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Science, ISSN 0036-8075, 07/2017, Volume 357, Issue 6349, pp. 409 - 413
The genomes of cancers deficient in mismatch repair contain exceptionally high numbers of somatic mutations. In a proof-of-concept study, we previously showed... 
CELL LUNG-CANCER | SURVIVAL | COLORECTAL CARCINOMAS | RECEIVING NIVOLUMAB | IMMUNOTHERAPY | MICROSATELLITE INSTABILITY | MULTIDISCIPLINARY SCIENCES | LONG-TERM SAFETY | NEOANTIGENS | CHECKPOINT BLOCKADE | LYMPHOCYTES | Neoplastic Syndromes, Hereditary - immunology | Colorectal Neoplasms - genetics | Humans | Middle Aged | Male | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Neoplastic Syndromes, Hereditary - mortality | Young Adult | Colorectal Neoplasms - therapy | Brain Neoplasms - immunology | DNA Mismatch Repair | Aged, 80 and over | Adult | Female | Neoplastic Syndromes, Hereditary - genetics | Brain Neoplasms - mortality | Biomarkers, Tumor - antagonists & inhibitors | Colorectal Neoplasms - mortality | Antibodies, Monoclonal, Humanized - therapeutic use | Antigens, Neoplasm - immunology | Brain Neoplasms - genetics | Disease-Free Survival | Colorectal Neoplasms - immunology | Cell Cycle Checkpoints - drug effects | Brain Neoplasms - therapy | Neoplastic Syndromes, Hereditary - therapy | T-Lymphocytes - immunology | Aged | Mutation | Programmed Cell Death 1 Receptor - immunology | Colorectal cancer | Genetic aspects | Nucleotide sequencing | Health aspects | DNA repair | Methods | Tumors | DNA sequencing | Yeast | PD-1 protein | Antibodies | Clinical trials | Genomes | Functional analysis | Lymphocytes T | Patients | Survival | Colon cancer | Immune checkpoint | Immunotherapy | Mismatch repair | Pancreatic cancer | Biomarkers | Bioindicators | Colon | Solid tumors | Genetic recombination | Repair | Cancer | Apoptosis | Index Medicus
Journal Article
The American Journal of Surgical Pathology, ISSN 0147-5185, 03/2017, Volume 41, Issue 3, pp. 326 - 333
Mismatch repair (MMR)-deficient endometrial carcinomas (ECs) bearing Lynch syndrome (LS)-associated germline mutations or sporadic MLH1 promoter... 
PD-L1 | mismatch repair | endometrial carcinoma | MLH1 hypermethylation | immunotherapy | Lynch syndrome | SURGERY | MICROSATELLITE INSTABILITY | INFILTRATING LYMPHOCYTES | IMMUNOSCORE | PATHOLOGY | LUNG-CANCER | PROGNOSTIC-FACTOR | IMMUNE-SYSTEM | MICROENVIRONMENT | COLORECTAL-CANCER | BLOCKADE | Immunohistochemistry | Neoplastic Syndromes, Hereditary - pathology | Prognosis | Follow-Up Studies | Endometrial Neoplasms - mortality | Colorectal Neoplasms - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - pathology | Humans | Middle Aged | Brain Neoplasms - pathology | Endometrial Neoplasms - metabolism | Gene Expression Regulation, Neoplastic | Neoplastic Syndromes, Hereditary - metabolism | Brain Neoplasms - metabolism | Neoplastic Syndromes, Hereditary - mortality | Colorectal Neoplasms, Hereditary Nonpolyposis - mortality | DNA Methylation | Endometrial Neoplasms - genetics | DNA Mismatch Repair | Biomarkers, Tumor - metabolism | Female | Neoplastic Syndromes, Hereditary - genetics | Brain Neoplasms - mortality | Colorectal Neoplasms - metabolism | Colorectal Neoplasms - mortality | Promoter Regions, Genetic | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Brain Neoplasms - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - metabolism | B7-H1 Antigen - metabolism | MutL Protein Homolog 1 - genetics | Endometrial Neoplasms - pathology | Aged | Biomarkers, Tumor - genetics | Colorectal Neoplasms - pathology | Index Medicus
Journal Article
Journal of Urology, The, ISSN 0022-5347, 2007, Volume 177, Issue 6, pp. 2074 - 2080
Journal Article
Gastroenterology, ISSN 0016-5085, 2009, Volume 136, Issue 7, pp. 2137 - 2148
Journal Article
Gastroenterology, ISSN 0016-5085, 2015, Volume 149, Issue 4, pp. 897 - 906.e19
Background & Aims Germline mutations in the cadherin 1, type 1, E-cadherin gene ( CDH1 ) cause a predisposition to gastric cancer. We evaluated the ability of... 
Gastroenterology and Hepatology | Genetic Risk Factor | Stomach | LBC | Carcinogenesis | ENDOSCOPIC SURVEILLANCE | TOTAL GASTRECTOMY | LOBULAR BREAST-CANCER | E-CADHERIN MUTATIONS | FAMILY-HISTORY | CLINICAL MANAGEMENT | MISSENSE MUTATIONS | SPLICING SIGNALS | COLORECTAL-CANCER | EARLY-ONSET | GASTROENTEROLOGY & HEPATOLOGY | Predictive Value of Tests | Carcinoma, Lobular - pathology | Neoplastic Syndromes, Hereditary - pathology | Prognosis | Humans | Middle Aged | Male | Stomach Neoplasms - pathology | Carcinoma, Lobular - mortality | Neoplastic Syndromes, Hereditary - mortality | Breast Neoplasms - therapy | Young Adult | Netherlands | Carcinoma, Lobular - therapy | Carcinoma, Lobular - genetics | Time Factors | DNA Mutational Analysis | Germ-Line Mutation | Adult | Female | Neoplastic Syndromes, Hereditary - genetics | Retrospective Studies | Cadherins - genetics | Stomach Neoplasms - genetics | Genetic Predisposition to Disease | Risk Factors | Kaplan-Meier Estimate | Proportional Hazards Models | Stomach Neoplasms - therapy | Survival Rate | Heredity | Phenotype | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Pedigree | Neoplastic Syndromes, Hereditary - therapy | Breast Neoplasms - mortality | Aged | Stomach Neoplasms - mortality | Care and treatment | Gene mutations | Patient outcomes | Medical genetics | Medical tests | Diagnosis | Stomach cancer | Cancer | Index Medicus | Abridged Index Medicus
Journal Article
Pediatric Blood & Cancer, ISSN 1545-5009, 01/2018, Volume 65, Issue 1, pp. e26720 - n/a
Journal Article
British Journal of Cancer, ISSN 0007-0920, 09/2016, Volume 115, Issue 7, pp. 776 - 783
Journal Article
British Journal of Cancer, ISSN 0007-0920, 06/2017, Volume 117, Issue 1, pp. 41 - 50
Background: Some highly penetrant familial cancer syndromes exhibit elevated leukaemia risk, and there is evidence for familial clustering of lung cancer and... 
familial clustering | lung cancer | high-energy beam | ionising radiation | myeloid leukaemia | space radiation exposure | mice | BRCA2 MUTATION CARRIERS | CATALYTIC SUBUNIT | EFFECTIVENESS RBE VALUES | BIOLOGICAL EFFECTIVENESS | ATOMIC-BOMB SURVIVORS | RETROSPECTIVE COHORT | BREAST-CANCER | LUNG-CANCER | SPACE RADIATION | ONCOLOGY | MYELOID-LEUKEMIA | Carcinoma, Hepatocellular - mortality | Harderian Gland | Neoplasms - etiology | Gamma Rays - adverse effects | Adenoma - genetics | Adenoma - mortality | Lung Neoplasms - mortality | Adenocarcinoma - etiology | Leukemia, Myeloid - genetics | Sebaceous Gland Neoplasms - etiology | Liver Neoplasms, Experimental - mortality | Neoplastic Syndromes, Hereditary - etiology | Neoplastic Syndromes, Hereditary - mortality | Neoplasms, Radiation-Induced - mortality | Neoplasms, Radiation-Induced - genetics | Lung Neoplasms - etiology | Neoplasms - genetics | Carcinoma, Hepatocellular - genetics | Adenocarcinoma - genetics | Carcinoma, Hepatocellular - etiology | Liver Neoplasms, Experimental - genetics | Neoplastic Syndromes, Hereditary - genetics | Leukemia, Myeloid - mortality | Radiation, Ionizing | Lung Neoplasms - genetics | Sebaceous Gland Neoplasms - genetics | Proportional Hazards Models | Neoplasms - mortality | Adenoma - etiology | Liver Neoplasms, Experimental - etiology | Leukemia, Myeloid - etiology | Animals | Sebaceous Gland Neoplasms - mortality | Mice | Adenocarcinoma - mortality | Adenocarcinoma | Beams (radiation) | Correlation | Leukemia | Lung cancer | Disorders | Hepatocellular carcinoma | Risk factors | Energy | Risk assessment | Circularity | Background radiation | Radiation effects | Particle beams | γ Radiation | Breeding | Periodicity | Health risks | Ions | Exposure | Clustering | Radiation dosage | Gamma rays | Gamma radiation | Irradiation | Charged particles | Health risk assessment | Cancer | Tumors | Index Medicus | Translational Therapeutics
Journal Article
Familial Cancer, ISSN 1389-9600, 1/2018, Volume 17, Issue 1, pp. 91 - 100
Journal Article
Journal Article