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Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2015, Volume 112, Issue 39, pp. 12163 - 12168
Pathologic ocular neovascularization commonly causes blindness. It is critical to identify the factors altered in pathologically proliferating versus normally quiescent vessels to develop effective targeted therapeutics... 
MiR-150 | MicroRNA | Retinopathy | Neovascularization | Endothelial cells | B-CELL DEVELOPMENT | PROLIFERATIVE RETINOPATHY | endothelial cells | ANGIOGENESIS | OXYGEN-INDUCED RETINOPATHY | MULTIDISCIPLINARY SCIENCES | neovascularization | MOUSE | C-MYB | MODEL | HYPOXIA | retinopathy | microRNA | miR-150 | INDUCED CHOROIDAL NEOVASCULARIZATION | Intravitreal Injections | Humans | 3' Untranslated Regions - genetics | Laser Capture Microdissection | Molecular Sequence Data | MicroRNAs - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Retinal Neovascularization - metabolism | MicroRNAs - pharmacology | Luciferases | Base Sequence | HEK293 Cells | Retinal Vessels - cytology | Receptors, CXCR4 - genetics | Retinal Neovascularization - genetics | Membrane Proteins - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Retinal Vessels - metabolism | Endothelial Cells - metabolism | Membrane Proteins - genetics | MicroRNAs - administration & dosage | Frizzled Receptors - metabolism | Mice, Knockout | Receptors, CXCR4 - metabolism | Gene Expression Regulation - drug effects | Cell Movement - drug effects | Animals | Choroidal Neovascularization - metabolism | Frizzled Receptors - genetics | Cell Proliferation - drug effects | Mice | MicroRNAs - genetics | Choroidal Neovascularization - genetics | Physiological aspects | Genetic aspects | Blindness | Biological Sciences
Journal Article
PloS one, ISSN 1932-6203, 01/2017, Volume 12, Issue 1, p. e0168550
Background We previously reported improved pathologic complete response (pCR) in a prospective phase II study using neoadjuvant bevacizumab in combination... 
MULTIDISCIPLINARY SCIENCES | Bevacizumab - therapeutic use | Prospective Studies | Angiopoietin-2 - genetics | Humans | Middle Aged | Male | Vascular Endothelial Growth Factor A - genetics | Ethnic Groups | Matrix Metalloproteinase 9 - genetics | Observational Studies as Topic | Adult | Female | Neoadjuvant Therapy | Breast Neoplasms - ethnology | Gene Frequency | Genotype | Treatment Outcome | Breast Neoplasms - drug therapy | Receptor, TIE-2 - genetics | Angiopoietin-1 - genetics | Regression Analysis | Breast Neoplasms - genetics | Fibroblast Growth Factor 2 - genetics | Neovascularization, Pathologic - genetics | Aged | Polymorphism, Single Nucleotide | Clinical Trials, Phase II as Topic | Care and treatment | Drug metabolism | Development and progression | Genetic aspects | Breast cancer | Single nucleotide polymorphisms | Health aspects | Fibroblast growth factor | Genetic variability | Angiopoietin | Genes | Oncology | Systematic review | Single-nucleotide polymorphism | Metastasis | Matrix metalloproteinase | Cancer therapies | Bevacizumab | Angiogenesis | Regression models | Race | Metalloproteinase | Vascular endothelial growth factor | Protein-tyrosine kinase | Genotypes | Deoxyribonucleic acid--DNA | Fibroblast growth factor 2 | Tyrosine | Hematology | Heredity | FDA approval | Regression analysis | Patients | Survival | Gelatinase B | Polymerase chain reaction | Studies | Genetic variance | Chemotherapy | Genotyping | Gene frequency | Biomarkers | Cancer | Deoxyribonucleic acid | DNA
Journal Article
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 2016, Volume 150, Issue 4, pp. 982 - 997.e30
.... In a search for ways to inhibit pathologic production or activities of VEGF without affecting its normal production or functions, we investigated the post-transcriptional regulation of VEGF... 
Gastroenterology and Hepatology | Alternative RNA Processing | Portal Hypertension | Cytoplasmic Polyadenylation | CPEB | CELLS | RECRUITMENT | VEGF | P110-ALPHA ISOFORM | TRANSLATIONAL CONTROL | MESSENGER-RNA | SIGNALING PATHWAY | GENE-EXPRESSION | MICE | GASTROENTEROLOGY & HEPATOLOGY | PORTAL-HYPERTENSION | Hypertension, Portal - genetics | RNA-Binding Proteins - genetics | mRNA Cleavage and Polyadenylation Factors - metabolism | Humans | Middle Aged | Transcription Factors - deficiency | Neovascularization, Pathologic | Male | Vascular Endothelial Growth Factor A - metabolism | Mice, 129 Strain | RNA, Messenger - metabolism | mRNA Cleavage and Polyadenylation Factors - deficiency | Case-Control Studies | Transfection | RNA Interference | Time Factors | Liver Cirrhosis - metabolism | Adult | Female | 3' Untranslated Regions | mRNA Cleavage and Polyadenylation Factors - genetics | Disease Models, Animal | Cell Line | Signal Transduction | Hypertension, Portal - pathology | Mice, Inbred C57BL | RNA, Messenger - genetics | Gene Expression Regulation | Liver Cirrhosis, Biliary - pathology | Transcription Factors - genetics | Liver Cirrhosis, Biliary - genetics | Rats, Sprague-Dawley | Transcription Factors - metabolism | Animals | Liver Cirrhosis - virology | Hypertension, Portal - metabolism | Polyadenylation | Liver Cirrhosis - pathology | Chronic Disease | Liver Cirrhosis, Biliary - metabolism | RNA-Binding Proteins - metabolism | Hypertension | Liver diseases | Genetic research | Research institutes | Binding proteins | Vascular endothelial growth factor | Protein binding
Journal Article
Journal Article
Nature cell biology, ISSN 1476-4679, 2010, Volume 12, Issue 3, pp. 247 - 256
MicroRNAs (miRNAs) are increasingly implicated in regulating the malignant progression of cancer. Here we show that miR-9, which is upregulated in breast... 
ADHESION | STEM-CELLS | INVASION | N-MYC | C-MYC | TUMOR ANGIOGENESIS | HUMAN BREAST-CANCER | MESENCHYMAL TRANSITION | EXPRESSION | MAMMARY EPITHELIAL-CELLS | CELL BIOLOGY | Oncogene Proteins - genetics | RNA, Small Interfering - genetics | Protein Binding - genetics | Cell Proliferation | MicroRNAs - antagonists & inhibitors | Cadherins - metabolism | Gene Expression - genetics | Humans | 3' Untranslated Regions - genetics | Vascular Endothelial Growth Factor A - genetics | N-Myc Proto-Oncogene Protein | Cadherins - genetics | Oncogene Proteins - metabolism | Vascular Endothelial Growth Factor A - blood | Epithelial Cells - pathology | DNA - metabolism | Neuroblastoma - diagnosis | beta Catenin - metabolism | Down-Regulation - genetics | Cell Line, Tumor | Mice, Inbred NOD | Mice | Mice, Inbred BALB C | Neovascularization, Pathologic - metabolism | Neuroblastoma - metabolism | Proto-Oncogene Proteins c-myc - genetics | Histones - metabolism | MicroRNAs - physiology | Neoplasms - metabolism | Epithelial Cells - metabolism | Vimentin - metabolism | Lung Neoplasms - pathology | Breast Neoplasms - metabolism | Neovascularization, Pathologic - pathology | Neoplasms - blood | Transfection | Lung Neoplasms - secondary | Neoplasm Invasiveness - pathology | Female | Nuclear Proteins - genetics | Gene Expression Regulation, Neoplastic - physiology | Neuroblastoma - pathology | Cell Line | Neuroblastoma - genetics | Nuclear Proteins - metabolism | Gene Dosage | Mice, SCID | Proto-Oncogene Proteins c-myc - metabolism | beta Catenin - genetics | Neoplasm Metastasis - genetics | Animals | Breast Neoplasms - pathology | Neoplasm Metastasis - pathology | Signal Transduction - physiology | Transplantation, Heterologous - pathology | Neoplasm Invasiveness - genetics | Neoplasms - pathology | MicroRNA | Physiological aspects | Cadherins | Development and progression | Genetic aspects | Metastasis | Research | Oncogenes
Journal Article
Nature medicine, ISSN 1546-170X, 2008, Volume 14, Issue 4, pp. 448 - 453
Journal Article
Free radical biology & medicine, ISSN 0891-5849, 2010, Volume 49, Issue 11, pp. 1603 - 1616
Extensive research during the past 2 decades has revealed the mechanism by which continued oxidative stress can lead to chronic inflammation, which in turn... 
Antioxidants | Oxidative stress | NF-κB | Free radicals | Pro-oxidants | Inflammation | Cancer | PROTEIN-KINASE-C | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | Pro oxidants | MATRIX-METALLOPROTEINASE EXPRESSION | BREAST-CANCER | TUMOR-NECROSIS-FACTOR | REACTIVE OXYGEN | PROSTATE-CANCER | ENDOCRINOLOGY & METABOLISM | HYDROGEN-PEROXIDE | NF-KAPPA-B | TRANSCRIPTION FACTOR | NF kappa B | Inflammation - pathology | Cell Proliferation | Neoplasms - etiology | Tumor Escape - genetics | Humans | Oxidative Stress - physiology | Neovascularization, Pathologic - etiology | Neovascularization, Pathologic - pathology | Inflammation - complications | Neoplasms - genetics | Cell Transformation, Neoplastic - genetics | Tumor Escape - immunology | Cell Survival - drug effects | Oxidative Stress - genetics | Neoplasms - blood supply | Drug Resistance, Neoplasm - immunology | Signal Transduction - genetics | Cell Survival - radiation effects | Cell Transformation, Neoplastic - metabolism | Inflammation - etiology | Drug Resistance, Neoplasm - genetics | Animals | Models, Biological | Inflammation - genetics | Neovascularization, Pathologic - genetics | Signal Transduction - physiology | Cell Transformation, Neoplastic - pathology | Neoplasms - pathology | Oxidases | Phosphatases | Sarcoma | Chronic diseases | Superoxide | Endothelium | Nitric oxide | Heme | Stem cells | Tumor proteins | Growth factors | Protein kinases | Mitogens | Anti-oxidants
Journal Article
Blood, ISSN 1528-0020, 2012, Volume 120, Issue 14, pp. 2925 - 2929
Inflammatory cytokines and growth factors drive angiogenesis independently; however, their integrated role in pathologic and physiologic angiogenesis is not fully understood... 
RETINAL NEOVASCULARIZATION | SUPPRESSOR | OXYGEN-INDUCED RETINOPATHY | ENDOTHELIAL-CELLS | GROWTH | RESISTANCE | HEMATOLOGY | EXPRESSION | BRAIN | Endothelium, Vascular - cytology | Tumor Necrosis Factor-alpha - metabolism | Cell Proliferation | TOR Serine-Threonine Kinases - metabolism | Tumor Necrosis Factor-alpha - genetics | Male | Insulin-Like Growth Factor I - genetics | Carcinoma, Lewis Lung - blood supply | Neovascularization, Pathologic - etiology | Melanoma, Experimental - prevention & control | TOR Serine-Threonine Kinases - genetics | Integrases - metabolism | Neovascularization, Pathologic - prevention & control | Real-Time Polymerase Chain Reaction | Paraneoplastic Syndromes, Ocular - prevention & control | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Paraneoplastic Syndromes, Ocular - pathology | Melanoma, Experimental - blood supply | Signal Transduction | Mice, Inbred C57BL | RNA, Messenger - genetics | Melanoma, Experimental - pathology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Carcinoma, Lewis Lung - prevention & control | Suppressor of Cytokine Signaling 3 Protein | Animals | Endothelium, Vascular - metabolism | Hypoxia - pathology | Carcinoma, Lewis Lung - pathology | Suppressor of Cytokine Signaling Proteins - physiology | Mice | Insulin-Like Growth Factor I - metabolism | Brief Report | Vascular Biology
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2008, Volume 105, Issue 32, pp. 11043 - 11049
Aminoacylation of transfer RNAs establishes the rules of the genetic code. The reactions are catalyzed by an ancient group of 20 enzymes... 
Enzymes | Nervous system diseases | Perspective | Cytokines | Amino acids | Autoimmune diseases | Genetic diseases | Genetic mutation | Transfer RNA | Cancer | Tumors | Multifunctional protein | AIMP | GENETIC-CODE AMBIGUITY | MARIE-TOOTH-DISEASE | multifunctional protein | INTERACTING MULTIFUNCTIONAL PROTEIN | RIBONUCLEIC-ACID SYNTHETASE | MULTIDISCIPLINARY SCIENCES | AMYOTROPHIC-LATERAL-SCLEROSIS | NONCANONICAL FUNCTION | TRANSLATIONAL CONTROL | SPINAL MUSCULAR-ATROPHY | INFLAMMATORY MYOFIBROBLASTIC TUMOR | SUPEROXIDE-DISMUTASE | Nervous System Diseases - enzymology | Metabolic Diseases - enzymology | Humans | Multienzyme Complexes - immunology | Metabolic Diseases - immunology | Multienzyme Complexes - metabolism | Nervous System Diseases - genetics | Autoimmune Diseases - genetics | Neovascularization, Pathologic - enzymology | Neoplasms - genetics | Neovascularization, Pathologic - immunology | Enzyme Stability - genetics | Amino Acyl-tRNA Synthetases - metabolism | Cytokines - genetics | Cytokines - immunology | Amino Acyl-tRNA Synthetases - genetics | Autoimmune Diseases - enzymology | Cytokines - metabolism | Autoimmune Diseases - immunology | Transfer RNA Aminoacylation - genetics | Neoplasms - enzymology | Multienzyme Complexes - genetics | Animals | Neoplasms - immunology | Metabolic Diseases - genetics | Neovascularization, Pathologic - genetics | Mutation | Nervous System Diseases - immunology | Evaluation | Biochemical genetics | Research | Aminoacyl-tRNA synthetases | Properties | Enzyme kinetics | Causes and theories of causation | Diseases
Journal Article