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Molecular Neurobiology, ISSN 0893-7648, 11/2016, Volume 53, Issue 9, pp. 6459 - 6475
We investigated the effects of an acute intrastriatal QUIN administration on cellular redox and bioenergetics homeostasis, as well as on important signaling... 
Signaling pathways | Neurology | Energy metabolism | Neurosciences | Biomedicine | Redox homeostasis | Glutaric acidemia | Neurobiology | Inflammatory response | Quinolinic acid | Cell Biology | PLASMA-MEMBRANES | 3-HYDROXYGLUTARIC ACID | NMDA RECEPTORS | NITRIC-OXIDE SYNTHASE | FACTOR-KAPPA-B | GLUTAMATE UPTAKE | NEUROSCIENCES | CEREBRAL-CORTEX | PRIMARY NEURONAL CULTURES | ANTIOXIDANT RESPONSE ELEMENT | CREATINE-KINASE | Brain Diseases, Metabolic - pathology | Glutaryl-CoA Dehydrogenase - metabolism | Glutathione - metabolism | Antioxidants - metabolism | Fluoresceins - metabolism | Nitrites - metabolism | NF-kappa B - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Electron Transport Complex IV - metabolism | Amino Acid Metabolism, Inborn Errors - metabolism | Sulfhydryl Compounds - metabolism | Neostriatum - drug effects | Lipid Peroxidation - drug effects | Neostriatum - metabolism | Quinolinic Acid - administration & dosage | Quinolinic Acid - toxicity | Amino Acid Metabolism, Inborn Errors - pathology | Brain Diseases, Metabolic - enzymology | Proto-Oncogene Proteins c-akt - metabolism | Superoxide Dismutase - metabolism | Malondialdehyde - metabolism | Glutathione Peroxidase - metabolism | Neostriatum - pathology | Oxidation-Reduction | Brain Diseases, Metabolic - metabolism | Mice, Knockout | Nitrates - metabolism | Animals | Lactates - metabolism | Diet | Signal Transduction - drug effects | Models, Biological | NF-E2-Related Factor 2 - metabolism | Oxidative Stress - drug effects | Amino Acid Metabolism, Inborn Errors - enzymology | Energy Metabolism - drug effects | Glutaryl-CoA Dehydrogenase - deficiency | Antioxidants | Lysine | Creatine kinase | Glutathione transferase | Physiological aspects | Superoxide | Inflammation | Creatine | Homeostasis | Signal transduction | Oxidative stress | Bioenergetics | Index Medicus
Journal Article
Cell Metabolism, ISSN 1550-4131, 06/2012, Volume 15, Issue 6, pp. 827 - 837
Journal Article
Neuron, ISSN 0896-6273, 01/2015, Volume 85, Issue 2, pp. 296 - 302
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 11/2012, Volume 53, Issue 10, pp. 1857 - 1867
Huntington's disease (HD) is a CAG repeat disorder affecting the HD gene, which encodes for huntingtin (Htt) and is characterized by prominent cell death in... 
Striatal cells | Oxidative stress | Reactive oxygen species | Huntingtin | Huntington disease | MRP1 | PROTEIN | INCREASED OXIDATIVE DAMAGE | BASAL GANGLIA | BIOCHEMISTRY & MOLECULAR BIOLOGY | MUTANT HUNTINGTIN | GENE | MOUSE MODEL | ENDOCRINOLOGY & METABOLISM | MITOCHONDRIAL DYSFUNCTION | STRESS | BRAIN | Reactive Oxygen Species - metabolism | Oxidative Stress | Glutathione - metabolism | Glutathione Reductase - metabolism | Huntington Disease - pathology | Caspase 3 - metabolism | RNA, Messenger - metabolism | Corpus Striatum - cytology | Corpus Striatum - metabolism | Glutathione - pharmacology | Biological Transport | Multidrug Resistance-Associated Proteins - genetics | Neostriatum - metabolism | Glutamate-Cysteine Ligase - metabolism | Glutathione Synthase - metabolism | Nuclear Proteins - genetics | Glutathione Peroxidase - metabolism | Glutathione - analogs & derivatives | Oxidation-Reduction | RNA, Messenger - genetics | Cells, Cultured | Glutathione Transferase - metabolism | Nuclear Proteins - metabolism | gamma-Glutamyltransferase - metabolism | Huntington Disease - metabolism | Nerve Tissue Proteins - genetics | Gene Knock-In Techniques | Nerve Tissue Proteins - metabolism | Huntingtin Protein | Animals | Huntington Disease - genetics | Mice | Mutation | Multidrug Resistance-Associated Proteins - metabolism | Antioxidants | Drug resistance in microorganisms | Messenger RNA | Thiols | Huntington's chorea | Ligases | Glutathione transferase | Cell death | Analysis | Peroxidase | Cells | Index Medicus
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 08/2010, Volume 19, Issue 15, pp. 3053 - 3067
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 07/2010, Volume 19, Issue 20, pp. 3919 - 3935
Although a direct causative pathway from the gene mutation to the selective neostriatal neurodegeneration remains unclear in Huntington's disease (HD), one... 
CYTOCHROME-C | TOXIN 3-NITROPROPIONIC ACID | COMPONENT FIS1P | DEGENERATIVE CHANGES | BUDDING YEAST | BIOCHEMISTRY & MOLECULAR BIOLOGY | MUTANT HUNTINGTIN | GENETICS & HEREDITY | HEREDITARY OPTIC NEUROPATHY | TRANSCRIPTION FACTOR | NEURODEGENERATIVE DISEASES | TRANSGENIC MICE | Neurons - pathology | Neostriatum - ultrastructure | Microtubule-Associated Proteins - metabolism | Humans | Huntington Disease - pathology | Electron Transport Complex IV - analysis | Gene Expression Profiling | DNA-Binding Proteins - metabolism | Calbindins | Mitochondrial Membrane Transport Proteins | DNA, Mitochondrial - genetics | Mitochondria - genetics | Mitochondrial Proteins - metabolism | Membrane Potential, Mitochondrial | Polymerase Chain Reaction | Membrane Transport Proteins - metabolism | Neostriatum - metabolism | Nuclear Proteins - genetics | S100 Calcium Binding Protein G - analysis | Gene Expression | Superoxide Dismutase - analysis | DNA, Mitochondrial - metabolism | Neurons - chemistry | Cytochromes c - immunology | Mitochondria - metabolism | Cytochromes c - analysis | Mitochondria - pathology | Huntington Disease - metabolism | Nerve Tissue Proteins - genetics | Transcription Factors - metabolism | Huntingtin Protein | Superoxide Dismutase - immunology | GTP Phosphohydrolases - metabolism | Energy Metabolism | Fluorescent Antibody Technique | Peroxisome Proliferator-Activated Receptors - metabolism | Huntington Disease - genetics | Index Medicus
Journal Article
Molecular Neurobiology, ISSN 0893-7648, 10/2016, Volume 53, Issue 8, pp. 5782 - 5795
Clinical evidences showing zinc (Zn) accumulation in the post-mortem brain of Parkinson’s disease (PD) patients and experimental studies on rodents chronically... 
Neurology | Oxidative stress | Neurosciences | Biomedicine | Neurodegeneration | Neurobiology | Inflammation | Zinc | Cell Biology | Apoptosis | ACTIVATION | INDUCED PARKINSONS-DISEASE | ALPHA TNF-ALPHA | NEUROSCIENCES | NEURODEGENERATIVE DISEASES | CYTOCHROME-C | INHIBITION | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | MOUSE MODEL | IN-VIVO | Tumor Necrosis Factor-alpha - metabolism | Inflammation - pathology | Tyrosine 3-Monooxygenase - metabolism | Rats, Wistar | Substantia Nigra - pathology | Antigens, Nuclear - metabolism | Apoptosis - drug effects | Dopaminergic Neurons - pathology | bcl-X Protein - genetics | Nerve Degeneration - genetics | Apoptosis - genetics | Male | NF-kappa B - metabolism | RNA, Messenger - metabolism | Behavior, Animal | Proto-Oncogene Proteins c-bcl-2 - metabolism | Inflammation - metabolism | Interleukin-1beta - metabolism | Dopaminergic Neurons - metabolism | Lipid Peroxidation - drug effects | Apoptosis Regulatory Proteins - genetics | Dopamine - metabolism | Neostriatum - pathology | Cytochromes c - metabolism | RNA, Messenger - genetics | bcl-2-Associated X Protein - metabolism | Metabolome | Mitochondria - metabolism | Mitochondria - drug effects | Nerve Degeneration - pathology | Apoptosis Regulatory Proteins - metabolism | Gene Expression Regulation - drug effects | Nerve Tissue Proteins - metabolism | Animals | Serotonin - metabolism | Oxidative Stress - drug effects | Zinc - pharmacology | bcl-X Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Tyrosine | Parkinson's disease | Corticosteroids | Neurons | Mitochondrial DNA | Superoxide | Sulfates | Cytochrome c | Zinc compounds | Metabolites | Interleukins | Physiological aspects | Lymphomas | Tumor proteins | Index Medicus
Journal Article
European Journal of Neuroscience, ISSN 0953-816X, 04/2017, Volume 45, Issue 7, pp. 922 - 931
Although certain drugs of abuse are known to disrupt brain glucose metabolism ( BG luM), the effects of opiates on BG luM are not well characterized. Moreover,... 
brain imaging | brain energy metabolism | opiate addition | drug self‐administration | drug self-administration | 2-DEOXYGLUCOSE | SMALL ANIMAL PET | NALOXONE | NEUROSCIENCES | ADDICTION | DEPENDENCE | POSITRON-EMISSION-TOMOGRAPHY | NUCLEUS | RECEPTORS | WITHDRAWAL | BRAIN | Anesthetics, Inhalation - pharmacology | Fluorodeoxyglucose F18 - pharmacokinetics | Radiopharmaceuticals - pharmacokinetics | Anesthetics, Inhalation - administration & dosage | Isoflurane - pharmacology | Morphine - pharmacology | Substance Withdrawal Syndrome - etiology | Anesthesia, Intravenous - adverse effects | Analgesics, Opioid - pharmacology | Rats | Isoflurane - adverse effects | Male | Anesthetics, Inhalation - adverse effects | Corpus Striatum - metabolism | Rats, Sprague-Dawley | Positron Emission Tomography Computed Tomography | Analgesics, Opioid - adverse effects | Animals | Analgesics, Opioid - administration & dosage | Corpus Striatum - drug effects | Corpus Striatum - diagnostic imaging | Morphine - administration & dosage | Morphine - adverse effects | Glucose metabolism | Brain research | PET imaging | Physiological aspects | Anesthesia | Morphine | Glucose | Dextrose | Cerebellum | Brain | Cortex (olfactory) | Drug abuse | Basal ganglia | Intravenous administration | Mesencephalon | Emission analysis | Stimulation | Opiates | Hypothalamus | Infusion | Computed tomography | Rodents | Neostriatum | Thalamus | Defecation | Jugular vein | Self-administration | Narcotics | Therapeutic applications | Positron emission | Injection | Metabolism | Isoflurane | Ganglia | Emissions control | Positron emission tomography | Hippocampus | Index Medicus
Journal Article
Neuroscience, ISSN 0306-4522, 2001, Volume 106, Issue 3, pp. 481 - 503
The metabotropic glutamate receptors (mGluRs) have distinct distribution patterns in the CNS but subtypes within group I or group III mGluRs share similar... 
corticostriatal fiber | electron microscopy | dentate gyrus | immunohistochemistry | pre-embedding immunogold | glutamatergic synapse | Immunohistochemistry | Dentate gyrus | Corticostriatal fiber | Electron microscopy | Glutamatergic synapse | Pre-embedding immunogold | PROTEIN-KINASE-A | MOLECULAR CHARACTERIZATION | CYCLIC-AMP FORMATION | BASAL GANGLIA | NEUROSCIENCES | GYRUS IN-VITRO | SIGNAL-TRANSDUCTION | RAT CEREBELLAR CORTEX | LONG-TERM DEPRESSION | CENTRAL-NERVOUS-SYSTEM | Central Nervous System - ultrastructure | Central Nervous System - metabolism | Neostriatum - ultrastructure | Spinal Cord - metabolism | Synaptic Transmission - physiology | Purkinje Cells - ultrastructure | gamma-Aminobutyric Acid - metabolism | Brain Stem - metabolism | Brain Stem - ultrastructure | Male | Dendrites - ultrastructure | Receptors, Metabotropic Glutamate - metabolism | Presynaptic Terminals - ultrastructure | Spinal Cord - ultrastructure | Cerebral Cortex - metabolism | Olfactory Pathways - ultrastructure | Cerebral Cortex - ultrastructure | Epithalamus - metabolism | Hippocampus - ultrastructure | Neostriatum - metabolism | Epithalamus - ultrastructure | Dendrites - metabolism | Olfactory Pathways - metabolism | Purkinje Cells - metabolism | Microscopy, Electron | Synaptic Membranes - ultrastructure | Ventral Thalamic Nuclei - ultrastructure | Hippocampus - metabolism | Animals | Presynaptic Terminals - metabolism | Glutamic Acid - metabolism | Mice | Mice, Inbred BALB C | Synaptic Membranes - metabolism | Ventral Thalamic Nuclei - metabolism | Index Medicus
Journal Article