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1. Neovascular age-related macular degeneration: Potential therapies
by Chappelow, Aimee V and Kaiser, Peter K
Drugs (New York, N.Y.), ISSN 0012-6667, 2008, Volume 68, Issue 8, pp. 1029 - 1036
Sirolimus, therapeutic use | Age related macular degeneration, treatment | Ranibizumab, therapeutic use | Pazopanib, therapeutic use | Bevasiranib, therapeutic use | Vatalanib, therapeutic use | Research and development | TG 100801, therapeutic use | Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | RNA, Small Interfering - genetics | Sirolimus - therapeutic use | Serpins - genetics | Nerve Growth Factors - genetics | Protein Kinase Inhibitors - therapeutic use | Humans | Angiogenesis Inhibitors - therapeutic use | Nicotinic Antagonists - therapeutic use | Eye Proteins - genetics | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Vascular Endothelial Growth Factor A - genetics | Macular Degeneration - drug therapy
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2. Sigma receptors
: their role in disease and as therapeutic targets
by Smith, Sylvia B., editor and Su, Tsung-Ping, editor
2017, Advances in experimental medicine and biology, ISBN 3319501747, Volume 964., xiii, 312 pages
Neurodegenerative Diseases | Sigma receptors | drug therapy | agonists | physiology | Nervous system | Degeneration | Receptors, sigma
Book
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3. Full Text Systems pharmacology identifies drug targets for Stargardt disease-Associated retinal degeneration
by Chen, Yu and Palczewska, Grazyna and Mustafi, Debarshi and Golczak, Marcin and Dong, Zhiqian and Sawada, Osamu and Maeda, Tadao and Maeda, Akiko and Palczewski, Krzysztof
The Journal of clinical investigation, ISSN 0021-9738, 12/2013, Volume 123, Issue 12, pp. 5119 - 5134
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Receptors, Adrenergic, alpha-2 - genetics | Guanabenz - therapeutic use | Reactive Oxygen Species | Receptor, Serotonin, 5-HT2A - genetics | Doxazosin - pharmacology | Humans | Photoreceptor Cells, Vertebrate - drug effects | Adrenergic alpha-Antagonists - therapeutic use | Macaca fascicularis | Adrenergic alpha-Antagonists - pharmacology | Molecular Targeted Therapy | Photoreceptor Cells, Vertebrate - physiology | Macular Degeneration - drug therapy | Adenylyl Cyclase Inhibitors | Adrenergic alpha-Agonists - therapeutic use | Alcohol Oxidoreductases - genetics | ATP-Binding Cassette Transporters - deficiency | Photoreceptor Cells, Vertebrate - radiation effects | ATP-Binding Cassette Transporters - genetics | Adenine - therapeutic use | Doxazosin - therapeutic use | Nerve Tissue Proteins - biosynthesis | Receptors, Adrenergic, alpha-2 - biosynthesis | Drug Evaluation, Preclinical | Disease Models, Animal | Macular Degeneration - prevention & control | Receptor, Serotonin, 5-HT2A - biosynthesis | Adenine - analogs & derivatives | Signal Transduction | Cell Survival | Light - adverse effects | Serotonin Antagonists - therapeutic use | Receptors, G-Protein-Coupled - biosynthesis | Adenine - pharmacology | Serotonin Antagonists - pharmacology | Nerve Tissue Proteins - genetics | Mice, Knockout | Guanabenz - pharmacology | Animals | Macular Degeneration - congenital | Macular Degeneration - genetics | Adrenergic alpha-Agonists - pharmacology | Mice | Mice, Inbred BALB C | Receptors, G-Protein-Coupled - genetics | Photoreceptor Cells, Vertebrate - pathology | Alcohol Oxidoreductases - deficiency | Macular degeneration | Retinal degeneration | Research | Studies | Pathology | Signal transduction | Disease | Genes | Retina | Photoreceptors | Pharmacology | Index Medicus | Abridged Index Medicus
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4. Full Text Axon degeneration: mechanistic insights lead to therapeutic opportunities for the prevention and treatment of peripheral neuropathy
by DiAntonio, Aaron
Pain (Amsterdam), ISSN 0304-3959, 05/2019, Volume 160, Issue Suppl 1, pp. S17 - S22
Neurosciences | Clinical Neurology | Anesthesiology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Neurodegenerative Diseases - pathology | Cytoskeletal Proteins - antagonists & inhibitors | Humans | Enzyme Inhibitors - pharmacology | Axons - drug effects | Axons - metabolism | Neurodegenerative Diseases - metabolism | Neurodegenerative Diseases - drug therapy | Enzyme Inhibitors - therapeutic use | Nerve Degeneration - metabolism | Nerve Degeneration - pathology | Peripheral Nervous System Diseases - metabolism | Animals | Axons - pathology | Armadillo Domain Proteins - metabolism | Armadillo Domain Proteins - antagonists & inhibitors | Cytoskeletal Proteins - metabolism | Peripheral Nervous System Diseases - pathology | Nerve Degeneration - drug therapy | Peripheral Nervous System Diseases - drug therapy | Index Medicus | NAD | NMNAT2 | Sarmoptosis | DLK kinase | PHR1 ligase
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5. Full Text Developmental axon pruning mediated by BDNF-p75NTR-dependent axon degeneration
by Park, Katya J and Miller, Freda D and Hong, Elizabeth J and Greenberg, Michael E and Kramer, Bianca M and Kaplan, David R and Singh, Karun K
Nature neuroscience, ISSN 1097-6256, 06/2008, Volume 11, Issue 6, pp. 649 - 658
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Axotomy - methods | Nerve Degeneration - physiopathology | Visual Pathways - metabolism | Nerve Degeneration - genetics | Neurons - cytology | Axons - physiology | Green Fluorescent Proteins - genetics | Receptor, Nerve Growth Factor - deficiency | Dose-Response Relationship, Drug | Brain-Derived Neurotrophic Factor - pharmacology | Drug Interactions | Brain-Derived Neurotrophic Factor - physiology | Potassium Chloride - pharmacology | Gene Expression Regulation, Developmental - physiology | Animals, Newborn | Stilbamidines - metabolism | Superior Cervical Ganglion - growth & development | Cholera Toxin - metabolism | Visual Pathways - growth & development | Mice, Inbred C57BL | Cells, Cultured | Enzyme Inhibitors - pharmacology | Gene Expression Regulation, Developmental - drug effects | Receptor, Nerve Growth Factor - physiology | Axons - drug effects | Nerve Growth Factor - pharmacology | Rats | Mice, Transgenic | Superior Cervical Ganglion - cytology | Rats, Sprague-Dawley | Animals | Green Fluorescent Proteins - biosynthesis | Mice | Nerve Degeneration - drug therapy | Brain-derived neurotrophic factor | Physiological aspects | Nervous system | Degeneration | Research | Growth factor receptors | Risk factors | Index Medicus
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6. Full Text Multi-facetted impulsivity following nigral degeneration and dopamine replacement therapy
by Engeln, Michel and Ansquer, Solène and Dugast, Emilie and Bezard, Erwan and Belin, David and Fernagut, Pierre-Olivier
Neuropharmacology, ISSN 0028-3908, 10/2016, Volume 109, pp. 69 - 77
Impulsivity | Substantia nigra | Parkinson | Alpha-synuclein | Pramipexole | Pharmacology & Pharmacy | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Dopamine Agonists - pharmacology | Substantia Nigra - pathology | Dopaminergic Neurons - pathology | Dopamine Agonists - therapeutic use | Impulsive Behavior - drug effects | Conditioning, Operant - physiology | Rats | Male | Parkinson Disease - drug therapy | Substantia Nigra - metabolism | Rats, Sprague-Dawley | Nerve Degeneration - chemically induced | Nerve Degeneration - metabolism | Nerve Degeneration - pathology | Substantia Nigra - drug effects | Animals | Conditioning, Operant - drug effects | Dopaminergic Neurons - metabolism | Dopamine Agonists - toxicity | Dopaminergic Neurons - drug effects | Parkinson Disease - metabolism | Impulsive Behavior - physiology | Dopamine - metabolism | Phenols | Physiological aspects | Index Medicus
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7. Full Text Functional Self-Assembling Peptide Nanofiber Hydrogels Designed for Nerve Degeneration
by Sun, Yuqiao and Li, Wen and Wu, Xiaoli and Zhang, Na and Zhang, Yongnu and Ouyang, Songying and Song, Xiyong and Fang, Xinyu and Seeram, Ramakrishna and Xue, Wei and He, Liumin and Wu, Wutian
ACS applied materials & interfaces, ISSN 1944-8244, 01/2016, Volume 8, Issue 3, pp. 2348 - 2359
3D cell culture | nerve regeneration | self-assembling peptides | hydrogel | nanofiber | Science & Technology - Other Topics | Materials Science | Nanoscience & Nanotechnology | Technology | Materials Science, Multidisciplinary | Science & Technology | Molecular Sequence Data | Myelin Sheath - drug effects | Neural Stem Cells - cytology | Spectroscopy, Fourier Transform Infrared | Myelin Sheath - metabolism | Microscopy, Atomic Force | Circular Dichroism | Disease Models, Animal | Nanofibers - chemistry | Amino Acid Sequence | Cell Survival - drug effects | Green Fluorescent Proteins - metabolism | Nanofibers - ultrastructure | Peptides - chemistry | Protein Structure, Secondary | Rats, Transgenic | Neural Stem Cells - drug effects | Axons - drug effects | Models, Molecular | Rats, Sprague-Dawley | Peptides - pharmacology | Animals | Axons - pathology | Mice | Hydrogels - chemistry | Nerve Degeneration - drug therapy | Peptides - therapeutic use | Hydrogen-Ion Concentration | Index Medicus
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8. Full Text Degeneration and Regeneration of Subbasal Corneal Nerves after Infectious Keratitis: A Longitudinal in Vivo Confocal Microscopy Study
by Müller, Rodrigo T and Abedi, Farshad and Cruzat, Andrea and Witkin, Deborah and Baniasadi, Neda and Cavalcanti, Bernardo M and Jamali, Arsia and Chodosh, James and Dana, Reza and Pavan-Langston, Deborah and Hamrah, Pedram
Ophthalmology (Rochester, Minn.), ISSN 0161-6420, 03/2015, Volume 122, Issue 11, pp. 2200 - 2209
Life Sciences & Biomedicine | Ophthalmology | Science & Technology | Single-Blind Method | Prospective Studies | Follow-Up Studies | Humans | Middle Aged | Nerve Regeneration - physiology | Eye Infections - drug therapy | Male | Eye Infections - microbiology | Case-Control Studies | Anti-Bacterial Agents - therapeutic use | Corneal Ulcer - pathology | Eye Infections - parasitology | Adult | Corneal Ulcer - microbiology | Female | Trigeminal Nerve Diseases - pathology | Corneal Ulcer - parasitology | Eye Infections - pathology | Trigeminal Nerve - pathology | Nerve Degeneration - pathology | Corneal Ulcer - drug therapy | Microscopy, Confocal | Trigeminal Nerve - physiology | Cornea - innervation | Antiprotozoal Agents - therapeutic use | Physiological aspects | Keratitis | Microscope and microscopy | Analysis | Index Medicus
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9. Full Text Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury
by Wang, Haichen and Lynch, John R and Song, Pingping and Yang, Hyuk-Jun and Yates, Robert B and Mace, Brian and Warner, David S and Guyton, John R and Laskowitz, Daniel T
Experimental neurology, ISSN 0014-4886, 2007, Volume 206, Issue 1, pp. 59 - 69
Interleukin 6 | TNFα | Traumatic brain injury | Cerebral blood flow | Simvastatin | Nitric oxide | Atorvastatin | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Injuries of the nervous system and the skull. Diseases due to physical agents | Neurology | Biological and medical sciences | Medical sciences | Traumas. Diseases due to physical agents | Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases | Cerebrovascular Circulation - physiology | Recovery of Function - drug effects | Male | Brain Injuries - physiopathology | RNA, Messenger - metabolism | Simvastatin - pharmacology | Chemotaxis, Leukocyte - physiology | Encephalitis - physiopathology | Chemotaxis, Leukocyte - drug effects | Anti-Inflammatory Agents - therapeutic use | Recovery of Function - physiology | Neurons - metabolism | Cytokines - genetics | Heptanoic Acids - pharmacology | Disease Models, Animal | Brain Edema - etiology | Anti-Inflammatory Agents - pharmacology | Endothelial Cells - metabolism | Brain Ischemia - physiopathology | Hippocampus - pathology | Cognition Disorders - drug therapy | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Brain Edema - physiopathology | Brain Ischemia - drug therapy | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Mice | Nerve Degeneration - etiology | Hippocampus - physiopathology | Encephalitis - etiology | Simvastatin - therapeutic use | Brain Injuries - drug therapy | Heptanoic Acids - therapeutic use | Nerve Degeneration - physiopathology | Hippocampus - drug effects | Encephalitis - drug therapy | Cognition Disorders - etiology | Neurons - drug effects | Pyrroles - therapeutic use | RNA, Messenger - drug effects | Cognition Disorders - physiopathology | Cerebrovascular Circulation - drug effects | Mice, Inbred C57BL | Treatment Outcome | Brain Ischemia - etiology | Atorvastatin Calcium | Pyrroles - pharmacology | Animals | Brain Edema - drug therapy | Brain Injuries - pathology | Nerve Degeneration - drug therapy | Endothelial Cells - drug effects | Physiological aspects | Brain | Injuries | Blood flow | Index Medicus
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10. Full Text Progesterone neuroprotection in traumatic CNS injury and motoneuron degeneration
by De Nicola, Alejandro F and Labombarda, Florencia and Deniselle, Maria Claudia Gonzalez and Gonzalez, Susana L and Garay, Laura and Meyer, Maria and Gargiulo, Gisella and Guennoun, Rachida and Schumacher, Michael
Frontiers in neuroendocrinology, ISSN 0091-3022, 2009, Volume 30, Issue 2, pp. 173 - 187
Endocrinology & Metabolism | Myelination | Spinal cord | Wobbler mouse | Neurodegeneration | Oligodendrocytes | Neuroactive steroid | Progesterone | Brain injury | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Neuroprotective Agents - therapeutic use | Oligodendroglia - metabolism | Trauma, Nervous System - drug therapy | Trauma, Nervous System - pathology | Spinal Cord Injuries - drug therapy | Brain Injuries - drug therapy | Humans | Nerve Degeneration - physiopathology | Brain Injuries - physiopathology | Mice, Neurologic Mutants | Motor Neurons - pathology | Myelin Sheath - metabolism | Receptors, Progesterone - metabolism | Spinal Cord Injuries - pathology | Neuroprotective Agents - pharmacology | Oligodendroglia - drug effects | Motor Neurons - cytology | Brain-Derived Neurotrophic Factor - metabolism | Oligodendroglia - cytology | Motor Neurons - drug effects | Disease Models, Animal | Clinical Trials as Topic | Nerve Degeneration - pathology | Motor Neurons - metabolism | Trauma, Nervous System - physiopathology | Animals | Sex Factors | Mice | Spinal Cord Injuries - physiopathology | Brain Injuries - pathology | Nerve Degeneration - drug therapy | Brain | Messenger RNA | Metabolites | Physiological aspects | Peptide hormones | Growth factors | Injuries | Index Medicus
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