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Clinical Ophthalmology, ISSN 1177-5483, 01/2019, Volume 13, pp. 1289 - 1295
Purpose: To review published evidence for a treatment interval extension to ≥12-weeks in neovascular macular degeneration treated with intravitreal... 
Macular degeneration | Studies | Clinical trials | Systematic review | Clinical medicine | Ophthalmology | Vascular endothelial growth factor | Drug dosages | Age | neovascular age-related macular degeneration | intravitreal anti-VEGF injections | proactive treatment | review | AMD | long-term outcome | treat-and-extend | Aflibercept
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2015, Volume 290, Issue 36, pp. 21773 - 21786
The development of dual targeting antibodies promises therapies with improved efficacy over mono-specific antibodies. Here, we engineered a Two-in-One... 
LIBRARIES | DISPLAY | DOMAIN | STRATEGY | VEGF | BIOCHEMISTRY & MOLECULAR BIOLOGY | MATURATION | BINDING | 2-IN-ONE ANTIBODY | ENDOTHELIAL GROWTH-FACTOR | CONFORMATIONS | Complementarity Determining Regions - genetics | Macular Degeneration - immunology | Protein Engineering - methods | Humans | Antibodies, Monoclonal - therapeutic use | Antibody Affinity - immunology | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Angiopoietin-2 - metabolism | Macular Degeneration - drug therapy | Feasibility Studies | Angiopoietin-2 - immunology | Antibody Specificity - immunology | Angiogenesis Inducing Agents - metabolism | Drug Design | Antibodies, Monoclonal - chemistry | Antibodies, Monoclonal - immunology | Molecular Targeted Therapy - methods | Protein Structure, Tertiary | Reproducibility of Results | Models, Molecular | Vascular Endothelial Growth Factor A - immunology | Protein Binding - immunology | Angiogenesis Inducing Agents - immunology | Macular Degeneration - metabolism | Complementarity Determining Regions - immunology | High-Throughput Nucleotide Sequencing | Immunoglobulin Fab Fragments - immunology | Kinetics | Mutation | Angiogenesis Inducing Agents - chemistry | Angiopoietin-2 - antagonists & inhibitors | Index Medicus | antibody engineering | angiopoietin2 (Ang2) | neovascular age-related macular degeneration | Protein Structure and Folding | dual specificity | cooperativity | drug discovery | deep mutational scanning | deep sequencing | crystal structure | vascular endothelial growth factor (VEGF)
Journal Article
Journal Article
Journal Article