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Nature Cell Biology, ISSN 1465-7392, 03/2007, Volume 9, Issue 3, pp. 324 - 330
The mitogen-activated protein kinase (MAPK) network is a conserved signalling module that regulates cell fate by transducing a myriad of growth-factor signals.... 
ACTIVATION | PROTEIN | SPECIFICITY | PHOSPHORYLATION | DYNAMICS | RAF-1 | CASCADE | IDENTIFICATION | SIGNAL-REGULATED KINASE | TRANSIENT | CELL BIOLOGY | RNA, Small Interfering - genetics | MAP Kinase Signaling System - physiology | Tetradecanoylphorbol Acetate - pharmacology | Receptor, trkA - antagonists & inhibitors | Extracellular Signal-Regulated MAP Kinases - metabolism | PC12 Cells | MAP Kinase Kinase 1 - genetics | Flow Cytometry | Mitogen-Activated Protein Kinase 1 - genetics | Phosphorylation - drug effects | Cell Differentiation - physiology | Proto-Oncogene Proteins B-raf - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Proto-Oncogene Proteins c-raf - genetics | Nerve Growth Factor - pharmacology | Rats | MAP Kinase Kinase 1 - metabolism | Protein Kinase C - antagonists & inhibitors | Proto-Oncogene Proteins c-raf - metabolism | Animals | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Cell Differentiation - drug effects | Intercellular Signaling Peptides and Proteins - pharmacology | Models, Biological | Proto-Oncogene Proteins B-raf - genetics | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Epidermal Growth Factor - pharmacology | Cell Cycle - drug effects | Monte Carlo Method | Mitogen-Activated Protein Kinase 1 - metabolism | Cell proliferation | Evaluation | Pheochromocytoma | Physiological aspects | Cell differentiation | Properties | Protein kinases | Growth factors
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2004, Volume 101, Issue 47, pp. 16489 - 16494
Journal Article
Pharmacological research, ISSN 1043-6618, 04/2019, p. 104240
The pharmacology of Nerve Growth Factor (NGF) and the discovery and development of tanezumab, a monoclonal anti-NGF antibody for the treatment of pain... 
Journal Article
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 01/2010, Volume 30, Issue 3, pp. 1166 - 1175
We report that rapamycin, an allosteric inhibitor of certain but not all actions of the key cellular kinase mammalian target of rapamycin ( mTOR), protects... 
MAMMALIAN TARGET | ACTIVATION | CELLULAR-MODELS | GENE-EXPRESSION | NIGRAL NEURONS | AKT | AUTOPHAGY | IMMUNOPHILIN LIGANDS | NEUROSCIENCES | MTOR | NERVE GROWTH-FACTOR | Neuroprotective Agents - therapeutic use | Tyrosine 3-Monooxygenase - metabolism | Humans | Male | Green Fluorescent Proteins - genetics | Intracellular Signaling Peptides and Proteins - metabolism | PC12 Cells | Dose-Response Relationship, Drug | Transfection - methods | Time Factors | Transcription Factors - pharmacology | Cell Death - drug effects | Neurons - drug effects | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology | Sirolimus - therapeutic use | Drug Administration Schedule | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Nerve Growth Factor - pharmacology | Rats | Transcription Factors - antagonists & inhibitors | Parkinsonian Disorders - chemically induced | Transcription Factors - genetics | Serine - metabolism | Cycloheximide - pharmacology | Gene Expression Regulation - drug effects | Parkinson Disease | Transcription Factors - metabolism | Oxidopamine - toxicity | Animals | Analysis of Variance | Parkinsonian Disorders - pathology | Mice | Parkinsonian Disorders - prevention & control | TOR Serine-Threonine Kinases
Journal Article
Science, ISSN 0036-8075, 11/2001, Volume 294, Issue 5548, pp. 1945 - 1948
Neurotrophins are growth factors that promote cell survival, differentiation, and cell death. They are synthesized as proforms that can be cleaved... 
Hair | Receptors | Odors | HEK293 cells | Neurons | Antibodies | Ligands | Reports | PC12 cells | Endothelial cells | Apoptosis | APOPTOSIS | COEXPRESSION | NEUROTROPHIC FACTOR | BIOSYNTHESIS | MULTIDISCIPLINARY SCIENCES | RECEPTOR | DEATH | EXPRESSION | BINDING | SMOOTH-MUSCLE CELLS | NERVE GROWTH-FACTOR | Nerve Growth Factor - secretion | Brain-Derived Neurotrophic Factor - secretion | Apoptosis - drug effects | Protein Precursors - chemistry | Humans | Protein Precursors - secretion | Neurons - cytology | Nerve Growth Factors - metabolism | Receptors, Nerve Growth Factor - metabolism | Nerve Growth Factors - pharmacology | Brain-Derived Neurotrophic Factor - pharmacology | Nerve Growth Factor - chemistry | Inhibitory Concentration 50 | Furin | Brain-Derived Neurotrophic Factor - metabolism | Subtilisins - metabolism | Cell Death - drug effects | Phosphorylation - drug effects | Neurons - drug effects | Fibrinolysin - metabolism | Cell Line | Cell Survival - drug effects | Nerve Growth Factor - metabolism | Nerve Growth Factors - secretion | Nerve Growth Factor - pharmacology | Rats | Nerve Growth Factors - chemistry | Receptor, Nerve Growth Factor | Protein Precursors - metabolism | Protein Precursors - pharmacology | Brain-Derived Neurotrophic Factor - chemistry | Animals | Receptor, trkA - metabolism | Cell Differentiation - drug effects | Mice | Protein Processing, Post-Translational | Matrix Metalloproteinases - metabolism | Growth factors | Neurotropin | Research | Brain | Nervous system | Cellular biology | Cells
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2014, Volume 9, Issue 12, p. e113798
We have investigated the effects of light-emitting diode (LED)-induced phototoxicity (LIP) on cone-photoreceptors and their protection with brimonidine (BMD),... 
RETINAL GANGLION-CELLS | EPITHELIUM-DERIVED FACTOR | OPTICAL COHERENCE TOMOGRAPHY | MULTIDISCIPLINARY SCIENCES | RAT RETINA | ADULT ALBINO | FIBROBLAST-GROWTH-FACTOR | CILIARY NEUROTROPHIC FACTOR | PIGMENT-EPITHELIUM | SPATIAL-DISTRIBUTION | ALBINO SWISS MICE | Retinal Cone Photoreceptor Cells - radiation effects | Cell Survival - drug effects | Tomography, Optical Coherence | Light - adverse effects | Fibroblast Growth Factor 2 - pharmacology | Electronics | Brimonidine Tartrate | Cell Survival - radiation effects | Rats, Sprague-Dawley | Serpins - pharmacology | Nerve Growth Factors - pharmacology | Quinoxalines - pharmacology | Brain-Derived Neurotrophic Factor - pharmacology | Animals | Neuroprotective Agents - pharmacology | Time Factors | Retinal Cone Photoreceptor Cells - pathology | Retinal Cone Photoreceptor Cells - drug effects | Female | Disease Models, Animal | Eye Proteins - pharmacology | Circuit components | Brimonidine | Fibroblast growth factors | Ciliary neurotrophic factor | Light-emitting diodes | Neuroprotection | Brain | Fibroblast growth factor | Cornea | Pigment ePithelium-derived factor | Dark adaptation | Retina | Rods | Neurodegeneration | Circularity | Degeneration | Light emitting | Stains | Cross sections | Fibroblast growth factor 2 | Photoreception | Light emitting diodes | Epithelium | Light effects | Brain-derived neurotrophic factor | Optical Coherence Tomography | Cones | Phototoxicity | Retinal degeneration | Photoreceptors | Bone mineral density
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 03/2011, Volume 150, Issue 2, pp. 157 - 163
Growth factors are potent molecules that regulate cell functions including survival, self renewal, differentiation and proliferation. High-efficacy delivery of... 
Delivery vehicle | Self assembly | Heparin | Growth factors | Controlled release | MATRIX | GLYCOSAMINOGLYCANS | TISSUE | CHEMISTRY, MULTIDISCIPLINARY | DELIVERY-SYSTEM | AFFINITY | POLYSACCHARIDES | DEGRADATION | PHARMACOLOGY & PHARMACY | HEPARAN-SULFATE | PROTEINS | BINDING | Fibroblast Growth Factor 2 - chemistry | Humans | Fibroblast Growth Factor 2 - pharmacology | Intercellular Signaling Peptides and Proteins - chemistry | Polyethylenes - chemical synthesis | Biological Availability | Neurons - cytology | PC12 Cells | Azo Compounds - chemistry | Methylene Blue - analogs & derivatives | Nerve Growth Factor - administration & dosage | Intercellular Signaling Peptides and Proteins - pharmacokinetics | Nerve Growth Factor - chemistry | Light | Scattering, Radiation | Intercellular Signaling Peptides and Proteins - administration & dosage | Polyethylenes - chemistry | Microscopy, Electron, Scanning | Polyamines - chemistry | Epoxy Resins - chemistry | Cells, Cultured | Nerve Growth Factor - pharmacology | Rats | Nerve Growth Factor - pharmacokinetics | Fibroblast Growth Factor 2 - administration & dosage | Static Electricity | Arginine - chemistry | Particle Size | Animals | Benzenesulfonates - chemistry | Cell Differentiation - drug effects | Endothelial Cells - cytology | Intercellular Signaling Peptides and Proteins - pharmacology | Fibroblast Growth Factor 2 - pharmacokinetics | Cell Proliferation - drug effects | Aspartic Acid - chemistry | Drug Delivery Systems - methods | Methylene Blue - chemistry | Heparin - chemistry | Endothelial Cells - drug effects | Polyamines - chemical synthesis | Nerve growth factor | Fibroblast growth factors | Product enhancement
Journal Article
Nature Neuroscience, ISSN 1097-6256, 06/2008, Volume 11, Issue 6, pp. 649 - 658
The mechanisms that regulate the pruning of mammalian axons are just now being elucidated. Here, we describe a mechanism by which, during developmental... 
SURVIVAL | P75 NEUROTROPHIN RECEPTOR | TRKA | BDNF | WALLERIAN DEGENERATION | IN-VIVO | SYMPATHETIC NEURONS | TARGET INNERVATION | NEUROSCIENCES | NERVE GROWTH-FACTOR | RAT EYE | Axotomy - methods | Nerve Degeneration - physiopathology | Visual Pathways - metabolism | Nerve Degeneration - genetics | Neurons - cytology | Axons - physiology | Green Fluorescent Proteins - genetics | Receptor, Nerve Growth Factor - deficiency | Dose-Response Relationship, Drug | Brain-Derived Neurotrophic Factor - pharmacology | Drug Interactions | Brain-Derived Neurotrophic Factor - physiology | Potassium Chloride - pharmacology | Gene Expression Regulation, Developmental - physiology | Animals, Newborn | Stilbamidines - metabolism | Superior Cervical Ganglion - growth & development | Cholera Toxin - metabolism | Visual Pathways - growth & development | Mice, Inbred C57BL | Cells, Cultured | Enzyme Inhibitors - pharmacology | Gene Expression Regulation, Developmental - drug effects | Receptor, Nerve Growth Factor - physiology | Axons - drug effects | Nerve Growth Factor - pharmacology | Rats | Mice, Transgenic | Superior Cervical Ganglion - cytology | Rats, Sprague-Dawley | Animals | Green Fluorescent Proteins - biosynthesis | Mice | Nerve Degeneration - drug therapy | Brain-derived neurotrophic factor | Physiological aspects | Nervous system | Degeneration | Research | Growth factor receptors | Risk factors | Index Medicus
Journal Article
Journal Article