume 39, Issue 5, pp. 2647 - 2659
The aim of the present study was to analyze metastasized breast cancer (BC) patients with regard to the discordance of estrogen receptor (ER), progesterone... 
Lymph Nodes - pathology | Receptor, ErbB-2 - genetics | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Lymph Nodes - metabolism | Neoplasm Recurrence, Local - drug therapy | Receptors, Progesterone - genetics | Breast - metabolism | Breast Neoplasms - drug therapy | Neoplasm Recurrence, Local - pathology | Neoplasm Metastasis | Breast Neoplasms - genetics | Estrogen Receptor alpha - genetics | Breast Neoplasms - pathology | Adult | Female | Neoplasm Recurrence, Local - genetics | Aged | Biomarkers, Tumor - genetics | Neoplasms, Second Primary - genetics | Neoplasms, Second Primary - drug therapy | Breast - pathology | Neoplasms, Second Primary - pathology
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