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The Oncologist, ISSN 1083-7159, 02/2014, Volume 19, Issue 2, pp. 193 - 201
Learning Objectives Explain the characteristics and treatment of malignant peripheral nerve sheath tumors, both in relation to neurofibromatosis type I and... 
Clinical trials | Molecular targeted therapy | Neurofibromatosis type 1 | Sarcoma | Malignant peripheral nerve sheath tumor | MAMMALIAN TARGET | NEUROFIBROMATOSIS TYPE-I | PHASE-II | SOFT-TISSUE | MPNST | GENE | ONCOLOGY | SARCOMA | NF1 | INHIBITOR | TYPE-1 | Animals | Nerve Sheath Neoplasms - therapy | Humans | Nerve Sheath Neoplasms - pathology | Nerve Sheath Neoplasms - diagnosis | Sarcomas
Journal Article
Annals of Surgical Oncology, ISSN 1068-9265, 3/2012, Volume 19, Issue 3, pp. 878 - 885
Journal Article
Journal Article
Cancer Discovery, ISSN 2159-8274, 2014, Volume 4, Issue 9, pp. 1062 - 1073
Journal Article
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2012, Volume 82, Issue 2, pp. 773 - 778
Purpose To evaluate the effectiveness of fractionated stereotactic radiotherapy (SFRT) in the treatment of optic nerve sheath meningioma (ONSM). Methods and... 
Radiology | Hematology, Oncology and Palliative Medicine | Optic nerve sheath meningioma | Radiotherapy | MANAGEMENT | EFFICACY | RESECTED MENINGIOMAS | RADIOSURGERY | RADIATION-THERAPY | IRRADIATION | ONCOLOGY | BENIGN | CONFORMAL RADIOTHERAPY | RETINOPATHY | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Pituitary Function Tests | Visual Acuity - radiation effects | Humans | Middle Aged | Male | Young Adult | Radiotherapy, Adjuvant - adverse effects | Aged, 80 and over | Adult | Dose Fractionation | Female | Remission Induction - methods | Retrospective Studies | Ocular Motility Disorders - radiotherapy | Ocular Motility Disorders - etiology | Meningioma - surgery | Optic Nerve Neoplasms - surgery | Tumor Burden | Disease Progression | Meningioma - pathology | Optic Nerve Neoplasms - pathology | Meningeal Neoplasms - surgery | Radiotherapy, Adjuvant - methods | Adolescent | Radiotherapy, Conformal - adverse effects | Aged | Meningeal Neoplasms - radiotherapy | Meningioma - radiotherapy | Meningeal Neoplasms - pathology | Optic Nerve Neoplasms - radiotherapy | Radiotherapy, Conformal - methods | Vision Disorders - etiology | Care and treatment | Nuclear radiation | Meningioma | Sects | Ophthalmology | PATIENTS | EYES | NEOPLASMS | RADIOLOGY AND NUCLEAR MEDICINE | PITUITARY GLAND | RADIATION DOSES | RADIOTHERAPY | SIDE EFFECTS | CONTROL
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 514, Issue 7521, pp. 247 - 251
The polycomb repressive complex 2 (PRC2) exerts oncogenic effects in many tumour types(1). However, loss-of-function mutations in PRC2 components occur in a... 
SUPPRESSOR | GENE | MULTIDISCIPLINARY SCIENCES | MICE | NF1 MICRODELETION PATIENTS | MUTATIONS | BET BROMODOMAIN INHIBITION | CANCER | TUMORS | NEUROFIBROMATOSIS TYPE-1 | EZH2 | Chromatin - metabolism | Transcription, Genetic - drug effects | Polycomb Repressive Complex 2 - genetics | Humans | Transcription Factors - deficiency | ras Proteins - metabolism | Neurofibromin 1 - deficiency | Glioma - genetics | Neoplasms - genetics | Melanoma - genetics | Tumor Suppressor Proteins - deficiency | Glioma - pathology | Nerve Sheath Neoplasms - pathology | Nuclear Proteins - deficiency | Tumor Suppressor Proteins - genetics | Epigenesis, Genetic - drug effects | Cell Death - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Nuclear Proteins - genetics | Chromatin - drug effects | Nerve Sheath Neoplasms - drug therapy | Disease Models, Animal | Triazoles - therapeutic use | Nerve Sheath Neoplasms - genetics | Tumor Suppressor Proteins - metabolism | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | ras Proteins - antagonists & inhibitors | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Melanoma - pathology | Transcription Factors - genetics | Azepines - therapeutic use | Neoplasms - drug therapy | Azepines - pharmacology | Transcription Factors - metabolism | Triazoles - pharmacology | Animals | Polycomb Repressive Complex 2 - deficiency | Melanoma - drug therapy | Nuclear Proteins - antagonists & inhibitors | Mice | Neoplasms - pathology | Polycomb Repressive Complex 2 - metabolism | Chromatin - genetics | Neurofibromin 1 - genetics | Glioma - drug therapy | Epigenetic inheritance | Ras genes | Genetic transcription | Research | Gliomas | Studies | Mutation | Genes | Tumors | Defects
Journal Article
Journal Article
Human Pathology, ISSN 0046-8177, 2015, Volume 50, pp. 15 - 23
Summary The glycosyltransferases chondroitin sulfate synthase 1 (CHSY1) and exostoses-like 3 (EXTL3) specifically function in biosynthesis of the glycans... 
Pathology | Heparan sulfate | Soft tissue sarcoma | Chondroitin sulfate | CHSY1 | EXTL3 | BIOSYNTHESIS | HEPARAN-SULFATE | PATHOLOGY | CELL | Immunohistochemistry | Nerve Sheath Neoplasms - mortality | Humans | Middle Aged | Fibrosarcoma - mortality | Fibroma - therapy | Liposarcoma, Myxoid - pathology | Male | Nerve Sheath Neoplasms - enzymology | Young Adult | Fibrosarcoma - pathology | Neoplasm Grading | Time Factors | N-Acetylgalactosaminyltransferases - genetics | Nerve Sheath Neoplasms - pathology | Aged, 80 and over | Adult | Female | Liposarcoma, Myxoid - enzymology | Fibroma - enzymology | Liposarcoma, Myxoid - genetics | Soft Tissue Neoplasms - enzymology | Child | Soft Tissue Neoplasms - genetics | Liposarcoma, Myxoid - mortality | Soft Tissue Neoplasms - therapy | Fibroma - mortality | Nerve Sheath Neoplasms - genetics | Soft Tissue Neoplasms - mortality | Biomarkers, Tumor - analysis | Kaplan-Meier Estimate | Proportional Hazards Models | Fibrosarcoma - therapy | Treatment Outcome | Fibroma - genetics | Fibroma - pathology | N-Acetylgalactosaminyltransferases - analysis | Fibrosarcoma - genetics | N-Acetylglucosaminyltransferases - analysis | Adolescent | Soft Tissue Neoplasms - pathology | Aged | Biomarkers, Tumor - genetics | Fibrosarcoma - enzymology | Neoplasm Staging | Nerve Sheath Neoplasms - therapy | Liposarcoma, Myxoid - therapy | Physiological aspects | Sarcoma | Sulfates | Transferases | Chondroitin | Biotechnology | Antigens | Enzymes | Immunoglobulins | Committees | Colorectal cancer | Multivariate analysis | Medical prognosis | Classification | Extracellular matrix | Tumors
Journal Article