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Nature (London), ISSN 1476-4687, 2015, Volume 525, Issue 7570, pp. 538 - 542
.... Here we use primary mouse haematopoietic stem and progenitor cells immortalized with the fusion protein MLL-AF9 to generate several single-cell clones that demonstrate resistance, in vitro... 
SELECTIVE-INHIBITION | ACCURATE | CHROMATIN | MECHANISM | MULTIDISCIPLINARY SCIENCES | ACUTE MYELOID-LEUKEMIA | DRUG-RESISTANCE | MUTATIONS | SEQUENCING DATA | CANCER | DISCOVERY | Chromatin - metabolism | Transcription, Genetic - drug effects | Clone Cells - drug effects | Neoplastic Stem Cells - drug effects | Epigenesis, Genetic | Humans | Leukemia, Myeloid, Acute - metabolism | Molecular Targeted Therapy | Neoplastic Stem Cells - metabolism | Leukemia, Myeloid, Acute - drug therapy | Neoplastic Stem Cells - pathology | Gene Expression Regulation, Neoplastic - drug effects | Hematopoietic Stem Cells - drug effects | Benzodiazepines - pharmacology | Leukemia, Myeloid, Acute - pathology | Cells, Cultured | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Hematopoietic Stem Cells - metabolism | Clone Cells - metabolism | beta Catenin - metabolism | Azepines - pharmacology | Transcription Factors - metabolism | Triazoles - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Clone Cells - pathology | Wnt Signaling Pathway - drug effects | Genes, myc - genetics | Hematopoietic Stem Cells - cytology | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Mice | Cell Cycle Proteins | Drug Resistance, Neoplasm - drug effects | Leukemia, Myeloid, Acute - genetics | Proteins | Leukemia | Cloning | Cell cycle | Stem cells | Epigenetics | Apoptosis
Journal Article
PloS one, ISSN 1932-6203, 2011, Volume 6, Issue 8, p. e24099
...) and HDAC inhibitor Vorinostat (SAHA). Methodology/ Principal Findings: Re-expression of miR-34a in human pancreatic cancer stem cells (CSCs... 
BIOMARKERS | NERVOUS-SYSTEM | APOPTOSIS | TRAIL | SIGNALING PATHWAY | P53 PROTEIN | MULTIDISCIPLINARY SCIENCES | NOTCH | TUMOR-SUPPRESSOR | MICRORNAS | EXPRESSION | Cell Cycle - genetics | Chromatin - metabolism | Apoptosis - drug effects | Neoplastic Stem Cells - drug effects | Humans | Spheroids, Cellular - pathology | Apoptosis - genetics | Epithelial-Mesenchymal Transition - drug effects | MicroRNAs - metabolism | Epithelial-Mesenchymal Transition - genetics | Pancreatic Neoplasms - drug therapy | Neoplastic Stem Cells - metabolism | Neoplastic Stem Cells - pathology | Epigenesis, Genetic - drug effects | Spheroids, Cellular - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Hydroxamic Acids - pharmacology | Tumor Stem Cell Assay | Neoplasm Invasiveness | Pancreatic Neoplasms - pathology | Spheroids, Cellular - metabolism | Pancreatic Neoplasms - genetics | Up-Regulation - genetics | Up-Regulation - drug effects | Azacitidine - pharmacology | Cell Movement - drug effects | Cell Line, Tumor | Hydroxamic Acids - therapeutic use | Cell Proliferation - drug effects | MicroRNAs - genetics | Cell Cycle - drug effects | Azacitidine - therapeutic use | Prevention | Epigenetic inheritance | Care and treatment | Chemotherapy | Chromatin | Pancreatic cancer | Stem cells | Development and progression | Tumor proteins | Cancer | Apoptosis | Bcl-2 protein | p53 Protein | Metastasis | Caspase-3 | Cancer therapies | Toxicology | Scholarships & fellowships | Cell growth | N-Cadherin | Restoration | Physiology | Tumorigenesis | Inhibition | Gene expression | SIRT1 protein | Pathology | Biomarkers | Notch protein | Mutation | Cell proliferation | Azacytidine | Histone deacetylase | Transcription | Mesenchyme | Laboratories | Leukemia | Gene regulation | Multiple myeloma | E-cadherin | Modulators | Cell cycle | miRNA | Inducers | Departments | Caspase | Pharmacology | Breast cancer | Tumor cell lines | Ribonucleic acid--RNA | Medicine | Cyclin-dependent kinase inhibitor p21 | Medical prognosis | Reagents | Epigenetics | Cyclin-dependent kinase inhibitor p27 | Prostate cancer | RNA | Ribonucleic acid
Journal Article
Blood, ISSN 1528-0020, 2013, Volume 121, Issue 10, pp. 1824 - 1838
Journal Article
Stem cells (Dayton, Ohio), ISSN 1066-5099, 2016, Volume 34, Issue 5, pp. 1163 - 1176
In solid tumors, cancer stem cells (CSCs) can arise independently of epithelial‐mesenchymal transition (EMT... 
Mitochondrial metabolism | Glutaminolysis | Cancer stem cells | Epithelial‐mesenchymal transition | Metabolic flux analysis | Warburg effect | Epithelial-mesenchymal transition | GLYCINE | NETWORK | FIBROBLASTS | GLUTAMINE-METABOLISM | CELL & TISSUE ENGINEERING | CELL BIOLOGY | HETEROGENEITY | SERINE | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GROWTH | HEMATOLOGY | EXPRESSION | PLASTICITY | FOLATE | Metabolomics | Transcription, Genetic - drug effects | Epithelial Cells - metabolism | Neoplastic Stem Cells - drug effects | Epithelial Cells - drug effects | Genes, Neoplasm | Humans | Spheroids, Cellular - pathology | Epithelial-Mesenchymal Transition - drug effects | Gene Expression Profiling | Epithelial-Mesenchymal Transition - genetics | Glycolysis - drug effects | Glycolysis - genetics | Amino Acids - metabolism | Neoplastic Stem Cells - metabolism | Neoplastic Stem Cells - pathology | Spheroids, Cellular - drug effects | NADP - metabolism | Pyruvate Dehydrogenase Complex - metabolism | Cell Proliferation - genetics | Spheroids, Cellular - metabolism | Citric Acid Cycle - drug effects | Epithelial Cells - pathology | Mitochondria - metabolism | Mitochondria - drug effects | Disease Progression | Citric Acid Cycle - genetics | Cell Line, Tumor | Glucose - metabolism | Cell Proliferation - drug effects | Oxidative Stress - drug effects | Mesoderm - pathology | Fatty Acids - biosynthesis | Hydrogen-Ion Concentration | Stem cells | Development and progression | Metastasis | Prostate cancer | Fatty acids | Cancer | Glutamine | Metabolism | epithelial-mesenchymal transition | metabolic flux analysis | mitochondrial metabolism | glutaminolysis
Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 1, p. e54193
Introduction: Inherent and acquired cisplatin resistance reduces the effectiveness of this agent in the management of non-small cell lung cancer (NSCLC... 
OVEREXPRESSION | ARREST | IN-VITRO | DNA | PHARMACOLOGY | MULTIDISCIPLINARY SCIENCES | SENSITIVITY | AGENTS | COPPER | OVARIAN-CANCER | IDENTIFICATION | Proto-Oncogene Proteins c-met - metabolism | DNA Adducts - drug effects | Homeodomain Proteins - metabolism | Humans | Lung Neoplasms - metabolism | Glycoproteins - metabolism | Lung Neoplasms - pathology | Antigens, CD - metabolism | SOXB1 Transcription Factors - metabolism | Dose-Response Relationship, Drug | Flow Cytometry | Peptides - metabolism | Neoplastic Stem Cells - metabolism | Hyaluronan Receptors - metabolism | Biomarkers, Tumor - metabolism | Antineoplastic Agents - pharmacology | Aldehyde Dehydrogenase - metabolism | Carcinoma, Non-Small-Cell Lung - pathology | Cell Survival - drug effects | Nanog Homeobox Protein | Carcinoma, Non-Small-Cell Lung - metabolism | Cisplatin - pharmacology | AC133 Antigen | beta Catenin - metabolism | Octamer Transcription Factor-3 - metabolism | Cell Line, Tumor | Cell Proliferation - drug effects | Cell Cycle - drug effects | Drug Resistance, Neoplasm - drug effects | Proteins | Cell death | Analysis | Stem cells | Lung cancer, Small cell | Lung cancer, Non-small cell | Cisplatin | Cell proliferation | Health sciences | Biotechnology | Flow cytometry | Dehydrogenases | Oct-4 protein | Lung cancer | DNA damage | Oncology | Cancer therapies | Signal transduction | Platinum | CD44 antigen | Cell cycle | Deoxyribonucleic acid--DNA | G1 phase | Medical research | Subpopulations | Damage assessment | Cell survival | Markers | Non-small cell lung carcinoma | Tumor cell lines | Survival | Medicine | Hospitals | Molecular modelling | β-Catenin | Sensitivity enhancement | DNA adducts | Pluripotency | Tumors | Apoptosis | Cancer | Deoxyribonucleic acid
Journal Article
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 2011, Volume 141, Issue 1, pp. 279 - 291.e5
Background & Aims Some cancer cells have activities that are similar to those of stem cells from normal tissues, and cell dedifferentiation correlates with poor prognosis... 
Gastroenterology and Hepatology | Gene Regulation | Tumor Development | Systems Biology | Colon Cancer | A33 ANTIGEN | TRANSCRIPTION FACTOR SNAIL | E-CADHERIN | NECK-CANCER | TUMOR-INITIATING CELLS | EPITHELIAL-MESENCHYMAL TRANSITION | HUMAN COLON-CANCER | PROSTATE-CANCER | GENE-EXPRESSION | GASTROENTEROLOGY & HEPATOLOGY | PROGRESSION | Interleukin-8 - genetics | Oligonucleotide Array Sequence Analysis | Neoplastic Stem Cells - drug effects | Colorectal Neoplasms - genetics | Humans | Middle Aged | Radiation Tolerance | Drug Resistance, Neoplasm | Epithelial-Mesenchymal Transition - drug effects | Fetal Proteins - metabolism | Antigens, CD - metabolism | Neoplastic Stem Cells - metabolism | Time Factors | Colorectal Neoplasms - drug therapy | Hyaluronan Receptors - metabolism | Aged, 80 and over | Neoplastic Stem Cells - pathology | Antimetabolites, Antineoplastic - pharmacology | Interleukin-8 - metabolism | Signal Transduction - radiation effects | Binding Sites | Carcinoma - drug therapy | Colorectal Neoplasms - immunology | Signal Transduction - drug effects | Mice, Nude | Carcinoma - genetics | Fluorouracil - pharmacology | Mice | Interleukin-8 - immunology | Dose-Response Relationship, Radiation | Gene Expression Regulation, Neoplastic | Neoplastic Stem Cells - immunology | Dose-Response Relationship, Drug | Transfection | Adult | Cell Adhesion Molecules, Neuronal - metabolism | Tumor Cells, Cultured | Carcinoma - pathology | Spheroids, Cellular | Snail Family Transcription Factors | Colorectal Neoplasms - metabolism | Neoplastic Stem Cells - radiation effects | Carcinoma - immunology | Gene Expression Profiling - methods | Transcription Factors - genetics | E-Box Elements | Antibodies - pharmacology | HT29 Cells | Transcription Factors - metabolism | Xenograft Model Antitumor Assays | Animals | Tumor Burden - drug effects | Aged | Cell Proliferation - drug effects | Carcinoma - metabolism | Colorectal Neoplasms - pathology | Antigen-antibody reactions | Developmental biology | Antibodies | Development and progression | Viral antibodies | Anopheles | Colon cancer | Epidermal growth factor | Interleukins | Stem cells | Genetic research | Fibroblast growth factors | Universities and colleges | Tumors
Journal Article
Oncogene, ISSN 1476-5594, 2017, Volume 36, Issue 34, pp. 4887 - 4900
Our recent perplexing findings that polyploid giant cancer cells (PGCCs) acquired embryonic-like stemness and were capable of tumor initiation raised two important unanswered questions... 
OVARIAN TUMORIGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-CELLS | CELLULAR SENESCENCE | FAILURE | CLEAVAGE-STAGE EMBRYOS | ESCAPE | CELL BIOLOGY | IN-VITRO | CYTOKINESIS | THERAPY | ONCOLOGY | GENETICS & HEREDITY | DIFFERENTIATION | Embryonic Stem Cells - metabolism | Paclitaxel - pharmacology | Neoplastic Stem Cells - drug effects | Giant Cells - drug effects | Humans | Ovarian Neoplasms - pathology | Carcinogenesis - metabolism | Blastomeres - drug effects | Blastomeres - metabolism | Neoplastic Stem Cells - metabolism | Female | Ovarian Neoplasms - metabolism | Cell Differentiation - physiology | Ovarian Neoplasms - drug therapy | Neoplastic Stem Cells - physiology | Polyploidy | Giant Cells - metabolism | Blastomeres - pathology | Carcinogenesis - drug effects | Carcinogenesis - pathology | Drug Resistance, Neoplasm - genetics | Embryonic Stem Cells - drug effects | Cell Differentiation - drug effects | Embryonic Stem Cells - pathology | Cell Line, Tumor | Signal Transduction - physiology | Giant Cells - pathology | Cellular signal transduction | Research | Cell differentiation | Cancer cells | Blastomeres | Senescence | Carcinoma | Mesenchyme | Mitosis | Oct-4 protein | Embryo cells | Benign | Compaction | Cytokinesis | Embryos | Spheroids | Ovarian cancer | Yes-associated protein | Chemotherapy | Developmental stages | Somatic cells | Paclitaxel | Stem cells | Giant cells | Tumorigenesis | Budding | Cancer | Tumors | Original
Journal Article