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1. Full Text Aldehyde dehydrogenase 1A1 in stem cells and cancer
by Tomita, Hiroyuki and Tanaka, Kaori and Tanaka, Takuji and Hara, Akira
Oncotarget, ISSN 1949-2553, 2016, Volume 7, Issue 10, pp. 11018 - 11032
The human genome contains 19 putatively functional aldehyde dehydrogenase (ALDH) genes, which encode enzymes critical for detoxification of endogenous and... 
ALDH | Aldehyde dehydrogenase | Stem cell | ALDH1A1 | Cancer | Animals | Humans | Neoplasms - enzymology | Neoplastic Stem Cells - pathology | Neoplasms - pathology | Aldehyde Dehydrogenase - metabolism | Neoplastic Stem Cells - enzymology
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2. Full Text Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks
by Liu, Suling and Ginestier, Christophe and Ou, Sing J and Clouthier, Shawn G and Patel, Shivani H and Monville, Florence and Korkaya, Hasan and Heath, Amber and Dutcher, Julie and Kleer, Celina G and Jung, Younghun and Dontu, Gabriela and Taichman, Russell and Wicha, Max S
Cancer Research, ISSN 0008-5472, 01/2011, Volume 71, Issue 2, pp. 614 - 624
We have used in vitro and mouse xenograft models to examine the interaction between breast cancer stem cells (CSC) and bone marrow-derived mesenchymal stem... 
MULTIPLE-MYELOMA | IN-VITRO | METASTASIS | ONCOLOGY | DISEASE | NICHE | SELF-RENEWAL | ALPHA | FATE | EXPRESSION | TUMOR MICROENVIRONMENT | Mesenchymal Stromal Cells - enzymology | Aldehyde Dehydrogenase - analysis | Cytokines - metabolism | Bone Marrow Cells - cytology | Humans | Aldehyde Dehydrogenase - biosynthesis | Mesenchymal Stromal Cells - metabolism | Cell Communication - physiology | Transplantation, Heterologous | Mice, SCID | Breast Neoplasms - metabolism | Breast Neoplasms - enzymology | Animals | Neoplastic Stem Cells - metabolism | Breast Neoplasms - pathology | Neoplastic Stem Cells - pathology | Female | Mice, Inbred NOD | Mice | Mesenchymal Stromal Cells - pathology | Neoplastic Stem Cells - enzymology | Life Sciences | Cellular Biology | Cancer
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3. Full Text Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3
by Ping Mao and Kaushal Joshi and Jianfeng Li and Sung-Hak Kim and Peipei Li and Lucas Santana-Santos and Soumya Luthra and Uma R. Chandran and Panayiotis V. Benos and Luke Smith and Maode Wang and Bo Hu and Shi-Yuan Cheng and Robert W. Sobol and Ichiro Nakano
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2013, Volume 110, Issue 21, pp. 8644 - 8649
Tumor heterogeneity of high-grade glioma (HGG) is recognized by four clinically relevant subtypes based on core gene signatures. However, molecular signaling... 
Phenotypes | Dehydrogenases | Glioma | Stem cells | Cell lines | Glioblastoma | Brain neoplasms | Aldehydes | Tumors | Cancer | Cancer stem cell | Glioblastoma multiforme | Proneural-to-mesenchymal transition | Epithelial-to-mesenchymal transition | SURVIVAL | glioblastoma multiforme | COMPLEX | proneural-to-mesenchymal transition | GLIOBLASTOMA-MULTIFORME | MARKER | IDH1 | MULTIDISCIPLINARY SCIENCES | SUBGROUPS | epithelial-to-mesenchymal transition | TRANSITION | glioblastoma | cancer stem cell | GROWTH | Mesenchymal Stromal Cells - enzymology | Neoplasm Transplantation | Cell Proliferation | Glioma - enzymology | Signal Transduction | Neoplasm Proteins - biosynthesis | Humans | Aldehyde Dehydrogenase - biosynthesis | Aldehyde Dehydrogenase - genetics | Male | Transplantation, Heterologous | Animals | Gene Expression Regulation, Enzymologic - genetics | Glioma - pathology | Aldehyde Oxidoreductases | Glycolysis | Neoplastic Stem Cells - pathology | Female | Mice | Mesenchymal Stromal Cells - pathology | Tumor Cells, Cultured | Neoplasm Proteins - genetics | Neoplastic Stem Cells - enzymology | Gene Expression Regulation, Neoplastic - genetics | Physiological aspects | Genetic aspects | Gliomas | Biological Sciences
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4. Full Text ALDH1 Is a Marker of Normal and Malignant Human Mammary Stem Cells and a Predictor of Poor Clinical Outcome
by Ginestier, Christophe and Hur, Min Hee and Charafe-Jauffret, Emmanuelle and Monville, Florence and Dutcher, Julie and Brown, Marty and Jacquemier, Jocelyne and Viens, Patrice and Kleer, Celina G and Liu, Suling and Schott, Anne and Hayes, Dan and Birnbaum, Daniel and Wicha, Max S and Dontu, Gabriela
Cell Stem Cell, ISSN 1934-5909, 2007, Volume 1, Issue 5, pp. 555 - 567
Application of stem cell biology to breast cancer research has been limited by the lack of simple methods for identification and isolation of normal and... 
STEMCELL | CELLCYCLE | ADULT HUMAN BREAST | TRANSFORMATION | IN-VITRO | PROGENITOR | SUBPOPULATION | PROSPECTIVE IDENTIFICATION | ALDEHYDE DEHYDROGENASE-ACTIVITY | FUNCTIONAL-CHARACTERIZATION | ACUTE MYELOID-LEUKEMIA | CANCER | CELL BIOLOGY | Immunohistochemistry | Mammary Glands, Human - immunology | Up-Regulation | Cell Proliferation | Breast Neoplasms - immunology | Tissue Array Analysis | Humans | Neoplastic Stem Cells - immunology | Adult Stem Cells - immunology | Retinal Dehydrogenase | Breast Neoplasms - therapy | Stem Cell Transplantation | Breast Neoplasms - enzymology | Flow Cytometry | Isoenzymes - metabolism | Neoplastic Stem Cells - pathology | Female | Cell Differentiation | Aldehyde Dehydrogenase - metabolism | Adult Stem Cells - enzymology | Cell Separation | Biomarkers - analysis | Cells, Cultured | Treatment Outcome | Mice, SCID | Hyaluronan Receptors - analysis | Xenograft Model Antitumor Assays | Cell Lineage | Phenotype | Animals | Breast Neoplasms - pathology | CD24 Antigen - analysis | Survival Analysis | Mice, Inbred NOD | Mice | Mammary Glands, Human - enzymology | Neoplastic Stem Cells - enzymology
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5. Full Text Aldehyde Dehydrogenase 1–Positive Cancer Stem Cells Mediate Metastasis and Poor Clinical Outcome in Inflammatory Breast Cancer
by Emmanuelle Charafe-Jauffret and Christophe Ginestier and Flora Iovino and Carole Tarpin and Mark Diebel and Benjamin Esterni and Gilles Houvenaeghel and Jean-Marc Extra and François Bertucci and Jocelyne Jacquemier and Luc Xerri and Gabriela Dontu and Giorgio Stassi and Yi Xiao and Sanford H. Barsky and Daniel Birnbaum and Patrice Viens and Max S. Wicha
Clinical Cancer Research, ISSN 1078-0432, 01/2010, Volume 16, Issue 1, pp. 45 - 55
Purpose: To examine the role of cancer stem cells (CSC) in mediating metastasis in inflammatory breast cancer (IBC) and the association of these cells with... 
SUM149 | MARY-X | Metastasis | Aldehyde dehydrogenase | Inflammatory breast carcinoma | Stem cell | OVEREXPRESSION | LYMPHOVASCULAR EMBOLUS | ONCOLOGY | MARKER | GROWTH | PHENOTYPE | ACUTE MYELOID-LEUKEMIA | E-CADHERIN | EXPRESSION | CARCINOMA | XENOGRAFT MODEL | Neoplasm Transplantation | Humans | Treatment Outcome | Mice, SCID | Retinal Dehydrogenase | Breast Neoplasms - enzymology | Neoplasm Metastasis | Animals | Breast Neoplasms - pathology | Isoenzymes - metabolism | Biomarkers, Tumor - metabolism | Cell Line, Tumor | Breast Neoplasms - mortality | Female | Mice, Inbred NOD | Mice | Aldehyde Dehydrogenase - metabolism | Inflammation - enzymology | Neoplastic Stem Cells - enzymology | Life Sciences | Cellular Biology | Cancer
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6. Full Text Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche
by Lock, F.E and McDonald, P.C and Lou, Y and Serrano, I and Chafe, S.C and Ostlund, C and Aparicio, S and Winum, J.-Y and Supuran, C.T and Dedhar, S
Oncogene, ISSN 0950-9232, 10/2013, Volume 32, Issue 44, pp. 5210 - 5219
The sub-population of tumor cells termed 'cancer stem cells' (CSCs) possess the capability to generate tumors, undergo epithelial-mesenchymal transition (EMT)... 
mTOR | hypoxia | breast cancer | CAIX | cancer stem cell | EMT | EPITHELIAL-MESENCHYMAL-TRANSITION | MAMMALIAN TARGET | RAPAMYCIN | METASTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROLIFERATION | IDENTIFICATION | TUMOR-INITIATING CELLS | CELL BIOLOGY | OXYGEN | ONCOLOGY | GENETICS & HEREDITY | INHIBITORS | EXPRESSION | Cell Proliferation | Paclitaxel - pharmacology | Neoplastic Stem Cells - drug effects | Humans | Tumor Microenvironment | Spheroids, Cellular - enzymology | Carbonic Anhydrases - metabolism | Cell Hypoxia | Breast Neoplasms - enzymology | Lung Neoplasms - secondary | Antigens, Neoplasm - metabolism | Female | Antineoplastic Agents - pharmacology | Carbonic Anhydrase IX | Lung Neoplasms - enzymology | Stem Cell Niche | Neoplasm Invasiveness | Carbonic Anhydrase Inhibitors - pharmacology | Mice, SCID | Sulfonamides - pharmacology | Breast Neoplasms - drug therapy | Drug Synergism | Xenograft Model Antitumor Assays | Animals | Lung Neoplasms - prevention & control | Breast Neoplasms - pathology | Cell Line, Tumor | Mice, Inbred NOD | Mice | Phenylurea Compounds - pharmacology | Neoplastic Stem Cells - enzymology | Care and treatment | Breast cancer | Genetic aspects | Research | Health aspects | Stem cells | Oncology | Tumorigenesis | Metastasis | Tumors
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7. Full Text Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis
by Huang, Emina H and Hynes, Mark J and Zhang, Tao and Ginestier, Christophe and Dontu, Gabriela and Appelman, Henry and Fields, Jeremy Z and Wicha, Max S and Boman, Bruce M
Cancer Research, ISSN 0008-5472, 04/2009, Volume 69, Issue 8, pp. 3382 - 3389
Although the concept that cancers originate from stem cells (SC) is becoming scientifically accepted, mechanisms by which SC contribute to tumor initiation and... 
PHENOTYPIC CHARACTERIZATION | ADHESION | POPULATION | CANCER CELLS | MECHANISM | ONCOLOGY | FAMILIAL ADENOMATOUS POLYPOSIS | IDENTIFICATION | TUMORS | EXPRESSION | CD44 | Immunohistochemistry | Stem Cells - immunology | Colon - enzymology | Peptides | Antigens, CD - biosynthesis | Humans | Aldehyde Dehydrogenase - biosynthesis | Colon - immunology | Transplantation, Heterologous | Biomarkers, Tumor | Retinal Dehydrogenase | Flow Cytometry | Stem Cells - enzymology | Colonic Neoplasms - immunology | Colon - pathology | Epithelial Cells - pathology | Hyaluronan Receptors - biosynthesis | Mice, SCID | AC133 Antigen | Cell Transformation, Neoplastic - metabolism | Glycoproteins - biosynthesis | Cell Transformation, Neoplastic - immunology | Animals | Colonic Neoplasms - pathology | Epithelial Cells - immunology | Epithelial Cells - enzymology | Stem Cells - pathology | Mice, Inbred NOD | Colonic Neoplasms - enzymology | Mice | Cell Transformation, Neoplastic - pathology | Isoenzymes - biosynthesis | Life Sciences | Cellular Biology | Cancer
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8. Full Text Critical role for lysyl oxidase in mesenchymal stem cell-driven breast cancer malignancy
by Christelle P. El-Haibi and George W. Bell and Jiangwen Zhang and Anthony Y. Collmann and David Wood and Cally M. Scherber and Eva Csizmadia and Odette Mariani and Cuihua Zhu and Antoine Campagne and Mehmet Toner and Sangeeta N. Bhatia and Daniel Irimia and Anne Vincent-Salomon and Antoine E. Karnoub
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2012, Volume 109, Issue 43, pp. 17460 - 17465
Mesenchymal stem cells (MSCs) are multipotent progenitor cells with the ability to differentiate into multiple mesoderm lineages in the course of normal tissue... 
Oxidases | Phenotypes | Epithelial cells | Stem cells | Bones | Breast cancer | Metastasis | Mesenchymal stem cells | Tumors | Cancer | TRANSITION | METASTASIS | MULTIDISCIPLINARY SCIENCES | HYALURONAN | GENERATION | BONE | TUMORS | CARCINOMA | CD44 | Mesenchymal Stromal Cells - enzymology | Neoplasm Invasiveness | Humans | RNA, Messenger - genetics | Breast Neoplasms - enzymology | Neoplasm Metastasis | Breast Neoplasms - pathology | Epithelial-Mesenchymal Transition | Protein-Lysine 6-Oxidase - metabolism | Cell Line, Tumor | Female | Protein-Lysine 6-Oxidase - genetics | Neoplastic Stem Cells - enzymology | Physiological aspects | Development and progression | Research | Health aspects | Biological Sciences
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9. Full Text Aldehyde dehydrogenase-expressing colon stem cells contribute to tumorigenesis in the transition from colitis to cancer
by Carpentino, Joseph E and Hynes, Mark J and Appelman, Henry D and Tong, Zheng and Steindler, Dennis A and Scott, Edward W and Huang, Emina H
Cancer Research, ISSN 0008-5472, 10/2009, Volume 69, Issue 20, pp. 8208 - 8215
Patients with chronic ulcerative colitis are at increased risk of developing colorectal cancer. Although current hypotheses suggest that sporadic colorectal... 
PHENOTYPIC CHARACTERIZATION | SURVEILLANCE COLONOSCOPY | INFLAMMATORY-BOWEL-DISEASE | EPITHELIAL-CELLS | ONCOLOGY | COLORECTAL-CANCER | ULCERATIVE-COLITIS | CRYPT | DYSPLASIA | STROMA | IDENTIFICATION | Precancerous Conditions - etiology | Colon - enzymology | Adenocarcinoma - pathology | Stromal Cells - pathology | Adenocarcinoma - etiology | Humans | Spheroids, Cellular - pathology | Colitis - pathology | Spheroids, Cellular - enzymology | Immunoenzyme Techniques | Stromal Cells - enzymology | Flow Cytometry | Neoplastic Stem Cells - pathology | Precancerous Conditions - pathology | Aldehyde Dehydrogenase - metabolism | Colonic Neoplasms - etiology | Precancerous Conditions - enzymology | Cytokines - metabolism | Colon - pathology | Adenocarcinoma - enzymology | Mice, SCID | Xenograft Model Antitumor Assays | Animals | Colitis - enzymology | Colonic Neoplasms - pathology | Fluorescent Antibody Technique | Protein Array Analysis | Mice, Inbred NOD | Colonic Neoplasms - enzymology | Mice | Neoplastic Stem Cells - enzymology | Xenograft | Colitis | tumor microenvironment | Aldehyde dehydrogenase | Colon Cancer | Colon sphere
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10. Full Text Serine/Threonine Kinase MLK4 Determines Mesenchymal Identity in Glioma Stem Cells in an NF-κB-dependent Manner
by Kim, Sung-Hak and Kim, Jonghwan and Ezhilarasan, Ravesanker and Phillips, Emma and Gallego-Perez, Daniel and Sparks, Amanda and Taylor, David and Ladner, Katherine and Furuta, Takuya and Sabit, Hemragul and Chhipa, Rishi and Cho, Ju Hwan and Mohyeldin, Ahmed and Beck, Samuel and Kurozumi, Kazuhiko and Kuroiwa, Toshihiko and Iwata, Ryoichi and Asai, Akio and Sulman, Erik P and Cheng, Shi-Yuan and Lee, L. James and Nakada, Mitsutoshi and Guttridge, Denis and DasGupta, Biplab and Goidts, Violaine and Bhat, Krishna P and Nakano, Ichiro
Cancer Cell, ISSN 1535-6108, 02/2016, Volume 29, Issue 2, pp. 201 - 213
Activation of nuclear factor κB (NF-κB) induces mesenchymal (MES) transdifferentiation and radioresistance in glioma stem cells (GSCs), but molecular... 
glioblastoma | proneural-mesenchymal transition | cancer stem cell | epithelial-to-mesenchymal transition | Cancer stem cell | Proneural-mesenchymal transition | Epithelial-to-mesenchymal transition | Glioblastoma | INITIATING CELLS | TRANSITION | GLIOBLASTOMA | MICROENVIRONMENT | ONCOLOGY | PATHWAY | GROWTH | RESISTANCE | CANCER | EGFR | NEGATIVE REGULATOR | CELL BIOLOGY | Mesenchymal Stromal Cells - enzymology | Brain Neoplasms - enzymology | Phosphorylation | Glioma - enzymology | Signal Transduction | MAP Kinase Kinase Kinases - genetics | Humans | Brain Neoplasms - pathology | Gene Silencing | NF-kappa B - metabolism | MAP Kinase Kinase Kinases - metabolism | Animals | Glioma - pathology | Neoplastic Stem Cells - pathology | Mice | Mesenchymal Stromal Cells - pathology | Neoplastic Stem Cells - enzymology | Apoptosis | proneural-Mesenchymal transition
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11. Full Text NOTCH Pathway Blockade Depletes CD133‐Positive Glioblastoma Cells and Inhibits Growth of Tumor Neurospheres and Xenografts
by Fan, Xing and Khaki, Leila and Zhu, Thant S and Soules, Mary E and Talsma, Caroline E and Gul, Naheed and Koh, Cheryl and Zhang, Jiangyang and Li, Yue‐Ming and Maciaczyk, Jarek and Nikkhah, Guido and DiMeco, Francesco and Piccirillo, Sara and Vescovi, Angelo L and Eberhart, Charles G
STEM CELLS, ISSN 1066-5099, 01/2010, Volume 28, Issue 1, pp. 5 - 16
Cancer stem cells (CSCs) are thought to be critical for the engraftment and long‐term growth of many tumors, including glioblastoma (GBM). The cells are at... 
NOTCH | γ‐Secretase inhibitor | Cancer Stem Cell | Glioblastoma | Cancer stem cell | γ-Secretase inhibitor | CANCER-CELLS | INITIATING CELLS | EMBRYONAL BRAIN-TUMORS | SIDE POPULATION | SELF-RENEWAL | INTERSTITIAL CHEMOTHERAPY | CELL & TISSUE ENGINEERING | CELL BIOLOGY | MALIGNANT GLIOMA | STEM-LIKE CELLS | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CENTRAL-NERVOUS-SYSTEM | HEMATOLOGY | gamma-Secretase inhibitor | Neurons - pathology | Glioblastoma - enzymology | Phosphorylation | Apoptosis - drug effects | Neoplastic Stem Cells - drug effects | Humans | Brain Neoplasms - pathology | Glycoproteins - metabolism | Neoplastic Stem Cells - immunology | Receptor, Notch2 - genetics | Antigens, CD - metabolism | Dose-Response Relationship, Drug | Brain Neoplasms - immunology | Peptides - metabolism | Transfection | Time Factors | Biomarkers, Tumor - metabolism | Neoplastic Stem Cells - pathology | Female | Antineoplastic Agents - pharmacology | Tumor Cells, Cultured | Neurons - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Spheroids, Cellular | STAT3 Transcription Factor - metabolism | Brain Neoplasms - enzymology | Enzyme Inhibitors - pharmacology | Neurons - immunology | Receptor, Notch2 - metabolism | Tumor Burden | Brain Neoplasms - drug therapy | AC133 Antigen | Xenograft Model Antitumor Assays | Amyloid Precursor Protein Secretases - metabolism | Animals | Glioblastoma - immunology | Signal Transduction - drug effects | Mice, Nude | Glioblastoma - pathology | Neurons - enzymology | Cell Proliferation - drug effects | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Glioblastoma - drug therapy | Neoplastic Stem Cells - enzymology
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12. Full Text Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation
by Mayle, A and Yang, LB and Rodriguez, B and Zhou, T and Chang, E and Curry, CV and Challen, GA and Li, W and Wheeler, D and Rebel, VI and Goodell, MA
BLOOD, ISSN 0006-4971, 01/2015, Volume 125, Issue 4, pp. 629 - 638
DNA methyltransferase 3A (DNMT3A) is mutated in hematologic malignancies affecting myeloid, mixed, and lymphoid lineages, and these mutations are associated... 
PATHOGENESIS | NEOPLASMS | DNA HYPERMETHYLATION | GENES | CLASSIFICATION | CLONAL EVOLUTION | CHROMATIN PATTERN | MUTATIONS | HEMATOLOGY | GENOME | BETHESDA PROPOSALS | Promoter Regions, Genetic | DNA, Neoplasm - metabolism | Hematologic Neoplasms - enzymology | Hematologic Neoplasms - pathology | Cell Transformation, Neoplastic - metabolism | DNA (Cytosine-5-)-Methyltransferases | Mice, Knockout | DNA Methylation | Animals | Cell Transformation, Neoplastic - genetics | Hematologic Neoplasms - genetics | Mice | DNA, Neoplasm - genetics | Cell Transformation, Neoplastic - pathology | Hematopoietic Stem Cells - enzymology | Hematopoiesis and Stem Cells
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